Trends in severe opioid-related poisonings and fatalities reported to the Paris poison control center - a 10-year retrospective observational study.

Abstract:

:France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10-year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives were to assess the evolution of the number of these cases and their severity defined by the use of fentanyl and its derivatives, the use of the opioid-poisoning treatment naloxone, and the number of fatalities. During 2008-2017, 268 511 cases were recorded, including 1 122 cases of opioid-related poisoning that required medical management. These poisonings involved tramadol (43%), codeine (25%), dextropropoxyphene (13%), and morphine (8%); most resulted from self-exposure (60%). During the 10-year study period, 130 opioid-related fatalities were recorded in the Paris area, mainly resulting from suicides (39%) in men and were attributed to morphine (27%), tramadol (24%), and methadone (21%). We did not identify an increase in the number of severe opioid-related poisonings or fatalities or in the use of fentanyl or its derivatives. Conversely, we observed an increase in the use of naloxone, suggesting an increase in the severity of opioid poisonings. Our findings show that, until 2017, the opioid overdose epidemiology in the Paris area is different to that in the USA. The systematic analysis of data from the PCCs could be a good tool for health monitoring. To assess trends in France, a national study over a longer period would also be useful.

journal_name

Fundam Clin Pharmacol

authors

Caré W,Langrand J,Vodovar D,Deveaux M,Alvarez JC,Mégarbane B,Dorandeu F

doi

10.1111/fcp.12534

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

495-503

issue

4

eissn

0767-3981

issn

1472-8206

journal_volume

34

pub_type

杂志文章
  • Do prescribers know the results of key clinical trials? GEP (Groupe d'étude de la Prescription).

    abstract::A survey was run on a sample of 134 French GPs from the Rhône-Alpes region, in an attempt to investigate the way they recollect important clinical trials that should have an impact on their practice. It was found that 1) most of them did not remember these trials (however, the awareness score did vary throughout the t...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1991.tb00721.x

    authors: Reveilleau S,Boissel JP,Alamercery Y

    更新日期:1991-01-01 00:00:00

  • (-)-Bay K 8644 liberates a contractant factor from the endothelium of the rat aorta.

    abstract::The contractile activity of (-)-Bay k 8644 was assessed in rat isolated aortic ring preparations bathed in a potassium-free medium. (-)-Bay k 8644 (0.01-3 microM) caused extracellular calcium-dependent contractile responses, which were significantly greater in tissues with, than deprived of a functional endothelium. I...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1989.tb00469.x

    authors: Lawson K,Cavero I

    更新日期:1989-01-01 00:00:00

  • Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes.

    abstract::Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert's syndrome with severe hyperbilirubinaemias and jaundice. We analysed the reactivities of some hydroxyquinoline derivatives, which are naturally...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2002.00097.x

    authors: Kanou M,Saeki K,Kato TA,Takahashi K,Mizutani T

    更新日期:2002-12-01 00:00:00

  • Experimental and clinical methods in the development of anti-Alzheimer drugs.

    abstract::Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.1998.tb00919.x

    authors: Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

    更新日期:1998-01-01 00:00:00

  • Clinical pharmacology of single- and multiple-ascending doses of ACT-178882, a new direct renin inhibitor, and its pharmacokinetic interaction with food and midazolam.

    abstract::This study investigated the tolerability, safety, pharmacokinetics, and pharmacodynamics of ACT-178882, a new direct renin inhibitor, as well as its interaction with food and midazolam. Healthy male subjects received either single (10-1000 mg) or multiple doses (30-600 mg) administered once daily for 14 days of ACT-17...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1472-8206.2012.01060.x

    authors: Dingemanse J,Nicolas L,Binkert C

    更新日期:2013-12-01 00:00:00

  • Dapsone-induced agranulocytosis-possible involvement of low-activity N-acetyltransferase 2.

    abstract::Dapsone-induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45-year-old male Caucasian patient developed agranulocytosis caused by dapsone (diamino-diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, ant...

