Effect of ponsinomycin on the pharmacokinetics of dihydroergotamine administered orally.

abstract：:A meta-analysis was performed on the results of clinical trials of buflomedil in intermittent claudication. The analysis used results from 744 patients enrolled in ten studies, conducted at 42 centers in seven countries. All studies were randomized, double-blind, placebo-controlled trials which measured improvement in...

journal_title：Fundamental & clinical pharmacology

authors： Walker GA,Mac Hannaford JC

更新日期：1995-01-01 00:00:00

abstract：:Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert's syndrome with severe hyperbilirubinaemias and jaundice. We analysed the reactivities of some hydroxyquinoline derivatives, which are naturally...

journal_title：Fundamental & clinical pharmacology

authors： Kanou M,Saeki K,Kato TA,Takahashi K,Mizutani T

更新日期：2002-12-01 00:00:00

abstract：:The efficacy of silymarin treatment in preventing biochemical and histological alterations in CCL4-induced liver cirrhosis in rats was studied. Four groups of rats were treated with: (1) CCL4; (2) mineral oil; (3) CCL4 + silymarin; and (4) silymarin. All animals were sacrificed 72 h after the end of treatments. The ac...

journal_title：Fundamental & clinical pharmacology

authors： Mourelle M,Muriel P,Favari L,Franco T

更新日期：1989-01-01 00:00:00

abstract：:Endocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2-arachidonoylglycerol. Recent pharmacological advances point ou...

journal_title：Fundamental & clinical pharmacology

authors： Smita K,Sushil Kumar V,Premendran JS

更新日期：2007-02-01 00:00:00

abstract：:Adverse reactions to antipsychotic drugs (APs) have been attributed to oxidative stress. Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death. We examined the protective properties of SF against AP-induced oxidative stress in dopaminergic neuroblastoma cells. Human neuroblastoma SK-N...

journal_title：Fundamental & clinical pharmacology

authors： Mas S,Gassó P,Trias G,Bernardo M,Lafuente A

更新日期：2012-12-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10-year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives...

journal_title：Fundamental & clinical pharmacology

authors： Caré W,Langrand J,Vodovar D,Deveaux M,Alvarez JC,Mégarbane B,Dorandeu F

更新日期：2020-08-01 00:00:00

abstract：:In therapeutic trials, quality of life studies are usually based on a health model which results in a restrictive view. Therefore, it is important to clearly define the concept of the quality of life, since ambiguous concepts can alter the results. The key to this problem is the clear distinction between the two compo...

journal_title：Fundamental & clinical pharmacology

authors： Gerin P,Dazord A,Boissel J,Chifflet R

更新日期：1992-01-01 00:00:00

abstract：:Thalidomide, a well-known immunomodulatory compound, has an anti-angiogenic activity, which may be utilized for the treatment of angiogenesis-related diseases such as hemangioendothelioma. The aim of the present study was to investigate both the antitumor role of thalidomide on hemangioendothelioma and the underlying ...

journal_title：Fundamental & clinical pharmacology

authors： Guo L,Wan Z,Xu B,Ren L,Liu H,Song N,Liu L

更新日期：2019-12-01 00:00:00

abstract：:In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal m...

journal_title：Fundamental & clinical pharmacology

authors： Daveluy A,Sauvaget L,Bastien A,Lapeyre-Mestre M,Collin C,Richard N,Haramburu F

更新日期：2018-10-01 00:00:00

abstract：:The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also meta...

journal_title：Fundamental & clinical pharmacology

authors： Bertrand C,Tschirhart E

更新日期：1993-01-01 00:00:00

abstract：:We have previously shown that kaolinite slowed down gastric emptying and intestinal transit and induced changes in enteric mechanical activities. As gastric emptying and intestinal transit have been shown to be regulated by nitric oxide (NO), the effect of an imposed ingestion of kaolinite on enteric nitrergic innerva...

journal_title：Fundamental & clinical pharmacology

authors： Voinot F,Fischer C,Schmidt C,Ehret-Sabatier L,Angel F

更新日期：2014-08-01 00:00:00

abstract：:During the phase I trials, from the juridical point of view, the responsibilities are shared between the pharmaceutical company and the physician who manages the trial. The pharmaceutical company is responsible for the product, the choice of methodology and respect for the regulations. On the financial side, the compa...

journal_title：Fundamental & clinical pharmacology

authors： Rouzioux JM

更新日期：1990-01-01 00:00:00

abstract：:Rats of the Fischer 344 (F344) and Wistar Kyoto (WKY) strains are known to present differences in stimuli responses involving the renin-angiotensin system and in cardiovascular responses to an acoustic startle stimulus. Here we compared the vascular reactivity to angiotensin II (ANG II) of these normotensive, inbred r...

journal_title：Fundamental & clinical pharmacology

authors： Herin L,Blanc J,Basset A,Laude D,Laurent S,Elghozi JL

更新日期：2003-06-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects. However, some controversy remains about its mechanism of action in...

journal_title：Fundamental & clinical pharmacology

authors： Figueiredo A,Ribeiro CA,Gonçalo M,Almeida L,Poiares-Baptista A,Teixeira F

