Inhibitory effects of tacrine and physostigmine on catecholamine secretion and membrane currents in guinea-pig adrenal chromaffin cells.

abstract：:Low temperatures may affect dose delivery efficacy and clinical effectiveness of medication aerosols. In this study we examine the effect of cold ambient temperature on the bronchodilatation produced by terbutaline delivered from a chlorofluorocarbon pressurized metered dose inhaler (pMDI) compared to a multi-dose dry...

journal_title：Fundamental & clinical pharmacology

authors： Ramón M,Juan G,Ciscar MA,Martí-Bonmatí E,Morcillo EJ,Marín J

更新日期：2000-03-01 00:00:00

abstract：:In addition to their direct effects on cardiac contractility, a number of positive inotropic agents also induce, through direct peripheral vasodilation, a reduction in afterload which is of major importance in their beneficial effects in the treatment of congestive heart failure. However, the induced increase in cardi...

journal_title：Fundamental & clinical pharmacology

authors： Gosgnach M,Gérard JL,Berdeaux A,Giudicelli JF

更新日期：1991-01-01 00:00:00

abstract：:Heart transplant is considered to be an extremely severe ischemia-reperfusion sequence. Post-ischemic dysfunction triggers multiple processes especially oxidative stress, but the mechanisms remain unclear. Free radical interactions lead to peroxynitrite generation, which seems to be involved in early post-transplant h...

journal_title：Fundamental & clinical pharmacology

authors： Lauzier B,Sicard P,Bouchot O,Delemasure S,Moreau D,Vergely C,Rochette L

更新日期：2007-04-01 00:00:00

abstract：:Occlusion of the artery of organs results in ischaemia. The opening of occluded artery results in tissue lesion identified as reperfusion injury (RI). Renin-angiotensin system seems to be involved in the RI. In this study we assessed the effects of different doses of two inhibitors of angiotensin converting enzyme (ca...

journal_title：Fundamental & clinical pharmacology

authors： Pazoki-Toroudi HR,Hesami A,Vahidi S,Sahebjam F,Seifi B,Djahanguiri B

更新日期：2003-10-01 00:00:00

abstract：:Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after...

journal_title：Fundamental & clinical pharmacology

authors： Zyoud SH,Awang R,Sulaiman SA,Al-Jabi SW

更新日期：2011-06-01 00:00:00

abstract：:In the present study, we analysed the effects of leptin on rabbit aorta and the mechanisms underlying these effects. Leptin (10(-12)-10(-9) m) induced concentration-dependent relaxation in intact rabbit aorta rings precontracted with phenylephrine (10(-6) m). Removal of endothelium abolished the effects of leptin. Pre...

journal_title：Fundamental & clinical pharmacology

authors： Sahin AS,Bariskaner H

更新日期：2007-12-01 00:00:00

abstract：:A survey was run on a sample of 134 French GPs from the Rhône-Alpes region, in an attempt to investigate the way they recollect important clinical trials that should have an impact on their practice. It was found that 1) most of them did not remember these trials (however, the awareness score did vary throughout the t...

journal_title：Fundamental & clinical pharmacology

authors： Reveilleau S,Boissel JP,Alamercery Y

更新日期：1991-01-01 00:00:00

abstract：:A meta-analysis was performed on the results of clinical trials of buflomedil in intermittent claudication. The analysis used results from 744 patients enrolled in ten studies, conducted at 42 centers in seven countries. All studies were randomized, double-blind, placebo-controlled trials which measured improvement in...

journal_title：Fundamental & clinical pharmacology

authors： Walker GA,Mac Hannaford JC

更新日期：1995-01-01 00:00:00

abstract：:The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

journal_title：Fundamental & clinical pharmacology

authors： Hellmich B,Gyermek L

更新日期：1997-01-01 00:00:00

abstract：:France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10-year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives...

