Effect of amitriptyline on gastric ulceration.

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:We reported that coronary spasm was induced in the transgenic mice with the increased phospholipase C (PLC)-δ1 activity. We investigated the effect of enhanced PLC-δ1 on Ca2+ influx and its underlying mechanisms. We used human embryonic kidney (HEK)-293 and coronary arteries smooth muscle cells (CASMC). Intracellular ...

journal_title：Fundamental & clinical pharmacology

authors： Murakami K,Osanai T,Tanaka M,Nishizaki K,Kinjo T,Tanno T,Ishida Y,Suzuki A,Endo T,Tomita H,Okumura K

更新日期：2017-08-01 00:00:00

abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...

journal_title：Fundamental & clinical pharmacology

authors： Bénard-Laribière A,Miremont-Salamé G,Pérault-Pochat MC,Noize P,Haramburu F,EMIR Study Group on behalf of the French network of pharmacovigilance centres.

更新日期：2015-02-01 00:00:00

abstract：:Gait disorders form one component of the axial disorders observed in Parkinson's disease (PD). Indeed, short steps with a forward-leaning stance are diagnostic criteria for PD in the early stages of the condition. Gait disorders also represent a major source of therapeutic failure in the advanced stages of PD (with th...

journal_title：Fundamental & clinical pharmacology

authors： Devos D,Defebvre L,Bordet R

更新日期：2010-08-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:The purpose of this study was to assess in rats the pharmacological parameters and effects on gene expression in the liver of the triterpene glycoside actein. Actein, an active component from the herb black cohosh, has been shown to inhibit the proliferation of human breast cancer cells. To conduct our assessment, we ...

journal_title：Fundamental & clinical pharmacology

authors： Einbond LS,Soffritti M,Esposti DD,Park T,Cruz E,Su T,Wu HA,Wang X,Zhang YJ,Ham J,Goldberg IJ,Kronenberg F,Vladimirova A

更新日期：2009-06-01 00:00:00

abstract：:Developing drugs for rare disease can be challenging due to specific rare disease characteristics. The French Medical Pharmacology is structured and positioned to play a major role in orphan drug research and development due to the required expertise concentrated into pharmacology departments, exclusively implemented ...

journal_title：Fundamental & clinical pharmacology

authors： Micallef J,Boutouyrie P,Blin O

更新日期：2017-12-01 00:00:00

abstract：:The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to af...

journal_title：Fundamental & clinical pharmacology

authors： Noize P,Sauer M,Bruneval P,Moreau M,Pathak A,Bagheri H,Montastruc JL

更新日期：2006-12-01 00:00:00

abstract：:Suriclone is a novel cyclopyrrolone exhibiting anxiolytic activity. Twelve healthy Caucasian male volunteers participated in the study. A single dose of suriclone 0.4 mg, imipramine 75 mg, suriclone 0.4 mg + imipramine 75 mg, or placebo was given according to a 4 x 4 Latin-square design in order to assess the effect o...

journal_title：Fundamental & clinical pharmacology

authors： Perault MC,Chapelle G,Bouquet S,Chevalier P,Montay G,Gaillot J,Chakroun H,Guillet P,Vandel B

更新日期：1994-01-01 00:00:00

abstract：:Several recent reports have described the antiarrhythmic effects of a single high oral dose of amiodarone but clinical electrophysiologic effects have not been reported. The present study was performed to assess electrophysiologic effects in 12 patients. After baseline electrophysiologic studies (EPS) patients were ad...

journal_title：Fundamental & clinical pharmacology

authors： Deharo JC,Durand A,Macaluso G,Malaterre H,Le Tallec L,Panagides D,Bory M,Djiane P

更新日期：1997-01-01 00:00:00

abstract：:Stepwise multiple regression analyses were applied to 44 atazanavir pharmacokinetic profiles from 44 HIV-1 infected patients concomitantly treated with raltegravir with the goal of identifying limited sampling strategies for the prediction of drug AUC(0-12) . Atazanavir trough-based equations failed to reliably predic...

journal_title：Fundamental & clinical pharmacology

authors： Cattaneo D,Ripamonti D,Baldelli S,Cozzi V,Fucile S,Clementi E

更新日期：2013-04-01 00:00:00

abstract：:The effects of Ketotifen and disodium cromoglycate were investigated on human and rabbit platelet activation. Ketotifen inhibited dose-dependently human and rabbit platelet aggregation. The paf-acether pathway was the most markedly influenced by Ketotifen in human and rabbit platelets (IC50 = 38.8 +/- 7.7 microM and 7...

journal_title：Fundamental & clinical pharmacology

authors： Devillier P,Arnoux B,Lalau Keraly C,Landes A,Marsac J,Benveniste J

更新日期：1990-01-01 00:00:00

abstract：:The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...

journal_title：Fundamental & clinical pharmacology

authors： Paris A,Cornu C,Auquier P,Maison P,Radauceanu A,Brandt C,Salvat-Melis M,Hommel M,Cracowski JL

