Reviews of individual patient data (IPD) are useful for geriatrics: an overview of available IPD reviews.

Abstract:

OBJECTIVES:To determine how many individual patient data (IPD) reviews that included older people were available in MEDLINE and whether the effectiveness of treatments differed between older and younger individuals. DESIGN:Overview of IPD reviews. SETTING:A MEDLINE search was conducted for IPD reviews of randomized controlled trials published before July 2012. PARTICIPANTS:IPD reviews that presented a regression model that included age as a factor or a subgroup analysis of individuals aged 70 and older or in which all participants were aged 70 and older. MEASUREMENTS:Whether the IPD reviews reported similar conclusions for the younger and older populations was evaluated. RESULTS:Twenty-six IPD reviews with a subgroup of older individuals and eight reviews with only older individuals were included (median N = 3,351). The most important reason for choosing an IPD review was the ability to perform a subgroup analysis in the older population. Fourteen IPD reviews suggested that older people should receive different treatments from younger people because of differences in effectiveness, six of which indicated that the investigated treatment(s) should be avoided in older adults. CONCLUSION:IPD review is a valuable approach for generating evidence in older adults. Treatment effects frequently differed between older and younger individuals. Still, IPD results should be applied to older adults cautiously, because they are often excluded from primary trials. The collaborative sharing of raw data should be promoted to improve evidence-based decisions for this group.

journal_name

J Am Geriatr Soc

authors

van de Glind EM,Rhodius-Meester HF,Reitsma JB,Hooft L,van Munster BC

doi

10.1111/jgs.12830

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

1133-8

issue

6

eissn

0002-8614

issn

1532-5415

journal_volume

62

pub_type

杂志文章,评审
  • Racial differences in use of cancer prevention services among older Americans.

    abstract:CONTEXT:Racial differences in receipt of cancer prevention services may be related to poorer outcomes for minorities. Understanding reasons for such differences could help target appropriate interventions. OBJECTIVES:To determine if racial differences exist in the use of cancer prevention services among older blacks a...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2000.tb04746.x

    authors: Hegarty V,Burchett BM,Gold DT,Cohen HJ

    更新日期:2000-07-01 00:00:00

  • New or Worsening Symptoms and Signs in Community-Dwelling Persons with Dementia: Incidence and Relation to Use of Acute Medical Services.

    abstract:OBJECTIVES:To understand the range of symptoms that present to family caregivers of community-dwelling persons with Alzheimer's disease and related dementias (ADRD). DESIGN:Six-month longitudinal prospective study to identify the incidence of new or worsening symptoms and their association with acute care medical serv...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14672

    authors: Sloane PD,Schifeling CH,Beeber AS,Ward KT,Reed D,Gwyther LP,Matchar B,Zimmerman S

    更新日期:2017-04-01 00:00:00

  • Vitamin D deficiency in older people.

    abstract::Because of changes that occur with aging, older people with any other risk factors for vitamin D deficiency are likely to have inadequate stores of this vitamin. The consequences of vitamin D deficiency are likely to be losses in bone, strength, and function and the development of pain. Many questions remain regarding...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.1995.tb07059.x

    authors: Gloth FM 3rd,Tobin JD

    更新日期:1995-07-01 00:00:00

  • Cognitive performance correlates with cerebrovascular impairments in multi-infarct dementia.

    abstract::Cerebral blood flow (CBF) was measured by the 133Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Scre...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1986.tb04318.x

    authors: Judd BW,Meyer JS,Rogers RL,Gandhi S,Tanahashi N,Mortel KF,Tawaklna T

    更新日期:1986-05-01 00:00:00

  • Senile dementia, Alzheimer's type: the family and the health care delivery system.

    abstract::Senile dementia is one of the important medical-social-economic problems facing our society, estimated to affect some 60% of nursing home patients and of persons residing in the community. The course of dementia in these patients is affected not only by their age, medical complications, and the disease itself, but als...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1981.tb01261.x

    authors: Aronson MK,Lipkowitz R

    更新日期:1981-12-01 00:00:00

  • Lifestyle and the risk of dementia in Japanese-american men.