journal_title：Fundamental & clinical pharmacology

authors： Caré W,Langrand J,Vodovar D,Deveaux M,Alvarez JC,Mégarbane B,Dorandeu F

更新日期：2020-08-01 00:00:00

abstract：:During the phase I trials, from the juridical point of view, the responsibilities are shared between the pharmaceutical company and the physician who manages the trial. The pharmaceutical company is responsible for the product, the choice of methodology and respect for the regulations. On the financial side, the compa...

journal_title：Fundamental & clinical pharmacology

authors： Rouzioux JM

更新日期：1990-01-01 00:00:00

abstract：:This systematic review analyses the efficacy, tolerability and safety of combinations of different medicines used to treat dyslipidemias in clinical practice. A PubMed search up to January 2009, was conducted to identify relevant studies. Criteria used to identify studies included (1) English language, (2) published s...

journal_title：Fundamental & clinical pharmacology

authors： Reiner Z

更新日期：2010-02-01 00:00:00

abstract：:Considering the diseases of the stomach and duodenum, peptic ulcer has been the one with a significant clinical impact. The pathophysiology of peptic ulcer has centred on an imbalance between aggressive and protective factors. The discovery of Helicobacter pylori as a cause of peptic ulcer has changed our approach gre...

journal_title：Fundamental & clinical pharmacology

authors： Sivri B

更新日期：2004-02-01 00:00:00

abstract：:The phylogenetically old renin-angiotensin-system (RAS) was originally described as a circulating hormonal system and a main cardiovascular regulator. However, there also exist 'local RASs' which are situated in cardiovascular as well as non-cardiovascular tissues where they are involved in physiological and patho-phy...

journal_title：Fundamental & clinical pharmacology

authors： Steckelings UM,Rompe F,Kaschina E,Unger T

更新日期：2009-12-01 00:00:00

abstract：:Vanadium pharmacokinetic parameters and oral bioavailability were determined after administration of vanadyl sulfate, an antidiabetic agent, to male Wistar rats. An optimal sampling design was used over a 21-day period; vanadium was measured in blood by atomic absorption spectrophotometry (AAS). After i.v. bolus injec...

journal_title：Fundamental & clinical pharmacology

authors： Azay J,Brès J,Krosniak M,Teissedre PL,Cabanis JC,Serrano JJ,Cros G

更新日期：2001-10-01 00:00:00

abstract：:Torsades de pointes is the most typical ventricular tachycardia involving QT-interval prolongation. It is a rather unusual but potentially lethal ventricular tachycardia with a distinctive morphology favored by bradycardia, antiarrhythmic drugs and hypokalemia and requires specific treatment. Torsades de pointes has b...

journal_title：Fundamental & clinical pharmacology

authors： Weissenburger J,Davy JM,Chézalviel F

更新日期：1993-01-01 00:00:00

abstract：:The effects of sub-chronic cold stress on the functioning of hippocampal 5-HT1A receptors in old isolated rats and the possible protective effects of Ginkgo biloba extract (EGb 761) were investigated. Cold exposure during five days, produced a significant reduction of the inhibitory effect of 8-hydroxy-2-(di-n-propyla...

journal_title：Fundamental & clinical pharmacology

authors： Bolaños-Jiménez F,Manhães de Castro R,Sarhan H,Prudhomme N,Drieu K,Fillion G

更新日期：1995-01-01 00:00:00

abstract：:Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

journal_title：Fundamental & clinical pharmacology

authors： Reid IA,Chiu YJ

更新日期：1995-01-01 00:00:00

abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

journal_title：Fundamental & clinical pharmacology

authors：

更新日期：1997-01-01 00:00:00

abstract：:We examined the effects of the benzoylguanidine derivative HOE 694, an inhibitor of Na(+)-H+ exchange, against veratrine-induced diastolic contractures and action potentials recorded in rat isolated left atria. Concentration-dependent protective effects against veratrine-contractures, in the absence of negative inotro...