    journal_title:Fundamental & clinical pharmacology

    pub_type:

    doi:10.1111/fcp.12287

    authors: Potočnjak I,Likić R,Šimić I,Juričić Nahal D,Čegec I,Ganoci L,Božina N

    更新日期:2017-10-01 00:00:00

  • A nonpeptide vasopressin V(1a) receptor antagonist, SR 49059, does not prevent cisplatin-induced emesis in piglets.

    abstract::We determined the pharmacological and the antiemetic properties of SR 49059, a selective nonpeptide V(1a) receptor antagonist, on cisplatin-induced emesis in the piglet. Firstly, we clearly demonstrate that SR 49059 is a potent V(1a) receptor antagonist in vitro and in vivo in the piglet. In binding studies, [3H]-SR 4...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2001.00027.x

    authors: Grélot L,Girod V,Dapzol J,Maffrand JP,Serradeil-Le Gal C

    更新日期:2001-06-01 00:00:00

  • Rabbit articular chondrocytes: an in vitro model for studying the effect of sodium aurothiopropanol sulfonate on proliferation kinetics, type II collagen phenotype and mitochondrial activity.

    abstract::Despite the benefits of chrysotherapy the responsible mechanism of action of gold compounds remains unclear. At a concentration of 5 x 10(-4) M, sodium aurothiopropanol sulfonate (SAS) modified the in vitro proliferation kinetics of articular chondrocytes by reducing growth, viability and plating efficiency. Flow cyto...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1988.tb00621.x

    authors: Ronot X,Hainque B,Christen MO,Froger B,Hartmann DJ,Adolphe M,Lechat P

    更新日期:1988-01-01 00:00:00

  • Experimental models of torsades de pointes.

    abstract::Torsades de pointes is the most typical ventricular tachycardia involving QT-interval prolongation. It is a rather unusual but potentially lethal ventricular tachycardia with a distinctive morphology favored by bradycardia, antiarrhythmic drugs and hypokalemia and requires specific treatment. Torsades de pointes has b...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.1993.tb00215.x

    authors: Weissenburger J,Davy JM,Chézalviel F

    更新日期:1993-01-01 00:00:00

  • Pharmacokinetic-pharmacodynamic modeling of the inhibitory effect of erythromycin on tumour necrosis factor-alpha and interleukin-6 production.

    abstract::Erythromycin inhibits the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL6) induced by heat-killed Streptococcus pneumoniae in human whole blood ex-vivo. The objective of the present study was to determine and characterize the concentration-effect relationship of this phenomenon in order t...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2001.00054.x

    authors: Guchelaar HJ,Schultz MJ,van der Poll T,Koopmans RP

    更新日期:2001-12-01 00:00:00

  • Drug interactions between antihypertensive drugs and non-steroidal anti-inflammatory agents: a descriptive study using the French Pharmacovigilance database.

    abstract::Drug-drug interactions (DDIs) between antihypertensive drugs and non-steroidal anti-inflammatory drugs (NSAIDs) can lead to adverse drug reactions (ADRs). Guidelines are available to help prescribers deal with these drug associations, but their implementation is not well evaluated. The aims of this study were to asses...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12014

    authors: Fournier JP,Sommet A,Durrieu G,Poutrain JC,Lapeyre-Mestre M,Montastruc JL,French Network of Regional Pharmacovigilance Centres.

    更新日期:2014-04-01 00:00:00

  • Cardioprotective effect of hemin in isoprenaline-induced myocardial infarction: role of ATP-sensitive potassium channel and endothelial nitric oxide synthase.

    abstract::Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti-inflammatory agents with cardioprotective effects is an urgent task. We aimed to eva...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12529

    authors: Refaie MMM,Rifaai RA,Bayoumi AMA,Shehata S

    更新日期:2020-06-01 00:00:00

  • Nitric oxide: an ubiquitous messenger.

