Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist.

Abstract:

:Adrenoceptors are involved in the control of the activity of the autonomic nervous system and especially the sympathetic nervous system. Activation of alpha 2-adrenoceptors decreases sympathetic tone whereas their blockade has an opposite effect. However, previous investigations have shown that yohimbine (a potent alpha 2-adrenoceptor antagonist) increases salivary secretion through activation of cholinergic pathways. The aim of the present experiment was to investigate the involvement of both the sympathetic and the parasympathetic system in several pharmacological effects of yohimbine. For this purpose, salivary secretion and various endocrino-metabolic parameters (noradrenaline and insulin secretions, lipomobilization) were evaluated in conscious fasting dogs before and after blockade of either the sympathetic (with the beta-adrenoceptor antagonist agent nadolol) or the parasympathetic (with the anticholinergic agent atropine) systems. Yohimbine alone (0.4 mg.kg-1, i.v.) increased within 5-15 minutes, plasma noradrenaline (600%), insulin levels (300%), free-fatty acids (79%) and salivary secretion (143%). Atropine (0.2 mg.kg-1, i.v.) suppressed yohimbine-induced salivary secretion (90%) but did not significantly modify the yohimbine induced changes in noradrenaline (312%), insulin (277%) and free-fatty acids (102%) plasma levels. Administration of nadolol (1 mg.kg-1, i.v.) did not change the magnitude of the increase in both noradrenaline plasma levels (550%) and salivary secretion (300%) induced by yohimbine. However, nadolol totally blunted the increase in insulin (15%) and free-fatty acids (4%) plasma levels. These results show that yohimbine-induced increase in salivary secretion is a cholinergic effect whereas the increase in insulin and free fatty acids can be explained by an increase in sympathetic tone.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Fundam Clin Pharmacol

authors

Bagheri H,Chale JJ,Guyen LN,Tran MA,Berlan M,Montastruc JL

doi

10.1111/j.1472-8206.1995.tb00292.x

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

248-54

issue

3

eissn

0767-3981

issn

1472-8206

pii

0767398196803549

journal_volume

9

pub_type

杂志文章
  • Effect of simvastatin on the antihypertensive activity of losartan in hypertensive hypercholesterolemic animals and patients: role of nitric oxide, oxidative stress, and high-sensitivity C-reactive protein.

    abstract::This study investigated whether simvastatin has antihypertensive activity and can enhance the antihypertensive effect of losartan in hypertensive hypercholesterolemic animals and patients. Hypertension and hypercholesterolemia were induced in rats by L-NAME and cholesterol-enriched diet, respectively. In these animals...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1111/fcp.12020

    authors: Abdel-Zaher AO,Elkoussi AE,Abudahab LH,Elbakry MH,Elsayed EA

    更新日期:2014-06-01 00:00:00

  • C.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function.

    abstract::Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12398

    authors: Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

    更新日期:2019-02-01 00:00:00

  • Effects of cooling and warming on 5-hydroxytryptamine- and acetylcholine-induced contractions of human umbilical vessels: role of nitric oxide.

    abstract::The effects of cooling (to 28 degrees C) and warming (to 41 degrees C) on the vasoconstrictions induced by 5-hydroxytryptamine (5-HT) and acetylcholine (ACh) and the role of nitric oxide in these effects were analyzed in human umbilical artery and vein. 5-HT (10(-9)-10(-4) M) and ACh (10(-9)-10(-4) M) induced concentr...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2007.00562.x

    authors: Atalik KE,Kiliç M,Nurullahoğlu ZU,Doğan N

    更新日期:2008-02-01 00:00:00

  • Pharmacotherapy of polycystic ovary syndrome--an update.

    abstract::Polycystic ovary syndrome (PCOS) is a persisting challenge to clinical and basic research scientists as none of the presently available medications have been fully able to combat these consequences. The aim of the present review is to summarize the different lines of treatment available for the different symptomologie...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2010.00916.x

    authors: Saha L,Kaur S,Saha PK

    更新日期:2012-02-01 00:00:00

  • Genetic polymorphisms of drug metabolism.

    abstract::The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.1990.tb00041.x

    authors: Meyer UA

    更新日期:1990-01-01 00:00:00

  • Trends in severe opioid-related poisonings and fatalities reported to the Paris poison control center - a 10-year retrospective observational study.

    abstract::France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10-year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12534

    authors: Caré W,Langrand J,Vodovar D,Deveaux M,Alvarez JC,Mégarbane B,Dorandeu F

    更新日期:2020-08-01 00:00:00

  • Clinical effects and outcomes with new P2Y12 inhibitors in ACS.

    abstract::Thienopyridines have become the cornerstone of treatment for percutaneous coronary intervention although no survival benefit has ever been shown with clopidogrel despite increasing loading doses. Newly developed P2Y12 inhibitors are more potent, more predictable, and have a faster onset of action than clopidogrel, cha...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2011.00984.x

    authors: Collet JP,O'Connor S

    更新日期:2012-02-01 00:00:00

  • Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone.

