Relaxation of rabbit middle cerebral arteries in vitro by H1 histaminergic agonists is inhibited by indomethacin and tranylcypromine.

abstract：:The blood-brain barrier (BBB) is responsible for the control of solutes' concentration in the brain. Tight junctions and multiple ATP-binding cassette (ABC) and SoLute Carrier (SLC) efflux transporters protect brain cells from xenobiotics, therefore reducing brain exposure to intentionally administered drugs. In epile...

journal_title：Fundamental & clinical pharmacology

authors： Soares RV,Do TM,Mabondzo A,Pons G,Chhun S

更新日期：2016-04-01 00:00:00

abstract：:Multiple standard software packages for population pharmacokinetics (PK) modeling are currently available. These programs may significantly vary in the algorithms used for modeling plasma concentrations as a function of time course. We compared the population PK parameters obtained by using two standard software packa...

journal_title：Fundamental & clinical pharmacology

authors： Finkelstein Y,Nava-Ocampo AA,Schechter T,Grant R,St Pierre E,Goldman R,Walker S,Koren G

更新日期：2009-02-01 00:00:00

abstract：:The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC-MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery. Dextromoramide was rapidly absorbed from the gastrointesti...

journal_title：Fundamental & clinical pharmacology

authors： Pagani I,Barzaghi N,Crema F,Perucca E,Ego D,Rovei V

更新日期：1989-01-01 00:00:00

abstract：:In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and arterial compliance abnormalities which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain antihypertensive agen...

journal_title：Fundamental & clinical pharmacology

authors： Khder Y,Bray des Boscs L,el Ghawi R,Meilhac B,Montestruc F,Stoltz JF,Zannad F

更新日期：1998-01-01 00:00:00

abstract：:Adrenoceptors are involved in the control of the activity of the autonomic nervous system and especially the sympathetic nervous system. Activation of alpha 2-adrenoceptors decreases sympathetic tone whereas their blockade has an opposite effect. However, previous investigations have shown that yohimbine (a potent alp...

journal_title：Fundamental & clinical pharmacology

authors： Bagheri H,Chale JJ,Guyen LN,Tran MA,Berlan M,Montastruc JL

更新日期：1995-01-01 00:00:00

abstract：:The impact of an acute coronary syndrome (ACS) event, such as an acute myocardial infarction (MI), is not limited to the acute management phase; patients face an elevated risk of residual atherothrombotic events that commonly requires chronic management for months or even years. Significant advances have been made in ...

journal_title：Fundamental & clinical pharmacology

authors： Atar D,Bode C,Stuerzenbecher A,Verheugt FW

更新日期：2014-08-01 00:00:00

abstract：:The aim of this review is to comment the results described in the literature concerning the possible pharmacodynamic mechanisms involved in the improvement of quality of life of angiotensin converting enzyme inhibitors that is just a working hypothesis. These drugs, widely used in the treatment of hypertension, preven...

journal_title：Fundamental & clinical pharmacology

authors： Govantes C,Marín J

更新日期：1996-01-01 00:00:00

abstract：:We determined the pharmacological and the antiemetic properties of SR 49059, a selective nonpeptide V(1a) receptor antagonist, on cisplatin-induced emesis in the piglet. Firstly, we clearly demonstrate that SR 49059 is a potent V(1a) receptor antagonist in vitro and in vivo in the piglet. In binding studies, [3H]-SR 4...

journal_title：Fundamental & clinical pharmacology

authors： Grélot L,Girod V,Dapzol J,Maffrand JP,Serradeil-Le Gal C

更新日期：2001-06-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a common infectious disease in the world. Two percent of the patients with chronic HBV infection will develop cirrhosis each year, and will die prematurely from cirrhosis or hepatocellular carcinoma. So far interferon alfa and lamivudine are the only effective drugs. Interf...

journal_title：Fundamental & clinical pharmacology

authors： Ormeci N

更新日期：2003-12-01 00:00:00

abstract：:Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of elevated plus maze (EPM), open field, Rotarod and barbitu...

journal_title：Fundamental & clinical pharmacology

authors： Melo FH,Venâncio ET,de Sousa DP,de França Fonteles MM,de Vasconcelos SM,Viana GS,de Sousa FC

更新日期：2010-08-01 00:00:00

abstract：:Overdose cardiac effects of imipramine are due to fast Na channel blockade and are clinically reversed by administration of sodium lactate which induces alkalosis (about pH 7.50) and hypernatremia (about 8 mM). The mechanisms of this beneficial effect of Na lactate were explored in vitro on guinea-pig ventricular myoc...

journal_title：Fundamental & clinical pharmacology

authors： Adamantidis MM,Adnet-Bonte C,Adnet P,Durocher A,Dupuis BA

更新日期：1992-01-01 00:00:00

abstract：:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

更新日期：2005-10-01 00:00:00

abstract：:Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

journal_title：Fundamental & clinical pharmacology

authors： Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

更新日期：2019-06-01 00:00:00

abstract：:Chelerythrine, a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on inositol phosphate (IP) metabolism in newborn rat cardiomyocytes in culture. In a first step, we evaluated the effect of chelerythrine on IP accumulation in basal conditions. For a 10(-4) M dose, 5-phosphatase activity (which ...

