Abstract:
:Low temperatures may affect dose delivery efficacy and clinical effectiveness of medication aerosols. In this study we examine the effect of cold ambient temperature on the bronchodilatation produced by terbutaline delivered from a chlorofluorocarbon pressurized metered dose inhaler (pMDI) compared to a multi-dose dry powder inhaler (DPI). Fourteen stable asthmatics were studied on two consecutive days. On day 1, after measuring FEV1 at room temperature (22 degrees C), each patient was randomized to receive 500 microg of terbutaline delivered from pMDI or DPI stored for 24 h at 22 degrees C with FEV1 recorded 20 min post-dose; then, patients were placed in a chamber at -10 degrees C, and after obtaining FEV1, each patient received 500 microg of terbutaline delivered from pMDI or DPI (same formulation as previously administered) stored for 24 h at -10 degrees C, and FEV1 was obtained 20 min post-dose. On day 2, a similar protocol was followed but each patient received terbutaline as the alternative to the formulation administered on day 1. Pairwise comparisons of the FEV1 (% predicted) values obtained on day 1 and day 2 at 22 degrees C and -10 degrees C (pre-dose) showed no significant differences. Similar bronchodilatations were observed for terbutaline DPI administration at 22 degrees C and -10 degrees C (24.85 +/- 11.72 and 20.08 +/- 6.27% increase of FEV1; P > 0.05). By contrast, the bronchodilatation obtained for terbutaline pMDI at 22 degrees C (21.07 +/- 8.55% increase in FEV1) was not reproduced at -10 degrees C (0.72 +/- 2.84%; P < 0.05 from 22 degrees C). In five asthmatics a cumulative dose-response curve for terbutaline pMDI was obtained. This part of the study showed that a higher dose of terbutaline pMDI was necessary at -10 degrees C to obtain a bronchodilator response (10.04 +/- 6.75% increase of FEV1 after 2,000 microg) that remained lower than the bronchodilatation for 500 microg terbutaline pMDI at -10 degrees C. In conclusion, the clinical effectiveness of terbutaline delivered from chlorofluorocarbon pMDIs is compromised by cold storage while DPIs are not affected.
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Ramón M,Juan G,Ciscar MA,Martí-Bonmatí E,Morcillo EJ,Marín Jdoi
10.1111/j.1472-8206.2000.tb00401.xsubject
Has Abstractpub_date
2000-03-01 00:00:00pages
133-8issue
2eissn
0767-3981issn
1472-8206pii
S076739810000133Xjournal_volume
14pub_type
临床试验,杂志文章,随机对照试验abstract::The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章,评审
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abstract::The present study was designed to test whether tramadol is effective in the control of neuropathic pain in rats. Chronic constriction injury (CCI) of the sciatic nerve was induced over the left hind limb in male Sprague-Dawley rats. Identical surgery was performed on the opposite side except that the sciatic nerve was...
journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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abstract::Recent in vitro evidence suggests that T-type Ca(2+) channels are implicated in the mechanisms of ischemia-induced delayed neuronal cell death. The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca(2+) channel inhibitors, in an in vivo rat model of global ischemia. ...
journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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abstract::Incubation of striatal slices with sodium nitroprusside (SNP) or hydroxylamine (HA) for 60 min caused a dose-dependent increase in dopamine (DA) release. This effect was inhibited completely by tetrodotoxin (TTX) (1 microM) if low concentrations of SNP (1 microM) or HA (10 and 100 microM) were tested. Although-higher ...
journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
doi:10.1111/j.1472-8206.1997.tb00857.x
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abstract::Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...
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pub_type: 杂志文章,评审
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
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journal_title:Fundamental & clinical pharmacology
pub_type: 杂志文章
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