    abstract::The aim of this study was to characterize the model of oxidative stress consisting in the infection of malonate (3 mumol), an inhibitor of mitochondrial complex II, in the rat striatum. The striatal concentrations of both the reduced and oxidized forms of glutathione (the major endogenous antioxidant) were determined ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2004.00297.x

    authors: Paucard A,Besson VC,Plotkine M,Margaill I

    更新日期:2005-02-01 00:00:00

  • N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose.

    abstract::Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2010.00831.x

    authors: Zyoud SH,Awang R,Sulaiman SA,Al-Jabi SW

    更新日期:2011-06-01 00:00:00

  • Pharmacokinetic and pharmacodynamic study of suriclone imipramine interaction in man.

    abstract::Suriclone is a novel cyclopyrrolone exhibiting anxiolytic activity. Twelve healthy Caucasian male volunteers participated in the study. A single dose of suriclone 0.4 mg, imipramine 75 mg, suriclone 0.4 mg + imipramine 75 mg, or placebo was given according to a 4 x 4 Latin-square design in order to assess the effect o...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1472-8206.1994.tb00806.x

    authors: Perault MC,Chapelle G,Bouquet S,Chevalier P,Montay G,Gaillot J,Chakroun H,Guillet P,Vandel B

    更新日期:1994-01-01 00:00:00

  • Pharmacology and drug development in rare diseases: the attractiveness and expertise of the French medical pharmacology.

    abstract::Developing drugs for rare disease can be challenging due to specific rare disease characteristics. The French Medical Pharmacology is structured and positioned to play a major role in orphan drug research and development due to the required expertise concentrated into pharmacology departments, exclusively implemented ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12314

    authors: Micallef J,Boutouyrie P,Blin O

    更新日期:2017-12-01 00:00:00

  • A peroxynitrite decomposition catalyst: FeTPPS confers cardioprotection during reperfusion after cardioplegic arrest in a working isolated rat heart model.

    abstract::Heart transplant is considered to be an extremely severe ischemia-reperfusion sequence. Post-ischemic dysfunction triggers multiple processes especially oxidative stress, but the mechanisms remain unclear. Free radical interactions lead to peroxynitrite generation, which seems to be involved in early post-transplant h...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2007.00467.x

    authors: Lauzier B,Sicard P,Bouchot O,Delemasure S,Moreau D,Vergely C,Rochette L

    更新日期:2007-04-01 00:00:00

  • Beraprost sodium-fluindione combination in healthy subjects: pharmacokinetic and pharmacodynamic aspects.

    abstract::Beraprost sodium (BPS), an orally active PGI2 (prostaglandine 12) analogue possesses vasodilatating and platelet aggregation inhibiting properties. It is being developed in peripheral arterial occlusive disease. As in future clinical practice BPS might be co-prescribed with oral anticoagulants, we investigated its int...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1472-8206.2000.tb00021.x

    authors: Warot D,Berlin I,Aymard G,Ankri A,Fabry C,Besse B,Lechat P,Diquet B

    更新日期:2000-05-01 00:00:00

  • Experimental and clinical methods in the development of anti-Alzheimer drugs.

    abstract::Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.1998.tb00919.x

    authors: Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

    更新日期:1998-01-01 00:00:00

  • Comparative evaluation of scavenger properties of exifone, piracetam and vinburnine.

    abstract::The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto-toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1989.tb00673.x

    authors: Bentue-Ferrer D,Philouze V,Pape D,Reymann JM,Allain H,Van den Driessche J

    更新日期:1989-01-01 00:00:00

  • Combined therapy in the treatment of dyslipidemia.

    abstract::This systematic review analyses the efficacy, tolerability and safety of combinations of different medicines used to treat dyslipidemias in clinical practice. A PubMed search up to January 2009, was conducted to identify relevant studies. Criteria used to identify studies included (1) English language, (2) published s...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2009.00764.x

    authors: Reiner Z

    更新日期:2010-02-01 00:00:00

  • The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery.

    abstract::Research in the last two decades has unveiled an important role for neuroinflammation in the degeneration of the nigrostriatal dopaminergic (DA) pathway that constitutes the pathological basis of the prevailing movement disorder, Parkinson's disease (PD). Neuroinflammation is characterized by the activation of brain g...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2008.00616.x

    authors: Dutta G,Zhang P,Liu B

    更新日期:2008-10-01 00:00:00

  • Surrogate endpoints in randomized cardiovascular clinical trials.

    abstract::Surrogate endpoints predict the occurrence and timing of a clinical endpoint of interest (CEI). Substitution of a surrogate endpoint for a CEI can dramatically reduce the time and cost necessary to complete a Phase III clinical trial. However, assurance that use of a surrogate endpoint will result in a correct conclus...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2010.00865.x

    authors: Domanski M,Pocock S,Bernaud C,Borer J,Geller N,Revkin J,Zannad F

    更新日期:2011-08-01 00:00:00

  • Quercetin depletes intracellular Ca2+ stores and blunts ATP-triggered Ca2+ signaling in bEnd.3 endothelial cells.

