The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery.

abstract：:The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of...

journal_title：Fundamental & clinical pharmacology

authors： Berdaï D,Demotes-Mainard F,Philip F,Vinçon G,Montels R,Necciari J,Bannwarth B

更新日期：1994-01-01 00:00:00

abstract：:We have studied the effects of neurotensin (NT) on the release of [3H]dopamine ([3H]DA) evoked by terminal depolarization with either K+, veratridine or 4-aminopyridine (4-AP). NT (1-1000 nM) induced a net potentiation (up to 170%) of the K+ (25 mM)-evoked release of [3H]DA. The capacity of NT to potentiate the effect...

journal_title：Fundamental & clinical pharmacology

authors： Boireau A,Miquet JM,Olivier V

更新日期：1993-01-01 00:00:00

abstract：:A method has been proposed for extracting numerical data when only graphical results are presented. Reports with both graphical and tabular data were identified and the graphs were electronically scanned. The coordinates of each point were read using the cross-hair facility of Adobe Photoshop 7.0. To improve the preci...

journal_title：Fundamental & clinical pharmacology

authors： de Oliveira IR,Santos-Jesus R,Po AL,Poolsup N

更新日期：2003-08-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

journal_title：Fundamental & clinical pharmacology

authors： Hellmich B,Gyermek L

更新日期：1997-01-01 00:00:00

abstract：:Adrenoceptors are involved in the control of the activity of the autonomic nervous system and especially the sympathetic nervous system. Activation of alpha 2-adrenoceptors decreases sympathetic tone whereas their blockade has an opposite effect. However, previous investigations have shown that yohimbine (a potent alp...

journal_title：Fundamental & clinical pharmacology

authors： Bagheri H,Chale JJ,Guyen LN,Tran MA,Berlan M,Montastruc JL

更新日期：1995-01-01 00:00:00

abstract：:During ischemia, large amounts of catecholamine are released to the myocardium from the sympathetic nerve endings in the heart. It has not been clearly shown whether the released catecholamine has detrimental or beneficial effects on postischemic myocardial contractile function. The aim of the present study was to inv...

journal_title：Fundamental & clinical pharmacology

authors： Ishiguro Y,Morgan JP

更新日期：2001-04-01 00:00:00

abstract：:Prenatal exposure to valproic acid (VPA) has been shown to increase the risk of autism in children. This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats. Pregnant albino rats administered VPA (500 mg/kg, i.p.) or normal saline (10 mL/kg, i.p.; vehicle-control) on gestational day...

journal_title：Fundamental & clinical pharmacology

authors： Ishola IO,Balogun AO,Adeyemi OO

更新日期：2020-12-01 00:00:00

abstract：:This study investigated the tolerability, safety, pharmacokinetics, and pharmacodynamics of ACT-178882, a new direct renin inhibitor, as well as its interaction with food and midazolam. Healthy male subjects received either single (10-1000 mg) or multiple doses (30-600 mg) administered once daily for 14 days of ACT-17...

journal_title：Fundamental & clinical pharmacology

authors： Dingemanse J,Nicolas L,Binkert C

更新日期：2013-12-01 00:00:00

abstract：:Chloroquine (CQ) induces histamine-independent itch in human and mice. We recently reported the role of intradermal nitric oxide (NO)/cyclic guanosine monophosphate pathway in CQ-evoked scratching in mice. Chloroquine stimulates neuronal nitric oxide synthase (nNOS) activity to over-producing NO in the skin. Sumatript...

journal_title：Fundamental & clinical pharmacology

authors： Haddadi NS,Ostadhadi S,Shakiba S,Afshari K,Rahimi N,Foroutan A,Dehpour AR

更新日期：2018-02-01 00:00:00

abstract：:We studied the effects of KATP channel blockers on [3H]GABA release in the absence of glucose in rat hippocampal slices. The omission of glucose induced a marked increase in the efflux of [3H]GABA, which was antagonized by TTX (1 microM), but not by MK 801 (1 microM) or DNQX (100 microM). Glibenclamide (10-100 microM)...

