Inhibitory effects of tacrine and physostigmine on catecholamine secretion and membrane currents in guinea-pig adrenal chromaffin cells.

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:The insulin secreting B cell is fitted with the two types of purinergic receptors: P2 (for ATP and/or ADP) and P1 (for adenosine). The activation of P2 purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose-dependent between 10(-6) a...

journal_title：Fundamental & clinical pharmacology

authors： Hillaire-Buys D,Chapal J,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1994-01-01 00:00:00

abstract：:This study investigated whether simvastatin has antihypertensive activity and can enhance the antihypertensive effect of losartan in hypertensive hypercholesterolemic animals and patients. Hypertension and hypercholesterolemia were induced in rats by L-NAME and cholesterol-enriched diet, respectively. In these animals...

journal_title：Fundamental & clinical pharmacology

authors： Abdel-Zaher AO,Elkoussi AE,Abudahab LH,Elbakry MH,Elsayed EA

更新日期：2014-06-01 00:00:00

abstract：:The action of ouabain, a cell membrane Na+, K+-ATPase blocker, on contractions induced by manganese ions (Mn2+) in Ca2+-free, isotonic solutions with varying concentrations of K+ in the external medium were investigated in order to evaluate the underlying role of external Na+ in Mn2+-induced contractions in isolated t...

journal_title：Fundamental & clinical pharmacology

authors： Nasu T,Takahashi K

更新日期：2005-06-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (...

journal_title：Fundamental & clinical pharmacology

authors： Bantsiele GB,Bentué-Ferrer D,Amiot N,Allain H,Bourin M,Reymann JM

更新日期：2004-12-01 00:00:00

abstract：:We investigated the implication of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in the proliferation stimulated by angiotensin II (Ang II) and endothelin-1 (ET-1) in cultured rabbit gingival fibroblasts (CRGF). Ang II stimulated activation of ERK1/2 and the activation was inhibited by CV-11974, an A...

journal_title：Fundamental & clinical pharmacology

authors： Ohsawa M,Ohuchi N,Taniguchi Y,Kizawa Y,Koike K,Iwamoto K,Hayashi K,Murakami H

更新日期：2005-12-01 00:00:00

abstract：:Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert's syndrome with severe hyperbilirubinaemias and jaundice. We analysed the reactivities of some hydroxyquinoline derivatives, which are naturally...

journal_title：Fundamental & clinical pharmacology

authors： Kanou M,Saeki K,Kato TA,Takahashi K,Mizutani T

更新日期：2002-12-01 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00

abstract：:Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. I...

journal_title：Fundamental & clinical pharmacology

authors： Raghunathan S,Reynolds CL,Schwartz RJ,Stewart MD,McConnell BK

更新日期：2019-02-01 00:00:00

abstract：:The phylogenetically old renin-angiotensin-system (RAS) was originally described as a circulating hormonal system and a main cardiovascular regulator. However, there also exist 'local RASs' which are situated in cardiovascular as well as non-cardiovascular tissues where they are involved in physiological and patho-phy...

journal_title：Fundamental & clinical pharmacology

authors： Steckelings UM,Rompe F,Kaschina E,Unger T

更新日期：2009-12-01 00:00:00

abstract：:The effect known as the GTP-shift refers to the complete conversion of receptors from the high- to the low agonist-affinity state in the presence of an excess of GTP or one of its analogs. 5'-Guanylylimidodiphosphate (GppNHp) was able to fully suppress the high (-)-isoproterenol-affinity of beta-adrenoceptors (beta AR...

journal_title：Fundamental & clinical pharmacology

authors： Garnier V,Zini R,Tillement JP

更新日期：1999-01-01 00:00:00

abstract：:The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...

journal_title：Fundamental & clinical pharmacology

authors： Redrobe JP,Bourin M

更新日期：1997-01-01 00:00:00

abstract：:Alizapride is a new antidopaminergic-related benzamide with specific antiemetic properties. Pharmacokinetics at a high repetitive dose (16 mg/kg) shows a biexponential plasma decay with T1/2 alpha of 8.33 +/- 2.47 min and T1/2 beta 2.8 +/- 0.7 hr. Large Vdss and high total body clearance are apparent. We demonstrate a...

journal_title：Fundamental & clinical pharmacology

authors： Canal P,Roche H,Pasquier M,Bugat R,Berg D,Soula G,Carton M

更新日期：1987-01-01 00:00:00

abstract：:The effects of the dopamine receptor agonist, apomorphine, on the total catecholamine content of the adrenal medulla were studied in normotensive rats. Apomorphine (3, 15, 30 mg/kg SC) induced a dose-dependent decrease in catecholamine content of the adrenal gland. The action of apomorphine was suppressed by previous ...

journal_title：Fundamental & clinical pharmacology

authors： Montastruc JL,Gaillard G,Rascol O,Tran MA,Montastruc P

更新日期：1989-01-01 00:00:00

abstract：:Abstract The relationship between depression and dopamine deficiency in the mesolimbic pathway has been hypothesized for many years. The experimental studies with animal models of depression and the human studies implicate the role of the dopamine system in depression. Not only do dopaminergic receptor agonists, but a...

