Pharmacokinetic and pharmacodynamic study of suriclone imipramine interaction in man.

abstract：:Prostaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES. Among them, m...

journal_title：Fundamental & clinical pharmacology

authors： Kojima F,Kato S,Kawai S

更新日期：2005-06-01 00:00:00

abstract：:Many characters are genetically regulated as polymorphisms. This means that discrete groups are seen within the distribution of a certain character. Drug metabolism is no exception and the polymorphism of acetylation is recognised since the 50's. Polymorphic drug oxidation was discovered in the 70's and has been exten...

journal_title：Fundamental & clinical pharmacology

authors： Alván G

更新日期：1991-01-01 00:00:00

abstract：:The aim of the present study was to assess the role of vascular alpha 1D-adrenoceptors in the sympathetic vasopressor response in vivo. Specifically, we evaluated the effect of a selective alpha 1D-adrenoceptor antagonist, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)dec ane-7,9- dione 2HCl)...

journal_title：Fundamental & clinical pharmacology

authors： Castillo EF,López RM,Rodríguez-Silverio J,Bobadilla RA,Castillo C

更新日期：1998-01-01 00:00:00

abstract：:Gastric mucosa is frequently exposed to various gastric irritants, and there is a continuing requirement to develop new gastro-protective agents. This study compares the effects of three such agents, sucralfate, rebamipide, and cimetidine in both in vivo and in vitro indomethacin-induced gastric damage models. For the...

journal_title：Fundamental & clinical pharmacology

authors： Goineau S,Castagné V

更新日期：2017-04-01 00:00:00

abstract：:Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...

journal_title：Fundamental & clinical pharmacology

authors： Gilchrist SE,Alcorn J

更新日期：2010-04-01 00:00:00

abstract：:Incubation of striatal slices with sodium nitroprusside (SNP) or hydroxylamine (HA) for 60 min caused a dose-dependent increase in dopamine (DA) release. This effect was inhibited completely by tetrodotoxin (TTX) (1 microM) if low concentrations of SNP (1 microM) or HA (10 and 100 microM) were tested. Although-higher ...

journal_title：Fundamental & clinical pharmacology

authors： Büyükuysal RL

更新日期：1997-01-01 00:00:00

abstract：:This study evaluated the effect of lacosamide (LCM) on biochemical and mitochondrial parameters after PTZ kindling in mice. Male mice were treated on alternative days for a period of 11 days with LCM (20, 30, or 40 mg/kg), saline, or diazepam (2 mg/kg), before PTZ administration (50 mg/kg). The hippocampi were collect...

journal_title：Fundamental & clinical pharmacology

authors： Lazzarotto L,Pflüger P,Regner GG,Santos FM,Aguirre DG,Brito VB,Moura DJ,Dos Santos NM,Picada JN,Parmeggiani B,Frusciante MR,Leipnitz G,Pereira P

更新日期：2020-08-09 00:00:00

abstract：:Erythromycin inhibits the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL6) induced by heat-killed Streptococcus pneumoniae in human whole blood ex-vivo. The objective of the present study was to determine and characterize the concentration-effect relationship of this phenomenon in order t...

journal_title：Fundamental & clinical pharmacology

authors： Guchelaar HJ,Schultz MJ,van der Poll T,Koopmans RP

更新日期：2001-12-01 00:00:00

abstract：:Endocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2-arachidonoylglycerol. Recent pharmacological advances point ou...

journal_title：Fundamental & clinical pharmacology

authors： Smita K,Sushil Kumar V,Premendran JS

更新日期：2007-02-01 00:00:00

abstract：:Drug-drug interactions (DDIs) between antihypertensive drugs and non-steroidal anti-inflammatory drugs (NSAIDs) can lead to adverse drug reactions (ADRs). Guidelines are available to help prescribers deal with these drug associations, but their implementation is not well evaluated. The aims of this study were to asses...

journal_title：Fundamental & clinical pharmacology

authors： Fournier JP,Sommet A,Durrieu G,Poutrain JC,Lapeyre-Mestre M,Montastruc JL,French Network of Regional Pharmacovigilance Centres.

