Surrogate endpoints in randomized cardiovascular clinical trials.

abstract：:The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of...

journal_title：Fundamental & clinical pharmacology

authors： Berdaï D,Demotes-Mainard F,Philip F,Vinçon G,Montels R,Necciari J,Bannwarth B

更新日期：1994-01-01 00:00:00

abstract：:The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...

journal_title：Fundamental & clinical pharmacology

authors： Pourrias B,Marie C

更新日期：1992-01-01 00:00:00

abstract：:In therapeutic trials, quality of life studies are usually based on a health model which results in a restrictive view. Therefore, it is important to clearly define the concept of the quality of life, since ambiguous concepts can alter the results. The key to this problem is the clear distinction between the two compo...

journal_title：Fundamental & clinical pharmacology

authors： Gerin P,Dazord A,Boissel J,Chifflet R

更新日期：1992-01-01 00:00:00

abstract：:A survey was run on a sample of 134 French GPs from the Rhône-Alpes region, in an attempt to investigate the way they recollect important clinical trials that should have an impact on their practice. It was found that 1) most of them did not remember these trials (however, the awareness score did vary throughout the t...

journal_title：Fundamental & clinical pharmacology

authors： Reveilleau S,Boissel JP,Alamercery Y

更新日期：1991-01-01 00:00:00

abstract：:Allopurinol, oxypurinol, hypoxanthine and xanthine were assayed simultaneously using a highly specific method combining gas chromatography and mass spectrometry. Two hypo-uricaemic prescriptions were compared: i) 300 mg of allopurinol (AL); and ii) 100 mg of allopurinol plus 20 mg of benzbromarone (AL + BZB). When adm...

journal_title：Fundamental & clinical pharmacology

authors： Lartigue-Mattei C,Chabard JL,Ristori JM,Bussiere JL,Bargnoux H,Petit J,Berger JA

更新日期：1991-01-01 00:00:00

abstract：:Ivermectin, a parasiticide that long ago proved its worth in veterinary medicine, became one of the most effective tools for control programs against human filarial diseases in the 1980s. It is provided at no cost, is effective against microfilariae (blocking their transmission) and can be administered annually as a s...

journal_title：Fundamental & clinical pharmacology

authors： Richard-Lenoble D,Chandenier J,Gaxotte P

更新日期：2003-04-01 00:00:00

abstract：:The aim of the present study was to assess the role of vascular alpha 1D-adrenoceptors in the sympathetic vasopressor response in vivo. Specifically, we evaluated the effect of a selective alpha 1D-adrenoceptor antagonist, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)dec ane-7,9- dione 2HCl)...

journal_title：Fundamental & clinical pharmacology

authors： Castillo EF,López RM,Rodríguez-Silverio J,Bobadilla RA,Castillo C

更新日期：1998-01-01 00:00:00

abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...

journal_title：Fundamental & clinical pharmacology

authors： Bénard-Laribière A,Miremont-Salamé G,Pérault-Pochat MC,Noize P,Haramburu F,EMIR Study Group on behalf of the French network of pharmacovigilance centres.

更新日期：2015-02-01 00:00:00

abstract：:In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal m...

journal_title：Fundamental & clinical pharmacology

authors： Daveluy A,Sauvaget L,Bastien A,Lapeyre-Mestre M,Collin C,Richard N,Haramburu F

更新日期：2018-10-01 00:00:00

abstract：:We investigated the underlying mechanisms of penehyclidine hydrochloride (PHC), a novel selective anticholinergic drug on isolated rat uterus. The method of radio-immunity assay was further employed to determine cyclic adenosine mono phosphate (cAMP) levels in isolated rat uterus for comparing with selective effect on...

journal_title：Fundamental & clinical pharmacology

authors： Xiao HT,Liao Z,Meng XM,Yan XY,Chen SJ,Mo ZJ

更新日期：2009-08-01 00:00:00

abstract：:Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti-inflammatory agents with cardioprotective effects is an urgent task. We aimed to eva...

