Pharmacokinetics of cyclophosphamide (CP) and 4-OH-CP/aldophosphamide in systemic vasculitis.

abstract：:We studied the effects of KATP channel blockers on [3H]GABA release in the absence of glucose in rat hippocampal slices. The omission of glucose induced a marked increase in the efflux of [3H]GABA, which was antagonized by TTX (1 microM), but not by MK 801 (1 microM) or DNQX (100 microM). Glibenclamide (10-100 microM)...

journal_title：Fundamental & clinical pharmacology

authors： Margaill I,Miquet JM,Doble A,Blanchard JC,Boireau A

更新日期：1992-01-01 00:00:00

abstract：:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

更新日期：2005-10-01 00:00:00

abstract：:A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti-inflammatory of 4-PSQ. For this reason, the first objective of this study was to expand our previous findings by investig...

journal_title：Fundamental & clinical pharmacology

authors： Silva VDG,Reis AS,Pinz MP,da Fonseca CAR,Duarte LFB,Roehrs JA,Alves D,Luchese C,Wilhelm EA

更新日期：2017-10-01 00:00:00

abstract：:This study investigated whether ivabradine, a selective If current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol-induced heart damage. Wistar rats were treated for 6 weeks: controls (n = 10), ivabradine (10 mg/kg/day orally; n = 10), isopr...

journal_title：Fundamental & clinical pharmacology

authors： Simko F,Baka T,Repova K,Aziriova S,Krajcirovicova K,Paulis L,Adamcova M

更新日期：2020-10-24 00:00:00

abstract：:This paper reports data on the effect of a new antioxidant, U-83836E, on the lipid peroxidation and antioxidant status of liver, red blood cells (RBCs) and blood serum of rats intoxicated with methanol (3.0 g/kg body weight). Methanol administration slightly increased the levels of peroxidation products in the liver, ...

journal_title：Fundamental & clinical pharmacology

authors： Skrzydlewska E,Farbiszewski R

更新日期：1997-01-01 00:00:00

abstract：:We estimated the effect of atorvastatin and fluvastatin on plasma antioxidative activity used in coronary heart disease (CHD) primary prevention. Anti-oxidative activity of blood plasma was determined by Bartosz et al. method [Curr. Top. Biophys. (1998)22:11-13], based on reduction of preformed cation radical of 2,2,a...

journal_title：Fundamental & clinical pharmacology

authors： Kowalski J,Pawlicki L,Grycewicz J,Błaszczyk J,Irzmański R,Cegliński T,Kowalczyk E

更新日期：2004-02-01 00:00:00

abstract：:Some combinations of antihypertensive agents were shown to reduce proteinuria in patients with renal failure. However, preventive effects of such combinations on renal structure and function are presently unknown when treatment is administered before the onset of renal abnormalities. We thus investigated the long-term...

journal_title：Fundamental & clinical pharmacology

authors： Renaud IM,Chainey A,Belair MF,Mandet C,Michel O,Myara I,Chevalier J,Plante GE

更新日期：2004-08-01 00:00:00

abstract：:Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n = 26) and old (23.0 ± 0.2 months, n = 27) male Fischer 344 rats followin...

journal_title：Fundamental & clinical pharmacology

authors： Mach J,Huizer-Pajkos A,Mitchell SJ,McKenzie C,Phillips L,Kane A,Jones B,de Cabo R,Cogger V,Le Couteur DG,Hilmer SN

更新日期：2016-02-01 00:00:00

abstract：:Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

journal_title：Fundamental & clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of Na+ , K+ -ATPase (NKA) involved in low concentration of ouabain (Oua, activating NKA)-induced protection of rat cerebral ischemia-reperfusion injury. The 2,3,5-triphenyltetrazolium chloride staining and neurological deficit scores were performed to evaluate rat...

journal_title：Fundamental & clinical pharmacology

authors： Li LL,Ke XY,Jiang C,Qin SQ,Liu YY,Xian XH,Liu LZ,He JC,Chen YM,An HF,Sun N,Hu YH,Wang Y,Zhang LN,Lu QY

