Stress-induced 5-HT1A receptor desensitization: protective effects of Ginkgo biloba extract (EGb 761).


:The effects of sub-chronic cold stress on the functioning of hippocampal 5-HT1A receptors in old isolated rats and the possible protective effects of Ginkgo biloba extract (EGb 761) were investigated. Cold exposure during five days, produced a significant reduction of the inhibitory effect of 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) on forskolin-stimulated adenylyl cyclase activity. In contrast, neither the affinity nor the density of hippocampal [3H]8-OH-DPAT binding sites were affected indicating that the reduced sensitivity of 5-HT1A receptors induced by stress is probably due to a modification of their coupling mechanisms to adenylyl cyclase. The stress-induced desensitization of 5-HT1A receptors was prevented by the administration of EGb 761 (50 mg/kg per os/14 days). These results clearly indicate that 5-HT1A receptors are desensitized by stress and point out the reduced capacity of old rats to cope with the adverse effects of a chronic stressor. EGb 761 appears to restore the age-related decreased capacity to adapt to a chronic stressor.


Fundam Clin Pharmacol


Bolaños-Jiménez F,Manhães de Castro R,Sarhan H,Prudhomme N,Drieu K,Fillion G




Has Abstract


1995-01-01 00:00:00














  • The effects of fluoxetine on the human adipose-derived stem cell proliferation and differentiation.

    abstract::Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem cells are also present in adult tissues. Therefore, in the current study, we aimed to investigate the effects of fluoxetine (FLX) on both ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Khademi M,Taghizadeh Ghavamabadi R,Taghavi MM,Shabanizadeh A,Shariati-Kohbanani M,Hassanipour M,Taghipour Z

    更新日期:2019-06-01 00:00:00

  • The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice.

    abstract::The present study was carried out to investigate on the possible involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate (L-arginine/NO/cGMP) pathway in the aqueous extract of Muntingia calabura (AEMC) leaves antinociception in mice assessed by abdominal constriction test. The AEMC, obtained by soaking t...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Zakaria ZA,Sulaiman MR,Jais AM,Somchit MN,Jayaraman KV,Balakhrisnan G,Abdullah FC

    更新日期:2006-08-01 00:00:00

  • Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers.

    abstract::The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Charnet P,Ouadid H,Richard S,Nargeot J

    更新日期:1987-01-01 00:00:00

  • Pharmacokinetics of dextromoramide in surgical patients.

    abstract::The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC-MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery. Dextromoramide was rapidly absorbed from the gastrointesti...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Pagani I,Barzaghi N,Crema F,Perucca E,Ego D,Rovei V

    更新日期:1989-01-01 00:00:00

  • French adaptation and preliminary validation of a questionnaire to evaluate understanding of informed consent documents in phase I biomedical research.

    abstract::The content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of the information, i.e. the ability to understand its meaning and its consequences, is of utmost importance. The objective of this study was to descr...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Paris A,Cornu C,Auquier P,Maison P,Radauceanu A,Brandt C,Salvat-Melis M,Hommel M,Cracowski JL

    更新日期:2006-02-01 00:00:00

  • Spontaneous adverse event notifications by patients subsequent to the marketing of a new formulation of Levothyrox® amidst a drug media crisis: atypical profile as compared with other drugs.

    abstract::Since patients may report spontaneously adverse events associated with their medications, such notifications are constantly on the rise. In 2017, an unexpected rise of notifications associated with the marketing of a new formula of Levothyrox, differing from the 30-year-old drug only by minor elements, occurred in Fra...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Viard D,Parassol-Girard N,Romani S,Van Obberghen E,Rocher F,Berriri S,Drici MD

    更新日期:2019-08-01 00:00:00

  • Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson's disease.

    abstract::Gait disorders form one component of the axial disorders observed in Parkinson's disease (PD). Indeed, short steps with a forward-leaning stance are diagnostic criteria for PD in the early stages of the condition. Gait disorders also represent a major source of therapeutic failure in the advanced stages of PD (with th...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Devos D,Defebvre L,Bordet R

    更新日期:2010-08-01 00:00:00

  • Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs.

    abstract::Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic cough and airway hyperresponsiveness. The aim of this work was to assess in pigs the effects of bradykinin and tac...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Moreaux B,Advenier C,Gustin P

    更新日期:2001-02-01 00:00:00

  • NG-nitro-L-arginine methyl-ester: a muscarinic receptor antagonist?

    abstract::The effect of the nitric oxide synthase inhibitor NG-Nitro-L-arginine methyl ester (L-NAME) towards muscarinic receptors was studied in vitro and in vivo. L-NAME displaced the antimuscarinic ligand [3H]quinuclidinyl benzilate ([3H]QNB) from its specific binding sites in rat cerebral cortex and cerebellum homogenates w...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Hellmich B,Gyermek L

