Abstract:
:Two types of follicular change in the thyroid are described. The first represents an involutional change in which colloid cysts (macrofollicles) are often found. The second represents a hyperplastic-dysplastic (microfollicular) lesion. Two types of change in calcitonin (C) cells are also described, one of which may represent an involutional process, although this is not certain. The second is a hyperplastic (micronodular) lesion, but without evidence of dysplasia. An infiltration of lymphocytes is also commonly encountered. Only about 15% of cases after age 60 are free of the follicular and lymphoid lesions. Both the macro- and microfollicular lesions show a statistically significant increase with age, as do the lymphoid lesion and its derivative Hashimoto's thyroiditis. C cell micronodules also appear to increase with age, but there are too few such cases for a reliable statistical analysis. An analysis of combinations of the follicular and lymphoid lesions show a particularly frequent association of the microfollicular and lymphoid lesions. Evidence is presented suggesting that many microfollicular lesions may represent clones of mutated cells, and that the lymphocytes may be targeted to these microfollicles. Lymphocytes were rarely found in association with C cell micronodules. Within individual thyroids there is considerable variation in the proportion of each lesion when combinations are present. Thus with advancing age there is an increasing heterogeneity of thyroid structure that may confound attempts to correlate structural and physiological changes with age.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Blumenthal HT,Perlstein IBdoi
10.1111/j.1532-5415.1987.tb02337.xsubject
Has Abstractpub_date
1987-09-01 00:00:00pages
843-54issue
9eissn
0002-8614issn
1532-5415journal_volume
35pub_type
杂志文章abstract:OBJECTIVES:To evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia. DESIGN:Cross-sectional study. SETTING:Outpatient clinic in Greve in Chianti and Bagno a Ripoli, Italy. PARTICIPANTS:A total ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52466.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To determine the validity of the Minimum Data Set (MDS). DESIGN:MDS domain scores were correlated with a variety of independently obtained measures of basic behavioral and mental health functions of 513 nursing home residents. SETTING:All participants were residents of the Philadelphia Geriatric Center. PA...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1998.tb03809.x
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence and content of long-term care facility policies regarding the use of life-sustaining treatments (cardiopulmonary resuscitation (CPR), artificial hydration and nutrition, dialysis, antibiotics for life-threatening infections, transfer to acute care hospital) and advance directives in...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb06980.x
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Nursing facility (NF) residents are commonly hospitalized, and many of these hospitalizations may be avoidable. A Centers for Medicare & Medicaid Services (CMS) initiative enables participating NFs to bill Medicare for providing on-site acute care to long-stay residents diagnosed with one of six a...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16901
更新日期:2020-11-12 00:00:00
abstract::The elderly take more drugs than the young, and are therefore more susceptible to adverse drug interactions. Prescribing the minimum number of agents is recommended. Drug absorption, metabolism, and excretion may be altered by various interactions. Dose-response relationships of oral anticoagulants, oral hypoglycemics...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1982.tb01358.x
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVES:To determine the effect of cataract surgery on the occurrence of falls and mobility and balance problems in older adults with cataract. DESIGN:Longitudinal follow-up study. SETTING:Clinical Research Unit, University of Alabama at Birmingham. PARTICIPANTS:Persons aged 55 and older with a cataract were recr...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2006.00770.x
更新日期:2006-07-01 00:00:00
abstract::Cerebral blood flow (CBF) was measured by the 133Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Scre...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1986.tb04318.x
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the longer term changes in executive functioning among participants with cardiovascular disease (CVD) risk factors and cognitive impairments with no dementia (CIND) randomized to a diet and exercise intervention. DESIGN:A 2 (Exercise) × 2 (Dietary Approaches to Stop Hypertension [DASH] eating pl...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/jgs.16252
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship between insomnia and 6-year survival among older, community-dwelling, white women. DESIGN:Longitudinal study. SETTING:The sample was selected randomly from a 20-census tract area of Baltimore, Maryland. PARTICIPANTS:In 1984, 778 women aged 65 years and older participated in...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1998.tb04544.x
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:To assess whether catheter replacement is associated with better clinical outcomes in individuals with long-term urinary catheters. DESIGN:Prospective, noninterventional study. PARTICIPANTS:Individuals (mean age 79.2±11.5) who had had an indwelling urinary catheter for longer than 7 days and a symptomatic ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15517
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To investigate the effectiveness of an exercise program in improving ability to perform activities of daily living (ADLs), physical performance, and nutritional status and decreasing behavioral disturbance and depression in patients with Alzheimer's disease (AD). DESIGN:Randomized, controlled trial. SETTIN...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1532-5415.2007.01035.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. DESIGN:Prospective and retrospective longitudinal study. SETTING:Community. PARTICIPANTS:Long-term hospitalized patients and people in nursing homes (343 subjects, aged > or =65). MEASUREMENTS:Subjects we...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2010.02867.x
更新日期:2010-06-01 00:00:00
abstract::Leaders of geriatric programs at academic health centers (AHCs) face several challenges in seeking support for clinical program development. These challenges relate to how revenues from Medicare activities flow within AHCs. Typically, clinical departments such as the Department of Medicine see a very small proportion ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50174.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the association between hypothyroidism, and the health status of older Hispanic and non-Hispanic white (NHW) men and women. To accomplish this, we determined the prevalences of the treated and untreated conditions and examined the associations between an elevated serum thyroid stimulating hormone...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1999.tb01593.x
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To determine whether the management of heart failure by specialized multidisciplinary heart failure disease-management programs was associated with improved outcomes. BACKGROUND:The advent of angiotensin-converting enzyme inhibitors, beta-blockers, and spironolactone has revolutionized the management of heart ...
