Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions.

abstract：:Torsades de pointes is the most typical ventricular tachycardia involving QT-interval prolongation. It is a rather unusual but potentially lethal ventricular tachycardia with a distinctive morphology favored by bradycardia, antiarrhythmic drugs and hypokalemia and requires specific treatment. Torsades de pointes has b...

journal_title：Fundamental & clinical pharmacology

authors： Weissenburger J,Davy JM,Chézalviel F

更新日期：1993-01-01 00:00:00

abstract：:The formation of dopamine, from L-3,4-dihydroxyphenylalanine (L-dopa), in fragments of non-glandular and glandular stomach, duodenum, jejunum, ileum and proximal and distal colon of the rat was examined. The deamination of newly-formed dopamine into 3,4-dihydroxyphenylacetic acid (dopac) was also studied. The synthesi...

journal_title：Fundamental & clinical pharmacology

authors： Vieira-Coelho MA,Soares-da-Silva P

更新日期：1993-01-01 00:00:00

abstract：:We investigated the underlying mechanisms of penehyclidine hydrochloride (PHC), a novel selective anticholinergic drug on isolated rat uterus. The method of radio-immunity assay was further employed to determine cyclic adenosine mono phosphate (cAMP) levels in isolated rat uterus for comparing with selective effect on...

journal_title：Fundamental & clinical pharmacology

authors： Xiao HT,Liao Z,Meng XM,Yan XY,Chen SJ,Mo ZJ

更新日期：2009-08-01 00:00:00

abstract：:Research in the last two decades has unveiled an important role for neuroinflammation in the degeneration of the nigrostriatal dopaminergic (DA) pathway that constitutes the pathological basis of the prevailing movement disorder, Parkinson's disease (PD). Neuroinflammation is characterized by the activation of brain g...

journal_title：Fundamental & clinical pharmacology

authors： Dutta G,Zhang P,Liu B

更新日期：2008-10-01 00:00:00

abstract：:Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis. Cpn is an obligate intracellular gram-negative bacterium that is responsible for 10% of cases of community-acquired pneumonia. In addi...

journal_title：Fundamental & clinical pharmacology

authors： Deniset JF,Pierce GN

更新日期：2010-10-01 00:00:00

abstract：:Abstract The relationship between depression and dopamine deficiency in the mesolimbic pathway has been hypothesized for many years. The experimental studies with animal models of depression and the human studies implicate the role of the dopamine system in depression. Not only do dopaminergic receptor agonists, but a...

journal_title：Fundamental & clinical pharmacology

authors： Dailly E,Chenu F,Renard CE,Bourin M

更新日期：2004-12-01 00:00:00

abstract：:This study investigated whether ivabradine, a selective If current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol-induced heart damage. Wistar rats were treated for 6 weeks: controls (n = 10), ivabradine (10 mg/kg/day orally; n = 10), isopr...

journal_title：Fundamental & clinical pharmacology

authors： Simko F,Baka T,Repova K,Aziriova S,Krajcirovicova K,Paulis L,Adamcova M

更新日期：2020-10-24 00:00:00

abstract：:Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n = 26) and old (23.0 ± 0.2 months, n = 27) male Fischer 344 rats followin...

journal_title：Fundamental & clinical pharmacology

authors： Mach J,Huizer-Pajkos A,Mitchell SJ,McKenzie C,Phillips L,Kane A,Jones B,de Cabo R,Cogger V,Le Couteur DG,Hilmer SN

更新日期：2016-02-01 00:00:00

abstract：:This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

journal_title：Fundamental & clinical pharmacology

authors： Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

更新日期：2010-08-01 00:00:00

abstract：:The insulin secreting B cell is fitted with the two types of purinergic receptors: P2 (for ATP and/or ADP) and P1 (for adenosine). The activation of P2 purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose-dependent between 10(-6) a...

