Mechanism of action of doxepin in the treatment of chronic urticaria.

abstract：:We investigated the underlying mechanisms of penehyclidine hydrochloride (PHC), a novel selective anticholinergic drug on isolated rat uterus. The method of radio-immunity assay was further employed to determine cyclic adenosine mono phosphate (cAMP) levels in isolated rat uterus for comparing with selective effect on...

journal_title：Fundamental & clinical pharmacology

authors： Xiao HT,Liao Z,Meng XM,Yan XY,Chen SJ,Mo ZJ

更新日期：2009-08-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:The third generation aromatase inhibitors are currently the drugs of choice for the treatment of early and advanced breast cancer in postmenopausal women. One of the significant limiting factor during therapy is their negative impact on bone health. In this study, we compared the effects of a nonsteroidal (letrozole) ...

journal_title：Fundamental & clinical pharmacology

authors： Kalam A,Talegaonkar S,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:This paper reports data on the effect of a new antioxidant, U-83836E, on the lipid peroxidation and antioxidant status of liver, red blood cells (RBCs) and blood serum of rats intoxicated with methanol (3.0 g/kg body weight). Methanol administration slightly increased the levels of peroxidation products in the liver, ...

journal_title：Fundamental & clinical pharmacology

authors： Skrzydlewska E,Farbiszewski R

更新日期：1997-01-01 00:00:00

abstract：:Pharmacoepidemiological studies have reported an excess of mortality with selegiline, a MAO B inhibitor used in the treatment of Parkinson's disease. The mechanism of this putative adverse effect remains unknown but an interaction with the sympathetic nervous system was suggested. The aim of the present study was to i...

journal_title：Fundamental & clinical pharmacology

authors： Pelat M,Verwaerde P,Tran MA,Berlan M,Senard JM,Montastruc JL

更新日期：2001-08-01 00:00:00

abstract：:The formation of dopamine, from L-3,4-dihydroxyphenylalanine (L-dopa), in fragments of non-glandular and glandular stomach, duodenum, jejunum, ileum and proximal and distal colon of the rat was examined. The deamination of newly-formed dopamine into 3,4-dihydroxyphenylacetic acid (dopac) was also studied. The synthesi...

journal_title：Fundamental & clinical pharmacology

authors： Vieira-Coelho MA,Soares-da-Silva P

更新日期：1993-01-01 00:00:00

abstract：:This study investigated whether ivabradine, a selective If current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol-induced heart damage. Wistar rats were treated for 6 weeks: controls (n = 10), ivabradine (10 mg/kg/day orally; n = 10), isopr...

journal_title：Fundamental & clinical pharmacology

authors： Simko F,Baka T,Repova K,Aziriova S,Krajcirovicova K,Paulis L,Adamcova M

更新日期：2020-10-24 00:00:00

abstract：:HMG CoA reductase inhibitors (statins) have an established place in the treatment of coronary artery disease. However, their role in the treatment of heart failure (HF), including HF due to coronary artery disease, has been controversial since beneficial as well as possible harmful effects may occur. Several recent st...

journal_title：Fundamental & clinical pharmacology

authors： Gullestad L,Oie E,Ueland T,Yndestad A,Aukrust P

更新日期：2007-11-01 00:00:00

abstract：:Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by m...

journal_title：Fundamental & clinical pharmacology

authors： Grioli S,Lomeo C,Quattropani MC,Spignoli G,Villardita C

更新日期：1990-01-01 00:00:00

abstract：:This study aimed to investigate the modulation of nitric oxide/reactive oxygen species in sodium nitroprusside relaxation in mice aorta. Sodium nitroprusside induced relaxation in endothelium-intact (e+) and endothelium-denuded (e-) aortas with greater potency in e+ than in e-. The nitric oxide synthase inhibitor did ...

journal_title：Fundamental & clinical pharmacology

authors： Kangussu LM,Olivon VC,Arifa RD,Araújo N,Reis D,Assis MT,Soriani FM,de Souza Dda G,Bendhack LM,Bonaventura D

更新日期：2015-04-01 00:00:00

abstract：:Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after...

journal_title：Fundamental & clinical pharmacology

authors： Zyoud SH,Awang R,Sulaiman SA,Al-Jabi SW

更新日期：2011-06-01 00:00:00

abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...

journal_title：Fundamental & clinical pharmacology

authors： Silva RO,Sousa FB,Damasceno SR,Carvalho NS,Silva VG,Oliveira FR,Sousa DP,Aragão KS,Barbosa AL,Freitas RM,Medeiros JV

更新日期：2014-08-01 00:00:00

abstract：:Despite the benefits of chrysotherapy the responsible mechanism of action of gold compounds remains unclear. At a concentration of 5 x 10(-4) M, sodium aurothiopropanol sulfonate (SAS) modified the in vitro proliferation kinetics of articular chondrocytes by reducing growth, viability and plating efficiency. Flow cyto...

journal_title：Fundamental & clinical pharmacology

authors： Ronot X,Hainque B,Christen MO,Froger B,Hartmann DJ,Adolphe M,Lechat P

更新日期：1988-01-01 00:00:00

abstract：:The present study investigated the effects of positive end-expiratory pressure (PEEP) on propofol concentrations in humans. Eleven patients undergoing elective surgery were enrolled in this study. Anesthesia was induced with propofol, then maintained using 60% nitrous oxide in oxygen, fentanyl 10-20 microg/kg and cont...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa E,Ito N,Ishizeki J,Goto F,Hiraoka H,Takizawa D

