当前位置： SCI文献检索 > FUNDAMENTAL & CLINICAL PHARMACOLOGY期刊下所有文献 > Sulforaphane protects SK-N-SH cells against antipsychotic-induced oxidative stress.

Sulforaphane protects SK-N-SH cells against antipsychotic-induced oxidative stress.

Abstract：

:Adverse reactions to antipsychotic drugs (APs) have been attributed to oxidative stress. Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death. We examined the protective properties of SF against AP-induced oxidative stress in dopaminergic neuroblastoma cells. Human neuroblastoma SK-N-SH cells were treated with SF (0.5-5 μM), and 24 h later, haloperidol, risperidone or paliperidone (100 μM) was administered, either alone or in combination with dopamine (100 μM). To determine the antioxidant properties of SF, quinone oxidoreductase (NQO1) activity, glutathione S-transferase activity, and glutathione (GSH) levels were determined. Oxidative stress was measured by the increase in thiobarbituric acid reactive substances (TBARS) and in protein-bound quinones. Cell viability was also assessed. SF treatment increased GSH levels and induced NQO1 activity in SK-N-SH cells. Haloperidol was the only AP that increased TBARS when administered alone. When cells were cocultured with a drug in combination with dopamine, all three APs increased TBARS and protein-bound quinones and also induced neurotoxicity. In all the experimental conditions, 5 μM SF attenuated the accumulation of TBARS and protein-bound quinones and increased cell survival rates. Our results indicate that SF increases GSH levels and induces NQO1 activity and the removal of electrophilic quinones and radical oxygen species. Furthermore, SF could provide protective effects against AP-induced toxicity in dopaminergic cells.

journal_name

Fundam Clin Pharmacol

journal_title

Fundamental & clinical pharmacology

authors

Mas S,Gassó P,Trias G,Bernardo M,Lafuente A

doi

10.1111/j.1472-8206.2011.00988.x

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

712-21

issue

6

eissn

0767-3981

issn

1472-8206

journal_volume

26

pub_type

杂志文章

相关文献

FUNDAMENTAL & CLINICAL PHARMACOLOGY文献大全
  • Valvular heart disease in a patient taking benfluorex.

    abstract：:The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to af...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2006.00441.x

    authors： Noize P,Sauer M,Bruneval P,Moreau M,Pathak A,Bagheri H,Montastruc JL

    更新日期：2006-12-01 00:00:00

  • A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS-CoV-2.

    abstract：:Viral infections remain a major cause of economic loss with an unmet need for novel therapeutic agents. Ivermectin is a putative antiviral compound; the proposed mechanism is the inhibition of nuclear translocation of viral proteins, facilitated by mammalian host importins, a necessary process for propagation of infec...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/fcp.12644

    authors： Kinobe RT,Owens L

    更新日期：2021-01-11 00:00:00

  • Nitric oxide and the control of renin secretion.

    abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1472-8206.1995.tb00505.x

    authors： Reid IA,Chiu YJ

    更新日期：1995-01-01 00:00:00

  • Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo.

    abstract：:The aims of this study were: (i) To investigate the activity of recombinant AMPs HNP-1 and hBD-1 in combination with cefotaxime against Staphylococcus aureus strains (MSSA and MRSA) in vitro using checkerboard method; (ii) To investigate the activity of HNP-1 and hBD-1 encapsulated in silicon nanoparticles (niosomes) ...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/fcp.12499

    authors： Bolatchiev A,Baturin V,Bazikov I,Maltsev A,Kunitsina E

    更新日期：2020-02-01 00:00:00

  • Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.

    abstract：:The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. Although CGP 37849 was the more potent compound, both antago...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1999.tb00322.x

    authors： D'Hooge R,Raes A,Van de Vijver G,Van Bogaert PP,De Deyn PP

    更新日期：1999-01-01 00:00:00

  • Effects of oxazepam and acetaminophen on cicletanine metabolism in rat hepatocytes and liver microsomes.

    abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1999.tb00363.x

    authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

    更新日期：1999-01-01 00:00:00

  • Spontaneous adverse event notifications by patients subsequent to the marketing of a new formulation of Levothyrox® amidst a drug media crisis: atypical profile as compared with other drugs.

    abstract：:Since patients may report spontaneously adverse events associated with their medications, such notifications are constantly on the rise. In 2017, an unexpected rise of notifications associated with the marketing of a new formula of Levothyrox, differing from the 30-year-old drug only by minor elements, occurred in Fra...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/fcp.12446

    authors： Viard D,Parassol-Girard N,Romani S,Van Obberghen E,Rocher F,Berriri S,Drici MD

    更新日期：2019-08-01 00:00:00

  • Low glucocorticoid concentrations decrease oxidative phosphorylation of isolated rat brain mitochondria: an additional effect of dexamethasone.