journal_title：Fundamental & clinical pharmacology

authors： Dailly E,Chenu F,Renard CE,Bourin M

更新日期：2004-12-01 00:00:00

abstract：:The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...

journal_title：Fundamental & clinical pharmacology

authors： Ergün Y,Darendeli S,Imrek S,Kilinç M,Oksüz H

更新日期：2010-04-01 00:00:00

abstract：:It was reported that the pharmacokinetics of propofol was influenced by cardiac output (CO). The purpose of this study was to evaluate the effect of landiolol (short-acting beta-1-adrenergic blocker) on the dose requirement of propofol for induction of anesthesia. Forty patients were randomly allocated to the control ...

journal_title：Fundamental & clinical pharmacology

authors： Takizawa D,Saito S,Sato E,Hiraoka H,Kunimoto F,Goto F

更新日期：2005-10-01 00:00:00

abstract：:This systematic review analyses the efficacy, tolerability and safety of combinations of different medicines used to treat dyslipidemias in clinical practice. A PubMed search up to January 2009, was conducted to identify relevant studies. Criteria used to identify studies included (1) English language, (2) published s...

journal_title：Fundamental & clinical pharmacology

authors： Reiner Z

更新日期：2010-02-01 00:00:00

abstract：:Restenosis after coronary angioplasty, the main limitation of interventional cardiology, remains an unsolved issue. The failure to-date of all pharmacological attempts at prevention has prompted the development of alternative strategies. A mechanistic approach to the problem of restenosis is based on the assumption th...

journal_title：Fundamental & clinical pharmacology

authors： Feldman LJ,Riessen R,Steg PG

更新日期：1995-01-01 00:00:00

abstract：:The prevalence of end stage renal disease (ESRD) is growing in western countries. Patients with ESRD are more frequently elderly and diabetic and are exposed to very high cardiovascular morbidity and mortality. The main aim of the FOSIDIAL study is to assess the efficacy and safety of fosinopril, an angiotensin conver...

journal_title：Fundamental & clinical pharmacology

authors： Zannad F,Kessler M,Grünfeld JP,Thuilliez C,FOSInopril in DIALysis Investigators.

更新日期：2002-10-01 00:00:00

abstract：:Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of elevated plus maze (EPM), open field, Rotarod and barbitu...

journal_title：Fundamental & clinical pharmacology

authors： Melo FH,Venâncio ET,de Sousa DP,de França Fonteles MM,de Vasconcelos SM,Viana GS,de Sousa FC

更新日期：2010-08-01 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:We estimated the effect of pentoxifylline (PTX) on the respiratory burst (examined by chemiluminescence method) of unprimed and primed neutrophils with tumor necrosis factor-alpha (TNF-alpha) in patients with stable angina pectoris. Chemiluminescence of non-stimulated as well as formyl-methionyl-leucyl-phenylalanine (...

journal_title：Fundamental & clinical pharmacology

authors： Kowalski J,Kosmider M,Pasnik J,Zeman K,Baj Z,Janiszewska-Drobinska B,Czekalska R

更新日期：1999-01-01 00:00:00

abstract：:Stepwise multiple regression analyses were applied to 44 atazanavir pharmacokinetic profiles from 44 HIV-1 infected patients concomitantly treated with raltegravir with the goal of identifying limited sampling strategies for the prediction of drug AUC(0-12) . Atazanavir trough-based equations failed to reliably predic...

journal_title：Fundamental & clinical pharmacology

authors： Cattaneo D,Ripamonti D,Baldelli S,Cozzi V,Fucile S,Clementi E

更新日期：2013-04-01 00:00:00

abstract：:This paper reviews state-of-art statistical designs for dose-escalation procedures in first-into-man studies. The main focus will be on studies in oncology, as most statistical procedures for phase I trials have been proposed in this context. Extensions to situations such as the observation of bivariate outcomes and h...

journal_title：Fundamental & clinical pharmacology

authors： Zhou Y

更新日期：2004-06-01 00:00:00

abstract：:Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...

journal_title：Fundamental & clinical pharmacology

authors： Gilchrist SE,Alcorn J

更新日期：2010-04-01 00:00:00

abstract：:Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric v...

journal_title：Fundamental & clinical pharmacology

authors： Sen T,Abdulsalam CA,Pal S,Sen S,Karmakar S,Saravanan KS,Chaudhuri AK

更新日期：2002-08-01 00:00:00

abstract：:In the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10(-12)-10(-9) m) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10(-6) m). Removal of endothelium abolished the effects of leptin. Pre...

journal_title：Fundamental & clinical pharmacology

authors： Sahin AS,Bariskaner H

更新日期：2007-12-01 00:00:00

abstract：:Two 5HT(1A) receptor agonists and chlordiazepoxide were examined in open-field, elevated plus maze, and emergence tests. At doses with no effect in the open-field, chlordiazepoxide increased open and open/total arm visits as well as open arm duration in the elevated plus maze, whereas 5HT(1A) receptor agonists showed ...

journal_title：Fundamental & clinical pharmacology

authors： Lalonde R,Strazielle C

更新日期：2010-06-01 00:00:00