Electrophysiology of ion channels of the heart.

abstract：:Since patients may report spontaneously adverse events associated with their medications, such notifications are constantly on the rise. In 2017, an unexpected rise of notifications associated with the marketing of a new formula of Levothyrox, differing from the 30-year-old drug only by minor elements, occurred in Fra...

journal_title：Fundamental & clinical pharmacology

authors： Viard D,Parassol-Girard N,Romani S,Van Obberghen E,Rocher F,Berriri S,Drici MD

更新日期：2019-08-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work ...

journal_title：Fundamental & clinical pharmacology

authors： Bès S,Tatou E,Vandroux D,Tissier C,Rochette L,Athias P

更新日期：2004-06-01 00:00:00

abstract：:The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC-MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery. Dextromoramide was rapidly absorbed from the gastrointesti...

journal_title：Fundamental & clinical pharmacology

authors： Pagani I,Barzaghi N,Crema F,Perucca E,Ego D,Rovei V

更新日期：1989-01-01 00:00:00

abstract：:In therapeutic trials, quality of life studies are usually based on a health model which results in a restrictive view. Therefore, it is important to clearly define the concept of the quality of life, since ambiguous concepts can alter the results. The key to this problem is the clear distinction between the two compo...

journal_title：Fundamental & clinical pharmacology

authors： Gerin P,Dazord A,Boissel J,Chifflet R

更新日期：1992-01-01 00:00:00

abstract：:Incubation of striatal slices with sodium nitroprusside (SNP) or hydroxylamine (HA) for 60 min caused a dose-dependent increase in dopamine (DA) release. This effect was inhibited completely by tetrodotoxin (TTX) (1 microM) if low concentrations of SNP (1 microM) or HA (10 and 100 microM) were tested. Although-higher ...

journal_title：Fundamental & clinical pharmacology

authors： Büyükuysal RL

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study was to investigate quantitatively the action of and the interaction between beta-adrenergic receptor agonists in desensitizing guinea pig isolated trachea. It was also to evaluate the influence of substances whose effects on desensitization are either disputed (theophylline, indomethacin, ketotif...

journal_title：Fundamental & clinical pharmacology

authors： Matran R,Naline E,Advenier C,Duroux P

更新日期：1989-01-01 00:00:00

abstract：:Ivermectin, a parasiticide that long ago proved its worth in veterinary medicine, became one of the most effective tools for control programs against human filarial diseases in the 1980s. It is provided at no cost, is effective against microfilariae (blocking their transmission) and can be administered annually as a s...

journal_title：Fundamental & clinical pharmacology

authors： Richard-Lenoble D,Chandenier J,Gaxotte P

更新日期：2003-04-01 00:00:00

abstract：:The aim of this analysis was to compare vasoreactive properties of internal thoracic arteries (ITA) grafts from diabetic (DM) to those of non-diabetic (ND) patients. Ring segments of ITA, taken from patients undergoing coronary artery bypass grafting, were suspended in organ bath chambers filled with modified Krebs-He...

journal_title：Fundamental & clinical pharmacology

authors： Grapow MT,Reineke DC,Kern T,Müller-Schweinitzer E,Carrel T,Eckstein FS

更新日期：2009-10-01 00:00:00

abstract：:Using an isolated non-working rat heart model, this study investigated the mechanisms of pharmacological pre-conditioning (PC) induced by P2Y receptor stimulation with pyridoxal-5'-phosphate (PLP). After 6-hydroxydopamine pretreatment and a 15-min stabilization period, isolated rat hearts were perfused for 25 min then...

journal_title：Fundamental & clinical pharmacology

authors： Millart H,Alouane L,Oszust F,Chevallier S,Robinet A

更新日期：2009-06-01 00:00:00

abstract：:Chloroquine (CQ) induces histamine-independent itch in human and mice. We recently reported the role of intradermal nitric oxide (NO)/cyclic guanosine monophosphate pathway in CQ-evoked scratching in mice. Chloroquine stimulates neuronal nitric oxide synthase (nNOS) activity to over-producing NO in the skin. Sumatript...

