KATP channels modulate GABA release in hippocampal slices in the absence of glucose.

abstract：:This study investigated the tolerability, safety, pharmacokinetics, and pharmacodynamics of ACT-178882, a new direct renin inhibitor, as well as its interaction with food and midazolam. Healthy male subjects received either single (10-1000 mg) or multiple doses (30-600 mg) administered once daily for 14 days of ACT-17...

journal_title：Fundamental & clinical pharmacology

authors： Dingemanse J,Nicolas L,Binkert C

更新日期：2013-12-01 00:00:00

abstract：:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

更新日期：2005-10-01 00:00:00

abstract：:Erythropoietin (EPO), the principal hematopoietic cytokine produced by the kidney and the liver in fetuses, regulates mammalian erythropoiesis and exhibits diverse cellular effects in non-hematopoietic tissues. The introduction of recombinant human EPO (rhEPO) has marked a significant advance in the management of anem...

journal_title：Fundamental & clinical pharmacology

authors： Joyeux-Faure M,Godin-Ribuot D,Ribuot C

更新日期：2005-08-01 00:00:00

abstract：:HMG CoA reductase inhibitors (statins) have an established place in the treatment of coronary artery disease. However, their role in the treatment of heart failure (HF), including HF due to coronary artery disease, has been controversial since beneficial as well as possible harmful effects may occur. Several recent st...

journal_title：Fundamental & clinical pharmacology

authors： Gullestad L,Oie E,Ueland T,Yndestad A,Aukrust P

更新日期：2007-11-01 00:00:00

abstract：:The formation of dopamine, from L-3,4-dihydroxyphenylalanine (L-dopa), in fragments of non-glandular and glandular stomach, duodenum, jejunum, ileum and proximal and distal colon of the rat was examined. The deamination of newly-formed dopamine into 3,4-dihydroxyphenylacetic acid (dopac) was also studied. The synthesi...

journal_title：Fundamental & clinical pharmacology

authors： Vieira-Coelho MA,Soares-da-Silva P

更新日期：1993-01-01 00:00:00

abstract：:Beraprost sodium (BPS), an orally active PGI2 (prostaglandine 12) analogue possesses vasodilatating and platelet aggregation inhibiting properties. It is being developed in peripheral arterial occlusive disease. As in future clinical practice BPS might be co-prescribed with oral anticoagulants, we investigated its int...

journal_title：Fundamental & clinical pharmacology

authors： Warot D,Berlin I,Aymard G,Ankri A,Fabry C,Besse B,Lechat P,Diquet B

更新日期：2000-05-01 00:00:00

abstract：:Atherosclerosis is a multifactorial condition characterized by endothelial injury, fatty streak deposition, and stiffening of the blood vessels. The pathogenesis is complex and mediated by adhesion molecules, inflammatory cells, and smooth muscle cells. Statins have been the major drugs in treating hypercholesterolemi...

journal_title：Fundamental & clinical pharmacology

authors： Priyadharsini RP

更新日期：2015-08-01 00:00:00

abstract：:Lithium causes erectile dysfunction in patients but its mechanism is yet unknown. The aim of our study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)- and endothelium-mediated relaxation of guinea pig isolated corpus cavernosum. Although lithium (0.5, 1, and 5mm) ha...

journal_title：Fundamental & clinical pharmacology

authors： Ghasemi M,Farrokhi-Khajeh-Pasha Y,Ostovaneh MR,Dehpour AR

更新日期：2011-04-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:The blood-brain barrier (BBB) is responsible for the control of solutes' concentration in the brain. Tight junctions and multiple ATP-binding cassette (ABC) and SoLute Carrier (SLC) efflux transporters protect brain cells from xenobiotics, therefore reducing brain exposure to intentionally administered drugs. In epile...

