Controlled ingestion of kaolinite (5%) modulates enteric nitrergic innervation in rats.

abstract：:Advances in paediatric clinical pharmacology are interdependent with a better understanding of the influence of growth on drug disposition and action. In this field, there is an increasing need for non-invasive drug monitoring approaches. This paper aims to discuss the role of positron emission tomography in such prac...

journal_title：Fundamental & clinical pharmacology

authors： Zimmer L

更新日期：2008-12-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...

journal_title：Fundamental & clinical pharmacology

authors： Silva RO,Sousa FB,Damasceno SR,Carvalho NS,Silva VG,Oliveira FR,Sousa DP,Aragão KS,Barbosa AL,Freitas RM,Medeiros JV

更新日期：2014-08-01 00:00:00

abstract：:The effect known as the GTP-shift refers to the complete conversion of receptors from the high- to the low agonist-affinity state in the presence of an excess of GTP or one of its analogs. 5'-Guanylylimidodiphosphate (GppNHp) was able to fully suppress the high (-)-isoproterenol-affinity of beta-adrenoceptors (beta AR...

journal_title：Fundamental & clinical pharmacology

authors： Garnier V,Zini R,Tillement JP

更新日期：1999-01-01 00:00:00

abstract：:The blood-brain barrier (BBB) is responsible for the control of solutes' concentration in the brain. Tight junctions and multiple ATP-binding cassette (ABC) and SoLute Carrier (SLC) efflux transporters protect brain cells from xenobiotics, therefore reducing brain exposure to intentionally administered drugs. In epile...

journal_title：Fundamental & clinical pharmacology

authors： Soares RV,Do TM,Mabondzo A,Pons G,Chhun S

更新日期：2016-04-01 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00

abstract：:Despite the benefits of chrysotherapy the responsible mechanism of action of gold compounds remains unclear. At a concentration of 5 x 10(-4) M, sodium aurothiopropanol sulfonate (SAS) modified the in vitro proliferation kinetics of articular chondrocytes by reducing growth, viability and plating efficiency. Flow cyto...

journal_title：Fundamental & clinical pharmacology

authors： Ronot X,Hainque B,Christen MO,Froger B,Hartmann DJ,Adolphe M,Lechat P

更新日期：1988-01-01 00:00:00

abstract：:This paper reviews state-of-art statistical designs for dose-escalation procedures in first-into-man studies. The main focus will be on studies in oncology, as most statistical procedures for phase I trials have been proposed in this context. Extensions to situations such as the observation of bivariate outcomes and h...

journal_title：Fundamental & clinical pharmacology

authors： Zhou Y

更新日期：2004-06-01 00:00:00

abstract：:To date, no reports of hypersensitivity reactions (HSRs) among nonsteroidal anti-inflammatory drugs (NSAIDs) according to cyclo-oxygenase (COX) selectivity and chemical groups have been published in a single study. The present study assessed the reporting frequency of HSRs for NSAIDs based on their relative inhibitory...

journal_title：Fundamental & clinical pharmacology

authors： Bakhriansyah M,Meyboom RHB,Souverein PC,de Boer A,Klungel OH

更新日期：2019-10-01 00:00:00

abstract：:Abstract Endothelin-1 (ET-1) appears to be involved in drug-induced proliferation of gingival fibroblasts. Thrombin induces proliferation of human gingival fibroblasts via protease-activated receptor 1 (PAR1). In this study, using cultured rat gingival fibroblasts, we investigated whether thrombin-induced proliferatio...

journal_title：Fundamental & clinical pharmacology

authors： Ohuchi N,Hayashi K,Iwamoto K,Koike K,Kizawa Y,Nukaga M,Kakegawa T,Murakami H

更新日期：2010-08-01 00:00:00

abstract：:This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

journal_title：Fundamental & clinical pharmacology

authors： Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

更新日期：2010-08-01 00:00:00

abstract：UNLABELLED:In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats. Wistar rats were treated with 0.9% saline (i.p., control group), LA (10mg/kg, i.p., LA group), ubiquinone [20mg/kg, i.p., ubiquinone (UQ) group], pilocarpin...

journal_title：Fundamental & clinical pharmacology

authors： de Freitas RM,Feng D,Jordán J

更新日期：2011-04-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

journal_title：Fundamental & clinical pharmacology

authors： Pari L,Sivasankari R

更新日期：2008-08-01 00:00:00

abstract：:Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of elevated plus maze (EPM), open field, Rotarod and barbitu...

journal_title：Fundamental & clinical pharmacology

authors： Melo FH,Venâncio ET,de Sousa DP,de França Fonteles MM,de Vasconcelos SM,Viana GS,de Sousa FC

更新日期：2010-08-01 00:00:00

abstract：:We reported that coronary spasm was induced in the transgenic mice with the increased phospholipase C (PLC)-δ1 activity. We investigated the effect of enhanced PLC-δ1 on Ca2+ influx and its underlying mechanisms. We used human embryonic kidney (HEK)-293 and coronary arteries smooth muscle cells (CASMC). Intracellular ...