    abstract：:The effects of hydrocortisone, triamcinolone, prednisolone and dexamethasone have been investigated in vitro using mitochondria isolated from rat brain. Respiratory control ratio (RCR), oxygen consumption, ATP synthesis, enzymatic activities of involved complexes and superoxide anion generation have been measured to a...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2000.tb00432.x

    authors： Morin C,Zini R,Simon N,Charbonnier P,Tillement JP,Le Louet H

    更新日期：2000-09-01 00:00:00

  • Human internal thoracic arteries from diabetic patients are resistant to endothelial dysfunction.

    abstract：:The aim of this analysis was to compare vasoreactive properties of internal thoracic arteries (ITA) grafts from diabetic (DM) to those of non-diabetic (ND) patients. Ring segments of ITA, taken from patients undergoing coronary artery bypass grafting, were suspended in organ bath chambers filled with modified Krebs-He...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2009.00707.x

    authors： Grapow MT,Reineke DC,Kern T,Müller-Schweinitzer E,Carrel T,Eckstein FS

    更新日期：2009-10-01 00:00:00

  • HOE 694 affords protection versus veratrine contractures in rat atria by Na+ channel blockade.

    abstract：:We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effects against veratrine-contractures, in the absence of negative inotro...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1996.tb00602.x

    authors： Le Grand B,Marty A,Talmant JM,John GW

    更新日期：1996-01-01 00:00:00

  • Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs.

    abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2006.00394.x

    authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

    更新日期：2006-04-01 00:00:00

  • Restoration of brain protein synthesis in mature and aged rats by a DA agonist, piribedil.

    abstract：:Brain ageing affects numerous cerebral metabolic pathways such as cerebral glucose consumption or protein synthesis rate. The pharmacological effect of a mixed D1-D2 dopaminergic agonist, piribedil, on this last metabolism is reported. Cerebral Protein Synthesis Rate (CPSR) was measured by the [35S]L-methionine autora...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1995.tb00521.x

    authors： Bustany P,Trenque T,Crambes O,Moulin M

    更新日期：1995-01-01 00:00:00

  • Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone.

    abstract：:The aim of this study was to characterize the model of oxidative stress consisting in the infection of malonate (3 mumol), an inhibitor of mitochondrial complex II, in the rat striatum. The striatal concentrations of both the reduced and oxidized forms of glutathione (the major endogenous antioxidant) were determined ...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2004.00297.x

    authors： Paucard A,Besson VC,Plotkine M,Margaill I

    更新日期：2005-02-01 00:00:00

  • The effects of fluoxetine on the human adipose-derived stem cell proliferation and differentiation.

    abstract：:Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/fcp.12426

    authors： Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

    更新日期：2019-06-01 00:00:00

  • Choice of designs and doses for early phase trials.

    abstract：:This paper reviews state-of-art statistical designs for dose-escalation procedures in first-into-man studies. The main focus will be on studies in oncology, as most statistical procedures for phase I trials have been proposed in this context. Extensions to situations such as the observation of bivariate outcomes and h...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1472-8206.2004.00226.x

    authors： Zhou Y

    更新日期：2004-06-01 00:00:00

  • Epithelial factors: modulation of the airway smooth muscle tone.

    abstract：:The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also meta...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1472-8206.1993.tb00240.x

    authors： Bertrand C,Tschirhart E

    更新日期：1993-01-01 00:00:00

  • Effects of tilting in the anaesthetized and mechanically ventilated rat: a model of orthostatic hypotension.

    abstract：:The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1992.tb00092.x

    authors： Pourrias B,Marie C

    更新日期：1992-01-01 00:00:00

  • Influence of food and body weight on the pharmacokinetics of penticainide.

    abstract：:The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1994.tb00825.x

    authors： Berdaï D,Demotes-Mainard F,Philip F,Vinçon G,Montels R,Necciari J,Bannwarth B

    更新日期：1994-01-01 00:00:00

  • Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells.

    abstract：:Microparticles are membrane vesicles with procoagulant and proinflammatory properties released during cell activation or apoptosis. Microparticles from monocytes have been implicated in atherosclerosis and vascular inflammation, but their direct effects on endothelial cells are not completely elucidated. The present s...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2010.00898.x

    authors： Mastronardi ML,Mostefai HA,Soleti R,Agouni A,Martínez MC,Andriantsitohaina R

    更新日期：2011-12-01 00:00:00

  • C.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function.

    abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/fcp.12398

    authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

    更新日期：2019-02-01 00:00:00

  • High glucose induced calcium overload via impairment of SERCA/PLN pathway and mitochondrial dysfunction leads to oxidative stress in H9c2 cells and amelioration with ferulic acid.

