Abstract：
:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituitary and other endocrine glands, and evidence is accumulating that it contributes to the regulation of the secretion of renin by the kidneys. The enzyme nitric oxide synthetase is present in vascular and tubular elements of the kidney, particularly in cells of the macula densa, a structure that plays an important role in the control of renin secretion. Guanylyl cyclase, a major target for nitric oxide, is also present in the kidney and is responsive to changes in nitric oxide levels. Drugs that inhibit nitric oxide synthesis generally suppress renin release in vivo and in vitro, suggesting a stimulatory role for the L-arginine-nitric oxide pathway in the control of renin secretion. Under some conditions, however, blockade of nitric oxide synthesis increases renin secretion. Recent studies indicate that nitric oxide not only contributes to the regulation of basal renin secretion, but also participates in the renin secretory responses to activation of the renal baroreceptor, macula densa and beta adrenoceptor mechanisms that regulate renin secretion. Future research should clarify the mechanisms by which nitric oxide regulates the secretion of renin and establish the physiological significance of this regulation.
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Reid IA,Chiu YJdoi
10.1111/j.1472-8206.1995.tb00505.xsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
309-23issue
4eissn
0767-3981issn
1472-8206pii
0767398196803987journal_volume
9pub_type
杂志文章,评审abstract：:Ivermectin, a parasiticide that long ago proved its worth in veterinary medicine, became one of the most effective tools for control programs against human filarial diseases in the 1980s. It is provided at no cost, is effective against microfilariae (blocking their transmission) and can be administered annually as a s...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1046/j.1472-8206.2003.00170.x
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abstract：:Anticonvulsant action of CGP 40116, a competitive antagonist of N-methyl-D-aspartate type of excitatory amino acid receptors, was studied in rats during development (7, 12, 18, 25 and 90 days old). Two types of motor seizures were elicited by a subcutaneous injection of pentylenetetrazol. Pretreatment with CGP 40116 d...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1998.tb00981.x
更新日期：1998-01-01 00:00:00
abstract：:The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1992.tb00092.x
更新日期：1992-01-01 00:00:00
abstract：:A method has been proposed for extracting numerical data when only graphical results are presented. Reports with both graphical and tabular data were identified and the graphs were electronically scanned. The coordinates of each point were read using the cross-hair facility of Adobe Photoshop 7.0. To improve the preci...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1472-8206.2003.00180.x
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abstract：:Several recent reports have described the antiarrhythmic effects of a single high oral dose of amiodarone but clinical electrophysiologic effects have not been reported. The present study was performed to assess electrophysiologic effects in 12 patients. After baseline electrophysiologic studies (EPS) patients were ad...
journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章
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更新日期：1997-01-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1998.tb00990.x
更新日期：1998-01-01 00:00:00
abstract：:Macrophage inflammatory protein (MIP)-1beta and RANTES (regulated on activation, normal T-cells expressed and secreted) are members of the CC-family of chemokines. Although these two peptides are structurally and functionally related to one another, each exhibits distinct features, which allows it to independently reg...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2003.00227.x
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1996.tb00608.x
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1990.tb01011.x
更新日期：1990-01-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1993.tb00237.x
更新日期：1993-01-01 00:00:00
abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12049
更新日期：2014-08-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12175
更新日期：2016-04-01 00:00:00
abstract：:During the last decade, a multitude of experimental arguments have led to the concept that EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone but also in vascular homeostasis, neuronal and immunological functions. Regardless of its origin, endogenous NO is produced through the co...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/j.1472-8206.1993.tb01037.x
更新日期：1993-01-01 00:00:00
abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12088
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1472-8206.2002.00097.x
更新日期：2002-12-01 00:00:00
abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2009.00772.x
更新日期：2010-06-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1989.tb00467.x
更新日期：1989-01-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2005.00391.x
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journal_title：Fundamental & clinical pharmacology
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1992.tb00123.x
更新日期：1992-01-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章,meta分析
doi：10.1111/j.1472-8206.1995.tb00515.x
更新日期：1995-01-01 00:00:00
abstract：:This study investigated whether simvastatin has antihypertensive activity and can enhance the antihypertensive effect of losartan in hypertensive hypercholesterolemic animals and patients. Hypertension and hypercholesterolemia were induced in rats by L-NAME and cholesterol-enriched diet, respectively. In these animals...
journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章
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abstract：:We determined the pharmacological and the antiemetic properties of SR 49059, a selective nonpeptide V(1a) receptor antagonist, on cisplatin-induced emesis in the piglet. Firstly, we clearly demonstrate that SR 49059 is a potent V(1a) receptor antagonist in vitro and in vivo in the piglet. In binding studies, [3H]-SR 4...
journal_title：Fundamental & clinical pharmacology
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abstract：:The effects of two single oral doses (5 mg and 20 mg) of a new angiotensin I-converting enzyme inhibitor, imidapril, on a) systemic hemodynamics (arterial pressure, heart rate, cardiac output), b) brachial and common carotid arteries' hemodynamics (diameter and blood flow, pulsed Doppler technique), c) cerebral hemody...
journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1472-8206.1994.tb00783.x
更新日期：1994-01-01 00:00:00
abstract：:The effects of sub-chronic cold stress on the functioning of hippocampal 5-HT1A receptors in old isolated rats and the possible protective effects of Ginkgo biloba extract (EGb 761) were investigated. Cold exposure during five days, produced a significant reduction of the inhibitory effect of 8-hydroxy-2-(di-n-propyla...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1995.tb00277.x
更新日期：1995-01-01 00:00:00
abstract：:Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2009.00760.x
更新日期：2010-04-01 00:00:00
abstract：:We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications. ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2007.00564.x
更新日期：2008-04-01 00:00:00
