Abstract:
:The formation of dopamine, from L-3,4-dihydroxyphenylalanine (L-dopa), in fragments of non-glandular and glandular stomach, duodenum, jejunum, ileum and proximal and distal colon of the rat was examined. The deamination of newly-formed dopamine into 3,4-dihydroxyphenylacetic acid (dopac) was also studied. The synthesis of dopamine in tissues incubated with 500 microM L-dopa for 20 min in conditions of catechol-O-methyltransferase (Comt) inhibition was found to be in the duodenum, jejunum and ileum 2-fold that in the proximal colon, 6-fold that in the glandular stomach and 120-fold that in the non-glandular stomach and distal colon. The formation of dopac in these tissues followed the pattern of amine formation. In the jejunum, the formation of dopamine and dopac was found to be dependent on the concentration of L-dopa (50 to 5000 microM) used. In another set of experiments, it was found that the formation of dopamine in jejunal segments loaded with increasing concentrations of L-dopa (50, 100 and 500 microM) was a time-dependent process. The rate constant (k) of formation of dopamine as a function of time was found to be similar (0.050 +/- 0.005) with either concentration of L-dopa; the rate constant of dopac formation in these experiments was, in contrast, found to be greater at the highest concentrations of L-dopa (100 and 500 microM). Aromatic L-amino acid decarboxylase (Aaad) activity determined in homogenates of the jejunal mucosa was found to be twice that observed in homogenates of the remaining jejunal wall (muscular).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Vieira-Coelho MA,Soares-da-Silva Pdoi
10.1111/j.1472-8206.1993.tb00237.xsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
235-43issue
5eissn
0767-3981issn
1472-8206journal_volume
7pub_type
杂志文章abstract::During the last decade, a multitude of experimental arguments have led to the concept that EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone but also in vascular homeostasis, neuronal and immunological functions. Regardless of its origin, endogenous NO is produced through the co...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1111/j.1472-8206.1993.tb01037.x
更新日期:1993-01-01 00:00:00
abstract::The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...
journal_title:Fundamental & clinical pharmacology
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abstract::The contractile activity of (-)-Bay k 8644 was assessed in rat isolated aortic ring preparations bathed in a potassium-free medium. (-)-Bay k 8644 (0.01-3 microM) caused extracellular calcium-dependent contractile responses, which were significantly greater in tissues with, than deprived of a functional endothelium. I...
journal_title:Fundamental & clinical pharmacology
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更新日期:1989-01-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1111/j.1472-8206.1990.tb00041.x
更新日期:1990-01-01 00:00:00
abstract::We studied the effects of KATP channel blockers on [3H]GABA release in the absence of glucose in rat hippocampal slices. The omission of glucose induced a marked increase in the efflux of [3H]GABA, which was antagonized by TTX (1 microM), but not by MK 801 (1 microM) or DNQX (100 microM). Glibenclamide (10-100 microM)...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic cough and airway hyperresponsiveness. The aim of this work was to assess in pigs the effects of bradykinin and tac...
journal_title:Fundamental & clinical pharmacology
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更新日期:2001-02-01 00:00:00
abstract::The ATP-binding cassette (ABC) transporter ABCB1, or P-glycoprotein, is a transmembrane efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 substrates include either drugs, such as antiretrovirals and immunomodulators, or physiological molecules like phospholipids. Pharmacogenetic a...
journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
doi:10.1111/fcp.12567
更新日期:2020-12-01 00:00:00
abstract::Prostaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES. Among them, m...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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更新日期:1989-01-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
doi:10.1111/fcp.12184
更新日期:2016-06-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
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doi:10.1111/j.1472-8206.1995.tb00537.x
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abstract::The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...
journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1472-8206.1988.tb00648.x
更新日期:1988-01-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
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更新日期:1990-01-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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更新日期:1998-01-01 00:00:00
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journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1111/fcp.12644
更新日期:2021-01-11 00:00:00
abstract::The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also meta...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1111/j.1472-8206.1993.tb00240.x
更新日期:1993-01-01 00:00:00
abstract::The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...
journal_title:Fundamental & clinical pharmacology
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doi:10.1111/j.1472-8206.2009.00748.x
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abstract::Cyclophosphamide given in association with corticosteroids has markedly improved the prognosis of systemic vasculitis. Little information has been reported on cyclophosphamide pharmacokinetics in these diseases and data evaluating its metabolite, 4-hydroxycyclophosphamide/aldophosphamide, pharmacokinetics and concentr...
journal_title:Fundamental & clinical pharmacology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1472-8206.2000.tb00424.x
更新日期:2000-07-01 00:00:00