journal_title：Fundamental & clinical pharmacology

authors： Le Corvoisier P,Lacotte J,Laplace M,Crozatier B

更新日期：2002-02-01 00:00:00

abstract：:Over the past 10 years, more than 40 potentially oncogenic genes, termed protooncogenes, have been identified in the human genome. Little is known of the physiological role of the proteins encoded by these genes, but they seem to be involved in the reception and transmission of hormonal and other environmental informa...

journal_title：Fundamental & clinical pharmacology

authors： Rey I,Soubigou P,Cartwright T,Tocqué B

更新日期：1990-01-01 00:00:00

abstract：:Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis. Cpn is an obligate intracellular gram-negative bacterium that is responsible for 10% of cases of community-acquired pneumonia. In addi...

journal_title：Fundamental & clinical pharmacology

authors： Deniset JF,Pierce GN

更新日期：2010-10-01 00:00:00

abstract：:A method has been proposed for extracting numerical data when only graphical results are presented. Reports with both graphical and tabular data were identified and the graphs were electronically scanned. The coordinates of each point were read using the cross-hair facility of Adobe Photoshop 7.0. To improve the preci...

journal_title：Fundamental & clinical pharmacology

authors： de Oliveira IR,Santos-Jesus R,Po AL,Poolsup N

更新日期：2003-08-01 00:00:00

abstract：:Many characters are genetically regulated as polymorphisms. This means that discrete groups are seen within the distribution of a certain character. Drug metabolism is no exception and the polymorphism of acetylation is recognised since the 50's. Polymorphic drug oxidation was discovered in the 70's and has been exten...

journal_title：Fundamental & clinical pharmacology

authors： Alván G

更新日期：1991-01-01 00:00:00

abstract：:Abstract The relationship between depression and dopamine deficiency in the mesolimbic pathway has been hypothesized for many years. The experimental studies with animal models of depression and the human studies implicate the role of the dopamine system in depression. Not only do dopaminergic receptor agonists, but a...

journal_title：Fundamental & clinical pharmacology

authors： Dailly E,Chenu F,Renard CE,Bourin M

更新日期：2004-12-01 00:00:00

abstract：:The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. Although CGP 37849 was the more potent compound, both antago...

journal_title：Fundamental & clinical pharmacology

authors： D'Hooge R,Raes A,Van de Vijver G,Van Bogaert PP,De Deyn PP

更新日期：1999-01-01 00:00:00

abstract：:Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by m...

journal_title：Fundamental & clinical pharmacology

authors： Grioli S,Lomeo C,Quattropani MC,Spignoli G,Villardita C

更新日期：1990-01-01 00:00:00

abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

journal_title：Fundamental & clinical pharmacology

authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

更新日期：1999-01-01 00:00:00

abstract：:New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for central nervous system (CNS) and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 cells and activity against erythrocytic stages of Plasmodium falciparum was determined. Compound...

journal_title：Fundamental & clinical pharmacology

authors： Kedzierska E,Orzelska J,Perković I,Knežević D,Fidecka S,Kaiser M,Zorc B

更新日期：2016-02-01 00:00:00

abstract：:Patients with rheumatoid arthritis (RA) appear to have increased plasma levels of leptin and adiponectin. These adipokines may be implicated in the pathophysiology of RA. Tumour necrosis factor alpha (TNF-alpha) is a potential modulator of adipokines. The effects of long-term anti-TNF treatment on plasma levels of lep...

journal_title：Fundamental & clinical pharmacology

authors： Derdemezis CS,Filippatos TD,Voulgari PV,Tselepis AD,Drosos AA,Kiortsis DN

更新日期：2009-10-01 00:00:00

abstract：:The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

journal_title：Fundamental & clinical pharmacology

authors： Hellmich B,Gyermek L

更新日期：1997-01-01 00:00:00

abstract：UNLABELLED:In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats. Wistar rats were treated with 0.9% saline (i.p., control group), LA (10mg/kg, i.p., LA group), ubiquinone [20mg/kg, i.p., ubiquinone (UQ) group], pilocarpin...

journal_title：Fundamental & clinical pharmacology

authors： de Freitas RM,Feng D,Jordán J

更新日期：2011-04-01 00:00:00

abstract：:An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms. We sought to determine whether CCK and BZD are also antagonistic in their effects on brain neurotransmitter levels in the rat. No effect on the noradrenergic system was induced in any brain area by C...

journal_title：Fundamental & clinical pharmacology

authors： Rybarczyk MC,Orosco M,Rouch C,Jacquot C,Cohen Y

更新日期：1990-01-01 00:00:00

abstract：:The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to af...

journal_title：Fundamental & clinical pharmacology

authors： Noize P,Sauer M,Bruneval P,Moreau M,Pathak A,Bagheri H,Montastruc JL

更新日期：2006-12-01 00:00:00

abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...

journal_title：Fundamental & clinical pharmacology

authors： Lalonde R,Strazielle C

更新日期：2010-06-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00