The mechanisms of vasorelaxant effect of leptin on isolated rabbit aorta.

Abstract:

:In the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10(-12)-10(-9) m) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10(-6) m). Removal of endothelium abolished the effects of leptin. Pretreatment of rings with N(omega)-nitro-l-arginine methyl ester (10(-4) m 20 min) or catalase (1200 U/mL 20 min) significantly reduced the relaxant response to leptin when compared with the control group. The incubation of brefeldin A (3.5 x 10(-5) m 90 min), indomethacin (10(-5) m 20 min), tetraethylammonium (10(-4) m 20 min), and glibenclamide (10(-5) m, 20 min) did not affect the leptin-induced vasodilation. These results suggest that leptin relaxes the rabbit aorta. The relaxation is mediated by endothelium-derived nitric oxide and hydrogen peroxide.

journal_name

Fundam Clin Pharmacol

authors

Sahin AS,Bariskaner H

doi

10.1111/j.1472-8206.2007.00541.x

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

595-600

issue

6

eissn

0767-3981

issn

1472-8206

pii

FCP541

journal_volume

21

pub_type

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