Abstract:
:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control and landiolol group. Induction of anesthesia commenced 10 min after the infusion of 0.9% saline or landiolol, using a Diprifusor set to achieve propofol plasma concentration of 6.0 microg/mL. Induction of anesthesia was defined as the first lack of response to command. Propofol dose was 2.22+/- 0.21 mg/kg for the control group and 1.79+/- 0.28 mg/kg for the landiolol group (P<0.0001). The quantity of propofol required for the induction of anesthesia was reduced by the administration of landiolol.
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto Fdoi
10.1111/j.1472-8206.2005.00351.xsubject
Has Abstractpub_date
2005-10-01 00:00:00pages
597-9issue
5eissn
0767-3981issn
1472-8206pii
FCP351journal_volume
19pub_type
杂志文章,随机对照试验abstract::The aim of this analysis was to compare vasoreactive properties of internal thoracic arteries (ITA) grafts from diabetic (DM) to those of non-diabetic (ND) patients. Ring segments of ITA, taken from patients undergoing coronary artery bypass grafting, were suspended in organ bath chambers filled with modified Krebs-He...
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journal_title:Fundamental & clinical pharmacology
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