journal_title：Fundamental & clinical pharmacology

authors： Margaill I,Miquet JM,Doble A,Blanchard JC,Boireau A

更新日期：1992-01-01 00:00:00

abstract：:Paracetamol is an analgesic commonly used by people of all ages, which is well documented to cause severe hepatotoxicity with acute overexposures. The risk of hepatotoxicity from nonacute paracetamol exposures is less extensively studied, and this is the exposure most common in older adults. Evidence on the effectiven...

journal_title：Fundamental & clinical pharmacology

authors： Kane AE,Huizer-Pajkos A,Mach J,McKenzie C,Mitchell SJ,de Cabo R,Jones B,Cogger V,Le Couteur DG,Hilmer SN

更新日期：2016-06-01 00:00:00

abstract：:We determined the pharmacological and the antiemetic properties of SR 49059, a selective nonpeptide V(1a) receptor antagonist, on cisplatin-induced emesis in the piglet. Firstly, we clearly demonstrate that SR 49059 is a potent V(1a) receptor antagonist in vitro and in vivo in the piglet. In binding studies, [3H]-SR 4...

journal_title：Fundamental & clinical pharmacology

authors： Grélot L,Girod V,Dapzol J,Maffrand JP,Serradeil-Le Gal C

更新日期：2001-06-01 00:00:00

abstract：:Recent in vitro evidence suggests that T-type Ca(2+) channels are implicated in the mechanisms of ischemia-induced delayed neuronal cell death. The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca(2+) channel inhibitors, in an in vivo rat model of global ischemia. ...

journal_title：Fundamental & clinical pharmacology

authors： Bancila M,Copin JC,Daali Y,Schatlo B,Gasche Y,Bijlenga P

更新日期：2011-08-01 00:00:00

abstract：:The phylogenetically old renin-angiotensin-system (RAS) was originally described as a circulating hormonal system and a main cardiovascular regulator. However, there also exist 'local RASs' which are situated in cardiovascular as well as non-cardiovascular tissues where they are involved in physiological and patho-phy...

journal_title：Fundamental & clinical pharmacology

authors： Steckelings UM,Rompe F,Kaschina E,Unger T

更新日期：2009-12-01 00:00:00

abstract：:The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity. Seventy-five healthy adults were randomized to receive therapeutic oral d...

journal_title：Fundamental & clinical pharmacology

authors： Asimus S,Elsherbiny D,Hai TN,Jansson B,Huong NV,Petzold MG,Simonsson US,Ashton M

更新日期：2007-06-01 00:00:00

abstract：:The present study was designed to test whether tramadol is effective in the control of neuropathic pain in rats. Chronic constriction injury (CCI) of the sciatic nerve was induced over the left hind limb in male Sprague-Dawley rats. Identical surgery was performed on the opposite side except that the sciatic nerve was...

journal_title：Fundamental & clinical pharmacology

authors： Tsai YC,Sung YH,Chang PJ,Kang FC,Chu KS

更新日期：2000-07-01 00:00:00

abstract：:The present study investigated the effects of positive end-expiratory pressure (PEEP) on propofol concentrations in humans. Eleven patients undergoing elective surgery were enrolled in this study. Anesthesia was induced with propofol, then maintained using 60% nitrous oxide in oxygen, fentanyl 10-20 microg/kg and cont...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa E,Ito N,Ishizeki J,Goto F,Hiraoka H,Takizawa D

更新日期：2006-10-01 00:00:00

abstract：:The hypothesis of an interaction between trimetazidine and the immunosuppressive effect of cyclosporin A was investigated in two models: a) ex vivo, the lymphoproliferative response of normal human lymphocytes to phytohemagglutinin and a murine monoclonal antibody against the CD3 T-lymphocyte membrane complex; b) in v...

journal_title：Fundamental & clinical pharmacology

authors： Albengres E,Tillement JP,d'Athis P,Salducci D,Chauvet-Monges AM,Crevat A

更新日期：1996-01-01 00:00:00

abstract：:France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10-year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives...