journal_title：Fundamental & clinical pharmacology

authors： Le Grand B,Marty A,Talmant JM,John GW

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of intracoronary bradykinin (BK) infusion on noradrenaline release and ventricular arrhythmias induced by coronary occlusion and reperfusion in the anesthetized dog. METHODS:14 anesthetized adult mongrel dogs of either sex underwent a 60 min occlusion of t...

journal_title：Fundamental & clinical pharmacology

authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Adam A,Nadeau R

更新日期：1994-01-01 00:00:00

abstract：:In epileptic patients cyproheptadine is frequently prescribed as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of 'serotonin syndrome' in depressed epileptic patients. However, the study of serotonergic and histaminergic pathway shows that the decreased...

journal_title：Fundamental & clinical pharmacology

authors： Singh D,Goel RK

更新日期：2010-08-01 00:00:00

abstract：:Adrenoceptors are involved in the control of the activity of the autonomic nervous system and especially the sympathetic nervous system. Activation of alpha 2-adrenoceptors decreases sympathetic tone whereas their blockade has an opposite effect. However, previous investigations have shown that yohimbine (a potent alp...

journal_title：Fundamental & clinical pharmacology

authors： Bagheri H,Chale JJ,Guyen LN,Tran MA,Berlan M,Montastruc JL

更新日期：1995-01-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:Since patients may report spontaneously adverse events associated with their medications, such notifications are constantly on the rise. In 2017, an unexpected rise of notifications associated with the marketing of a new formula of Levothyrox, differing from the 30-year-old drug only by minor elements, occurred in Fra...

journal_title：Fundamental & clinical pharmacology

authors： Viard D,Parassol-Girard N,Romani S,Van Obberghen E,Rocher F,Berriri S,Drici MD

更新日期：2019-08-01 00:00:00

abstract：:The impact of an acute coronary syndrome (ACS) event, such as an acute myocardial infarction (MI), is not limited to the acute management phase; patients face an elevated risk of residual atherothrombotic events that commonly requires chronic management for months or even years. Significant advances have been made in ...

journal_title：Fundamental & clinical pharmacology

authors： Atar D,Bode C,Stuerzenbecher A,Verheugt FW

更新日期：2014-08-01 00:00:00

abstract：:The purpose of this study was to assess in rats the pharmacological parameters and effects on gene expression in the liver of the triterpene glycoside actein. Actein, an active component from the herb black cohosh, has been shown to inhibit the proliferation of human breast cancer cells. To conduct our assessment, we ...

journal_title：Fundamental & clinical pharmacology

authors： Einbond LS,Soffritti M,Esposti DD,Park T,Cruz E,Su T,Wu HA,Wang X,Zhang YJ,Ham J,Goldberg IJ,Kronenberg F,Vladimirova A

更新日期：2009-06-01 00:00:00

abstract：:A combination of sub-effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test. ...

journal_title：Fundamental & clinical pharmacology

authors： Vohora D,Pal SN,Pillai KK

更新日期：2005-10-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of Na+ , K+ -ATPase (NKA) involved in low concentration of ouabain (Oua, activating NKA)-induced protection of rat cerebral ischemia-reperfusion injury. The 2,3,5-triphenyltetrazolium chloride staining and neurological deficit scores were performed to evaluate rat...

journal_title：Fundamental & clinical pharmacology

authors： Li LL,Ke XY,Jiang C,Qin SQ,Liu YY,Xian XH,Liu LZ,He JC,Chen YM,An HF,Sun N,Hu YH,Wang Y,Zhang LN,Lu QY

更新日期：2021-01-22 00:00:00

abstract：:Stepwise multiple regression analyses were applied to 44 atazanavir pharmacokinetic profiles from 44 HIV-1 infected patients concomitantly treated with raltegravir with the goal of identifying limited sampling strategies for the prediction of drug AUC(0-12) . Atazanavir trough-based equations failed to reliably predic...

journal_title：Fundamental & clinical pharmacology

authors： Cattaneo D,Ripamonti D,Baldelli S,Cozzi V,Fucile S,Clementi E

更新日期：2013-04-01 00:00:00