更新日期：2014-04-01 00:00:00

abstract：:The hypothesis of an interaction between trimetazidine and the immunosuppressive effect of cyclosporin A was investigated in two models: a) ex vivo, the lymphoproliferative response of normal human lymphocytes to phytohemagglutinin and a murine monoclonal antibody against the CD3 T-lymphocyte membrane complex; b) in v...

journal_title：Fundamental & clinical pharmacology

authors： Albengres E,Tillement JP,d'Athis P,Salducci D,Chauvet-Monges AM,Crevat A

更新日期：1996-01-01 00:00:00

abstract：:Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert's syndrome with severe hyperbilirubinaemias and jaundice. We analysed the reactivities of some hydroxyquinoline derivatives, which are naturally...

journal_title：Fundamental & clinical pharmacology

authors： Kanou M,Saeki K,Kato TA,Takahashi K,Mizutani T

更新日期：2002-12-01 00:00:00

abstract：:The contractile activity of (-)-Bay k 8644 was assessed in rat isolated aortic ring preparations bathed in a potassium-free medium. (-)-Bay k 8644 (0.01-3 microM) caused extracellular calcium-dependent contractile responses, which were significantly greater in tissues with, than deprived of a functional endothelium. I...

journal_title：Fundamental & clinical pharmacology

authors： Lawson K,Cavero I

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to assess in rats the pharmacological parameters and effects on gene expression in the liver of the triterpene glycoside actein. Actein, an active component from the herb black cohosh, has been shown to inhibit the proliferation of human breast cancer cells. To conduct our assessment, we ...

journal_title：Fundamental & clinical pharmacology

authors： Einbond LS,Soffritti M,Esposti DD,Park T,Cruz E,Su T,Wu HA,Wang X,Zhang YJ,Ham J,Goldberg IJ,Kronenberg F,Vladimirova A

更新日期：2009-06-01 00:00:00

abstract：:The H1-histaminergic agonists 2-pyridylethylamine (2-PEA) and 2-methylhistamine relaxed potassium-constricted, perfused, rabbit middle cerebral arteries at low concentrations (3 x 10(-11) to 3 x 10(-8) M) and constricted them at high concentrations (3 x 10(-7) to 3 x 10(-4) M). The relaxation and the contraction were ...

journal_title：Fundamental & clinical pharmacology

authors： Ea Kim L,Sercombe R,Oudart N

更新日期：1988-01-01 00:00:00

abstract：:Anticonvulsant action of CGP 40116, a competitive antagonist of N-methyl-D-aspartate type of excitatory amino acid receptors, was studied in rats during development (7, 12, 18, 25 and 90 days old). Two types of motor seizures were elicited by a subcutaneous injection of pentylenetetrazol. Pretreatment with CGP 40116 d...

journal_title：Fundamental & clinical pharmacology

authors： Haugvicová R,Mares P

更新日期：1998-01-01 00:00:00

abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...

journal_title：Fundamental & clinical pharmacology

authors： Silva RO,Sousa FB,Damasceno SR,Carvalho NS,Silva VG,Oliveira FR,Sousa DP,Aragão KS,Barbosa AL,Freitas RM,Medeiros JV

更新日期：2014-08-01 00:00:00

abstract：:We investigated the underlying mechanisms of penehyclidine hydrochloride (PHC), a novel selective anticholinergic drug on isolated rat uterus. The method of radio-immunity assay was further employed to determine cyclic adenosine mono phosphate (cAMP) levels in isolated rat uterus for comparing with selective effect on...

journal_title：Fundamental & clinical pharmacology

authors： Xiao HT,Liao Z,Meng XM,Yan XY,Chen SJ,Mo ZJ

更新日期：2009-08-01 00:00:00

abstract：:Low temperatures may affect dose delivery efficacy and clinical effectiveness of medication aerosols. In this study we examine the effect of cold ambient temperature on the bronchodilatation produced by terbutaline delivered from a chlorofluorocarbon pressurized metered dose inhaler (pMDI) compared to a multi-dose dry...

journal_title：Fundamental & clinical pharmacology

authors： Ramón M,Juan G,Ciscar MA,Martí-Bonmatí E,Morcillo EJ,Marín J

更新日期：2000-03-01 00:00:00

abstract：:Adverse reactions to antipsychotic drugs (APs) have been attributed to oxidative stress. Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death. We examined the protective properties of SF against AP-induced oxidative stress in dopaminergic neuroblastoma cells. Human neuroblastoma SK-N...