    abstract::During the last decade, a multitude of experimental arguments have led to the concept that EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone but also in vascular homeostasis, neuronal and immunological functions. Regardless of its origin, endogenous NO is produced through the co...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.1993.tb01037.x

    authors: Berdeaux A

    更新日期:1993-01-01 00:00:00

  • A peroxynitrite decomposition catalyst: FeTPPS confers cardioprotection during reperfusion after cardioplegic arrest in a working isolated rat heart model.

    abstract::Heart transplant is considered to be an extremely severe ischemia-reperfusion sequence. Post-ischemic dysfunction triggers multiple processes especially oxidative stress, but the mechanisms remain unclear. Free radical interactions lead to peroxynitrite generation, which seems to be involved in early post-transplant h...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2007.00467.x

    authors: Lauzier B,Sicard P,Bouchot O,Delemasure S,Moreau D,Vergely C,Rochette L

    更新日期:2007-04-01 00:00:00

  • Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblastsdagger.

    abstract::We investigated the implication of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in the proliferation stimulated by angiotensin II (Ang II) and endothelin-1 (ET-1) in cultured rabbit gingival fibroblasts (CRGF). Ang II stimulated activation of ERK1/2 and the activation was inhibited by CV-11974, an A...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2005.00372.x

    authors: Ohsawa M,Ohuchi N,Taniguchi Y,Kizawa Y,Koike K,Iwamoto K,Hayashi K,Murakami H

    更新日期:2005-12-01 00:00:00

  • Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs.

    abstract::Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic cough and airway hyperresponsiveness. The aim of this work was to assess in pigs the effects of bradykinin and tac...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2001.00008.x

    authors: Moreaux B,Advenier C,Gustin P

    更新日期:2001-02-01 00:00:00

  • Controlled ingestion of kaolinite (5%) modulates enteric nitrergic innervation in rats.

    abstract::We have previously shown that kaolinite slowed down gastric emptying and intestinal transit and induced changes in enteric mechanical activities. As gastric emptying and intestinal transit have been shown to be regulated by nitric oxide (NO), the effect of an imposed ingestion of kaolinite on enteric nitrergic innerva...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12040

    authors: Voinot F,Fischer C,Schmidt C,Ehret-Sabatier L,Angel F

    更新日期:2014-08-01 00:00:00

  • KATP channels modulate GABA release in hippocampal slices in the absence of glucose.

    abstract::We studied the effects of KATP channel blockers on [3H]GABA release in the absence of glucose in rat hippocampal slices. The omission of glucose induced a marked increase in the efflux of [3H]GABA, which was antagonized by TTX (1 microM), but not by MK 801 (1 microM) or DNQX (100 microM). Glibenclamide (10-100 microM)...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1992.tb00123.x

    authors: Margaill I,Miquet JM,Doble A,Blanchard JC,Boireau A

    更新日期:1992-01-01 00:00:00

  • Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo.

    abstract::The aims of this study were: (i) To investigate the activity of recombinant AMPs HNP-1 and hBD-1 in combination with cefotaxime against Staphylococcus aureus strains (MSSA and MRSA) in vitro using checkerboard method; (ii) To investigate the activity of HNP-1 and hBD-1 encapsulated in silicon nanoparticles (niosomes) ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12499

    authors: Bolatchiev A,Baturin V,Bazikov I,Maltsev A,Kunitsina E

    更新日期:2020-02-01 00:00:00

  • Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats.

    abstract::Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2008.00609.x

    authors: Pari L,Sivasankari R

    更新日期:2008-08-01 00:00:00

  • The possible role of CREB-BDNF signaling pathway in neuroprotective effects of minocycline against alcohol-induced neurodegeneration: molecular and behavioral evidences.

    abstract::Abuse of alcohol triggers neurodegeneration in human brain. Minocycline has characteristics conferring neuroprotection. Current study evaluates the role of the CREB-BDNF signaling pathway in mediating minocycline's neuroprotective effects against alcohol-induced neurodegeneration. Seventy adult male rats were randomly...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12584

    authors: Motaghinejad M,Mashayekh R,Motevalian M,Safari S

    更新日期:2020-06-24 00:00:00

  • Interaction of chelerythrine with inositol phosphate metabolism.

