Trolox-derivative antioxidant protects against methanol-induced damage.

abstract：:Gait disorders form one component of the axial disorders observed in Parkinson's disease (PD). Indeed, short steps with a forward-leaning stance are diagnostic criteria for PD in the early stages of the condition. Gait disorders also represent a major source of therapeutic failure in the advanced stages of PD (with th...

journal_title：Fundamental & clinical pharmacology

authors： Devos D,Defebvre L,Bordet R

更新日期：2010-08-01 00:00:00

abstract：:Using an isolated non-working rat heart model, this study investigated the mechanisms of pharmacological pre-conditioning (PC) induced by P2Y receptor stimulation with pyridoxal-5'-phosphate (PLP). After 6-hydroxydopamine pretreatment and a 15-min stabilization period, isolated rat hearts were perfused for 25 min then...

journal_title：Fundamental & clinical pharmacology

authors： Millart H,Alouane L,Oszust F,Chevallier S,Robinet A

更新日期：2009-06-01 00:00:00

abstract：:The aim of this review is to comment the results described in the literature concerning the possible pharmacodynamic mechanisms involved in the improvement of quality of life of angiotensin converting enzyme inhibitors that is just a working hypothesis. These drugs, widely used in the treatment of hypertension, preven...

journal_title：Fundamental & clinical pharmacology

authors： Govantes C,Marín J

更新日期：1996-01-01 00:00:00

abstract：:Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

journal_title：Fundamental & clinical pharmacology

authors： Pari L,Sivasankari R

更新日期：2008-08-01 00:00:00

abstract：:Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of elevated plus maze (EPM), open field, Rotarod and barbitu...

journal_title：Fundamental & clinical pharmacology

authors： Melo FH,Venâncio ET,de Sousa DP,de França Fonteles MM,de Vasconcelos SM,Viana GS,de Sousa FC

更新日期：2010-08-01 00:00:00

abstract：:Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-methyl-d-aspartate antagonists that are alternatives to be recommended in first-line NP treatment, memantine has...

journal_title：Fundamental & clinical pharmacology

authors： Pickering G,Morel V

更新日期：2018-02-01 00:00:00

abstract：:Viral infections remain a major cause of economic loss with an unmet need for novel therapeutic agents. Ivermectin is a putative antiviral compound; the proposed mechanism is the inhibition of nuclear translocation of viral proteins, facilitated by mammalian host importins, a necessary process for propagation of infec...

journal_title：Fundamental & clinical pharmacology

authors： Kinobe RT,Owens L

更新日期：2021-01-11 00:00:00

abstract：:Ponsinomycin is a new macrolide antibiotic. Its effect on DHE pharmacokinetics was investigated in this study. Twelve young healthy volunteers received a single 9 mg oral dose of DHE before and on the 8th day of treatment (800 mg twice daily) with ponsinomycin. DHE was assayed in plasma by RIA. Because of low plasma l...

journal_title：Fundamental & clinical pharmacology

authors： Couet W,Mathieu HP,Fourtillan JB

更新日期：1991-01-01 00:00:00

abstract：:Changes in neurobiological parameters were examined from early life (10 days post-natal) until late adulthood (8 months post-natal) in three successive generations of alcoholized rats. The mean daily consumption of alcohol by the 2nd and 3rd generation rats (7.40 +/- 0.22 and 7.70 +/- 0.20 g ethanol/kg body weight, re...

journal_title：Fundamental & clinical pharmacology

authors： Nevo I,Parvez S

更新日期：1994-01-01 00:00:00

abstract：:The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsi...

journal_title：Fundamental & clinical pharmacology

authors： Meyer UA

更新日期：1990-01-01 00:00:00

abstract：:We reported that coronary spasm was induced in the transgenic mice with the increased phospholipase C (PLC)-δ1 activity. We investigated the effect of enhanced PLC-δ1 on Ca2+ influx and its underlying mechanisms. We used human embryonic kidney (HEK)-293 and coronary arteries smooth muscle cells (CASMC). Intracellular ...

