Stress-induced 5-HT1A receptor desensitization: protective effects of Ginkgo biloba extract (EGb 761).


:The effects of sub-chronic cold stress on the functioning of hippocampal 5-HT1A receptors in old isolated rats and the possible protective effects of Ginkgo biloba extract (EGb 761) were investigated. Cold exposure during five days, produced a significant reduction of the inhibitory effect of 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) on forskolin-stimulated adenylyl cyclase activity. In contrast, neither the affinity nor the density of hippocampal [3H]8-OH-DPAT binding sites were affected indicating that the reduced sensitivity of 5-HT1A receptors induced by stress is probably due to a modification of their coupling mechanisms to adenylyl cyclase. The stress-induced desensitization of 5-HT1A receptors was prevented by the administration of EGb 761 (50 mg/kg per os/14 days). These results clearly indicate that 5-HT1A receptors are desensitized by stress and point out the reduced capacity of old rats to cope with the adverse effects of a chronic stressor. EGb 761 appears to restore the age-related decreased capacity to adapt to a chronic stressor.


Fundam Clin Pharmacol


Bolaños-Jiménez F,Manhães de Castro R,Sarhan H,Prudhomme N,Drieu K,Fillion G




Has Abstract


1995-01-01 00:00:00














  • Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain.

    abstract::The blood-brain barrier (BBB) is responsible for the control of solutes' concentration in the brain. Tight junctions and multiple ATP-binding cassette (ABC) and SoLute Carrier (SLC) efflux transporters protect brain cells from xenobiotics, therefore reducing brain exposure to intentionally administered drugs. In epile...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Soares RV,Do TM,Mabondzo A,Pons G,Chhun S

    更新日期:2016-04-01 00:00:00

  • Animal models to evaluate anti-atherosclerotic drugs.

    abstract::Atherosclerosis is a multifactorial condition characterized by endothelial injury, fatty streak deposition, and stiffening of the blood vessels. The pathogenesis is complex and mediated by adhesion molecules, inflammatory cells, and smooth muscle cells. Statins have been the major drugs in treating hypercholesterolemi...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Priyadharsini RP

    更新日期:2015-08-01 00:00:00

  • The comparison of the effects of anesthetic doses of ketamine, propofol, and etomidate on ischemia-reperfusion injury in skeletal muscle.

    abstract::The fact that a considerable amount of clinical conditions suffering from ischemia-reperfusion injury (IRI) occur under general anesthesia has triggered researchers to focus on the effects of anesthetic drugs on IRI. Hence, the aim of this study was to compare the use of different anesthetic drugs in a skeletal IRI mo...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Ergün Y,Darendeli S,Imrek S,Kilinç M,Oksüz H

    更新日期:2010-04-01 00:00:00

  • A new endogenous anxiolytic agent: L-pyroglutamic acid.

    abstract::By use of a simple anticonflict procedure (Vogel test), it was demonstrated that L-pyroglutamic acid (L-pyrrolidone carboxylic acid [L-PCA]), an amino acid naturally occurring in mammalian tissues and fluids, possesses anxiolytic activity. This tissues and fluids, possesses anxiolytic activity. This effect was stereos...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Beni M,Pellegrini-Giampietro DE,Moroni F

    更新日期:1988-01-01 00:00:00

  • Mechanism of action of doxepin in the treatment of chronic urticaria.

    abstract::The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects. However, some controversy remains about its mechanism of action in...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Figueiredo A,Ribeiro CA,Gonçalo M,Almeida L,Poiares-Baptista A,Teixeira F

    更新日期:1990-01-01 00:00:00

  • Isobolographic analysis of interaction between nisoxetine- and mepivacaine-induced spinal blockades in rats.

    abstract::Although nisoxetine has been shown to elicit cutaneous (peripheral) anesthesia, spinal (central) anesthesia with nisoxetine was not exposed. The aim of this study was to examine spinal anesthesia of nisoxetine and its influence on the antinociceptive action of mepivacaine. We compared nisoxetine with an established lo...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Leung YM,Chu CC,Kuo CS,Chen YW,Hung CH,Wang JJ

    更新日期:2014-02-01 00:00:00

  • PPARα is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke.

    abstract::There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti-inflammatory and ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Ouk T,Potey C,Laprais M,Gautier S,Hanf R,Darteil R,Staels B,Duriez P,Bordet R

    更新日期:2014-06-01 00:00:00

  • Tropisetron and paracetamol association in post-operative patients.

    abstract::Studies in animals and in healthy volunteers have demonstrated the central serotonergic analgesic mechanism of action of paracetamol involving the inhibition of this analgesia by tropisetron, a 5-HT3 antagonist. This randomized, double-blind, controlled study aims at studying this interaction in post-operative patient...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Pickering G,Faure M,Commun F,de Boissy EC,Roche G,Mom T,Simen E,Dubray C,Eschalier A,Gilain L

    更新日期:2012-06-01 00:00:00

  • Metformin potentiates the chemotherapeutic effects of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine-induced Mammary Carcinoma in rats.