journal_title：Fundamental & clinical pharmacology

authors： Caré W,Langrand J,Vodovar D,Deveaux M,Alvarez JC,Mégarbane B,Dorandeu F

更新日期：2020-08-01 00:00:00

abstract：:Adverse reactions to antipsychotic drugs (APs) have been attributed to oxidative stress. Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death. We examined the protective properties of SF against AP-induced oxidative stress in dopaminergic neuroblastoma cells. Human neuroblastoma SK-N...

journal_title：Fundamental & clinical pharmacology

authors： Mas S,Gassó P,Trias G,Bernardo M,Lafuente A

更新日期：2012-12-01 00:00:00

abstract：:The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...

journal_title：Fundamental & clinical pharmacology

authors： Ergün Y,Darendeli S,Imrek S,Kilinç M,Oksüz H

更新日期：2010-04-01 00:00:00

abstract：:We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effects against veratrine-contractures, in the absence of negative inotro...

journal_title：Fundamental & clinical pharmacology

authors： Le Grand B,Marty A,Talmant JM,John GW

更新日期：1996-01-01 00:00:00

abstract：:We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications. ...

journal_title：Fundamental & clinical pharmacology

authors： Uzzan B,Dumont-Fischer D,Lahlou N,Bihan H,Boissier MC,Alvarez JC,Perret GY,Cohen R

更新日期：2008-04-01 00:00:00

abstract：:Low temperatures may affect dose delivery efficacy and clinical effectiveness of medication aerosols. In this study we examine the effect of cold ambient temperature on the bronchodilatation produced by terbutaline delivered from a chlorofluorocarbon pressurized metered dose inhaler (pMDI) compared to a multi-dose dry...

journal_title：Fundamental & clinical pharmacology

authors： Ramón M,Juan G,Ciscar MA,Martí-Bonmatí E,Morcillo EJ,Marín J

更新日期：2000-03-01 00:00:00

abstract：:The H1-histaminergic agonists 2-pyridylethylamine (2-PEA) and 2-methylhistamine relaxed potassium-constricted, perfused, rabbit middle cerebral arteries at low concentrations (3 x 10(-11) to 3 x 10(-8) M) and constricted them at high concentrations (3 x 10(-7) to 3 x 10(-4) M). The relaxation and the contraction were ...

journal_title：Fundamental & clinical pharmacology

authors： Ea Kim L,Sercombe R,Oudart N

更新日期：1988-01-01 00:00:00

abstract：:The role of nitric oxide/protein kinase G (NO/PKG) in neurodegenerative disorders is controversial in different circumstances. PKG affects neurons both by itself and as a result of increased NO concentration. In this study, we examined the influence of PKG on spatial memory by intrahippocampal administration of three ...

journal_title：Fundamental & clinical pharmacology

authors： Shariatpanahi M,Khodagholi F,Ashabi G,Bonakdar Yazdi B,Hassani S,Azami K,Abdollahi M,Noorbakhsh F,Taghizadeh G,Sharifzadeh M

更新日期：2016-08-01 00:00:00

abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

journal_title：Fundamental & clinical pharmacology

authors：

更新日期：1997-01-01 00:00:00

abstract：:This study evaluated the effects of the isolated use of a low dose of methyltestosterone (MT) on cardiovascular reflexes and hormonal levels and its geno- and cytotoxic safety in ovariectomized rats. Female Wistar rats were divided into four groups (n = 6), respectively: SHAM (received vehicle methylcellulose 0.5%), S...

journal_title：Fundamental & clinical pharmacology

authors： Terra DG,de Lima EM,do Nascimento AM,Brasil GA,Filete PF,Kalil IC,Lenz D,Endringer DC,Bissoli NS,de Andrade TU

更新日期：2016-08-01 00:00:00

abstract：:An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms. We sought to determine whether CCK and BZD are also antagonistic in their effects on brain neurotransmitter levels in the rat. No effect on the noradrenergic system was induced in any brain area by C...

journal_title：Fundamental & clinical pharmacology

authors： Rybarczyk MC,Orosco M,Rouch C,Jacquot C,Cohen Y

更新日期：1990-01-01 00:00:00