Clinical effects and outcomes with new P2Y12 inhibitors in ACS.

abstract：:The role of nitric oxide/protein kinase G (NO/PKG) in neurodegenerative disorders is controversial in different circumstances. PKG affects neurons both by itself and as a result of increased NO concentration. In this study, we examined the influence of PKG on spatial memory by intrahippocampal administration of three ...

journal_title：Fundamental & clinical pharmacology

authors： Shariatpanahi M,Khodagholi F,Ashabi G,Bonakdar Yazdi B,Hassani S,Azami K,Abdollahi M,Noorbakhsh F,Taghizadeh G,Sharifzadeh M

更新日期：2016-08-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:Macrophage inflammatory protein (MIP)-1beta and RANTES (regulated on activation, normal T-cells expressed and secreted) are members of the CC-family of chemokines. Although these two peptides are structurally and functionally related to one another, each exhibits distinct features, which allows it to independently reg...

journal_title：Fundamental & clinical pharmacology

authors： Tavares E,Miñano FJ

更新日期：2004-04-01 00:00:00

abstract：:The aim of this study was to investigate quantitatively the action of and the interaction between beta-adrenergic receptor agonists in desensitizing guinea pig isolated trachea. It was also to evaluate the influence of substances whose effects on desensitization are either disputed (theophylline, indomethacin, ketotif...

journal_title：Fundamental & clinical pharmacology

authors： Matran R,Naline E,Advenier C,Duroux P

更新日期：1989-01-01 00:00:00

abstract：:HMG CoA reductase inhibitors (statins) have an established place in the treatment of coronary artery disease. However, their role in the treatment of heart failure (HF), including HF due to coronary artery disease, has been controversial since beneficial as well as possible harmful effects may occur. Several recent st...

journal_title：Fundamental & clinical pharmacology

authors： Gullestad L,Oie E,Ueland T,Yndestad A,Aukrust P

更新日期：2007-11-01 00:00:00

abstract：:Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor or an inducer of CYP3A affects HP pharmacokine...

journal_title：Fundamental & clinical pharmacology

authors： Watanabe M,Tateishi T,Asoh M,Nakura H,Tanaka M,Kumai T,Kobayashi S

更新日期：1999-01-01 00:00:00

abstract：:Atherosclerosis is a multifactorial condition characterized by endothelial injury, fatty streak deposition, and stiffening of the blood vessels. The pathogenesis is complex and mediated by adhesion molecules, inflammatory cells, and smooth muscle cells. Statins have been the major drugs in treating hypercholesterolemi...

journal_title：Fundamental & clinical pharmacology

authors： Priyadharsini RP

更新日期：2015-08-01 00:00:00

abstract：:A combination of sub-effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test. ...

journal_title：Fundamental & clinical pharmacology

authors： Vohora D,Pal SN,Pillai KK

更新日期：2005-10-01 00:00:00

abstract：:In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and arterial compliance abnormalities which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain antihypertensive agen...

journal_title：Fundamental & clinical pharmacology

authors： Khder Y,Bray des Boscs L,el Ghawi R,Meilhac B,Montestruc F,Stoltz JF,Zannad F

更新日期：1998-01-01 00:00:00

abstract：:This study aimed to investigate the modulation of nitric oxide/reactive oxygen species in sodium nitroprusside relaxation in mice aorta. Sodium nitroprusside induced relaxation in endothelium-intact (e+) and endothelium-denuded (e-) aortas with greater potency in e+ than in e-. The nitric oxide synthase inhibitor did ...

journal_title：Fundamental & clinical pharmacology

authors： Kangussu LM,Olivon VC,Arifa RD,Araújo N,Reis D,Assis MT,Soriani FM,de Souza Dda G,Bendhack LM,Bonaventura D

更新日期：2015-04-01 00:00:00

abstract：:Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti-inflammatory agents with cardioprotective effects is an urgent task. We aimed to eva...

journal_title：Fundamental & clinical pharmacology

authors： Refaie MMM,Rifaai RA,Bayoumi AMA,Shehata S

更新日期：2020-06-01 00:00:00

abstract：:Cyclophosphamide given in association with corticosteroids has markedly improved the prognosis of systemic vasculitis. Little information has been reported on cyclophosphamide pharmacokinetics in these diseases and data evaluating its metabolite, 4-hydroxycyclophosphamide/aldophosphamide, pharmacokinetics and concentr...

journal_title：Fundamental & clinical pharmacology

authors： Belfayol-Pisanté L,Guillevin L,Tod M,Fauvelle F

更新日期：2000-07-01 00:00:00

abstract：:ATP-Binding Cassette transporters such as ABCG2 confer resistance to various anticancer drugs including irinotecan and its active metabolite, SN38. Early quantitative evaluation of efflux transporter inhibitors-cytotoxic combination requires quantitative drug-disease models. A proof-of-concept study has been carried o...

journal_title：Fundamental & clinical pharmacology

authors： Sostelly A,Payen L,Guitton J,Di Pietro A,Falson P,Honorat M,Boumendjel A,Gèze A,Freyer G,Tod M

