Presynaptic imidazoline receptors mediate inhibition of noradrenaline release from sympathetic nerves in rat blood vessels.

abstract：:Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient die...

journal_title：Fundamental & clinical pharmacology

authors： Mi YN,Ping NN,Li B,Xiao X,Zhu YB,Cao L,Ren JK,Cao YX

更新日期：2017-10-01 00:00:00

abstract：:The efficacy of silymarin treatment in preventing biochemical and histological alterations in CCL4-induced liver cirrhosis in rats was studied. Four groups of rats were treated with: (1) CCL4; (2) mineral oil; (3) CCL4 + silymarin; and (4) silymarin. All animals were sacrificed 72 h after the end of treatments. The ac...

journal_title：Fundamental & clinical pharmacology

authors： Mourelle M,Muriel P,Favari L,Franco T

更新日期：1989-01-01 00:00:00

abstract：:The impact of an acute coronary syndrome (ACS) event, such as an acute myocardial infarction (MI), is not limited to the acute management phase; patients face an elevated risk of residual atherothrombotic events that commonly requires chronic management for months or even years. Significant advances have been made in ...

journal_title：Fundamental & clinical pharmacology

authors： Atar D,Bode C,Stuerzenbecher A,Verheugt FW

更新日期：2014-08-01 00:00:00

abstract：:Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-methyl-d-aspartate antagonists that are alternatives to be recommended in first-line NP treatment, memantine has...

journal_title：Fundamental & clinical pharmacology

authors： Pickering G,Morel V

更新日期：2018-02-01 00:00:00

abstract：:Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

journal_title：Fundamental & clinical pharmacology

authors： Pari L,Sivasankari R

更新日期：2008-08-01 00:00:00

abstract：UNLABELLED:In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats. Wistar rats were treated with 0.9% saline (i.p., control group), LA (10mg/kg, i.p., LA group), ubiquinone [20mg/kg, i.p., ubiquinone (UQ) group], pilocarpin...

journal_title：Fundamental & clinical pharmacology

authors： de Freitas RM,Feng D,Jordán J

更新日期：2011-04-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for central nervous system (CNS) and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 cells and activity against erythrocytic stages of Plasmodium falciparum was determined. Compound...

journal_title：Fundamental & clinical pharmacology

authors： Kedzierska E,Orzelska J,Perković I,Knežević D,Fidecka S,Kaiser M,Zorc B

更新日期：2016-02-01 00:00:00

abstract：:The aim of phase I studies per se is to explore the tolerance of new compounds which have demonstrated a certain level of activity in animals at sufficiently low non-toxic doses. In most cases, these studies are conducted in 2 steps in a limited number of healthy male volunteers: a single rising dose study followed by...

journal_title：Fundamental & clinical pharmacology

authors： Thiercelin JF

更新日期：1990-01-01 00:00:00

abstract：:During the last decade, a multitude of experimental arguments have led to the concept that EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone but also in vascular homeostasis, neuronal and immunological functions. Regardless of its origin, endogenous NO is produced through the co...

journal_title：Fundamental & clinical pharmacology

authors： Berdeaux A

更新日期：1993-01-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:The insulin secreting B cell is fitted with the two types of purinergic receptors: P2 (for ATP and/or ADP) and P1 (for adenosine). The activation of P2 purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose-dependent between 10(-6) a...

journal_title：Fundamental & clinical pharmacology

authors： Hillaire-Buys D,Chapal J,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1994-01-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00

abstract：:The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

journal_title：Fundamental & clinical pharmacology

authors： Hellmich B,Gyermek L

更新日期：1997-01-01 00:00:00

abstract：:The effects of tacrine and physostigmine on catecholamine secretion induced by veratridine and high K+, and on voltage-dependent Na+ and Ca2+ currents, were investigated in guinea-pig adrenal chromaffin cells. In perfused adrenal glands, tacrine (100 microM) caused an inhibition of veratridine-induced catecholamine se...

journal_title：Fundamental & clinical pharmacology

authors： Sugawara T,Kitamura N,Ohta T,Ito S,Nakazato Y

更新日期：1998-01-01 00:00:00

abstract：:Anticonvulsant action of CGP 40116, a competitive antagonist of N-methyl-D-aspartate type of excitatory amino acid receptors, was studied in rats during development (7, 12, 18, 25 and 90 days old). Two types of motor seizures were elicited by a subcutaneous injection of pentylenetetrazol. Pretreatment with CGP 40116 d...

journal_title：Fundamental & clinical pharmacology

authors： Haugvicová R,Mares P

更新日期：1998-01-01 00:00:00

abstract：:This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

journal_title：Fundamental & clinical pharmacology

authors： Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

更新日期：2020-09-09 00:00:00

abstract：:Gastric mucosa is frequently exposed to various gastric irritants, and there is a continuing requirement to develop new gastro-protective agents. This study compares the effects of three such agents, sucralfate, rebamipide, and cimetidine in both in vivo and in vitro indomethacin-induced gastric damage models. For the...