更新日期：2021-01-22 00:00:00

abstract：:The aim of this review is to comment the results described in the literature concerning the possible pharmacodynamic mechanisms involved in the improvement of quality of life of angiotensin converting enzyme inhibitors that is just a working hypothesis. These drugs, widely used in the treatment of hypertension, preven...

journal_title：Fundamental & clinical pharmacology

authors： Govantes C,Marín J

更新日期：1996-01-01 00:00:00

abstract：:To date, no reports of hypersensitivity reactions (HSRs) among nonsteroidal anti-inflammatory drugs (NSAIDs) according to cyclo-oxygenase (COX) selectivity and chemical groups have been published in a single study. The present study assessed the reporting frequency of HSRs for NSAIDs based on their relative inhibitory...

journal_title：Fundamental & clinical pharmacology

authors： Bakhriansyah M,Meyboom RHB,Souverein PC,de Boer A,Klungel OH

更新日期：2019-10-01 00:00:00

abstract：:The present study was carried out to investigate on the possible involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate (L-arginine/NO/cGMP) pathway in the aqueous extract of Muntingia calabura (AEMC) leaves antinociception in mice assessed by abdominal constriction test. The AEMC, obtained by soaking t...

journal_title：Fundamental & clinical pharmacology

authors： Zakaria ZA,Sulaiman MR,Jais AM,Somchit MN,Jayaraman KV,Balakhrisnan G,Abdullah FC

更新日期：2006-08-01 00:00:00

abstract：:The effects of cooling (to 28 degrees C) and warming (to 41 degrees C) on the vasoconstrictions induced by 5-hydroxytryptamine (5-HT) and acetylcholine (ACh) and the role of nitric oxide in these effects were analyzed in human umbilical artery and vein. 5-HT (10(-9)-10(-4) M) and ACh (10(-9)-10(-4) M) induced concentr...

journal_title：Fundamental & clinical pharmacology

authors： Atalik KE,Kiliç M,Nurullahoğlu ZU,Doğan N

更新日期：2008-02-01 00:00:00

abstract：:We determined the pharmacological and the antiemetic properties of SR 49059, a selective nonpeptide V(1a) receptor antagonist, on cisplatin-induced emesis in the piglet. Firstly, we clearly demonstrate that SR 49059 is a potent V(1a) receptor antagonist in vitro and in vivo in the piglet. In binding studies, [3H]-SR 4...

journal_title：Fundamental & clinical pharmacology

authors： Grélot L,Girod V,Dapzol J,Maffrand JP,Serradeil-Le Gal C

更新日期：2001-06-01 00:00:00

abstract：:Cyclo-oxygenase (COX) has been reported to play a significant role in neurodegeneration and other brain-related disorders. Recent studies have reported that COX plays a significant role in the pathophysiology of brain-related disorders and COX-2 inhibitors could be useful drug therapy in neurodegenerative disorders. T...

journal_title：Fundamental & clinical pharmacology

authors： Dhir A,Naidu PS,Kulkarni SK

更新日期：2006-06-01 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00

abstract：:The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

journal_title：Fundamental & clinical pharmacology

authors： Hellmich B,Gyermek L

更新日期：1997-01-01 00:00:00

abstract：:Patients with rheumatoid arthritis (RA) appear to have increased plasma levels of leptin and adiponectin. These adipokines may be implicated in the pathophysiology of RA. Tumour necrosis factor alpha (TNF-alpha) is a potential modulator of adipokines. The effects of long-term anti-TNF treatment on plasma levels of lep...

journal_title：Fundamental & clinical pharmacology

authors： Derdemezis CS,Filippatos TD,Voulgari PV,Tselepis AD,Drosos AA,Kiortsis DN

更新日期：2009-10-01 00:00:00

abstract：:The aim of the present study was to assess the role of vascular alpha 1D-adrenoceptors in the sympathetic vasopressor response in vivo. Specifically, we evaluated the effect of a selective alpha 1D-adrenoceptor antagonist, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)dec ane-7,9- dione 2HCl)...