    abstract：:Oxidative stress and associated complications are the major pathological concerns of diabetic cardiomyopathy (DC). We aim to elucidate the mechanisms by which high glucose (HG) induced alteration in calcium homeostasis and evaluation of the beneficial effect of two concentrations (10 and 25 μm) of ferulic acid (FA). H...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/fcp.12452

    authors： Salin Raj P,Swapna SUS,Raghu KG

    更新日期：2019-08-01 00:00:00

  • Pharmacokinetics of cyclophosphamide (CP) and 4-OH-CP/aldophosphamide in systemic vasculitis.

    abstract：:Cyclophosphamide given in association with corticosteroids has markedly improved the prognosis of systemic vasculitis. Little information has been reported on cyclophosphamide pharmacokinetics in these diseases and data evaluating its metabolite, 4-hydroxycyclophosphamide/aldophosphamide, pharmacokinetics and concentr...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1472-8206.2000.tb00424.x

    authors： Belfayol-Pisanté L,Guillevin L,Tod M,Fauvelle F

    更新日期：2000-07-01 00:00:00

  • Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task.

    abstract：:A combination of sub-effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test. ...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2005.00359.x

    authors： Vohora D,Pal SN,Pillai KK

    更新日期：2005-10-01 00:00:00

  • Genetic polymorphisms of drug metabolism.

    abstract：:The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1472-8206.1990.tb00041.x

    authors： Meyer UA

    更新日期：1990-01-01 00:00:00

  • Plasma iron status and lipid peroxidation following thrombolytic therapy for acute myocardial infarction.

    abstract：:Free radical species have been implicated as important agents involved in myocardial ischemic and reperfusion injuries. Superoxide is capable of mobilizing iron from ferritin and the released iron can cause hydroxyl formation from H2O2. The aim of this study was to evaluate the time-dependent increase in lipid peroxid...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1472-8206.1998.tb00947.x

    authors： Cottin Y,Doise JM,Maupoil V,Tannière-Zeller M,Dalloz F,Maynadié M,Walker MK,Louis P,Carli PM,Wolf JE,Rochette L

    更新日期：1998-01-01 00:00:00

  • Effects of a 6-month infliximab treatment on plasma levels of leptin and adiponectin in patients with rheumatoid arthritis.

    abstract：:Patients with rheumatoid arthritis (RA) appear to have increased plasma levels of leptin and adiponectin. These adipokines may be implicated in the pathophysiology of RA. Tumour necrosis factor alpha (TNF-alpha) is a potential modulator of adipokines. The effects of long-term anti-TNF treatment on plasma levels of lep...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1472-8206.2009.00717.x

    authors： Derdemezis CS,Filippatos TD,Voulgari PV,Tselepis AD,Drosos AA,Kiortsis DN

    更新日期：2009-10-01 00:00:00

  • Effects of pretreatment with clonidine, lithium and quinine on the activities of antidepressant drugs in the mouse tail suspension test.

    abstract：:The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1997.tb00199.x

    authors： Redrobe JP,Bourin M

    更新日期：1997-01-01 00:00:00

  • Involvement of P2Y receptors in pyridoxal-5'-phosphate-induced cardiac preconditioning.

    abstract：:Using an isolated non-working rat heart model, this study investigated the mechanisms of pharmacological pre-conditioning (PC) induced by P2Y receptor stimulation with pyridoxal-5'-phosphate (PLP). After 6-hydroxydopamine pretreatment and a 15-min stabilization period, isolated rat hearts were perfused for 25 min then...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.2009.00677.x

    authors： Millart H,Alouane L,Oszust F,Chevallier S,Robinet A

    更新日期：2009-06-01 00:00:00

  • Incidence of hospital admissions due to adverse drug reactions in France: the EMIR study.

    abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/fcp.12088

    authors： Bénard-Laribière A,Miremont-Salamé G,Pérault-Pochat MC,Noize P,Haramburu F,EMIR Study Group on behalf of the French network of pharmacovigilance centres.

    更新日期：2015-02-01 00:00:00

  • Vitamin E analogues reduce the incidence of ventricular fibrillations and scavenge free radicals.

    abstract：:The aim of our study was to analyse the protective effects of different alpha-tocopherol analogues 1) against fibrillations induced by an ischemia-reperfusion sequence, and 2) to further investigate in vitro the radical scavenging properties of these analogues by two sensitive methods. Concerning 1: isolated rat heart...

    journal_title：Fundamental & clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1472-8206.1998.tb00937.x

    authors： Walker MK,Vergely C,Lecour S,Abadie C,Maupoil V,Rochette L

    更新日期：1998-01-01 00:00:00