更新日期：2006-10-01 00:00:00

abstract：:In rat vena cava and aorta preincubated with [3H]noradrenaline the involvement of imidazoline receptors in modulation of [3H]noradrenaline release from sympathetic nerves was investigated. In the vena cava, the guanidine 1,3-di(2-tolyl)guanidine (DTG) inhibited the electrically evoked [3H]noradrenaline release; the in...

journal_title：Fundamental & clinical pharmacology

authors： Molderings GJ,Göthert M

更新日期：1998-01-01 00:00:00

abstract：:Erythromycin inhibits the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL6) induced by heat-killed Streptococcus pneumoniae in human whole blood ex-vivo. The objective of the present study was to determine and characterize the concentration-effect relationship of this phenomenon in order t...

journal_title：Fundamental & clinical pharmacology

authors： Guchelaar HJ,Schultz MJ,van der Poll T,Koopmans RP

更新日期：2001-12-01 00:00:00

abstract：:The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...

journal_title：Fundamental & clinical pharmacology

authors： Paris A,Cornu C,Auquier P,Maison P,Radauceanu A,Brandt C,Salvat-Melis M,Hommel M,Cracowski JL

更新日期：2006-02-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work ...

journal_title：Fundamental & clinical pharmacology

authors： Bès S,Tatou E,Vandroux D,Tissier C,Rochette L,Athias P

更新日期：2004-06-01 00:00:00

abstract：:The main of the present study was to determine the experimental conditions for an animal model of orthostatic hypotension based on tilting in rats. Blood pressure, heart rate and plasma catecholamine levels were measured before and after tilting in conscious and anaesthetized rats either breathing spontaneously or mec...

journal_title：Fundamental & clinical pharmacology

authors： Pourrias B,Marie C

更新日期：1992-01-01 00:00:00

abstract：:The monoterpene alcohol (-)-borneol has many biological effects such as sedative, anti-inflammatory, analgesic, anti-nociceptive, antithrombotic and vasorelaxant effects. Our objective in this study was to investigate the mechanism of action of (-)-borneol and determine its vasorelaxant effect. (-)-Borneol was tested ...

journal_title：Fundamental & clinical pharmacology

authors： Santos SE,Ribeiro FPRA,Menezes PMN,Duarte-Filho LAM,Quintans JSS,Quintans-Junior LJ,Silva FS,Ribeiro LAA

更新日期：2019-04-01 00:00:00

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:Vanadium pharmacokinetic parameters and oral bioavailability were determined after administration of vanadyl sulfate, an antidiabetic agent, to male Wistar rats. An optimal sampling design was used over a 21-day period; vanadium was measured in blood by atomic absorption spectrophotometry (AAS). After i.v. bolus injec...

journal_title：Fundamental & clinical pharmacology

authors： Azay J,Brès J,Krosniak M,Teissedre PL,Cabanis JC,Serrano JJ,Cros G

更新日期：2001-10-01 00:00:00

abstract：:In the present study, contractile responses and [3H]-noradrenaline overflow evoked by electrical field stimulation were assessed, respectively, in the small mesenteric artery and in tail artery removed from rats pre-treated with either saline or lipopolysaccharide (LPS). In small mesenteric arteries, LPS treatment did...

journal_title：Fundamental & clinical pharmacology

authors： Ohlmann P,Martínez MC,Bucher B,Andriantsitohaina R,Muller B,Schneider F,Stoclet JC

更新日期：2000-11-01 00:00:00

abstract：:Beraprost sodium (BPS), an orally active PGI2 (prostaglandine 12) analogue possesses vasodilatating and platelet aggregation inhibiting properties. It is being developed in peripheral arterial occlusive disease. As in future clinical practice BPS might be co-prescribed with oral anticoagulants, we investigated its int...

journal_title：Fundamental & clinical pharmacology

authors： Warot D,Berlin I,Aymard G,Ankri A,Fabry C,Besse B,Lechat P,Diquet B

更新日期：2000-05-01 00:00:00

abstract：:The contribution of Na+, Ca2+, and various K+ currents to the shape of the cardiac action potential is outlined based on the relation between electrophysiological properties and structure of channel molecules. These currents have also been found in human ventricular myocytes, where the most prominent K+ current is a t...

journal_title：Fundamental & clinical pharmacology

authors： Ravens U,Wettwer E,Ohler A,Amos GJ,Mewes T

更新日期：1996-01-01 00:00:00

abstract：:The role of nitric oxide/protein kinase G (NO/PKG) in neurodegenerative disorders is controversial in different circumstances. PKG affects neurons both by itself and as a result of increased NO concentration. In this study, we examined the influence of PKG on spatial memory by intrahippocampal administration of three ...

journal_title：Fundamental & clinical pharmacology

authors： Shariatpanahi M,Khodagholi F,Ashabi G,Bonakdar Yazdi B,Hassani S,Azami K,Abdollahi M,Noorbakhsh F,Taghizadeh G,Sharifzadeh M

更新日期：2016-08-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...

journal_title：Fundamental & clinical pharmacology

authors： Lalonde R,Strazielle C

更新日期：2010-06-01 00:00:00

abstract：:We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (...

journal_title：Fundamental & clinical pharmacology

authors： Bantsiele GB,Bentué-Ferrer D,Amiot N,Allain H,Bourin M,Reymann JM

更新日期：2004-12-01 00:00:00

abstract：:Lithium causes erectile dysfunction in patients but its mechanism is yet unknown. The aim of our study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)- and endothelium-mediated relaxation of guinea pig isolated corpus cavernosum. Although lithium (0.5, 1, and 5mm) ha...

journal_title：Fundamental & clinical pharmacology

authors： Ghasemi M,Farrokhi-Khajeh-Pasha Y,Ostovaneh MR,Dehpour AR

更新日期：2011-04-01 00:00:00