journal_title：Fundamental & clinical pharmacology

authors： Murakami K,Osanai T,Tanaka M,Nishizaki K,Kinjo T,Tanno T,Ishida Y,Suzuki A,Endo T,Tomita H,Okumura K

更新日期：2017-08-01 00:00:00

abstract：:Angiotensin II AT1 receptor blockade (AT1-) has been shown to prolong survival in post-myocardial infarction (MI) heart failure in rats. In this study, we investigated whether an early AT1-induced improvement in coronary vasodilatation reserve (CVR) might be involved in this beneficial effect. Wistar rats with MI were...

journal_title：Fundamental & clinical pharmacology

authors： Gervais M,Richer C,Fornes P,De Gasparo M,Giudicelli JF

更新日期：1999-01-01 00:00:00

abstract：:Restenosis after coronary angioplasty, the main limitation of interventional cardiology, remains an unsolved issue. The failure to-date of all pharmacological attempts at prevention has prompted the development of alternative strategies. A mechanistic approach to the problem of restenosis is based on the assumption th...

journal_title：Fundamental & clinical pharmacology

authors： Feldman LJ,Riessen R,Steg PG

更新日期：1995-01-01 00:00:00

abstract：:The poor outcomes in advanced non-small-cell lung cancer (NSCLC) necessitate new treatments. Recent studies emphasize anisomycin as a promising anti-cancer drug candidate. In this work, we systematically investigated the efficacy of anisomycin alone and its combination with the standard-of-care drugs in NSCLC. We show...

journal_title：Fundamental & clinical pharmacology

authors： Tan H,Hu B,Xie F,Zhu C,Cheng Z

更新日期：2020-12-18 00:00:00

abstract：:The anti-anginal drug trimetazidine (TMZ) has been shown to increase the synthesis of phospholipids in ventricular myocytes, including phosphatidyl-inositol (PI). This study focused on the consequences of increasing PI metabolism on alpha-adrenergic signaling pathway in cultured rat cardiomyocytes. In the cells treate...

journal_title：Fundamental & clinical pharmacology

authors： Tabbi-Anneni I,Lucien A,Grynberg A

更新日期：2003-02-01 00:00:00

abstract：:Zinc is the authoritative metal which is present in our body, and reactive zinc metal is crucial for neuronal signaling and is largely distributed within presynaptic vesicles. Zinc also plays an important role in synaptic function. At cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in ...

journal_title：Fundamental & clinical pharmacology

authors： Prakash A,Bharti K,Majeed AB

更新日期：2015-04-01 00:00:00

abstract：:Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

journal_title：Fundamental & clinical pharmacology

authors： Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

更新日期：2019-06-01 00:00:00

abstract：:Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968...

journal_title：Fundamental & clinical pharmacology

authors： Michaud JC,Alonso R,Gueudet C,Fournier M,Calassi R,Brelière JC,Le Fur G,Soubrié P

更新日期：1998-01-01 00:00:00

abstract：:Rhodamine 123 is a fluorescent cationic dye commonly used as a mitochondrial probe and known or suspected to be transported by certain drug membrane transporters. The present study was designed to characterize the putative interactions of rhodamine 123 with human organic cation transporter (OCT) 1 and OCT2. Intracellu...

journal_title：Fundamental & clinical pharmacology

authors： Jouan E,Le Vee M,Denizot C,Da Violante G,Fardel O

更新日期：2014-02-01 00:00:00

abstract：:Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant-like action o...

journal_title：Fundamental & clinical pharmacology

authors： Melo CT,de Carvalho AM,Moura BA,Teixeira CP,Vasconcelos LF,Feitosa ML,de Oliveira GV,Barbosa-Filho JM,Chavez Gutierrez SJ,de França Fonteles MM,Vasconcelos SM,de Sousa FC

更新日期：2013-02-01 00:00:00

abstract：:Dapsone-induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45-year-old male Caucasian patient developed agranulocytosis caused by dapsone (diamino-diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, ant...