journal_title：Fundamental & clinical pharmacology

authors： Murakami K,Osanai T,Tanaka M,Nishizaki K,Kinjo T,Tanno T,Ishida Y,Suzuki A,Endo T,Tomita H,Okumura K

更新日期：2017-08-01 00:00:00

abstract：:Restenosis after coronary angioplasty, the main limitation of interventional cardiology, remains an unsolved issue. The failure to-date of all pharmacological attempts at prevention has prompted the development of alternative strategies. A mechanistic approach to the problem of restenosis is based on the assumption th...

journal_title：Fundamental & clinical pharmacology

authors： Feldman LJ,Riessen R,Steg PG

更新日期：1995-01-01 00:00:00

abstract：:An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms. We sought to determine whether CCK and BZD are also antagonistic in their effects on brain neurotransmitter levels in the rat. No effect on the noradrenergic system was induced in any brain area by C...

journal_title：Fundamental & clinical pharmacology

authors： Rybarczyk MC,Orosco M,Rouch C,Jacquot C,Cohen Y

更新日期：1990-01-01 00:00:00

abstract：:In addition to their direct effects on cardiac contractility, a number of positive inotropic agents also induce, through direct peripheral vasodilation, a reduction in afterload which is of major importance in their beneficial effects in the treatment of congestive heart failure. However, the induced increase in cardi...

journal_title：Fundamental & clinical pharmacology

authors： Gosgnach M,Gérard JL,Berdeaux A,Giudicelli JF

更新日期：1991-01-01 00:00:00

abstract：:In the present study, we investigated the mediators involved in the potentiation of antigen-induced contractions by indomethacin in tracheas isolated from ovalbumin (OA)-sensitized guinea-pigs. Indomethacin-induced potentiation of OA contraction was mimicked by prostaglandin DP/EP(1) /EP(2) receptor antagonist, AH-68...

journal_title：Fundamental & clinical pharmacology

authors： Bozkurt TE,Sahin-Erdemli I,Ilhan M

更新日期：2012-06-01 00:00:00

abstract：:Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

journal_title：Fundamental & clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

更新日期：1998-01-01 00:00:00

abstract：:In epileptic patients cyproheptadine is frequently prescribed as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of 'serotonin syndrome' in depressed epileptic patients. However, the study of serotonergic and histaminergic pathway shows that the decreased...

journal_title：Fundamental & clinical pharmacology

authors： Singh D,Goel RK

更新日期：2010-08-01 00:00:00

abstract：:The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...

journal_title：Fundamental & clinical pharmacology

authors： Meyer UA

更新日期：1990-01-01 00:00:00

abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...

journal_title：Fundamental & clinical pharmacology

authors： Lalonde R,Strazielle C

更新日期：2010-06-01 00:00:00

abstract：:The smooth muscle relaxant responses to NS-004, an activator of charybdotoxin-sensitive, large conductance Ca(2+)-dependent K+ channels (BKCa) were studied on the basal spontaneous tone in guinea-pig trachea in vitro. The sensitivity of these responses to a range of K+ channel inhibitors and antagonists were also eval...

journal_title：Fundamental & clinical pharmacology

authors： Lawson K,Barras M,Armstrong JM,Hicks PE

更新日期：1997-01-01 00:00:00

abstract：:The aim of this cross-sectional study was to investigate the association between sedative load and functional outcomes in community-dwelling older Australian men. A total of 1696 males aged ≥ 70 years, enrolled in the Concord Health and Ageing in Men Project, were studied. Participants underwent assessments during 200...

journal_title：Fundamental & clinical pharmacology

authors： Gnjidic D,Le Couteur DG,Hilmer SN,Cumming RG,Blyth FM,Naganathan V,Waite L,Handelsman DJ,Bell JS

更新日期：2014-02-01 00:00:00

abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...

journal_title：Fundamental & clinical pharmacology

authors： Bénard-Laribière A,Miremont-Salamé G,Pérault-Pochat MC,Noize P,Haramburu F,EMIR Study Group on behalf of the French network of pharmacovigilance centres.

更新日期：2015-02-01 00:00:00

abstract：:In experiments in vivo, we studied whether the endothelial dysfunction induced by nitric oxide (NO) synthesis inhibition is simultaneously or sequentially manifested as a reduced level of endothelium-dependent agonist-induced vasodilatation, an increased responsiveness to vasoconstrictors, and hypertension. Vascular r...

journal_title：Fundamental & clinical pharmacology

authors： López RM,Pérez T,Castillo C,Castillo MC,Castillo EF

更新日期：2011-06-01 00:00:00

abstract：:In the present study, contractile responses and [3H]-noradrenaline overflow evoked by electrical field stimulation were assessed, respectively, in the small mesenteric artery and in tail artery removed from rats pre-treated with either saline or lipopolysaccharide (LPS). In small mesenteric arteries, LPS treatment did...

journal_title：Fundamental & clinical pharmacology

authors： Ohlmann P,Martínez MC,Bucher B,Andriantsitohaina R,Muller B,Schneider F,Stoclet JC

更新日期：2000-11-01 00:00:00