    abstract::Quercetin is a flavonol polyphenol widely found in many vegetables, grains, and fruits. Quercetin has been shown to inhibit proliferation and invasion of various glioma cells and is regarded as a potential anticancer agent against glioma. However, whether and how this drug could affect brain blood vessels and endothel...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12514

    authors: Chen CY,Hour MJ,Shiao LR,Wong KL,Leung YM,Chan P,So EC

    更新日期:2020-04-01 00:00:00

  • Pharmacology and mechanisms of action of new oral anticoagulants.

    abstract::The new oral anticoagulants are announced as an important therapeutic revolution, particularly after their approval by authorities for stroke prevention in atrial fibrillation. However, the pharmacology of these new drugs is not homogeneous. In this review, we summarize the main pharmacological characteristics of the ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/fcp.12091

    authors: Salem JE,Sabouret P,Funck-Brentano C,Hulot JS

    更新日期:2015-02-01 00:00:00

  • Vanadium pharmacokinetics and oral bioavailability upon single-dose administration of vanadyl sulfate to rats.

    abstract::Vanadium pharmacokinetic parameters and oral bioavailability were determined after administration of vanadyl sulfate, an antidiabetic agent, to male Wistar rats. An optimal sampling design was used over a 21-day period; vanadium was measured in blood by atomic absorption spectrophotometry (AAS). After i.v. bolus injec...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2001.00043.x

    authors: Azay J,Brès J,Krosniak M,Teissedre PL,Cabanis JC,Serrano JJ,Cros G

    更新日期:2001-10-01 00:00:00

  • Effects of pretreatment with clonidine, lithium and quinine on the activities of antidepressant drugs in the mouse tail suspension test.

    abstract::The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1997.tb00199.x

    authors: Redrobe JP,Bourin M

    更新日期:1997-01-01 00:00:00

  • Interaction of cholecystokinin and diazepam: effects on brain monoamines.

    abstract::An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms. We sought to determine whether CCK and BZD are also antagonistic in their effects on brain neurotransmitter levels in the rat. No effect on the noradrenergic system was induced in any brain area by C...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1990.tb00491.x

    authors: Rybarczyk MC,Orosco M,Rouch C,Jacquot C,Cohen Y

    更新日期:1990-01-01 00:00:00

  • Metformin potentiates the chemotherapeutic effects of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine-induced Mammary Carcinoma in rats.

    abstract::This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12604

    authors: Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

    更新日期:2020-09-09 00:00:00

  • The evolving story of the RAAS in hypertension, diabetes and CV disease: moving from macrovascular to microvascular targets.

    abstract::The phylogenetically old renin-angiotensin-system (RAS) was originally described as a circulating hormonal system and a main cardiovascular regulator. However, there also exist 'local RASs' which are situated in cardiovascular as well as non-cardiovascular tissues where they are involved in physiological and patho-phy...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2009.00780.x

    authors: Steckelings UM,Rompe F,Kaschina E,Unger T

    更新日期:2009-12-01 00:00:00

  • Memantine for the treatment of general neuropathic pain: a narrative review.

    abstract::Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-methyl-d-aspartate antagonists that are alternatives to be recommended in first-line NP treatment, memantine has...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/fcp.12316

    authors: Pickering G,Morel V

    更新日期:2018-02-01 00:00:00

  • Effects of tilting in the anaesthetized and mechanically ventilated rat: a model of orthostatic hypotension.

    abstract::The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1992.tb00092.x

    authors: Pourrias B,Marie C

    更新日期:1992-01-01 00:00:00

  • Can positron emission tomography facilitate paediatric drug development?

    abstract::Advances in paediatric clinical pharmacology are interdependent with a better understanding of the influence of growth on drug disposition and action. In this field, there is an increasing need for non-invasive drug monitoring approaches. This paper aims to discuss the role of positron emission tomography in such prac...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2008.00650.x

    authors: Zimmer L

    更新日期:2008-12-01 00:00:00

  • Influence of landiolol on the dose requirement of propofol for induction of anesthesia.

    abstract::It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1472-8206.2005.00351.x

    authors: Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

    更新日期:2005-10-01 00:00:00

  • A GppNHp-insensitivity factor modulates the activation of beta-adrenoceptor-coupled Gs protein in rat cortex and cerebellum.

    abstract::The effect known as the GTP-shift refers to the complete conversion of receptors from the high- to the low agonist-affinity state in the presence of an excess of GTP or one of its analogs. 5'-Guanylylimidodiphosphate (GppNHp) was able to fully suppress the high (-)-isoproterenol-affinity of beta-adrenoceptors (beta AR...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1999.tb00335.x

    authors: Garnier V,Zini R,Tillement JP

    更新日期:1999-01-01 00:00:00