更新日期：2014-04-01 00:00:00

abstract：:This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

journal_title：Fundamental & clinical pharmacology

authors： Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

更新日期：2020-09-09 00:00:00

abstract：:The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...

journal_title：Fundamental & clinical pharmacology

authors： Paris A,Cornu C,Auquier P,Maison P,Radauceanu A,Brandt C,Salvat-Melis M,Hommel M,Cracowski JL

更新日期：2006-02-01 00:00:00

abstract：:Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...

journal_title：Fundamental & clinical pharmacology

authors： Gilchrist SE,Alcorn J

更新日期：2010-04-01 00:00:00

abstract：:High-dose benzodiazepine (BDZs) represents an important risk factor for dependence, particularly in a prison environment. In Lyon's prison, BDZs and/or opioid maintenance treatment are often prescribed to patients with mental disorders. The aim of this retrospective study was to assess the impact of psychiatrist and p...

journal_title：Fundamental & clinical pharmacology

authors： Lerat MC,Cabelguenne D,Lassia J,Meunier F,Zimmer L

更新日期：2011-12-01 00:00:00

abstract：:In therapeutic trials, quality of life studies are usually based on a health model which results in a restrictive view. Therefore, it is important to clearly define the concept of the quality of life, since ambiguous concepts can alter the results. The key to this problem is the clear distinction between the two compo...

journal_title：Fundamental & clinical pharmacology

authors： Gerin P,Dazord A,Boissel J,Chifflet R

更新日期：1992-01-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injections of dihydropyridine derivatives calcium channel agonist (BAY K8644) and antagonist (nifedipine, nicardipine, PN 200-110) induced opposite long-lasting changes in blood pressure (BP) in pentobarbital anesthetized spontaneously hypertensive rats (SMR). I.c.v. nifedipine (NIF), ...

journal_title：Fundamental & clinical pharmacology

authors： Laurent S,Brisac AM,Champeroux P,Lacolley P,Huguet F,Legrand M,Lucet B,Tsoucaris D,Briand V,Schmitt H

更新日期：1989-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a high-cholesterol diet in the presence and absence of statin on Cu-Zn-superoxide dismutase (Cu,Zn-SOD), malondialdehyde (MDA), protein carbonyl (PCO), and nitric oxide (NO) of blood and heart tissue, the antioxidant activity of serum paraoxonase-1 (PON-1), and o...

journal_title：Fundamental & clinical pharmacology

authors： Sozer V

更新日期：2015-12-01 00:00:00

abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

journal_title：Fundamental & clinical pharmacology

authors：

更新日期：1997-01-01 00:00:00

abstract：:Heart transplant is considered to be an extremely severe ischemia-reperfusion sequence. Post-ischemic dysfunction triggers multiple processes especially oxidative stress, but the mechanisms remain unclear. Free radical interactions lead to peroxynitrite generation, which seems to be involved in early post-transplant h...

journal_title：Fundamental & clinical pharmacology

authors： Lauzier B,Sicard P,Bouchot O,Delemasure S,Moreau D,Vergely C,Rochette L

更新日期：2007-04-01 00:00:00

abstract：:The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...

journal_title：Fundamental & clinical pharmacology

authors： Pourrias B,Marie C

更新日期：1992-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work ...

journal_title：Fundamental & clinical pharmacology

authors： Bès S,Tatou E,Vandroux D,Tissier C,Rochette L,Athias P

更新日期：2004-06-01 00:00:00

abstract：:In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal m...

journal_title：Fundamental & clinical pharmacology

authors： Daveluy A,Sauvaget L,Bastien A,Lapeyre-Mestre M,Collin C,Richard N,Haramburu F

更新日期：2018-10-01 00:00:00

abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

journal_title：Fundamental & clinical pharmacology

authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

更新日期：1999-01-01 00:00:00

abstract：:Adverse reactions to antipsychotic drugs (APs) have been attributed to oxidative stress. Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death. We examined the protective properties of SF against AP-induced oxidative stress in dopaminergic neuroblastoma cells. Human neuroblastoma SK-N...

journal_title：Fundamental & clinical pharmacology

authors： Mas S,Gassó P,Trias G,Bernardo M,Lafuente A

更新日期：2012-12-01 00:00:00

abstract：:Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after...

journal_title：Fundamental & clinical pharmacology

authors： Zyoud SH,Awang R,Sulaiman SA,Al-Jabi SW

更新日期：2011-06-01 00:00:00

abstract：:The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. Although CGP 37849 was the more potent compound, both antago...

journal_title：Fundamental & clinical pharmacology

authors： D'Hooge R,Raes A,Van de Vijver G,Van Bogaert PP,De Deyn PP

更新日期：1999-01-01 00:00:00

abstract：:Viral infections remain a major cause of economic loss with an unmet need for novel therapeutic agents. Ivermectin is a putative antiviral compound; the proposed mechanism is the inhibition of nuclear translocation of viral proteins, facilitated by mammalian host importins, a necessary process for propagation of infec...

journal_title：Fundamental & clinical pharmacology

authors： Kinobe RT,Owens L

更新日期：2021-01-11 00:00:00