Quality of life in patients with Alzheimer's disease as reported by patient proxies.

Abstract:

OBJECTIVE:To measure behaviors indicative of quality of life (QOL) in patients with Alzheimer's disease and to examine correlates of patient QOL. DESIGN:Cross-sectional investigation. SETTING:Multi-center study. PARTICIPANTS:Sample of 130 diagnosed patients. PRINCIPAL OUTCOME MEASURES: Proxy ratings of (1) the frequency, opportunity, and enjoyment of 15 non-ADL activities potentially within the capacity of a demented person, and (2) the frequency of a series of positive and negative affects, evident in clearly demarcated facial and bodily expressions. RESULTS:QOL ratings were reliably elicited. Family and institutional caregivers differed only in reports of opportunity for patient activity. Frequency of activities declined with increasing severity of dementia. The frequency of negative affects increased and positive affects declined with increasing severity of dementia, but correlations were weak. High QOL, defined by frequent activity and positive affect, was evident in a quarter of the sample. In multivariate models, functional and cognitive status independently predicted QOL among community-resident older adults; only absence of antipsychotics was related to QOL among older people in nursing homes. Patient education, a marker of premorbid state, independently predicted some activity patterns. CONCLUSIONS:Although the subjective world of the demented patient is not directly accessible, readily observable behaviors offer a basis for assessing QOL.

journal_name

J Am Geriatr Soc

authors

Albert SM,Del Castillo-Castaneda C,Sano M,Jacobs DM,Marder K,Bell K,Bylsma F,Lafleche G,Brandt J,Albert M,Stern Y

doi

10.1111/j.1532-5415.1996.tb01405.x

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1342-7

issue

11

eissn

0002-8614

issn

1532-5415

journal_volume

44

pub_type

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