journal_title：Fundamental & clinical pharmacology

authors： Hillaire-Buys D,Chapal J,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1994-01-01 00:00:00

abstract：:Changes in neurobiological parameters were examined from early life (10 days post-natal) until late adulthood (8 months post-natal) in three successive generations of alcoholized rats. The mean daily consumption of alcohol by the 2nd and 3rd generation rats (7.40 +/- 0.22 and 7.70 +/- 0.20 g ethanol/kg body weight, re...

journal_title：Fundamental & clinical pharmacology

authors： Nevo I,Parvez S

更新日期：1994-01-01 00:00:00

abstract：:Recent in vitro evidence suggests that T-type Ca(2+) channels are implicated in the mechanisms of ischemia-induced delayed neuronal cell death. The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca(2+) channel inhibitors, in an in vivo rat model of global ischemia. ...

journal_title：Fundamental & clinical pharmacology

authors： Bancila M,Copin JC,Daali Y,Schatlo B,Gasche Y,Bijlenga P

更新日期：2011-08-01 00:00:00

abstract：:The present study investigated the effects of positive end-expiratory pressure (PEEP) on propofol concentrations in humans. Eleven patients undergoing elective surgery were enrolled in this study. Anesthesia was induced with propofol, then maintained using 60% nitrous oxide in oxygen, fentanyl 10-20 microg/kg and cont...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa E,Ito N,Ishizeki J,Goto F,Hiraoka H,Takizawa D

更新日期：2006-10-01 00:00:00

abstract：:A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti-inflammatory of 4-PSQ. For this reason, the first objective of this study was to expand our previous findings by investig...

journal_title：Fundamental & clinical pharmacology

authors： Silva VDG,Reis AS,Pinz MP,da Fonseca CAR,Duarte LFB,Roehrs JA,Alves D,Luchese C,Wilhelm EA

更新日期：2017-10-01 00:00:00

abstract：:In previous studies, the relaxant, anticholinergic (functional antagonism) antihistaminic, effects of Nigella sativa have been demonstrated on guinea-pig tracheal chains. In the present study, the prophylactic effect of boiled extract of N. sativa on asthmatic disease was examined. Twenty-nine asthmatic adults were ra...

journal_title：Fundamental & clinical pharmacology

authors： Boskabady MH,Javan H,Sajady M,Rakhshandeh H

更新日期：2007-10-01 00:00:00

abstract：:The aim of this review is to comment the results described in the literature concerning the possible pharmacodynamic mechanisms involved in the improvement of quality of life of angiotensin converting enzyme inhibitors that is just a working hypothesis. These drugs, widely used in the treatment of hypertension, preven...

journal_title：Fundamental & clinical pharmacology

authors： Govantes C,Marín J

更新日期：1996-01-01 00:00:00

abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...

journal_title：Fundamental & clinical pharmacology

authors： Lalonde R,Strazielle C

更新日期：2010-06-01 00:00:00

abstract：:Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor or an inducer of CYP3A affects HP pharmacokine...

journal_title：Fundamental & clinical pharmacology

authors： Watanabe M,Tateishi T,Asoh M,Nakura H,Tanaka M,Kumai T,Kobayashi S

更新日期：1999-01-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:Rhodamine 123 is a fluorescent cationic dye commonly used as a mitochondrial probe and known or suspected to be transported by certain drug membrane transporters. The present study was designed to characterize the putative interactions of rhodamine 123 with human organic cation transporter (OCT) 1 and OCT2. Intracellu...

journal_title：Fundamental & clinical pharmacology

authors： Jouan E,Le Vee M,Denizot C,Da Violante G,Fardel O

更新日期：2014-02-01 00:00:00

abstract：:The effects of two single oral doses (5 mg and 20 mg) of a new angiotensin I-converting enzyme inhibitor, imidapril, on a) systemic hemodynamics (arterial pressure, heart rate, cardiac output), b) brachial and common carotid arteries' hemodynamics (diameter and blood flow, pulsed Doppler technique), c) cerebral hemody...

