Effect of endogenous catecholamine on myocardial stunning in a simulated ischemia model.

abstract：:Clinical and experimental studies have shown that gender differences exist in cardiac repolarization in various animal species and human, as is evidenced by significantly longer QT, JT intervals and action potential duration in females than in males due to a reduced repolarization reserve in females. The latter is sho...

journal_title：Fundamental & clinical pharmacology

authors： Cheng J

更新日期：2006-02-01 00:00:00

abstract：:The aim of this study was to investigate quantitatively the action of and the interaction between beta-adrenergic receptor agonists in desensitizing guinea pig isolated trachea. It was also to evaluate the influence of substances whose effects on desensitization are either disputed (theophylline, indomethacin, ketotif...

journal_title：Fundamental & clinical pharmacology

authors： Matran R,Naline E,Advenier C,Duroux P

更新日期：1989-01-01 00:00:00

abstract：:Anticonvulsant action of CGP 40116, a competitive antagonist of N-methyl-D-aspartate type of excitatory amino acid receptors, was studied in rats during development (7, 12, 18, 25 and 90 days old). Two types of motor seizures were elicited by a subcutaneous injection of pentylenetetrazol. Pretreatment with CGP 40116 d...

journal_title：Fundamental & clinical pharmacology

authors： Haugvicová R,Mares P

更新日期：1998-01-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a common infectious disease in the world. Two percent of the patients with chronic HBV infection will develop cirrhosis each year, and will die prematurely from cirrhosis or hepatocellular carcinoma. So far interferon alfa and lamivudine are the only effective drugs. Interf...

journal_title：Fundamental & clinical pharmacology

authors： Ormeci N

更新日期：2003-12-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:The venom from the scorpion Leiurus quinquestriatus quinquestriatus has previously been shown to alter the excitability of the neural and skeletal muscle preparations. The present study was undertaken to explore the effects of the venom in cardiac potential signals at the animal, tissue and the cell level in rats hear...

journal_title：Fundamental & clinical pharmacology

authors： Purali N,Yagcioglu S

更新日期：2002-06-01 00:00:00

abstract：:A meta-analysis was performed on the results of clinical trials of buflomedil in intermittent claudication. The analysis used results from 744 patients enrolled in ten studies, conducted at 42 centers in seven countries. All studies were randomized, double-blind, placebo-controlled trials which measured improvement in...

journal_title：Fundamental & clinical pharmacology

authors： Walker GA,Mac Hannaford JC

更新日期：1995-01-01 00:00:00

abstract：:The present study was carried out to investigate on the possible involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate (L-arginine/NO/cGMP) pathway in the aqueous extract of Muntingia calabura (AEMC) leaves antinociception in mice assessed by abdominal constriction test. The AEMC, obtained by soaking t...

journal_title：Fundamental & clinical pharmacology

authors： Zakaria ZA,Sulaiman MR,Jais AM,Somchit MN,Jayaraman KV,Balakhrisnan G,Abdullah FC

更新日期：2006-08-01 00:00:00

abstract：:Thienopyridines have become the cornerstone of treatment for percutaneous coronary intervention although no survival benefit has ever been shown with clopidogrel despite increasing loading doses. Newly developed P2Y12 inhibitors are more potent, more predictable, and have a faster onset of action than clopidogrel, cha...

journal_title：Fundamental & clinical pharmacology

authors： Collet JP,O'Connor S

更新日期：2012-02-01 00:00:00

abstract：:The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...

journal_title：Fundamental & clinical pharmacology

authors： Pourrias B,Marie C

更新日期：1992-01-01 00:00:00

abstract：:Changes in neurobiological parameters were examined from early life (10 days post-natal) until late adulthood (8 months post-natal) in three successive generations of alcoholized rats. The mean daily consumption of alcohol by the 2nd and 3rd generation rats (7.40 +/- 0.22 and 7.70 +/- 0.20 g ethanol/kg body weight, re...

journal_title：Fundamental & clinical pharmacology

authors： Nevo I,Parvez S

更新日期：1994-01-01 00:00:00

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:Alizapride is a new antidopaminergic-related benzamide with specific antiemetic properties. Pharmacokinetics at a high repetitive dose (16 mg/kg) shows a biexponential plasma decay with T1/2 alpha of 8.33 +/- 2.47 min and T1/2 beta 2.8 +/- 0.7 hr. Large Vdss and high total body clearance are apparent. We demonstrate a...

journal_title：Fundamental & clinical pharmacology

authors： Canal P,Roche H,Pasquier M,Bugat R,Berg D,Soula G,Carton M

更新日期：1987-01-01 00:00:00

abstract：:The aim of this review is to comment the results described in the literature concerning the possible pharmacodynamic mechanisms involved in the improvement of quality of life of angiotensin converting enzyme inhibitors that is just a working hypothesis. These drugs, widely used in the treatment of hypertension, preven...

journal_title：Fundamental & clinical pharmacology

authors： Govantes C,Marín J

更新日期：1996-01-01 00:00:00

abstract：:The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...

journal_title：Fundamental & clinical pharmacology

authors： Redrobe JP,Bourin M

更新日期：1997-01-01 00:00:00

abstract：:In experiments in vivo, we studied whether the endothelial dysfunction induced by nitric oxide (NO) synthesis inhibition is simultaneously or sequentially manifested as a reduced level of endothelium-dependent agonist-induced vasodilatation, an increased responsiveness to vasoconstrictors, and hypertension. Vascular r...