journal_title：Fundamental & clinical pharmacology

authors： Castillo EF,López RM,Rodríguez-Silverio J,Bobadilla RA,Castillo C

更新日期：1998-01-01 00:00:00

abstract：:We have studied the effects of neurotensin (NT) on the release of [3H]dopamine ([3H]DA) evoked by terminal depolarization with either K+, veratridine or 4-aminopyridine (4-AP). NT (1-1000 nM) induced a net potentiation (up to 170%) of the K+ (25 mM)-evoked release of [3H]DA. The capacity of NT to potentiate the effect...

journal_title：Fundamental & clinical pharmacology

authors： Boireau A,Miquet JM,Olivier V

更新日期：1993-01-01 00:00:00

abstract：:The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...

journal_title：Fundamental & clinical pharmacology

authors： Meyer UA

更新日期：1990-01-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injections of dihydropyridine derivatives calcium channel agonist (BAY K8644) and antagonist (nifedipine, nicardipine, PN 200-110) induced opposite long-lasting changes in blood pressure (BP) in pentobarbital anesthetized spontaneously hypertensive rats (SMR). I.c.v. nifedipine (NIF), ...

journal_title：Fundamental & clinical pharmacology

authors： Laurent S,Brisac AM,Champeroux P,Lacolley P,Huguet F,Legrand M,Lucet B,Tsoucaris D,Briand V,Schmitt H

更新日期：1989-01-01 00:00:00

abstract：:Suriclone is a novel cyclopyrrolone exhibiting anxiolytic activity. Twelve healthy Caucasian male volunteers participated in the study. A single dose of suriclone 0.4 mg, imipramine 75 mg, suriclone 0.4 mg + imipramine 75 mg, or placebo was given according to a 4 x 4 Latin-square design in order to assess the effect o...

journal_title：Fundamental & clinical pharmacology

authors： Perault MC,Chapelle G,Bouquet S,Chevalier P,Montay G,Gaillot J,Chakroun H,Guillet P,Vandel B

更新日期：1994-01-01 00:00:00

abstract：:A method has been proposed for extracting numerical data when only graphical results are presented. Reports with both graphical and tabular data were identified and the graphs were electronically scanned. The coordinates of each point were read using the cross-hair facility of Adobe Photoshop 7.0. To improve the preci...

journal_title：Fundamental & clinical pharmacology

authors： de Oliveira IR,Santos-Jesus R,Po AL,Poolsup N

更新日期：2003-08-01 00:00:00

abstract：:The action of ouabain, a cell membrane Na+, K+-ATPase blocker, on contractions induced by manganese ions (Mn2+) in Ca2+-free, isotonic solutions with varying concentrations of K+ in the external medium were investigated in order to evaluate the underlying role of external Na+ in Mn2+-induced contractions in isolated t...

journal_title：Fundamental & clinical pharmacology

authors： Nasu T,Takahashi K

更新日期：2005-06-01 00:00:00

abstract：:The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...

journal_title：Fundamental & clinical pharmacology

authors： Ergün Y,Darendeli S,Imrek S,Kilinç M,Oksüz H

更新日期：2010-04-01 00:00:00

abstract：:Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric v...

journal_title：Fundamental & clinical pharmacology

authors： Sen T,Abdulsalam CA,Pal S,Sen S,Karmakar S,Saravanan KS,Chaudhuri AK

更新日期：2002-08-01 00:00:00

abstract：:The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC-MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery. Dextromoramide was rapidly absorbed from the gastrointesti...

journal_title：Fundamental & clinical pharmacology

authors： Pagani I,Barzaghi N,Crema F,Perucca E,Ego D,Rovei V

更新日期：1989-01-01 00:00:00

abstract：:Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis. Cpn is an obligate intracellular gram-negative bacterium that is responsible for 10% of cases of community-acquired pneumonia. In addi...

journal_title：Fundamental & clinical pharmacology

authors： Deniset JF,Pierce GN

更新日期：2010-10-01 00:00:00