    abstract::Chelerythrine, a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on inositol phosphate (IP) metabolism in newborn rat cardiomyocytes in culture. In a first step, we evaluated the effect of chelerythrine on IP accumulation in basal conditions. For a 10(-4) M dose, 5-phosphatase activity (which ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2002.00069.x

    authors: Le Corvoisier P,Lacotte J,Laplace M,Crozatier B

    更新日期:2002-02-01 00:00:00

  • Cholinesterase activity in pig airways and epithelial cells.

    abstract::Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) activities were detected in bronchial and bronchial epithelial cell homogenates of the pig. In the bronchial homogenates, the maximal upstroke velocity (Vmax) of AChE and the maximal velocity after second substrate fixation (Vss) of B...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1997.tb00186.x

    authors: Taisne C,Norel X,Walch L,Labat C,Verriest C,Mazmanian GM,Brink C

    更新日期:1997-01-01 00:00:00

  • Drug reimbursement and GPs' prescribing decisions: a randomized case-vignette study about the pharmacotherapy of obesity associated with type 2 diabetes: how GPs react to drug reimbursement.

    abstract::This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1472-8206.2009.00779.x

    authors: Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

    更新日期:2010-08-01 00:00:00

  • Medicinal plants and the treatment of diabetes in Senegal: survey with patients.

    abstract::Diabetes is the most common metabolic disorder worldwide and is a major public health problem. Its frequency increases every day in all countries. However, in developing African countries, few people have access to drugs. In addition, in Africa, traditional beliefs induce people to use medicinal plants whenever they h...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.2007.00563.x

    authors: Dièye AM,Sarr A,Diop SN,Ndiaye M,Sy GY,Diarra M,Rajraji Gaffary I,Ndiaye Sy A,Faye B

    更新日期:2008-04-01 00:00:00

  • Different vascular responsiveness to angiotensin II in two normotensive rat strains.

    abstract::Rats of the Fischer 344 (F344) and Wistar Kyoto (WKY) strains are known to present differences in stimuli responses involving the renin-angiotensin system and in cardiovascular responses to an acoustic startle stimulus. Here we compared the vascular reactivity to angiotensin II (ANG II) of these normotensive, inbred r...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1046/j.1472-8206.2003.00145.x

    authors: Herin L,Blanc J,Basset A,Laude D,Laurent S,Elghozi JL

    更新日期:2003-06-01 00:00:00

  • Blockade of angiogenin by thalidomide inhibits the tumorigenesis of murine hemangioendothelioma.

    abstract::Thalidomide, a well-known immunomodulatory compound, has an anti-angiogenic activity, which may be utilized for the treatment of angiogenesis-related diseases such as hemangioendothelioma. The aim of the present study was to investigate both the antitumor role of thalidomide on hemangioendothelioma and the underlying ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/fcp.12478

    authors: Guo L,Wan Z,Xu B,Ren L,Liu H,Song N,Liu L

    更新日期:2019-12-01 00:00:00

  • Similia similibus obscurantur: the pharmacological clinical activity bias I. A prototype model to correct a disease-drug interaction leading to misestimations of drug-attributable side effects.

    abstract::Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1995.tb00537.x

    authors: Bernheim JL,Vrana I

    更新日期:1995-01-01 00:00:00

  • Prostaglandin E synthase in the pathophysiology of arthritis.

    abstract::Prostaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES. Among them, m...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1472-8206.2005.00316.x

    authors: Kojima F,Kato S,Kawai S

    更新日期:2005-06-01 00:00:00

  • Effects of graded hemorrhage on short-term variability of blood pressure in conscious rats.

    abstract::A controlled graded bleeding was performed in conscious rats with 15 min intervals between two withdrawals, in order to induce a 25% blood loss without hypotension. Heart rate (HR) was unaffected as well. The spectral profiles of systolic blood pressure (SBP) analyzed on 51.2 s segments exhibited increases in the high...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1472-8206.1996.tb00608.x

    authors: Baujard C,Ponchon P,Elghozi JL

    更新日期:1996-01-01 00:00:00