Abstract:
:Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) activities were detected in bronchial and bronchial epithelial cell homogenates of the pig. In the bronchial homogenates, the maximal upstroke velocity (Vmax) of AChE and the maximal velocity after second substrate fixation (Vss) of BChE were 5.70 +/- 0.46 and 7.87 +/- 0.81 mU/mg protein, respectively. In the epithelial cell homogenates, a smaller amount of cholinesterase (ChE) was found: Vmax was 0.62 +/- 0.29 and Vss was 1.56 +/- 0.33 mU/mg protein for AChE and BChE, respectively. AChE activity was increased by 21 +/- 5% in the bronchial homogenates and by 54 +/- 14% in the epithelial cell homogenates, when intact bronchial segments were incubated with a cyclooxygenase inhibitor, indomethacin (INDO). These results suggest that prostanoids may be involved in the regulation of AChE activity in pig airways.
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Taisne C,Norel X,Walch L,Labat C,Verriest C,Mazmanian GM,Brink Cdoi
10.1111/j.1472-8206.1997.tb00186.xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
201-5issue
3eissn
0767-3981issn
1472-8206pii
S0767398197833270journal_volume
11pub_type
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