更新日期：1990-01-01 00:00:00

abstract：:Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of elevated plus maze (EPM), open field, Rotarod and barbitu...

journal_title：Fundamental & clinical pharmacology

authors： Melo FH,Venâncio ET,de Sousa DP,de França Fonteles MM,de Vasconcelos SM,Viana GS,de Sousa FC

更新日期：2010-08-01 00:00:00

abstract：:Vanadium pharmacokinetic parameters and oral bioavailability were determined after administration of vanadyl sulfate, an antidiabetic agent, to male Wistar rats. An optimal sampling design was used over a 21-day period; vanadium was measured in blood by atomic absorption spectrophotometry (AAS). After i.v. bolus injec...

journal_title：Fundamental & clinical pharmacology

authors： Azay J,Brès J,Krosniak M,Teissedre PL,Cabanis JC,Serrano JJ,Cros G

更新日期：2001-10-01 00:00:00

abstract：:HMG CoA reductase inhibitors (statins) have an established place in the treatment of coronary artery disease. However, their role in the treatment of heart failure (HF), including HF due to coronary artery disease, has been controversial since beneficial as well as possible harmful effects may occur. Several recent st...

journal_title：Fundamental & clinical pharmacology

authors： Gullestad L,Oie E,Ueland T,Yndestad A,Aukrust P

更新日期：2007-11-01 00:00:00

abstract：:Paracetamol is an analgesic commonly used by people of all ages, which is well documented to cause severe hepatotoxicity with acute overexposures. The risk of hepatotoxicity from nonacute paracetamol exposures is less extensively studied, and this is the exposure most common in older adults. Evidence on the effectiven...

journal_title：Fundamental & clinical pharmacology

authors： Kane AE,Huizer-Pajkos A,Mach J,McKenzie C,Mitchell SJ,de Cabo R,Jones B,Cogger V,Le Couteur DG,Hilmer SN

更新日期：2016-06-01 00:00:00

abstract：:Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant-like action o...

journal_title：Fundamental & clinical pharmacology

authors： Melo CT,de Carvalho AM,Moura BA,Teixeira CP,Vasconcelos LF,Feitosa ML,de Oliveira GV,Barbosa-Filho JM,Chavez Gutierrez SJ,de França Fonteles MM,Vasconcelos SM,de Sousa FC

更新日期：2013-02-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a persisting challenge to clinical and basic research scientists as none of the presently available medications have been fully able to combat these consequences. The aim of the present review is to summarize the different lines of treatment available for the different symptomologie...

journal_title：Fundamental & clinical pharmacology

authors： Saha L,Kaur S,Saha PK

更新日期：2012-02-01 00:00:00

abstract：:Surrogate endpoints predict the occurrence and timing of a clinical endpoint of interest (CEI). Substitution of a surrogate endpoint for a CEI can dramatically reduce the time and cost necessary to complete a Phase III clinical trial. However, assurance that use of a surrogate endpoint will result in a correct conclus...

journal_title：Fundamental & clinical pharmacology

authors： Domanski M,Pocock S,Bernaud C,Borer J,Geller N,Revkin J,Zannad F

更新日期：2011-08-01 00:00:00

abstract：:The effects of cooling (to 28 degrees C) and warming (to 41 degrees C) on the vasoconstrictions induced by 5-hydroxytryptamine (5-HT) and acetylcholine (ACh) and the role of nitric oxide in these effects were analyzed in human umbilical artery and vein. 5-HT (10(-9)-10(-4) M) and ACh (10(-9)-10(-4) M) induced concentr...

journal_title：Fundamental & clinical pharmacology

authors： Atalik KE,Kiliç M,Nurullahoğlu ZU,Doğan N

更新日期：2008-02-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:The effects of tacrine and physostigmine on catecholamine secretion induced by veratridine and high K+, and on voltage-dependent Na+ and Ca2+ currents, were investigated in guinea-pig adrenal chromaffin cells. In perfused adrenal glands, tacrine (100 microM) caused an inhibition of veratridine-induced catecholamine se...

journal_title：Fundamental & clinical pharmacology

authors： Sugawara T,Kitamura N,Ohta T,Ito S,Nakazato Y

更新日期：1998-01-01 00:00:00

abstract：:The prevalence of end stage renal disease (ESRD) is growing in western countries. Patients with ESRD are more frequently elderly and diabetic and are exposed to very high cardiovascular morbidity and mortality. The main aim of the FOSIDIAL study is to assess the efficacy and safety of fosinopril, an angiotensin conver...

journal_title：Fundamental & clinical pharmacology

authors： Zannad F,Kessler M,Grünfeld JP,Thuilliez C,FOSInopril in DIALysis Investigators.

更新日期：2002-10-01 00:00:00

abstract：:Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

journal_title：Fundamental & clinical pharmacology

authors： Pari L,Sivasankari R

更新日期：2008-08-01 00:00:00

abstract：:There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti-inflammatory and ...

journal_title：Fundamental & clinical pharmacology

authors： Ouk T,Potey C,Laprais M,Gautier S,Hanf R,Darteil R,Staels B,Duriez P,Bordet R

更新日期：2014-06-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00