journal_title：Fundamental & clinical pharmacology

authors： Mas S,Gassó P,Trias G,Bernardo M,Lafuente A

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to investigate the effects of a high-cholesterol diet in the presence and absence of statin on Cu-Zn-superoxide dismutase (Cu,Zn-SOD), malondialdehyde (MDA), protein carbonyl (PCO), and nitric oxide (NO) of blood and heart tissue, the antioxidant activity of serum paraoxonase-1 (PON-1), and o...

journal_title：Fundamental & clinical pharmacology

authors： Sozer V

更新日期：2015-12-01 00:00:00

abstract：:We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effects against veratrine-contractures, in the absence of negative inotro...

journal_title：Fundamental & clinical pharmacology

authors： Le Grand B,Marty A,Talmant JM,John GW

更新日期：1996-01-01 00:00:00

abstract：:We studied the effects of KATP channel blockers on [3H]GABA release in the absence of glucose in rat hippocampal slices. The omission of glucose induced a marked increase in the efflux of [3H]GABA, which was antagonized by TTX (1 microM), but not by MK 801 (1 microM) or DNQX (100 microM). Glibenclamide (10-100 microM)...

journal_title：Fundamental & clinical pharmacology

authors： Margaill I,Miquet JM,Doble A,Blanchard JC,Boireau A

更新日期：1992-01-01 00:00:00

abstract：:In the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10(-12)-10(-9) m) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10(-6) m). Removal of endothelium abolished the effects of leptin. Pre...

journal_title：Fundamental & clinical pharmacology

authors： Sahin AS,Bariskaner H

更新日期：2007-12-01 00:00:00

abstract：:The ATP-binding cassette (ABC) transporter ABCB1, or P-glycoprotein, is a transmembrane efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 substrates include either drugs, such as antiretrovirals and immunomodulators, or physiological molecules like phospholipids. Pharmacogenetic a...

journal_title：Fundamental & clinical pharmacology

authors： Jeannesson E,Albertini L,Siest G,Gomes AM,Ribeiro V,Aslanidis C,Schmitz G,Visvikis-Siest S

更新日期：2007-08-01 00:00:00

abstract：:Lithium causes erectile dysfunction in patients but its mechanism is yet unknown. The aim of our study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)- and endothelium-mediated relaxation of guinea pig isolated corpus cavernosum. Although lithium (0.5, 1, and 5mm) ha...

journal_title：Fundamental & clinical pharmacology

authors： Ghasemi M,Farrokhi-Khajeh-Pasha Y,Ostovaneh MR,Dehpour AR

更新日期：2011-04-01 00:00:00

abstract：:Rats of the Fischer 344 (F344) and Wistar Kyoto (WKY) strains are known to present differences in stimuli responses involving the renin-angiotensin system and in cardiovascular responses to an acoustic startle stimulus. Here we compared the vascular reactivity to angiotensin II (ANG II) of these normotensive, inbred r...

journal_title：Fundamental & clinical pharmacology

authors： Herin L,Blanc J,Basset A,Laude D,Laurent S,Elghozi JL

更新日期：2003-06-01 00:00:00

abstract：:It has been suggested that salicylate hydroxylation can be used to detect hydroxyl radical formation in vivo. In the present study we investigated the effects of verapamil and or ryanodine on salicylate (SA) and its hydroxylated adduct; 2,3-dihydroxybenzoic acid (2,3-DHBA) levels in glutamate induced neurotoxicity of ...

journal_title：Fundamental & clinical pharmacology

authors： Gepdiremen A,Singh G,Marsden CA

更新日期：2000-01-01 00:00:00

abstract：:Gait disorders form one component of the axial disorders observed in Parkinson's disease (PD). Indeed, short steps with a forward-leaning stance are diagnostic criteria for PD in the early stages of the condition. Gait disorders also represent a major source of therapeutic failure in the advanced stages of PD (with th...

journal_title：Fundamental & clinical pharmacology

authors： Devos D,Defebvre L,Bordet R

更新日期：2010-08-01 00:00:00

abstract：:Childhood digestive disorders are a common occurrence and are sometimes unexplained. Maternal medication during the development of the foetus' digestive system may contribute to the increase in childhood digestive disorders, especially with drugs acting on the cholinergic system. This study investigated the associatio...

journal_title：Fundamental & clinical pharmacology

authors： Benevent J,Hurault-Delarue C,Araujo M,Montastruc F,Montastruc JL,Lacroix I,Damase-Michel C

更新日期：2019-06-01 00:00:00