journal_title：Fundamental & clinical pharmacology

authors： Soares RV,Do TM,Mabondzo A,Pons G,Chhun S

更新日期：2016-04-01 00:00:00

abstract：:Erythromycin inhibits the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL6) induced by heat-killed Streptococcus pneumoniae in human whole blood ex-vivo. The objective of the present study was to determine and characterize the concentration-effect relationship of this phenomenon in order t...

journal_title：Fundamental & clinical pharmacology

authors： Guchelaar HJ,Schultz MJ,van der Poll T,Koopmans RP

更新日期：2001-12-01 00:00:00

abstract：:Chelerythrine, a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on inositol phosphate (IP) metabolism in newborn rat cardiomyocytes in culture. In a first step, we evaluated the effect of chelerythrine on IP accumulation in basal conditions. For a 10(-4) M dose, 5-phosphatase activity (which ...

journal_title：Fundamental & clinical pharmacology

authors： Le Corvoisier P,Lacotte J,Laplace M,Crozatier B

更新日期：2002-02-01 00:00:00

abstract：:What is the place of fish oils in the care of coronary heart disease (CHD) patients? As several clinical trials have already addressed this question without giving definitive answers, we did a meta-analysis of trials regarding the efficacy of omega-3 fatty acids in preventing cardiovascular mortality and morbidity. We...

journal_title：Fundamental & clinical pharmacology

authors： Yzebe D,Lievre M

更新日期：2004-10-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00

abstract：:Overdose cardiac effects of imipramine are due to fast Na channel blockade and are clinically reversed by administration of sodium lactate which induces alkalosis (about pH 7.50) and hypernatremia (about 8 mM). The mechanisms of this beneficial effect of Na lactate were explored in vitro on guinea-pig ventricular myoc...

journal_title：Fundamental & clinical pharmacology

authors： Adamantidis MM,Adnet-Bonte C,Adnet P,Durocher A,Dupuis BA

更新日期：1992-01-01 00:00:00

abstract：:The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto-toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties...

journal_title：Fundamental & clinical pharmacology

authors： Bentue-Ferrer D,Philouze V,Pape D,Reymann JM,Allain H,Van den Driessche J

更新日期：1989-01-01 00:00:00

abstract：:The prevalence of end stage renal disease (ESRD) is growing in western countries. Patients with ESRD are more frequently elderly and diabetic and are exposed to very high cardiovascular morbidity and mortality. The main aim of the FOSIDIAL study is to assess the efficacy and safety of fosinopril, an angiotensin conver...

journal_title：Fundamental & clinical pharmacology

authors： Zannad F,Kessler M,Grünfeld JP,Thuilliez C,FOSInopril in DIALysis Investigators.

更新日期：2002-10-01 00:00:00

abstract：:The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of...

journal_title：Fundamental & clinical pharmacology

authors： Berdaï D,Demotes-Mainard F,Philip F,Vinçon G,Montels R,Necciari J,Bannwarth B

更新日期：1994-01-01 00:00:00

abstract：:A meta-analysis was performed on the results of clinical trials of buflomedil in intermittent claudication. The analysis used results from 744 patients enrolled in ten studies, conducted at 42 centers in seven countries. All studies were randomized, double-blind, placebo-controlled trials which measured improvement in...

journal_title：Fundamental & clinical pharmacology

authors： Walker GA,Mac Hannaford JC

更新日期：1995-01-01 00:00:00

abstract：:This paper reports data on the effect of a new antioxidant, U-83836E, on the lipid peroxidation and antioxidant status of liver, red blood cells (RBCs) and blood serum of rats intoxicated with methanol (3.0 g/kg body weight). Methanol administration slightly increased the levels of peroxidation products in the liver, ...

journal_title：Fundamental & clinical pharmacology

authors： Skrzydlewska E,Farbiszewski R

更新日期：1997-01-01 00:00:00

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti-inflammatory and ...

journal_title：Fundamental & clinical pharmacology

authors： Ouk T,Potey C,Laprais M,Gautier S,Hanf R,Darteil R,Staels B,Duriez P,Bordet R

