Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients.

abstract：:New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for central nervous system (CNS) and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 cells and activity against erythrocytic stages of Plasmodium falciparum was determined. Compound...

journal_title：Fundamental & clinical pharmacology

authors： Kedzierska E,Orzelska J,Perković I,Knežević D,Fidecka S,Kaiser M,Zorc B

更新日期：2016-02-01 00:00:00

abstract：:Abstract Endothelin-1 (ET-1) appears to be involved in drug-induced proliferation of gingival fibroblasts. Thrombin induces proliferation of human gingival fibroblasts via protease-activated receptor 1 (PAR1). In this study, using cultured rat gingival fibroblasts, we investigated whether thrombin-induced proliferatio...

journal_title：Fundamental & clinical pharmacology

authors： Ohuchi N,Hayashi K,Iwamoto K,Koike K,Kizawa Y,Nukaga M,Kakegawa T,Murakami H

更新日期：2010-08-01 00:00:00

abstract：:What is the place of fish oils in the care of coronary heart disease (CHD) patients? As several clinical trials have already addressed this question without giving definitive answers, we did a meta-analysis of trials regarding the efficacy of omega-3 fatty acids in preventing cardiovascular mortality and morbidity. We...

journal_title：Fundamental & clinical pharmacology

authors： Yzebe D,Lievre M

更新日期：2004-10-01 00:00:00

abstract：:Interferon (IFN)-γ is known to downregulate expression of drug detoxifying proteins such as cytochromes P-450 (CYPs) in human hepatocytes. The present study was designed to determine whether IFN-γ may also impair expression of influx and efflux drug transporters, which constitute important determinants of the liver de...

journal_title：Fundamental & clinical pharmacology

authors： Le Vee M,Jouan E,Moreau A,Fardel O

更新日期：2011-02-01 00:00:00

abstract：:The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...

journal_title：Fundamental & clinical pharmacology

authors： Redrobe JP,Bourin M

更新日期：1997-01-01 00:00:00

abstract：:Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

journal_title：Fundamental & clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

更新日期：1998-01-01 00:00:00

abstract：:The aim of the present study was to assess the role of vascular alpha 1D-adrenoceptors in the sympathetic vasopressor response in vivo. Specifically, we evaluated the effect of a selective alpha 1D-adrenoceptor antagonist, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)dec ane-7,9- dione 2HCl)...

journal_title：Fundamental & clinical pharmacology

authors： Castillo EF,López RM,Rodríguez-Silverio J,Bobadilla RA,Castillo C

更新日期：1998-01-01 00:00:00

abstract：:Suriclone is a novel cyclopyrrolone exhibiting anxiolytic activity. Twelve healthy Caucasian male volunteers participated in the study. A single dose of suriclone 0.4 mg, imipramine 75 mg, suriclone 0.4 mg + imipramine 75 mg, or placebo was given according to a 4 x 4 Latin-square design in order to assess the effect o...

journal_title：Fundamental & clinical pharmacology

authors： Perault MC,Chapelle G,Bouquet S,Chevalier P,Montay G,Gaillot J,Chakroun H,Guillet P,Vandel B

更新日期：1994-01-01 00:00:00

abstract：:Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

journal_title：Fundamental & clinical pharmacology

authors： Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

更新日期：2019-06-01 00:00:00

abstract：:There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti-inflammatory and ...

journal_title：Fundamental & clinical pharmacology

authors： Ouk T,Potey C,Laprais M,Gautier S,Hanf R,Darteil R,Staels B,Duriez P,Bordet R

更新日期：2014-06-01 00:00:00

abstract：:By use of a simple anticonflict procedure (Vogel test), it was demonstrated that L-pyroglutamic acid (L-pyrrolidone carboxylic acid [L-PCA]), an amino acid naturally occurring in mammalian tissues and fluids, possesses anxiolytic activity. This tissues and fluids, possesses anxiolytic activity. This effect was stereos...