journal_title：Fundamental & clinical pharmacology

authors： Refaie MMM,Rifaai RA,Bayoumi AMA,Shehata S

更新日期：2020-06-01 00:00:00

abstract：:We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effects against veratrine-contractures, in the absence of negative inotro...

journal_title：Fundamental & clinical pharmacology

authors： Le Grand B,Marty A,Talmant JM,John GW

更新日期：1996-01-01 00:00:00

abstract：:This study evaluated the effect of lacosamide (LCM) on biochemical and mitochondrial parameters after PTZ kindling in mice. Male mice were treated on alternative days for a period of 11 days with LCM (20, 30, or 40 mg/kg), saline, or diazepam (2 mg/kg), before PTZ administration (50 mg/kg). The hippocampi were collect...

journal_title：Fundamental & clinical pharmacology

authors： Lazzarotto L,Pflüger P,Regner GG,Santos FM,Aguirre DG,Brito VB,Moura DJ,Dos Santos NM,Picada JN,Parmeggiani B,Frusciante MR,Leipnitz G,Pereira P

更新日期：2020-08-09 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00

abstract：:The effects of Ketotifen and disodium cromoglycate were investigated on human and rabbit platelet activation. Ketotifen inhibited dose-dependently human and rabbit platelet aggregation. The paf-acether pathway was the most markedly influenced by Ketotifen in human and rabbit platelets (IC50 = 38.8 +/- 7.7 microM and 7...

journal_title：Fundamental & clinical pharmacology

authors： Devillier P,Arnoux B,Lalau Keraly C,Landes A,Marsac J,Benveniste J

更新日期：1990-01-01 00:00:00

abstract：:Angiotensin II AT1 receptor blockade (AT1-) has been shown to prolong survival in post-myocardial infarction (MI) heart failure in rats. In this study, we investigated whether an early AT1-induced improvement in coronary vasodilatation reserve (CVR) might be involved in this beneficial effect. Wistar rats with MI were...

journal_title：Fundamental & clinical pharmacology

authors： Gervais M,Richer C,Fornes P,De Gasparo M,Giudicelli JF

更新日期：1999-01-01 00:00:00

abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

journal_title：Fundamental & clinical pharmacology

authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

更新日期：1999-01-01 00:00:00

abstract：:The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...

journal_title：Fundamental & clinical pharmacology

authors： Redrobe JP,Bourin M

更新日期：1997-01-01 00:00:00

abstract：:The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects. However, some controversy remains about its mechanism of action in...

journal_title：Fundamental & clinical pharmacology

authors： Figueiredo A,Ribeiro CA,Gonçalo M,Almeida L,Poiares-Baptista A,Teixeira F

更新日期：1990-01-01 00:00:00

abstract：:Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant-like action o...

journal_title：Fundamental & clinical pharmacology

authors： Melo CT,de Carvalho AM,Moura BA,Teixeira CP,Vasconcelos LF,Feitosa ML,de Oliveira GV,Barbosa-Filho JM,Chavez Gutierrez SJ,de França Fonteles MM,Vasconcelos SM,de Sousa FC

更新日期：2013-02-01 00:00:00

abstract：:The anti-anginal drug trimetazidine (TMZ) has been shown to increase the synthesis of phospholipids in ventricular myocytes, including phosphatidyl-inositol (PI). This study focused on the consequences of increasing PI metabolism on alpha-adrenergic signaling pathway in cultured rat cardiomyocytes. In the cells treate...

journal_title：Fundamental & clinical pharmacology

authors： Tabbi-Anneni I,Lucien A,Grynberg A

更新日期：2003-02-01 00:00:00

abstract：:During ischemia, large amounts of catecholamine are released to the myocardium from the sympathetic nerve endings in the heart. It has not been clearly shown whether the released catecholamine has detrimental or beneficial effects on postischemic myocardial contractile function. The aim of the present study was to inv...

