Abstract:
:The contractile activity of (-)-Bay k 8644 was assessed in rat isolated aortic ring preparations bathed in a potassium-free medium. (-)-Bay k 8644 (0.01-3 microM) caused extracellular calcium-dependent contractile responses, which were significantly greater in tissues with, than deprived of a functional endothelium. In preparations with an endothelium, the contraction was attenuated by quinacrine (1 microM), indomethacin (10 microM) and diclofenac (0.1 microM), but not changed by nordihydroguaiaretic acid (30 microM) or dazoxiben (10 microM). Thus, in the rat aorta bathed in K(+)-free medium, (-)-Bay k 8644 can cause contractile effects, apparently due to the release of an endothelium-derived contractant factor (EDCF) which is proposed to be a cyclo-oxygenase product.
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Lawson K,Cavero Idoi
10.1111/j.1472-8206.1989.tb00469.xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
687-93issue
6eissn
0767-3981issn
1472-8206journal_volume
3pub_type
杂志文章abstract::Recent in vitro evidence suggests that T-type Ca(2+) channels are implicated in the mechanisms of ischemia-induced delayed neuronal cell death. The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca(2+) channel inhibitors, in an in vivo rat model of global ischemia. ...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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abstract::A combination of sub-effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test. ...
journal_title:Fundamental & clinical pharmacology
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