更新日期：2014-06-01 00:00:00

abstract：:The efficacy of silymarin treatment in preventing biochemical and histological alterations in CCL4-induced liver cirrhosis in rats was studied. Four groups of rats were treated with: (1) CCL4; (2) mineral oil; (3) CCL4 + silymarin; and (4) silymarin. All animals were sacrificed 72 h after the end of treatments. The ac...

journal_title：Fundamental & clinical pharmacology

authors： Mourelle M,Muriel P,Favari L,Franco T

更新日期：1989-01-01 00:00:00

abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...

journal_title：Fundamental & clinical pharmacology

authors： Silva RO,Sousa FB,Damasceno SR,Carvalho NS,Silva VG,Oliveira FR,Sousa DP,Aragão KS,Barbosa AL,Freitas RM,Medeiros JV

更新日期：2014-08-01 00:00:00

abstract：:The effects of hydrocortisone, triamcinolone, prednisolone and dexamethasone have been investigated in vitro using mitochondria isolated from rat brain. Respiratory control ratio (RCR), oxygen consumption, ATP synthesis, enzymatic activities of involved complexes and superoxide anion generation have been measured to a...

journal_title：Fundamental & clinical pharmacology

authors： Morin C,Zini R,Simon N,Charbonnier P,Tillement JP,Le Louet H

更新日期：2000-09-01 00:00:00

abstract：:The aim of our study was to analyse the protective effects of different alpha-tocopherol analogues 1) against fibrillations induced by an ischemia-reperfusion sequence, and 2) to further investigate in vitro the radical scavenging properties of these analogues by two sensitive methods. Concerning 1: isolated rat heart...

journal_title：Fundamental & clinical pharmacology

authors： Walker MK,Vergely C,Lecour S,Abadie C,Maupoil V,Rochette L

更新日期：1998-01-01 00:00:00

abstract：:Many characters are genetically regulated as polymorphisms. This means that discrete groups are seen within the distribution of a certain character. Drug metabolism is no exception and the polymorphism of acetylation is recognised since the 50's. Polymorphic drug oxidation was discovered in the 70's and has been exten...

journal_title：Fundamental & clinical pharmacology

authors： Alván G

更新日期：1991-01-01 00:00:00

abstract：:In this review, the major enzyme systems involved in vivo in the oxidative metabolism of xenobiotic amines in humans are discussed, i.e. the monooxygenases [cytochrome P450 system (CYPs) and flavin-containing monooxygenases (FMOs)] and the amine oxidases (AOs). Concerning the metabolism of xenobiotic amines (drugs in ...

journal_title：Fundamental & clinical pharmacology

authors： Strolin Benedetti M,Tipton KF,Whomsley R

更新日期：2007-10-01 00:00:00

abstract：:Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n = 26) and old (23.0 ± 0.2 months, n = 27) male Fischer 344 rats followin...

journal_title：Fundamental & clinical pharmacology

authors： Mach J,Huizer-Pajkos A,Mitchell SJ,McKenzie C,Phillips L,Kane A,Jones B,de Cabo R,Cogger V,Le Couteur DG,Hilmer SN

更新日期：2016-02-01 00:00:00

abstract：:This study evaluated the effect of lacosamide (LCM) on biochemical and mitochondrial parameters after PTZ kindling in mice. Male mice were treated on alternative days for a period of 11 days with LCM (20, 30, or 40 mg/kg), saline, or diazepam (2 mg/kg), before PTZ administration (50 mg/kg). The hippocampi were collect...

journal_title：Fundamental & clinical pharmacology

authors： Lazzarotto L,Pflüger P,Regner GG,Santos FM,Aguirre DG,Brito VB,Moura DJ,Dos Santos NM,Picada JN,Parmeggiani B,Frusciante MR,Leipnitz G,Pereira P

更新日期：2020-08-09 00:00:00