Abstract：
OBJECTIVES:To evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia. DESIGN:Cross-sectional study. SETTING:Outpatient clinic in Greve in Chianti and Bagno a Ripoli, Italy. PARTICIPANTS:A total of 597 subjects aged 65 to 93 without DM or dementia. MEASUREMENTS:Anthropometric measurements; plasma fasting levels of glucose, insulin, cholesterol (total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol), and insulin-like growth factor-1 (IGF-1); homeostasis model assessment (HOMA) to estimate degree of IR; Trail Making Test (TMT) A; TMT-B; TMT-B minus TMT-A (DIFF B-A); and Mini-Mental State Examination (MMSE). RESULTS:IR (HOMA) was associated with longer TMT-B (correlation coefficient (r)=0.11; P=.006) and DIFF B-A times (r=0.10; P=.022). Subjects in the upper tertile of IR were older and had longer TMT-B and DIFF B-A than participants in the lowest tertile. After adjusting for age, sex, and years of formal education, IR was significantly correlated with TMT-A, TMT-B, and DIFF B-A. After adjusting for age, sex, education, body mass index, waist:hip girth ratio, HDL-C, triglycerides, IGF-1, hypertension, drug intake, and physical activity, the results did not significantly change. After introducing MMSE score into the model, IR continued to be an independent determinant of TMT-A (beta=11.005; P=.021), TMT-B (beta=28.379; P<.001), and DIFF B-A (beta=17.374; P=.011). CONCLUSION:IR is independently associated with frontal cortex function evidenced by poor TMT times in older persons without DM or dementia.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Abbatecola AM,Paolisso G,Lamponi M,Bandinelli S,Lauretani F,Launer L,Ferrucci Ldoi
10.1111/j.1532-5415.2004.52466.xsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
1713-8issue
10eissn
0002-8614issn
1532-5415pii
JGS52466journal_volume
52pub_type
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journal_title：Journal of the American Geriatrics Society
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