journal_title：Fundamental & clinical pharmacology

authors： Haddadi NS,Ostadhadi S,Shakiba S,Afshari K,Rahimi N,Foroutan A,Dehpour AR

更新日期：2018-02-01 00:00:00

abstract：:Studies in animals and in healthy volunteers have demonstrated the central serotonergic analgesic mechanism of action of paracetamol involving the inhibition of this analgesia by tropisetron, a 5-HT3 antagonist. This randomized, double-blind, controlled study aims at studying this interaction in post-operative patient...

journal_title：Fundamental & clinical pharmacology

authors： Pickering G,Faure M,Commun F,de Boissy EC,Roche G,Mom T,Simen E,Dubray C,Eschalier A,Gilain L

更新日期：2012-06-01 00:00:00

abstract：:This study evaluated the effects of the isolated use of a low dose of methyltestosterone (MT) on cardiovascular reflexes and hormonal levels and its geno- and cytotoxic safety in ovariectomized rats. Female Wistar rats were divided into four groups (n = 6), respectively: SHAM (received vehicle methylcellulose 0.5%), S...

journal_title：Fundamental & clinical pharmacology

authors： Terra DG,de Lima EM,do Nascimento AM,Brasil GA,Filete PF,Kalil IC,Lenz D,Endringer DC,Bissoli NS,de Andrade TU

更新日期：2016-08-01 00:00:00

abstract：:Considering the diseases of the stomach and duodenum, peptic ulcer has been the one with a significant clinical impact. The pathophysiology of peptic ulcer has centred on an imbalance between aggressive and protective factors. The discovery of Helicobacter pylori as a cause of peptic ulcer has changed our approach gre...

journal_title：Fundamental & clinical pharmacology

authors： Sivri B

更新日期：2004-02-01 00:00:00

abstract：:The effects of tacrine and physostigmine on catecholamine secretion induced by veratridine and high K+, and on voltage-dependent Na+ and Ca2+ currents, were investigated in guinea-pig adrenal chromaffin cells. In perfused adrenal glands, tacrine (100 microM) caused an inhibition of veratridine-induced catecholamine se...

journal_title：Fundamental & clinical pharmacology

authors： Sugawara T,Kitamura N,Ohta T,Ito S,Nakazato Y

更新日期：1998-01-01 00:00:00

abstract：:In the present study, contractile responses and [3H]-noradrenaline overflow evoked by electrical field stimulation were assessed, respectively, in the small mesenteric artery and in tail artery removed from rats pre-treated with either saline or lipopolysaccharide (LPS). In small mesenteric arteries, LPS treatment did...

journal_title：Fundamental & clinical pharmacology

authors： Ohlmann P,Martínez MC,Bucher B,Andriantsitohaina R,Muller B,Schneider F,Stoclet JC

更新日期：2000-11-01 00:00:00

abstract：:A meta-analysis was performed on the results of clinical trials of buflomedil in intermittent claudication. The analysis used results from 744 patients enrolled in ten studies, conducted at 42 centers in seven countries. All studies were randomized, double-blind, placebo-controlled trials which measured improvement in...

journal_title：Fundamental & clinical pharmacology

authors： Walker GA,Mac Hannaford JC

更新日期：1995-01-01 00:00:00

abstract：:The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto-toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties...

journal_title：Fundamental & clinical pharmacology

authors： Bentue-Ferrer D,Philouze V,Pape D,Reymann JM,Allain H,Van den Driessche J

更新日期：1989-01-01 00:00:00

abstract：:The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of...

journal_title：Fundamental & clinical pharmacology

authors： Berdaï D,Demotes-Mainard F,Philip F,Vinçon G,Montels R,Necciari J,Bannwarth B