journal_title：Fundamental & clinical pharmacology

authors： Goineau S,Castagné V

更新日期：2017-04-01 00:00:00

abstract：:Anxiety following heart failure (HF) and/or myocardial infarction (MI) can impede recovery and constitute a major risk factor for further cardiac events. The present study was aimed to evaluate anxiety following doxorubicin (DOX)-induced cardiomyopathy, a rodent model for HF, in mice. Furthermore, the study investigat...

journal_title：Fundamental & clinical pharmacology

authors： Anwar MJ,Pillai KK,Khanam R,Akhtar M,Vohora D

更新日期：2012-06-01 00:00:00

abstract：:This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

journal_title：Fundamental & clinical pharmacology

authors： Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

更新日期：2010-08-01 00:00:00

abstract：:Zinc is the authoritative metal which is present in our body, and reactive zinc metal is crucial for neuronal signaling and is largely distributed within presynaptic vesicles. Zinc also plays an important role in synaptic function. At cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in ...

journal_title：Fundamental & clinical pharmacology

authors： Prakash A,Bharti K,Majeed AB

更新日期：2015-04-01 00:00:00

abstract：:France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10-year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives...

journal_title：Fundamental & clinical pharmacology

authors： Caré W,Langrand J,Vodovar D,Deveaux M,Alvarez JC,Mégarbane B,Dorandeu F

更新日期：2020-08-01 00:00:00

abstract：:Dapsone-induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45-year-old male Caucasian patient developed agranulocytosis caused by dapsone (diamino-diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, ant...

journal_title：Fundamental & clinical pharmacology

authors： Potočnjak I,Likić R,Šimić I,Juričić Nahal D,Čegec I,Ganoci L,Božina N

更新日期：2017-10-01 00:00:00

abstract：:We investigated the underlying mechanisms of penehyclidine hydrochloride (PHC), a novel selective anticholinergic drug on isolated rat uterus. The method of radio-immunity assay was further employed to determine cyclic adenosine mono phosphate (cAMP) levels in isolated rat uterus for comparing with selective effect on...

journal_title：Fundamental & clinical pharmacology

authors： Xiao HT,Liao Z,Meng XM,Yan XY,Chen SJ,Mo ZJ

更新日期：2009-08-01 00:00:00

abstract：:The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...

journal_title：Fundamental & clinical pharmacology

authors： Paris A,Cornu C,Auquier P,Maison P,Radauceanu A,Brandt C,Salvat-Melis M,Hommel M,Cracowski JL

更新日期：2006-02-01 00:00:00

abstract：:Interferon (IFN)-γ is known to downregulate expression of drug detoxifying proteins such as cytochromes P-450 (CYPs) in human hepatocytes. The present study was designed to determine whether IFN-γ may also impair expression of influx and efflux drug transporters, which constitute important determinants of the liver de...

journal_title：Fundamental & clinical pharmacology

authors： Le Vee M,Jouan E,Moreau A,Fardel O

更新日期：2011-02-01 00:00:00

abstract：:Chloroquine (CQ) induces histamine-independent itch in human and mice. We recently reported the role of intradermal nitric oxide (NO)/cyclic guanosine monophosphate pathway in CQ-evoked scratching in mice. Chloroquine stimulates neuronal nitric oxide synthase (nNOS) activity to over-producing NO in the skin. Sumatript...

journal_title：Fundamental & clinical pharmacology

authors： Haddadi NS,Ostadhadi S,Shakiba S,Afshari K,Rahimi N,Foroutan A,Dehpour AR

更新日期：2018-02-01 00:00:00

abstract：:The effects of tramadol versus placebo administration on behavioral indicators of ureteral pain, pelvic pain and referred lumbar muscle hyperalgesia were investigated in a rat model of viscero-visceral hyperalgesia from endometriosis plus ureteral calculosis (endo + stone). Fifty female Sprague-Dawley rats underwent s...

journal_title：Fundamental & clinical pharmacology

authors： Lopopolo M,Affaitati G,Fabrizio A,Massimini F,Lapenna D,Giamberardino MA,Costantini R

更新日期：2014-06-01 00:00:00

abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

journal_title：Fundamental & clinical pharmacology

authors：

更新日期：1997-01-01 00:00:00

abstract：:The hypothesis of an interaction between trimetazidine and the immunosuppressive effect of cyclosporin A was investigated in two models: a) ex vivo, the lymphoproliferative response of normal human lymphocytes to phytohemagglutinin and a murine monoclonal antibody against the CD3 T-lymphocyte membrane complex; b) in v...

journal_title：Fundamental & clinical pharmacology

authors： Albengres E,Tillement JP,d'Athis P,Salducci D,Chauvet-Monges AM,Crevat A

更新日期：1996-01-01 00:00:00