    更新日期:1997-01-01 00:00:00

  • Metformin potentiates the chemotherapeutic effects of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine-induced Mammary Carcinoma in rats.

    abstract::This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of doxorubicin on 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)-induced rat mammary carcinogenesis. Female Sprague -Dawley (SD) rats were divided into seven group...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Salim E,El-Sisi AE,Sokar S,El-Sayad M,Moussa E

    更新日期:2020-09-09 00:00:00

  • Changes in vascular alpha 1- and alpha 2-adrenoceptor responsiveness by selegiline treatment.

    abstract::Pharmacoepidemiological studies have reported an excess of mortality with selegiline, a MAO B inhibitor used in the treatment of Parkinson's disease. The mechanism of this putative adverse effect remains unknown but an interaction with the sympathetic nervous system was suggested. The aim of the present study was to i...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Pelat M,Verwaerde P,Tran MA,Berlan M,Senard JM,Montastruc JL

    更新日期:2001-08-01 00:00:00

  • Role of CYP3A in haloperidol N-dealkylation and pharmacokinetics in rats.

    abstract::Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor or an inducer of CYP3A affects HP pharmacokine...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Watanabe M,Tateishi T,Asoh M,Nakura H,Tanaka M,Kumai T,Kobayashi S

    更新日期:1999-01-01 00:00:00

  • Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.

    abstract::Potentiation of opioid analgesia by endothelin-A (ET(A)) receptor antagonist, BMS182874, and imidazoline receptor/α₂-adrenoceptor agonists such as clonidine and agmatine are well known. It is also known that agmatine blocks morphine hyperthermia in rats. However, the effect of agmatine on morphine or oxycodone hypothe...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Bhalla S,Andurkar SV,Gulati A

    更新日期:2013-10-01 00:00:00

  • Proconvulsant potential of cyproheptadine in experimental animal models.

    abstract::In epileptic patients cyproheptadine is frequently prescribed as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of 'serotonin syndrome' in depressed epileptic patients. However, the study of serotonergic and histaminergic pathway shows that the decreased...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Singh D,Goel RK

    更新日期:2010-08-01 00:00:00

  • Factitious increases in serum testosterone concentrations related to phenylbutazone therapy.

    abstract::We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications. ...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Uzzan B,Dumont-Fischer D,Lahlou N,Bihan H,Boissier MC,Alvarez JC,Perret GY,Cohen R

    更新日期:2008-04-01 00:00:00

  • Design of the cardiac insufficiency bisoprolol study II (CIBIS II). The CIBIS II Scientific Committee.

    abstract::Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1997-01-01 00:00:00

  • Tamper-resistant prescription forms for narcotics in France: Should we generalize them?

    abstract::In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal m...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Daveluy A,Sauvaget L,Bastien A,Lapeyre-Mestre M,Collin C,Richard N,Haramburu F

    更新日期:2018-10-01 00:00:00

  • Memantine for the treatment of general neuropathic pain: a narrative review.

    abstract::Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-methyl-d-aspartate antagonists that are alternatives to be recommended in first-line NP treatment, memantine has...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Pickering G,Morel V

    更新日期:2018-02-01 00:00:00

  • Vitamin E analogues reduce the incidence of ventricular fibrillations and scavenge free radicals.

    abstract::The aim of our study was to analyse the protective effects of different alpha-tocopherol analogues 1) against fibrillations induced by an ischemia-reperfusion sequence, and 2) to further investigate in vitro the radical scavenging properties of these analogues by two sensitive methods. Concerning 1: isolated rat heart...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Walker MK,Vergely C,Lecour S,Abadie C,Maupoil V,Rochette L

    更新日期:1998-01-01 00:00:00

  • Anandamide: an update.

    abstract::Endocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2-arachidonoylglycerol. Recent pharmacological advances point ou...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Smita K,Sushil Kumar V,Premendran JS

    更新日期:2007-02-01 00:00:00

  • Pancreas beta-cells morphology, liver antioxidant enzymes and liver oxidative parameters in alloxan-resistant and alloxan-susceptible Wistar rats: a viable model system for the study of concepts into reactive oxygen species.

    abstract::The aim of this study was to investigate biochemical and antioxidant parameters in alloxan-resistant (ALR) and alloxan-susceptible (ALS) rats. Diabetes was induced in 60-day-old male Wistar rats by a single intraperitonial injection of alloxan (AL, 150 mg/kg). Ten days after induction, a group of rats showed a signifi...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Behr GA,da Silva EG,Ferreira AR,Cerski CT,Dal-Pizzol F,Moreira JC