journal_title：Fundamental & clinical pharmacology

authors： Beni M,Pellegrini-Giampietro DE,Moroni F

更新日期：1988-01-01 00:00:00

abstract：:In addition to their direct effects on cardiac contractility, a number of positive inotropic agents also induce, through direct peripheral vasodilation, a reduction in afterload which is of major importance in their beneficial effects in the treatment of congestive heart failure. However, the induced increase in cardi...

journal_title：Fundamental & clinical pharmacology

authors： Gosgnach M,Gérard JL,Berdeaux A,Giudicelli JF

更新日期：1991-01-01 00:00:00

abstract：:This study investigated the tolerability, safety, pharmacokinetics, and pharmacodynamics of ACT-178882, a new direct renin inhibitor, as well as its interaction with food and midazolam. Healthy male subjects received either single (10-1000 mg) or multiple doses (30-600 mg) administered once daily for 14 days of ACT-17...

journal_title：Fundamental & clinical pharmacology

authors： Dingemanse J,Nicolas L,Binkert C

更新日期：2013-12-01 00:00:00

abstract：:Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor or an inducer of CYP3A affects HP pharmacokine...

journal_title：Fundamental & clinical pharmacology

authors： Watanabe M,Tateishi T,Asoh M,Nakura H,Tanaka M,Kumai T,Kobayashi S

更新日期：1999-01-01 00:00:00

abstract：:The aims of this study were: (i) To investigate the activity of recombinant AMPs HNP-1 and hBD-1 in combination with cefotaxime against Staphylococcus aureus strains (MSSA and MRSA) in vitro using checkerboard method; (ii) To investigate the activity of HNP-1 and hBD-1 encapsulated in silicon nanoparticles (niosomes) ...

journal_title：Fundamental & clinical pharmacology

authors： Bolatchiev A,Baturin V,Bazikov I,Maltsev A,Kunitsina E

更新日期：2020-02-01 00:00:00

abstract：:During the last decade, a multitude of experimental arguments have led to the concept that EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone but also in vascular homeostasis, neuronal and immunological functions. Regardless of its origin, endogenous NO is produced through the co...

journal_title：Fundamental & clinical pharmacology

authors： Berdeaux A

更新日期：1993-01-01 00:00:00

abstract：:In epileptic patients cyproheptadine is frequently prescribed as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of 'serotonin syndrome' in depressed epileptic patients. However, the study of serotonergic and histaminergic pathway shows that the decreased...

journal_title：Fundamental & clinical pharmacology

authors： Singh D,Goel RK

更新日期：2010-08-01 00:00:00

abstract：:The hypotensive and negative chronotropic effects of 5 calcium entry blockers (verapamil 200 micrograms/kg IV; diltiazem 300 micrograms/kg IV; nifedipine 5 micrograms/kg IV; nicardipine 50 micrograms/kg IV; and bepridil 5 mg/kg IV) were compared in control normotensive and acute neurogenic hypertensive anaesthetized d...

journal_title：Fundamental & clinical pharmacology

authors： Montastruc P,Valet P,Dang Tran L,Gaillard G,Montastruc JL

更新日期：1987-01-01 00:00:00

abstract：:Clinical and experimental studies have shown that gender differences exist in cardiac repolarization in various animal species and human, as is evidenced by significantly longer QT, JT intervals and action potential duration in females than in males due to a reduced repolarization reserve in females. The latter is sho...

journal_title：Fundamental & clinical pharmacology

authors： Cheng J

更新日期：2006-02-01 00:00:00

abstract：:Considering the diseases of the stomach and duodenum, peptic ulcer has been the one with a significant clinical impact. The pathophysiology of peptic ulcer has centred on an imbalance between aggressive and protective factors. The discovery of Helicobacter pylori as a cause of peptic ulcer has changed our approach gre...

journal_title：Fundamental & clinical pharmacology

authors： Sivri B

更新日期：2004-02-01 00:00:00

abstract：:Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric v...