journal_title：Fundamental & clinical pharmacology

authors： Démolis P,Annane D,Duhazé P,Giudicelli JF

更新日期：1994-01-01 00:00:00

abstract：:The effects of tramadol versus placebo administration on behavioral indicators of ureteral pain, pelvic pain and referred lumbar muscle hyperalgesia were investigated in a rat model of viscero-visceral hyperalgesia from endometriosis plus ureteral calculosis (endo + stone). Fifty female Sprague-Dawley rats underwent s...

journal_title：Fundamental & clinical pharmacology

authors： Lopopolo M,Affaitati G,Fabrizio A,Massimini F,Lapenna D,Giamberardino MA,Costantini R

更新日期：2014-06-01 00:00:00

abstract：:The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...

journal_title：Fundamental & clinical pharmacology

authors： Paris A,Cornu C,Auquier P,Maison P,Radauceanu A,Brandt C,Salvat-Melis M,Hommel M,Cracowski JL

更新日期：2006-02-01 00:00:00

abstract：:Zinc is the authoritative metal which is present in our body, and reactive zinc metal is crucial for neuronal signaling and is largely distributed within presynaptic vesicles. Zinc also plays an important role in synaptic function. At cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in ...

journal_title：Fundamental & clinical pharmacology

authors： Prakash A,Bharti K,Majeed AB

更新日期：2015-04-01 00:00:00

abstract：:Quercetin is a flavonol polyphenol widely found in many vegetables, grains, and fruits. Quercetin has been shown to inhibit proliferation and invasion of various glioma cells and is regarded as a potential anticancer agent against glioma. However, whether and how this drug could affect brain blood vessels and endothel...

journal_title：Fundamental & clinical pharmacology

authors： Chen CY,Hour MJ,Shiao LR,Wong KL,Leung YM,Chan P,So EC

更新日期：2020-04-01 00:00:00

abstract：:Since patients may report spontaneously adverse events associated with their medications, such notifications are constantly on the rise. In 2017, an unexpected rise of notifications associated with the marketing of a new formula of Levothyrox, differing from the 30-year-old drug only by minor elements, occurred in Fra...

journal_title：Fundamental & clinical pharmacology

authors： Viard D,Parassol-Girard N,Romani S,Van Obberghen E,Rocher F,Berriri S,Drici MD

更新日期：2019-08-01 00:00:00

abstract：:Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) activities were detected in bronchial and bronchial epithelial cell homogenates of the pig. In the bronchial homogenates, the maximal upstroke velocity (Vmax) of AChE and the maximal velocity after second substrate fixation (Vss) of B...

journal_title：Fundamental & clinical pharmacology

authors： Taisne C,Norel X,Walch L,Labat C,Verriest C,Mazmanian GM,Brink C

更新日期：1997-01-01 00:00:00

abstract：:A controlled graded bleeding was performed in conscious rats with 15 min intervals between two withdrawals, in order to induce a 25% blood loss without hypotension. Heart rate (HR) was unaffected as well. The spectral profiles of systolic blood pressure (SBP) analyzed on 51.2 s segments exhibited increases in the high...

journal_title：Fundamental & clinical pharmacology

authors： Baujard C,Ponchon P,Elghozi JL

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a high-cholesterol diet in the presence and absence of statin on Cu-Zn-superoxide dismutase (Cu,Zn-SOD), malondialdehyde (MDA), protein carbonyl (PCO), and nitric oxide (NO) of blood and heart tissue, the antioxidant activity of serum paraoxonase-1 (PON-1), and o...

journal_title：Fundamental & clinical pharmacology

authors： Sozer V

更新日期：2015-12-01 00:00:00

abstract：:The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to af...

journal_title：Fundamental & clinical pharmacology

authors： Noize P,Sauer M,Bruneval P,Moreau M,Pathak A,Bagheri H,Montastruc JL

更新日期：2006-12-01 00:00:00