更新日期：1994-01-01 00:00:00

abstract：:The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...

journal_title：Fundamental & clinical pharmacology

authors： Ergün Y,Darendeli S,Imrek S,Kilinç M,Oksüz H

更新日期：2010-04-01 00:00:00

abstract：:The third generation aromatase inhibitors are currently the drugs of choice for the treatment of early and advanced breast cancer in postmenopausal women. One of the significant limiting factor during therapy is their negative impact on bone health. In this study, we compared the effects of a nonsteroidal (letrozole) ...

journal_title：Fundamental & clinical pharmacology

authors： Kalam A,Talegaonkar S,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

journal_title：Fundamental & clinical pharmacology

authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

更新日期：1999-01-01 00:00:00

abstract：:This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

journal_title：Fundamental & clinical pharmacology

authors： Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

更新日期：2020-09-09 00:00:00

abstract：:Surrogate endpoints predict the occurrence and timing of a clinical endpoint of interest (CEI). Substitution of a surrogate endpoint for a CEI can dramatically reduce the time and cost necessary to complete a Phase III clinical trial. However, assurance that use of a surrogate endpoint will result in a correct conclus...

journal_title：Fundamental & clinical pharmacology

authors： Domanski M,Pocock S,Bernaud C,Borer J,Geller N,Revkin J,Zannad F

更新日期：2011-08-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injections of dihydropyridine derivatives calcium channel agonist (BAY K8644) and antagonist (nifedipine, nicardipine, PN 200-110) induced opposite long-lasting changes in blood pressure (BP) in pentobarbital anesthetized spontaneously hypertensive rats (SMR). I.c.v. nifedipine (NIF), ...

journal_title：Fundamental & clinical pharmacology

authors： Laurent S,Brisac AM,Champeroux P,Lacolley P,Huguet F,Legrand M,Lucet B,Tsoucaris D,Briand V,Schmitt H

更新日期：1989-01-01 00:00:00

abstract：:Some combinations of antihypertensive agents were shown to reduce proteinuria in patients with renal failure. However, preventive effects of such combinations on renal structure and function are presently unknown when treatment is administered before the onset of renal abnormalities. We thus investigated the long-term...

journal_title：Fundamental & clinical pharmacology

authors： Renaud IM,Chainey A,Belair MF,Mandet C,Michel O,Myara I,Chevalier J,Plante GE

更新日期：2004-08-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:Erythromycin inhibits the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL6) induced by heat-killed Streptococcus pneumoniae in human whole blood ex-vivo. The objective of the present study was to determine and characterize the concentration-effect relationship of this phenomenon in order t...

journal_title：Fundamental & clinical pharmacology

authors： Guchelaar HJ,Schultz MJ,van der Poll T,Koopmans RP

更新日期：2001-12-01 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00

abstract：:This study evaluated the effect of lacosamide (LCM) on biochemical and mitochondrial parameters after PTZ kindling in mice. Male mice were treated on alternative days for a period of 11 days with LCM (20, 30, or 40 mg/kg), saline, or diazepam (2 mg/kg), before PTZ administration (50 mg/kg). The hippocampi were collect...

journal_title：Fundamental & clinical pharmacology

authors： Lazzarotto L,Pflüger P,Regner GG,Santos FM,Aguirre DG,Brito VB,Moura DJ,Dos Santos NM,Picada JN,Parmeggiani B,Frusciante MR,Leipnitz G,Pereira P

更新日期：2020-08-09 00:00:00

abstract：:Gastric mucosa is frequently exposed to various gastric irritants, and there is a continuing requirement to develop new gastro-protective agents. This study compares the effects of three such agents, sucralfate, rebamipide, and cimetidine in both in vivo and in vitro indomethacin-induced gastric damage models. For the...

journal_title：Fundamental & clinical pharmacology

authors： Goineau S,Castagné V

更新日期：2017-04-01 00:00:00