journal_title：Fundamental & clinical pharmacology

authors： López RM,Pérez T,Castillo C,Castillo MC,Castillo EF

更新日期：2011-06-01 00:00:00

abstract：:Developing drugs for rare disease can be challenging due to specific rare disease characteristics. The French Medical Pharmacology is structured and positioned to play a major role in orphan drug research and development due to the required expertise concentrated into pharmacology departments, exclusively implemented ...

journal_title：Fundamental & clinical pharmacology

authors： Micallef J,Boutouyrie P,Blin O

更新日期：2017-12-01 00:00:00

abstract：:Angiotensin II AT1 receptor blockade (AT1-) has been shown to prolong survival in post-myocardial infarction (MI) heart failure in rats. In this study, we investigated whether an early AT1-induced improvement in coronary vasodilatation reserve (CVR) might be involved in this beneficial effect. Wistar rats with MI were...

journal_title：Fundamental & clinical pharmacology

authors： Gervais M,Richer C,Fornes P,De Gasparo M,Giudicelli JF

更新日期：1999-01-01 00:00:00

abstract：:We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications. ...

journal_title：Fundamental & clinical pharmacology

authors： Uzzan B,Dumont-Fischer D,Lahlou N,Bihan H,Boissier MC,Alvarez JC,Perret GY,Cohen R

更新日期：2008-04-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic cough and airway hyperresponsiveness. The aim of this work was to assess in pigs the effects of bradykinin and tac...

journal_title：Fundamental & clinical pharmacology

authors： Moreaux B,Advenier C,Gustin P

更新日期：2001-02-01 00:00:00

abstract：:Prenatal exposure to valproic acid (VPA) has been shown to increase the risk of autism in children. This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats. Pregnant albino rats administered VPA (500 mg/kg, i.p.) or normal saline (10 mL/kg, i.p.; vehicle-control) on gestational day...

journal_title：Fundamental & clinical pharmacology

authors： Ishola IO,Balogun AO,Adeyemi OO

更新日期：2020-12-01 00:00:00

abstract：:Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti-inflammatory agents with cardioprotective effects is an urgent task. We aimed to eva...

journal_title：Fundamental & clinical pharmacology

authors： Refaie MMM,Rifaai RA,Bayoumi AMA,Shehata S

更新日期：2020-06-01 00:00:00

abstract：:There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti-inflammatory and ...

journal_title：Fundamental & clinical pharmacology

authors： Ouk T,Potey C,Laprais M,Gautier S,Hanf R,Darteil R,Staels B,Duriez P,Bordet R

更新日期：2014-06-01 00:00:00

abstract：:The contribution of Na+, Ca2+, and various K+ currents to the shape of the cardiac action potential is outlined based on the relation between electrophysiological properties and structure of channel molecules. These currents have also been found in human ventricular myocytes, where the most prominent K+ current is a t...

journal_title：Fundamental & clinical pharmacology

authors： Ravens U,Wettwer E,Ohler A,Amos GJ,Mewes T

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of Na+ , K+ -ATPase (NKA) involved in low concentration of ouabain (Oua, activating NKA)-induced protection of rat cerebral ischemia-reperfusion injury. The 2,3,5-triphenyltetrazolium chloride staining and neurological deficit scores were performed to evaluate rat...

journal_title：Fundamental & clinical pharmacology

authors： Li LL,Ke XY,Jiang C,Qin SQ,Liu YY,Xian XH,Liu LZ,He JC,Chen YM,An HF,Sun N,Hu YH,Wang Y,Zhang LN,Lu QY

更新日期：2021-01-22 00:00:00

abstract：:A controlled graded bleeding was performed in conscious rats with 15 min intervals between two withdrawals, in order to induce a 25% blood loss without hypotension. Heart rate (HR) was unaffected as well. The spectral profiles of systolic blood pressure (SBP) analyzed on 51.2 s segments exhibited increases in the high...

journal_title：Fundamental & clinical pharmacology

authors： Baujard C,Ponchon P,Elghozi JL

更新日期：1996-01-01 00:00:00

abstract：:Heart transplant is considered to be an extremely severe ischemia-reperfusion sequence. Post-ischemic dysfunction triggers multiple processes especially oxidative stress, but the mechanisms remain unclear. Free radical interactions lead to peroxynitrite generation, which seems to be involved in early post-transplant h...

journal_title：Fundamental & clinical pharmacology

authors： Lauzier B,Sicard P,Bouchot O,Delemasure S,Moreau D,Vergely C,Rochette L

更新日期：2007-04-01 00:00:00

abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

journal_title：Fundamental & clinical pharmacology

authors：

更新日期：1997-01-01 00:00:00

abstract：:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

更新日期：2005-10-01 00:00:00

abstract：:Overdose cardiac effects of imipramine are due to fast Na channel blockade and are clinically reversed by administration of sodium lactate which induces alkalosis (about pH 7.50) and hypernatremia (about 8 mM). The mechanisms of this beneficial effect of Na lactate were explored in vitro on guinea-pig ventricular myoc...

journal_title：Fundamental & clinical pharmacology

authors： Adamantidis MM,Adnet-Bonte C,Adnet P,Durocher A,Dupuis BA

更新日期：1992-01-01 00:00:00