Low glucocorticoid concentrations decrease oxidative phosphorylation of isolated rat brain mitochondria: an additional effect of dexamethasone.

abstract：:We investigated the implication of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in the proliferation stimulated by angiotensin II (Ang II) and endothelin-1 (ET-1) in cultured rabbit gingival fibroblasts (CRGF). Ang II stimulated activation of ERK1/2 and the activation was inhibited by CV-11974, an A...

journal_title：Fundamental & clinical pharmacology

authors： Ohsawa M,Ohuchi N,Taniguchi Y,Kizawa Y,Koike K,Iwamoto K,Hayashi K,Murakami H

更新日期：2005-12-01 00:00:00

abstract：:Incubation of striatal slices with sodium nitroprusside (SNP) or hydroxylamine (HA) for 60 min caused a dose-dependent increase in dopamine (DA) release. This effect was inhibited completely by tetrodotoxin (TTX) (1 microM) if low concentrations of SNP (1 microM) or HA (10 and 100 microM) were tested. Although-higher ...

journal_title：Fundamental & clinical pharmacology

authors： Büyükuysal RL

更新日期：1997-01-01 00:00:00

abstract：:Abuse of alcohol triggers neurodegeneration in human brain. Minocycline has characteristics conferring neuroprotection. Current study evaluates the role of the CREB-BDNF signaling pathway in mediating minocycline's neuroprotective effects against alcohol-induced neurodegeneration. Seventy adult male rats were randomly...

journal_title：Fundamental & clinical pharmacology

authors： Motaghinejad M,Mashayekh R,Motevalian M,Safari S

更新日期：2020-06-24 00:00:00

abstract：:In therapeutic trials, quality of life studies are usually based on a health model which results in a restrictive view. Therefore, it is important to clearly define the concept of the quality of life, since ambiguous concepts can alter the results. The key to this problem is the clear distinction between the two compo...

journal_title：Fundamental & clinical pharmacology

authors： Gerin P,Dazord A,Boissel J,Chifflet R

更新日期：1992-01-01 00:00:00

abstract：:The effects of the dopamine receptor agonist, apomorphine, on the total catecholamine content of the adrenal medulla were studied in normotensive rats. Apomorphine (3, 15, 30 mg/kg SC) induced a dose-dependent decrease in catecholamine content of the adrenal gland. The action of apomorphine was suppressed by previous ...

journal_title：Fundamental & clinical pharmacology

authors： Montastruc JL,Gaillard G,Rascol O,Tran MA,Montastruc P

更新日期：1989-01-01 00:00:00

abstract：:Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric v...

journal_title：Fundamental & clinical pharmacology

authors： Sen T,Abdulsalam CA,Pal S,Sen S,Karmakar S,Saravanan KS,Chaudhuri AK

更新日期：2002-08-01 00:00:00

abstract：:Free radical species have been implicated as important agents involved in myocardial ischemic and reperfusion injuries. Superoxide is capable of mobilizing iron from ferritin and the released iron can cause hydroxyl formation from H2O2. The aim of this study was to evaluate the time-dependent increase in lipid peroxid...

journal_title：Fundamental & clinical pharmacology

authors： Cottin Y,Doise JM,Maupoil V,Tannière-Zeller M,Dalloz F,Maynadié M,Walker MK,Louis P,Carli PM,Wolf JE,Rochette L

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of intracoronary bradykinin (BK) infusion on noradrenaline release and ventricular arrhythmias induced by coronary occlusion and reperfusion in the anesthetized dog. METHODS:14 anesthetized adult mongrel dogs of either sex underwent a 60 min occlusion of t...

journal_title：Fundamental & clinical pharmacology

authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Adam A,Nadeau R

更新日期：1994-01-01 00:00:00

abstract：:We estimated the effect of atorvastatin and fluvastatin on plasma antioxidative activity used in coronary heart disease (CHD) primary prevention. Anti-oxidative activity of blood plasma was determined by Bartosz et al. method [Curr. Top. Biophys. (1998)22:11-13], based on reduction of preformed cation radical of 2,2,a...

