Cholinesterase activity in pig airways and epithelial cells.

Abstract:

:Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) activities were detected in bronchial and bronchial epithelial cell homogenates of the pig. In the bronchial homogenates, the maximal upstroke velocity (Vmax) of AChE and the maximal velocity after second substrate fixation (Vss) of BChE were 5.70 +/- 0.46 and 7.87 +/- 0.81 mU/mg protein, respectively. In the epithelial cell homogenates, a smaller amount of cholinesterase (ChE) was found: Vmax was 0.62 +/- 0.29 and Vss was 1.56 +/- 0.33 mU/mg protein for AChE and BChE, respectively. AChE activity was increased by 21 +/- 5% in the bronchial homogenates and by 54 +/- 14% in the epithelial cell homogenates, when intact bronchial segments were incubated with a cyclooxygenase inhibitor, indomethacin (INDO). These results suggest that prostanoids may be involved in the regulation of AChE activity in pig airways.

journal_name

Fundam Clin Pharmacol

authors

Taisne C,Norel X,Walch L,Labat C,Verriest C,Mazmanian GM,Brink C

doi

10.1111/j.1472-8206.1997.tb00186.x

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

201-5

issue

3

eissn

0767-3981

issn

1472-8206

pii

S0767398197833270

journal_volume

11

pub_type

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