    更新日期:2008-12-01 00:00:00

  • Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist.

    abstract::Adrenoceptors are involved in the control of the activity of the autonomic nervous system and especially the sympathetic nervous system. Activation of alpha 2-adrenoceptors decreases sympathetic tone whereas their blockade has an opposite effect. However, previous investigations have shown that yohimbine (a potent alp...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Bagheri H,Chale JJ,Guyen LN,Tran MA,Berlan M,Montastruc JL

    更新日期:1995-01-01 00:00:00

  • Beraprost sodium-fluindione combination in healthy subjects: pharmacokinetic and pharmacodynamic aspects.

    abstract::Beraprost sodium (BPS), an orally active PGI2 (prostaglandine 12) analogue possesses vasodilatating and platelet aggregation inhibiting properties. It is being developed in peripheral arterial occlusive disease. As in future clinical practice BPS might be co-prescribed with oral anticoagulants, we investigated its int...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Warot D,Berlin I,Aymard G,Ankri A,Fabry C,Besse B,Lechat P,Diquet B

    更新日期:2000-05-01 00:00:00

  • Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats.

    abstract::Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Pari L,Sivasankari R

    更新日期:2008-08-01 00:00:00

  • Dapsone-induced agranulocytosis-possible involvement of low-activity N-acetyltransferase 2.

    abstract::Dapsone-induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45-year-old male Caucasian patient developed agranulocytosis caused by dapsone (diamino-diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, ant...

    journal_title:Fundamental & clinical pharmacology



    authors: Potočnjak I,Likić R,Šimić I,Juričić Nahal D,Čegec I,Ganoci L,Božina N

    更新日期:2017-10-01 00:00:00

  • Effect of alprazolam on anxiety and cardiomyopathy induced by doxorubicin in mice.

    abstract::Anxiety following heart failure (HF) and/or myocardial infarction (MI) can impede recovery and constitute a major risk factor for further cardiac events. The present study was aimed to evaluate anxiety following doxorubicin (DOX)-induced cardiomyopathy, a rodent model for HF, in mice. Furthermore, the study investigat...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Anwar MJ,Pillai KK,Khanam R,Akhtar M,Vohora D

    更新日期:2012-06-01 00:00:00

  • A nonpeptide vasopressin V(1a) receptor antagonist, SR 49059, does not prevent cisplatin-induced emesis in piglets.

    abstract::We determined the pharmacological and the antiemetic properties of SR 49059, a selective nonpeptide V(1a) receptor antagonist, on cisplatin-induced emesis in the piglet. Firstly, we clearly demonstrate that SR 49059 is a potent V(1a) receptor antagonist in vitro and in vivo in the piglet. In binding studies, [3H]-SR 4...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Grélot L,Girod V,Dapzol J,Maffrand JP,Serradeil-Le Gal C

    更新日期:2001-06-01 00:00:00

  • Lack of pharmacodynamic interaction between trimetazidine and cyclosporin A in human lymphoproliferative and mouse delayed hypersensitivity response models.

    abstract::The hypothesis of an interaction between trimetazidine and the immunosuppressive effect of cyclosporin A was investigated in two models: a) ex vivo, the lymphoproliferative response of normal human lymphocytes to phytohemagglutinin and a murine monoclonal antibody against the CD3 T-lymphocyte membrane complex; b) in v...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Albengres E,Tillement JP,d'Athis P,Salducci D,Chauvet-Monges AM,Crevat A

    更新日期:1996-01-01 00:00:00

  • Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.

    abstract:UNLABELLED:In this study, we investigated the effects of lipoic acid (LA) in the hippocampus oxidative stress caused by pilocarpine-induced seizures in adult rats. Wistar rats were treated with 0.9% saline (i.p., control group), LA (10mg/kg, i.p., LA group), ubiquinone [20mg/kg, i.p., ubiquinone (UQ) group], pilocarpin...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: de Freitas RM,Feng D,Jordán J

    更新日期:2011-04-01 00:00:00

  • Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol-induced myocardial injury.

    abstract::This study investigated whether ivabradine, a selective If current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol-induced heart damage. Wistar rats were treated for 6 weeks: controls (n = 10), ivabradine (10 mg/kg/day orally; n = 10), isopr...

    journal_title:Fundamental & clinical pharmacology

    pub_type: 杂志文章


    authors: Simko F,Baka T,Repova K,Aziriova S,Krajcirovicova K,Paulis L,Adamcova M

    更新日期:2020-10-24 00:00:00