journal_title：Fundamental & clinical pharmacology

authors： Potočnjak I,Likić R,Šimić I,Juričić Nahal D,Čegec I,Ganoci L,Božina N

更新日期：2017-10-01 00:00:00

abstract：:In rat vena cava and aorta preincubated with [3H]noradrenaline the involvement of imidazoline receptors in modulation of [3H]noradrenaline release from sympathetic nerves was investigated. In the vena cava, the guanidine 1,3-di(2-tolyl)guanidine (DTG) inhibited the electrically evoked [3H]noradrenaline release; the in...

journal_title：Fundamental & clinical pharmacology

authors： Molderings GJ,Göthert M

更新日期：1998-01-01 00:00:00

abstract：:Developing drugs for rare disease can be challenging due to specific rare disease characteristics. The French Medical Pharmacology is structured and positioned to play a major role in orphan drug research and development due to the required expertise concentrated into pharmacology departments, exclusively implemented ...

journal_title：Fundamental & clinical pharmacology

authors： Micallef J,Boutouyrie P,Blin O

更新日期：2017-12-01 00:00:00

abstract：:Although nisoxetine has been shown to elicit cutaneous (peripheral) anesthesia, spinal (central) anesthesia with nisoxetine was not exposed. The aim of this study was to examine spinal anesthesia of nisoxetine and its influence on the antinociceptive action of mepivacaine. We compared nisoxetine with an established lo...

journal_title：Fundamental & clinical pharmacology

authors： Leung YM,Chu CC,Kuo CS,Chen YW,Hung CH,Wang JJ

更新日期：2014-02-01 00:00:00

abstract：:Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor or an inducer of CYP3A affects HP pharmacokine...

journal_title：Fundamental & clinical pharmacology

authors： Watanabe M,Tateishi T,Asoh M,Nakura H,Tanaka M,Kumai T,Kobayashi S

更新日期：1999-01-01 00:00:00

abstract：:We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (...

journal_title：Fundamental & clinical pharmacology

authors： Bantsiele GB,Bentué-Ferrer D,Amiot N,Allain H,Bourin M,Reymann JM

更新日期：2004-12-01 00:00:00

abstract：:We investigated the implication of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in the proliferation stimulated by angiotensin II (Ang II) and endothelin-1 (ET-1) in cultured rabbit gingival fibroblasts (CRGF). Ang II stimulated activation of ERK1/2 and the activation was inhibited by CV-11974, an A...

journal_title：Fundamental & clinical pharmacology

authors： Ohsawa M,Ohuchi N,Taniguchi Y,Kizawa Y,Koike K,Iwamoto K,Hayashi K,Murakami H

更新日期：2005-12-01 00:00:00

abstract：:Drugs have side effects that manifest as signs or symptoms which are sometimes undistinguishable from signs or symptoms of active disease. The conventional approximation of the rate of side effects of drugs is by subtracting the rate of signs and symptoms in the placebo group from that in the drug group. This measures...

journal_title：Fundamental & clinical pharmacology

authors： Bernheim JL,Vrana I

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to investigate which principal human cytochrome P450 (CYP450) enzymes are affected by artemisinin and to what degree the artemisinin derivatives differ with respect to their respective induction and inhibition capacity. Seventy-five healthy adults were randomized to receive therapeutic oral d...

journal_title：Fundamental & clinical pharmacology

authors： Asimus S,Elsherbiny D,Hai TN,Jansson B,Huong NV,Petzold MG,Simonsson US,Ashton M

更新日期：2007-06-01 00:00:00

abstract：:Thalidomide, a well-known immunomodulatory compound, has an anti-angiogenic activity, which may be utilized for the treatment of angiogenesis-related diseases such as hemangioendothelioma. The aim of the present study was to investigate both the antitumor role of thalidomide on hemangioendothelioma and the underlying ...

journal_title：Fundamental & clinical pharmacology

authors： Guo L,Wan Z,Xu B,Ren L,Liu H,Song N,Liu L

更新日期：2019-12-01 00:00:00