    abstract::This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

    更新日期:2020-09-09 00:00:00

  • Effect of nitric oxide donors on endogenous dopamine release from rat striatal slices. II: The role of voltage-dependent sodium channels, calcium channel activation, reverse transport mechanism, guanylate cyclase and endogenous glutamate.

    abstract::Incubation of striatal slices with sodium nitroprusside (SNP) or hydroxylamine (HA) for 60 min caused a dose-dependent increase in dopamine (DA) release. This effect was inhibited completely by tetrodotoxin (TTX) (1 microM) if low concentrations of SNP (1 microM) or HA (10 and 100 microM) were tested. Although-higher ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Büyükuysal RL

    更新日期:1997-01-01 00:00:00

  • Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats.

    abstract::Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Pari L,Sivasankari R

    更新日期:2008-08-01 00:00:00

  • Epithelial factors: modulation of the airway smooth muscle tone.

    abstract::The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also meta...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Bertrand C,Tschirhart E

    更新日期:1993-01-01 00:00:00

  • Anandamide: an update.

    abstract::Endocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2-arachidonoylglycerol. Recent pharmacological advances point ou...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Smita K,Sushil Kumar V,Premendran JS

    更新日期:2007-02-01 00:00:00

  • Lithium decreased endothelium-mediated, but not nonadrenergic noncholinergic, relaxation of guinea pig corpus cavernosum in vitro: a role for nitrergic system.

    abstract::Lithium causes erectile dysfunction in patients but its mechanism is yet unknown. The aim of our study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)- and endothelium-mediated relaxation of guinea pig isolated corpus cavernosum. Although lithium (0.5, 1, and 5mm) ha...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Ghasemi M,Farrokhi-Khajeh-Pasha Y,Ostovaneh MR,Dehpour AR

    更新日期:2011-04-01 00:00:00

  • Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats.

    abstract::The purpose of this study was to assess in rats the pharmacological parameters and effects on gene expression in the liver of the triterpene glycoside actein. Actein, an active component from the herb black cohosh, has been shown to inhibit the proliferation of human breast cancer cells. To conduct our assessment, we ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Einbond LS,Soffritti M,Esposti DD,Park T,Cruz E,Su T,Wu HA,Wang X,Zhang YJ,Ham J,Goldberg IJ,Kronenberg F,Vladimirova A

    更新日期:2009-06-01 00:00:00

  • Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids.

    abstract::Since solute carrier (SLC) and ATP-binding cassette (ABC) transporters play pivotal roles in the transport of both nutrients and drugs into breast milk, drug-nutrient transport interactions at the lactating mammary gland are possible. Our purpose was to characterize lactation stage-dependent changes in transporter exp...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Gilchrist SE,Alcorn J

    更新日期:2010-04-01 00:00:00

  • Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells.

    abstract::Microparticles are membrane vesicles with procoagulant and proinflammatory properties released during cell activation or apoptosis. Microparticles from monocytes have been implicated in atherosclerosis and vascular inflammation, but their direct effects on endothelial cells are not completely elucidated. The present s...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Mastronardi ML,Mostefai HA,Soleti R,Agouni A,Martínez MC,Andriantsitohaina R

    更新日期:2011-12-01 00:00:00

  • Drug reimbursement and GPs' prescribing decisions: a randomized case-vignette study about the pharmacotherapy of obesity associated with type 2 diabetes: how GPs react to drug reimbursement.

    abstract::This study sought to identify the effect of drug reimbursability--a decision made in France by the National Authority for Health--on physicians' prescribing practices for a diet drug such as rimonabant, approved for obese or overweight patients with type-2 diabetes. A cross-sectional survey of French general practitio...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Verger P,Rolland S,Paraponaris A,Bouvenot J,Ventelou B

    更新日期:2010-08-01 00:00:00

  • Who is responsible for what?

    abstract::During the phase I trials, from the juridical point of view, the responsibilities are shared between the pharmaceutical company and the physician who manages the trial. The pharmaceutical company is responsible for the product, the choice of methodology and respect for the regulations. On the financial side, the compa...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Rouzioux JM

    更新日期:1990-01-01 00:00:00

  • N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose.

    abstract::Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Zyoud SH,Awang R,Sulaiman SA,Al-Jabi SW

    更新日期:2011-06-01 00:00:00

  • Effect of peptidyl-dipeptidase inhibitors in experimental convulsions in mice.

    abstract::The anticonvulsant effect of compounds that inhibit peptidyl-dipeptidase (PDP) on bicuculline (BIC)- and strychnine (STRYC)-induced seizures was assessed after intracerebroventricular (ICV) or intraperitoneal (IP) administration in Swiss albino mice. STRYC-induced seizures were delayed by ICV injections and high IP do...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Miñano FJ,Serrano JS,Sancibrián M,Serrano MI

    更新日期:1987-01-01 00:00:00

  • Effect of alprazolam on anxiety and cardiomyopathy induced by doxorubicin in mice.

