Abstract:
:This study used a nested multiplex PCR method to detect three periodontal pathogens in subgingival plaque collected before treatment and at 2 and 6 months posttreatment from 107 patients with severe, generalized periodontitis. The proportions of the patients who harbored these bacteria before periodontal treatment were as follows: Tannerella forsythia, 81%; Porphyromonas gingivalis, 78%; and Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, 47%. At 2 months posttreatment there was a significant reduction in the numbers of patients harboring P. gingivalis (46%; P < 0.001) or T. forsythia (63%; P = 0.043) but not A. actinomycetemcomitans (50%) compared to pretreatment data. At 6 months posttreatment, significantly fewer patients harbored P. gingivalis (43%; P < 0.001); A. actinomycetemcomitans, (31%; P = 0.025), or T. forsythia (63%; P = 0.030). Interestingly, at baseline and at 2 months posttherapy, subjects who harbored only a single pathogen had a greater level of periodontal disease than subjects who harbored two, or all three, of these periodontal pathogens. These data suggest that a reduction in the number of species present may be associated with an increase in the severity of periodontal diseases.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Ready D,D'Aiuto F,Spratt DA,Suvan J,Tonetti MS,Wilson Mdoi
10.1128/JCM.01007-08subject
Has Abstractpub_date
2008-10-01 00:00:00pages
3380-3issue
10eissn
0095-1137issn
1098-660Xpii
JCM.01007-08journal_volume
46pub_type
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pub_type: 杂志文章
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journal_title:Journal of clinical microbiology
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journal_title:Journal of clinical microbiology
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of clinical microbiology
pub_type: 临床试验,杂志文章,多中心研究
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