更新日期：2006-02-01 00:00:00

abstract：:The smooth muscle relaxant responses to NS-004, an activator of charybdotoxin-sensitive, large conductance Ca(2+)-dependent K+ channels (BKCa) were studied on the basal spontaneous tone in guinea-pig trachea in vitro. The sensitivity of these responses to a range of K+ channel inhibitors and antagonists were also eval...

journal_title：Fundamental & clinical pharmacology

authors： Lawson K,Barras M,Armstrong JM,Hicks PE

更新日期：1997-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work ...

journal_title：Fundamental & clinical pharmacology

authors： Bès S,Tatou E,Vandroux D,Tissier C,Rochette L,Athias P

更新日期：2004-06-01 00:00:00

abstract：:The insulin secreting B cell is fitted with the two types of purinergic receptors: P2 (for ATP and/or ADP) and P1 (for adenosine). The activation of P2 purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose-dependent between 10(-6) a...

journal_title：Fundamental & clinical pharmacology

authors： Hillaire-Buys D,Chapal J,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1994-01-01 00:00:00

abstract：:The aim of this cross-sectional study was to investigate the association between sedative load and functional outcomes in community-dwelling older Australian men. A total of 1696 males aged ≥ 70 years, enrolled in the Concord Health and Ageing in Men Project, were studied. Participants underwent assessments during 200...

journal_title：Fundamental & clinical pharmacology

authors： Gnjidic D,Le Couteur DG,Hilmer SN,Cumming RG,Blyth FM,Naganathan V,Waite L,Handelsman DJ,Bell JS

更新日期：2014-02-01 00:00:00

abstract：:Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

journal_title：Fundamental & clinical pharmacology

authors： Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

更新日期：2019-06-01 00:00:00

abstract：:This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

journal_title：Fundamental & clinical pharmacology

authors： Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

更新日期：2020-09-09 00:00:00

abstract：:Multiple standard software packages for population pharmacokinetics (PK) modeling are currently available. These programs may significantly vary in the algorithms used for modeling plasma concentrations as a function of time course. We compared the population PK parameters obtained by using two standard software packa...

journal_title：Fundamental & clinical pharmacology

authors： Finkelstein Y,Nava-Ocampo AA,Schechter T,Grant R,St Pierre E,Goldman R,Walker S,Koren G

更新日期：2009-02-01 00:00:00

abstract：:We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effects against veratrine-contractures, in the absence of negative inotro...

journal_title：Fundamental & clinical pharmacology

authors： Le Grand B,Marty A,Talmant JM,John GW

更新日期：1996-01-01 00:00:00

abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...

journal_title：Fundamental & clinical pharmacology

authors： Lalonde R,Strazielle C

更新日期：2010-06-01 00:00:00

abstract：:The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...

journal_title：Fundamental & clinical pharmacology

authors： Ergün Y,Darendeli S,Imrek S,Kilinç M,Oksüz H

更新日期：2010-04-01 00:00:00

abstract：:Surrogate endpoints predict the occurrence and timing of a clinical endpoint of interest (CEI). Substitution of a surrogate endpoint for a CEI can dramatically reduce the time and cost necessary to complete a Phase III clinical trial. However, assurance that use of a surrogate endpoint will result in a correct conclus...

journal_title：Fundamental & clinical pharmacology

authors： Domanski M,Pocock S,Bernaud C,Borer J,Geller N,Revkin J,Zannad F

更新日期：2011-08-01 00:00:00

abstract：:Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. As oxazep...

journal_title：Fundamental & clinical pharmacology

authors： Menard C,Lamiable D,Vistelle R,Droy-Lefait MT,Ratanasavanh D

更新日期：1999-01-01 00:00:00

abstract：:The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. Although CGP 37849 was the more potent compound, both antago...

journal_title：Fundamental & clinical pharmacology

authors： D'Hooge R,Raes A,Van de Vijver G,Van Bogaert PP,De Deyn PP

更新日期：1999-01-01 00:00:00

abstract：:The effects of two single oral doses (5 mg and 20 mg) of a new angiotensin I-converting enzyme inhibitor, imidapril, on a) systemic hemodynamics (arterial pressure, heart rate, cardiac output), b) brachial and common carotid arteries' hemodynamics (diameter and blood flow, pulsed Doppler technique), c) cerebral hemody...

journal_title：Fundamental & clinical pharmacology

authors： Démolis P,Annane D,Duhazé P,Giudicelli JF

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of intracoronary bradykinin (BK) infusion on noradrenaline release and ventricular arrhythmias induced by coronary occlusion and reperfusion in the anesthetized dog. METHODS:14 anesthetized adult mongrel dogs of either sex underwent a 60 min occlusion of t...

journal_title：Fundamental & clinical pharmacology

authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Adam A,Nadeau R

更新日期：1994-01-01 00:00:00

abstract：:Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert's syndrome with severe hyperbilirubinaemias and jaundice. We analysed the reactivities of some hydroxyquinoline derivatives, which are naturally...

journal_title：Fundamental & clinical pharmacology

authors： Kanou M,Saeki K,Kato TA,Takahashi K,Mizutani T

更新日期：2002-12-01 00:00:00

abstract：:The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

journal_title：Fundamental & clinical pharmacology

authors： Hellmich B,Gyermek L

更新日期：1997-01-01 00:00:00