    abstract::Anxiety following heart failure (HF) and/or myocardial infarction (MI) can impede recovery and constitute a major risk factor for further cardiac events. The present study was aimed to evaluate anxiety following doxorubicin (DOX)-induced cardiomyopathy, a rodent model for HF, in mice. Furthermore, the study investigat...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Anwar MJ,Pillai KK,Khanam R,Akhtar M,Vohora D

    更新日期:2012-06-01 00:00:00

  • Severe excessive daytime sleepiness induced by hydroxyurea.

    abstract::Excessive daytime sleepiness (EDS) has been reported with many drugs, either as an extension of a hypnotic effect (e.g. central nervous system depressants) or as an idiosyncratic response of the patient. Here, we report unexpected and severe subjective and objective EDS induced by hydroxyurea therapy, with a favorable...

    journal_title:Fundamental & clinical pharmacology



    authors: Revol B,Joyeux-Faure M,Albahary MV,Gressin R,Mallaret M,Pepin JL,Launois SH

    更新日期:2017-06-01 00:00:00

  • Vanadium pharmacokinetics and oral bioavailability upon single-dose administration of vanadyl sulfate to rats.

    abstract::Vanadium pharmacokinetic parameters and oral bioavailability were determined after administration of vanadyl sulfate, an antidiabetic agent, to male Wistar rats. An optimal sampling design was used over a 21-day period; vanadium was measured in blood by atomic absorption spectrophotometry (AAS). After i.v. bolus injec...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Azay J,Brès J,Krosniak M,Teissedre PL,Cabanis JC,Serrano JJ,Cros G

    更新日期:2001-10-01 00:00:00

  • Differential sensitivities of pyrogenic chemokine fevers to CC chemokine receptor 5 antibodies.

    abstract::Macrophage inflammatory protein (MIP)-1beta and RANTES (regulated on activation, normal T-cells expressed and secreted) are members of the CC-family of chemokines. Although these two peptides are structurally and functionally related to one another, each exhibits distinct features, which allows it to independently reg...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Tavares E,Miñano FJ

    更新日期:2004-04-01 00:00:00

  • Drug interactions between antihypertensive drugs and non-steroidal anti-inflammatory agents: a descriptive study using the French Pharmacovigilance database.

    abstract::Drug-drug interactions (DDIs) between antihypertensive drugs and non-steroidal anti-inflammatory drugs (NSAIDs) can lead to adverse drug reactions (ADRs). Guidelines are available to help prescribers deal with these drug associations, but their implementation is not well evaluated. The aims of this study were to asses...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Fournier JP,Sommet A,Durrieu G,Poutrain JC,Lapeyre-Mestre M,Montastruc JL,French Network of Regional Pharmacovigilance Centres.

    更新日期:2014-04-01 00:00:00

  • Low glucocorticoid concentrations decrease oxidative phosphorylation of isolated rat brain mitochondria: an additional effect of dexamethasone.

    abstract::The effects of hydrocortisone, triamcinolone, prednisolone and dexamethasone have been investigated in vitro using mitochondria isolated from rat brain. Respiratory control ratio (RCR), oxygen consumption, ATP synthesis, enzymatic activities of involved complexes and superoxide anion generation have been measured to a...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Morin C,Zini R,Simon N,Charbonnier P,Tillement JP,Le Louet H

    更新日期:2000-09-01 00:00:00

  • Nitric oxide and the control of renin secretion.

    abstract::Research during recent years has established nitric oxide as a unique signaling molecule that plays important roles in the regulation of the cardiovascular, nervous, renal, immune and other systems. Nitric oxide has also been implicated in the control of the secretion of hormones by the pancreas, hypothalamus, pituita...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Reid IA,Chiu YJ

    更新日期:1995-01-01 00:00:00

  • Tramadol relieves thermal hyperalgesia in rats with chronic constriction injury of the sciatic nerve.

    abstract::The present study was designed to test whether tramadol is effective in the control of neuropathic pain in rats. Chronic constriction injury (CCI) of the sciatic nerve was induced over the left hind limb in male Sprague-Dawley rats. Identical surgery was performed on the opposite side except that the sciatic nerve was...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Tsai YC,Sung YH,Chang PJ,Kang FC,Chu KS

    更新日期:2000-07-01 00:00:00

  • Enhancement on reactive oxygen species and COX-1 mRNA levels modulate the vascular relaxation induced by sodium nitroprusside in denuded mice aorta.

    abstract::This study aimed to investigate the modulation of nitric oxide/reactive oxygen species in sodium nitroprusside relaxation in mice aorta. Sodium nitroprusside induced relaxation in endothelium-intact (e+) and endothelium-denuded (e-) aortas with greater potency in e+ than in e-. The nitric oxide synthase inhibitor did ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Kangussu LM,Olivon VC,Arifa RD,Araújo N,Reis D,Assis MT,Soriani FM,de Souza Dda G,Bendhack LM,Bonaventura D

    更新日期:2015-04-01 00:00:00