journal_title：Fundamental & clinical pharmacology

authors： Sen T,Abdulsalam CA,Pal S,Sen S,Karmakar S,Saravanan KS,Chaudhuri AK

更新日期：2002-08-01 00:00:00

abstract：:Chloroquine (CQ) induces histamine-independent itch in human and mice. We recently reported the role of intradermal nitric oxide (NO)/cyclic guanosine monophosphate pathway in CQ-evoked scratching in mice. Chloroquine stimulates neuronal nitric oxide synthase (nNOS) activity to over-producing NO in the skin. Sumatript...

journal_title：Fundamental & clinical pharmacology

authors： Haddadi NS,Ostadhadi S,Shakiba S,Afshari K,Rahimi N,Foroutan A,Dehpour AR

更新日期：2018-02-01 00:00:00

abstract：:Allopurinol, oxypurinol, hypoxanthine and xanthine were assayed simultaneously using a highly specific method combining gas chromatography and mass spectrometry. Two hypo-uricaemic prescriptions were compared: i) 300 mg of allopurinol (AL); and ii) 100 mg of allopurinol plus 20 mg of benzbromarone (AL + BZB). When adm...

journal_title：Fundamental & clinical pharmacology

authors： Lartigue-Mattei C,Chabard JL,Ristori JM,Bussiere JL,Bargnoux H,Petit J,Berger JA

更新日期：1991-01-01 00:00:00

abstract：:Anxiety following heart failure (HF) and/or myocardial infarction (MI) can impede recovery and constitute a major risk factor for further cardiac events. The present study was aimed to evaluate anxiety following doxorubicin (DOX)-induced cardiomyopathy, a rodent model for HF, in mice. Furthermore, the study investigat...

journal_title：Fundamental & clinical pharmacology

authors： Anwar MJ,Pillai KK,Khanam R,Akhtar M,Vohora D

更新日期：2012-06-01 00:00:00

abstract：:Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis. Cpn is an obligate intracellular gram-negative bacterium that is responsible for 10% of cases of community-acquired pneumonia. In addi...

journal_title：Fundamental & clinical pharmacology

authors： Deniset JF,Pierce GN

更新日期：2010-10-01 00:00:00

abstract：:Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert's syndrome with severe hyperbilirubinaemias and jaundice. We analysed the reactivities of some hydroxyquinoline derivatives, which are naturally...

journal_title：Fundamental & clinical pharmacology

authors： Kanou M,Saeki K,Kato TA,Takahashi K,Mizutani T

更新日期：2002-12-01 00:00:00

abstract：:The effects of tacrine and physostigmine on catecholamine secretion induced by veratridine and high K+, and on voltage-dependent Na+ and Ca2+ currents, were investigated in guinea-pig adrenal chromaffin cells. In perfused adrenal glands, tacrine (100 microM) caused an inhibition of veratridine-induced catecholamine se...

journal_title：Fundamental & clinical pharmacology

authors： Sugawara T,Kitamura N,Ohta T,Ito S,Nakazato Y

更新日期：1998-01-01 00:00:00

abstract：:Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) activities were detected in bronchial and bronchial epithelial cell homogenates of the pig. In the bronchial homogenates, the maximal upstroke velocity (Vmax) of AChE and the maximal velocity after second substrate fixation (Vss) of B...

journal_title：Fundamental & clinical pharmacology

authors： Taisne C,Norel X,Walch L,Labat C,Verriest C,Mazmanian GM,Brink C

更新日期：1997-01-01 00:00:00

abstract：:Quercetin is a flavonol polyphenol widely found in many vegetables, grains, and fruits. Quercetin has been shown to inhibit proliferation and invasion of various glioma cells and is regarded as a potential anticancer agent against glioma. However, whether and how this drug could affect brain blood vessels and endothel...

journal_title：Fundamental & clinical pharmacology

authors： Chen CY,Hour MJ,Shiao LR,Wong KL,Leung YM,Chan P,So EC

更新日期：2020-04-01 00:00:00

abstract：:This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

journal_title：Fundamental & clinical pharmacology

authors： Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

更新日期：2010-08-01 00:00:00