journal_title：Fundamental & clinical pharmacology

authors： Ishiguro Y,Morgan JP

更新日期：2001-04-01 00:00:00

abstract：:Despite the benefits of chrysotherapy the responsible mechanism of action of gold compounds remains unclear. At a concentration of 5 x 10(-4) M, sodium aurothiopropanol sulfonate (SAS) modified the in vitro proliferation kinetics of articular chondrocytes by reducing growth, viability and plating efficiency. Flow cyto...

journal_title：Fundamental & clinical pharmacology

authors： Ronot X,Hainque B,Christen MO,Froger B,Hartmann DJ,Adolphe M,Lechat P

更新日期：1988-01-01 00:00:00

abstract：:Chelerythrine, a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on inositol phosphate (IP) metabolism in newborn rat cardiomyocytes in culture. In a first step, we evaluated the effect of chelerythrine on IP accumulation in basal conditions. For a 10(-4) M dose, 5-phosphatase activity (which ...

journal_title：Fundamental & clinical pharmacology

authors： Le Corvoisier P,Lacotte J,Laplace M,Crozatier B

更新日期：2002-02-01 00:00:00

abstract：:The monoterpene alcohol (-)-borneol has many biological effects such as sedative, anti-inflammatory, analgesic, anti-nociceptive, antithrombotic and vasorelaxant effects. Our objective in this study was to investigate the mechanism of action of (-)-borneol and determine its vasorelaxant effect. (-)-Borneol was tested ...

journal_title：Fundamental & clinical pharmacology

authors： Santos SE,Ribeiro FPRA,Menezes PMN,Duarte-Filho LAM,Quintans JSS,Quintans-Junior LJ,Silva FS,Ribeiro LAA

更新日期：2019-04-01 00:00:00

abstract：:Abstract The relationship between depression and dopamine deficiency in the mesolimbic pathway has been hypothesized for many years. The experimental studies with animal models of depression and the human studies implicate the role of the dopamine system in depression. Not only do dopaminergic receptor agonists, but a...

journal_title：Fundamental & clinical pharmacology

authors： Dailly E,Chenu F,Renard CE,Bourin M

更新日期：2004-12-01 00:00:00

abstract：:The effects of hydrocortisone, triamcinolone, prednisolone and dexamethasone have been investigated in vitro using mitochondria isolated from rat brain. Respiratory control ratio (RCR), oxygen consumption, ATP synthesis, enzymatic activities of involved complexes and superoxide anion generation have been measured to a...

journal_title：Fundamental & clinical pharmacology

authors： Morin C,Zini R,Simon N,Charbonnier P,Tillement JP,Le Louet H

更新日期：2000-09-01 00:00:00

abstract：:The aim of phase I studies per se is to explore the tolerance of new compounds which have demonstrated a certain level of activity in animals at sufficiently low non-toxic doses. In most cases, these studies are conducted in 2 steps in a limited number of healthy male volunteers: a single rising dose study followed by...

journal_title：Fundamental & clinical pharmacology

authors： Thiercelin JF

更新日期：1990-01-01 00:00:00

abstract：:The effects of tramadol versus placebo administration on behavioral indicators of ureteral pain, pelvic pain and referred lumbar muscle hyperalgesia were investigated in a rat model of viscero-visceral hyperalgesia from endometriosis plus ureteral calculosis (endo + stone). Fifty female Sprague-Dawley rats underwent s...

journal_title：Fundamental & clinical pharmacology

authors： Lopopolo M,Affaitati G,Fabrizio A,Massimini F,Lapenna D,Giamberardino MA,Costantini R

更新日期：2014-06-01 00:00:00

abstract：:Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...

journal_title：Fundamental & clinical pharmacology

authors： Gilchrist SE,Alcorn J

更新日期：2010-04-01 00:00:00