journal_title:Journal of the American Geriatrics Society
pub_type: 评论,杂志文章
doi:10.1046/j.1532-5415.2002.50418.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:To determine if poorer healthcare and financial decision making forecasts adverse cognitive outcomes in old age. Specifically, we hypothesized that poorer decision making would be associated with an increased risk of incident Alzheimer's dementia, an increased risk of incident mild cognitive impairment (MCI)...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15880
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:To examine concerns that vulnerable populations, such as depressed or cognitively impaired beneficiaries would have challenges accessing Part D coverage. DESIGN:Logistic regression analysis was used to assess whether elderly Medicare beneficiaries with depression or cognitive impairment differentially plann...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02348.x
更新日期:2009-08-01 00:00:00
abstract::As life expectancy increases, so do the problems of the elderly population. One major problem is that of protein calorie malnutrition; another is the susceptibility of this population to pressure sores. The purpose of this study was to determine if a correlation exists between deteriorating nutritional status and the ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1986.tb03411.x
更新日期:1986-06-01 00:00:00
abstract::Primary carcinoma of the appendix, though rare, occurs often enough to warrant its inclusion in diagnostic possibilities when the symptoms of acute appendicitis, without leukocytosis, are present in geriatric patients. A case of mucinous adenocarcinoma of the appendix in an 88-year-old white woman is presented. The su...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1982.tb05665.x
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVES:To develop a reliable and valid dementia knowledge scale to address limitations of existing measures, support knowledge evaluation in diverse populations, and inform educational intervention development. DESIGN:A five-stage, systematic scale development process was employed to construct and assess the psych...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13707
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Elevated low-density lipoprotein cholesterol (LDL-C) in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). The strength of the association between LDL-C and ASCVD among older adults, however, is less understood. DESIGN:We examined individual-level...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16123
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To determine if pre-complication nutrient intake can be predicted based on an admission assessment. DESIGN:Survey (cross-sectional study). SETTING:Geriatric Rehabilitation Unit (GRU) of a Veterans Administration hospital. PATIENTS:Three-hundred-twelve randomly selected admissions to the GRU. MEASUREMENTS:...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb04967.x
更新日期:1994-05-01 00:00:00
abstract::Previous studies have identified postprandial systolic blood pressure reductions in old, frail institutionalized subjects, which do not occur in healthy, young subjects, after a morning meal. To evaluate the relative contributions of state of health and time of day to this potentially dangerous abnormality in cardiova...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1986.tb04222.x
更新日期:1986-04-01 00:00:00
abstract::In view of some controversies still existing about the real efficacy of ergot derivatives in the management of dementia, a double-blind, randomized, parallel group trial extending up to 6 months was carried out to compare the effects of nicergoline, 60 mg daily, and placebo in 315 patients suffering from mild to moder...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1532-5415.1989.tb05494.x
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVES:Use of objectively measured physical activity (PA) in older adults to assess relationship between PA and risk of all-causes mortality is scarce. This study evaluated the associations of PA based on accelerometry and a questionnaire with the risk of mortality among older adults from a city in Southern Brazil....
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16180
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To determine whether hospital costs are higher in patients with lower functional status at admission, defined as dependence in one or more activities of daily living (ADLs), after adjustment for Medicare Diagnosis-Related Group (DRG) payments. DESIGN:Prospective study. SETTING:General medical service at a ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2003.51556.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To quantitatively summarize changes in cognitive performance in individuals with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). DESIGN:Metaanalysis. PARTICIPANTS:Individuals undergoing TAVI (N = 1,065 (48.5% male) from 18 studies, average age ≥80). MEASUREMENTS:The MEDLI...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,meta分析,评审
doi:10.1111/jgs.15123
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) predict accelerated decline in muscular strength or onset of new disability in mobility and upper extremity functioning over a 3-year follow-up. DESIGN:A community-based prospective cohort study. PARTICIPANTS:S...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50219.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To estimate potential cost savings generated by a program of hip protectors in the nursing home from a Medicare perspective. DESIGN:A state-transition Markov model considering short-term and long-term outcomes of hip protectors for a hypothetical nursing home population, stratified by age, sex, and function...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.53102.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:To assess 1-week prevalence of International Classification of Disease, Tenth Edition (ICD-10) current depression, physical comorbidity, associated disability, and healthcare utilization in older primary care patients. Comparisons with younger patients are also reported. DESIGN:Cross-sectional, two-phase ep...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50011.x
更新日期:2002-01-01 00:00:00