journal_title：Fundamental & clinical pharmacology

authors： Kowalski J,Pawlicki L,Grycewicz J,Błaszczyk J,Irzmański R,Cegliński T,Kowalczyk E

更新日期：2004-02-01 00:00:00

abstract：:Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti-inflammatory agents with cardioprotective effects is an urgent task. We aimed to eva...

journal_title：Fundamental & clinical pharmacology

authors： Refaie MMM,Rifaai RA,Bayoumi AMA,Shehata S

更新日期：2020-06-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00

abstract：:Although nisoxetine has been shown to elicit cutaneous (peripheral) anesthesia, spinal (central) anesthesia with nisoxetine was not exposed. The aim of this study was to examine spinal anesthesia of nisoxetine and its influence on the antinociceptive action of mepivacaine. We compared nisoxetine with an established lo...

journal_title：Fundamental & clinical pharmacology

authors： Leung YM,Chu CC,Kuo CS,Chen YW,Hung CH,Wang JJ

更新日期：2014-02-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injections of dihydropyridine derivatives calcium channel agonist (BAY K8644) and antagonist (nifedipine, nicardipine, PN 200-110) induced opposite long-lasting changes in blood pressure (BP) in pentobarbital anesthetized spontaneously hypertensive rats (SMR). I.c.v. nifedipine (NIF), ...

journal_title：Fundamental & clinical pharmacology

authors： Laurent S,Brisac AM,Champeroux P,Lacolley P,Huguet F,Legrand M,Lucet B,Tsoucaris D,Briand V,Schmitt H

更新日期：1989-01-01 00:00:00

abstract：:Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...

journal_title：Fundamental & clinical pharmacology

authors： Gilchrist SE,Alcorn J

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of Na+ , K+ -ATPase (NKA) involved in low concentration of ouabain (Oua, activating NKA)-induced protection of rat cerebral ischemia-reperfusion injury. The 2,3,5-triphenyltetrazolium chloride staining and neurological deficit scores were performed to evaluate rat...

journal_title：Fundamental & clinical pharmacology

authors： Li LL,Ke XY,Jiang C,Qin SQ,Liu YY,Xian XH,Liu LZ,He JC,Chen YM,An HF,Sun N,Hu YH,Wang Y,Zhang LN,Lu QY

更新日期：2021-01-22 00:00:00

abstract：:The insulin secreting B cell is fitted with the two types of purinergic receptors: P2 (for ATP and/or ADP) and P1 (for adenosine). The activation of P2 purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose-dependent between 10(-6) a...

journal_title：Fundamental & clinical pharmacology

authors： Hillaire-Buys D,Chapal J,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1994-01-01 00:00:00

abstract：:Previous studies have demonstrated that excessive free radicals play an essential role in the initiation and progression of epilepsy and that a novel exogenous free radical scavenger edaravone (Ed) exerts some neuroprotective effects on seizure-induced neuronal damage. The purpose of this study was to elucidate the po...

journal_title：Fundamental & clinical pharmacology

authors： Hao L,Dong L,Yu Q,Shen W,Wei X

更新日期：2020-12-01 00:00:00

abstract：:The aim of phase I studies per se is to explore the tolerance of new compounds which have demonstrated a certain level of activity in animals at sufficiently low non-toxic doses. In most cases, these studies are conducted in 2 steps in a limited number of healthy male volunteers: a single rising dose study followed by...

journal_title：Fundamental & clinical pharmacology

authors： Thiercelin JF

更新日期：1990-01-01 00:00:00

abstract：:This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

journal_title：Fundamental & clinical pharmacology

authors： Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

更新日期：2010-08-01 00:00:00

abstract：:The hypotensive and negative chronotropic effects of 5 calcium entry blockers (verapamil 200 micrograms/kg IV; diltiazem 300 micrograms/kg IV; nifedipine 5 micrograms/kg IV; nicardipine 50 micrograms/kg IV; and bepridil 5 mg/kg IV) were compared in control normotensive and acute neurogenic hypertensive anaesthetized d...

