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Dopamine, depression and antidepressants.

Abstract：

:Abstract The relationship between depression and dopamine deficiency in the mesolimbic pathway has been hypothesized for many years. The experimental studies with animal models of depression and the human studies implicate the role of the dopamine system in depression. Not only do dopaminergic receptor agonists, but also antagonists such as olanzapine exhibit antidepressant effects associated with standard antidepressants in patients with treatment-resistant depression. This paradoxical result suggests that further investigations are necessary to understand the role played by dopamine in depression.

journal_name

Fundam Clin Pharmacol

journal_title

Fundamental & clinical pharmacology

authors

Dailly E,Chenu F,Renard CE,Bourin M

doi

10.1111/j.1472-8206.2004.00287.x

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

601-7

issue

6

eissn

0767-3981

issn

1472-8206

pii

FCP287

journal_volume

18

pub_type

杂志文章,评审

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