journal_title：Fundamental & clinical pharmacology

authors： Montastruc P,Valet P,Dang Tran L,Gaillard G,Montastruc JL

更新日期：1987-01-01 00:00:00

abstract：:Brain ageing affects numerous cerebral metabolic pathways such as cerebral glucose consumption or protein synthesis rate. The pharmacological effect of a mixed D1-D2 dopaminergic agonist, piribedil, on this last metabolism is reported. Cerebral Protein Synthesis Rate (CPSR) was measured by the [35S]L-methionine autora...

journal_title：Fundamental & clinical pharmacology

authors： Bustany P,Trenque T,Crambes O,Moulin M

更新日期：1995-01-01 00:00:00

abstract：:In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal m...

journal_title：Fundamental & clinical pharmacology

authors： Daveluy A,Sauvaget L,Bastien A,Lapeyre-Mestre M,Collin C,Richard N,Haramburu F

更新日期：2018-10-01 00:00:00

abstract：:Cyclophosphamide given in association with corticosteroids has markedly improved the prognosis of systemic vasculitis. Little information has been reported on cyclophosphamide pharmacokinetics in these diseases and data evaluating its metabolite, 4-hydroxycyclophosphamide/aldophosphamide, pharmacokinetics and concentr...

journal_title：Fundamental & clinical pharmacology

authors： Belfayol-Pisanté L,Guillevin L,Tod M,Fauvelle F

更新日期：2000-07-01 00:00:00

abstract：:The aims of this study were: (i) To investigate the activity of recombinant AMPs HNP-1 and hBD-1 in combination with cefotaxime against Staphylococcus aureus strains (MSSA and MRSA) in vitro using checkerboard method; (ii) To investigate the activity of HNP-1 and hBD-1 encapsulated in silicon nanoparticles (niosomes) ...

journal_title：Fundamental & clinical pharmacology

authors： Bolatchiev A,Baturin V,Bazikov I,Maltsev A,Kunitsina E

更新日期：2020-02-01 00:00:00

abstract：:Thienopyridines have become the cornerstone of treatment for percutaneous coronary intervention although no survival benefit has ever been shown with clopidogrel despite increasing loading doses. Newly developed P2Y12 inhibitors are more potent, more predictable, and have a faster onset of action than clopidogrel, cha...

journal_title：Fundamental & clinical pharmacology

authors： Collet JP,O'Connor S

更新日期：2012-02-01 00:00:00

abstract：:Heart transplant is considered to be an extremely severe ischemia-reperfusion sequence. Post-ischemic dysfunction triggers multiple processes especially oxidative stress, but the mechanisms remain unclear. Free radical interactions lead to peroxynitrite generation, which seems to be involved in early post-transplant h...

journal_title：Fundamental & clinical pharmacology

authors： Lauzier B,Sicard P,Bouchot O,Delemasure S,Moreau D,Vergely C,Rochette L

更新日期：2007-04-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:Considering the diseases of the stomach and duodenum, peptic ulcer has been the one with a significant clinical impact. The pathophysiology of peptic ulcer has centred on an imbalance between aggressive and protective factors. The discovery of Helicobacter pylori as a cause of peptic ulcer has changed our approach gre...

journal_title：Fundamental & clinical pharmacology

authors： Sivri B

更新日期：2004-02-01 00:00:00

abstract：:Despite the benefits of chrysotherapy the responsible mechanism of action of gold compounds remains unclear. At a concentration of 5 x 10(-4) M, sodium aurothiopropanol sulfonate (SAS) modified the in vitro proliferation kinetics of articular chondrocytes by reducing growth, viability and plating efficiency. Flow cyto...

journal_title：Fundamental & clinical pharmacology

authors： Ronot X,Hainque B,Christen MO,Froger B,Hartmann DJ,Adolphe M,Lechat P

更新日期：1988-01-01 00:00:00