    abstract:OBJECTIVES:To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia. DESIGN:Case-control study nested in a prospective cohort. SETTING:The Honolulu-Asia Aging Study, Oahu, Hawaii. PARTICIPANTS:Three thousand four hundred sixty-eight Japanese-American men (mean age 52 in 1965-19...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03768.x

    authors: Gelber RP,Petrovitch H,Masaki KH,Abbott RD,Ross GW,Launer LJ,White LR

    更新日期:2012-01-01 00:00:00

  • Do pedometers increase physical activity in sedentary older women? A randomized controlled trial.

    abstract:OBJECTIVES:To determine the effectiveness of a behavior change intervention (BCI) with or without a pedometer in increasing physical activity in sedentary older women. DESIGN:Prospective randomized controlled trial. SETTING:Primary care, City of Dundee, Scotland. PARTICIPANTS:Two hundred four sedentary women aged 70...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2010.03127.x

    authors: McMurdo ME,Sugden J,Argo I,Boyle P,Johnston DW,Sniehotta FF,Donnan PT

    更新日期:2010-11-01 00:00:00

  • Restarting the cycle: incidence and predictors of first acute care use after nursing home discharge.

    abstract:OBJECTIVES:To describe the time to first acute care use (e.g., emergency department (ED) use without hospitalization or rehospitalization) for older adults discharged to home after receiving postacute care in skilled nursing facilities (SNFs); to identify predictors of first acute care use. DESIGN:Retrospective cohort...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12602

    authors: Toles M,Anderson RA,Massing M,Naylor MD,Jackson E,Peacock-Hinton S,Colón-Emeric C

    更新日期:2014-01-01 00:00:00

  • Changes in a Frailty Index and Association with Mortality.

    abstract:BACKGROUND:Although frailty status is dynamic, whether improvements in frailty predict mortality is unknown. OBJECTIVE:Describe 1-year changes in a frailty index (FI) and association with 48-month mortality. DESIGN:Secondary analysis of the National Health in Aging Trends Study. SETTING:Community. PARTICIPANTS:Five...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.17002

    authors: Shi SM,Olivieri-Mui B,McCarthy EP,Kim DH

    更新日期:2020-12-29 00:00:00

  • Polymorphonuclear functions and aging in humans.

    abstract::To determine whether normal aging interferes with the functional capability of polymorphonuclear leukocytes (PMNs), 6 tests of PMN function were performed in 285 healthy subjects whose ages ranged from 20 to 97 years. A second selection based upon blood measurement and a review of medical histories 6 months later, eli...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1981.tb02376.x

    authors: Corberand J,Ngyen F,Laharrague P,Fontanilles AM,Gleyzes B,Gyrard E,Senegas C

    更新日期:1981-09-01 00:00:00

  • Lesbian, Gay, Bisexual, and Transgender Older Adults' Experiences With Elder Abuse and Neglect.

    abstract:BACKGROUND/OBJECTIVES:Little is known about elder abuse and neglect in the lesbian, gay, bisexual, and transgender (LGBT) community; however, this population faces a greater risk of abuse and likely experiences abuse differently and needs different resources. We conducted focus groups to investigate LGBT older adults' ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgs.16101

    authors: Bloemen EM,Rosen T,LoFaso VM,Lasky A,Church S,Hall P,Weber T,Clark S

    更新日期:2019-11-01 00:00:00

  • The necessity and safety of calcium and vitamin D in the elderly.

    abstract::The necessity and safety of an oral calcium (Ca) and vitamin D regimen was evaluated in a population of 66 independently living and 73 institutionalized elderly women over an 11-week winter period. The members of both groups were randomly assigned into trial and control groups. Serum Ca, creatinine, and calcidiol leve...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.1990.tb05700.x

    authors: Honkanen R,Alhava E,Parviainen M,Talasniemi S,Mönkkönen R

    更新日期:1990-08-01 00:00:00

  • Sarcopenia: alternative definitions and associations with lower extremity function.

    abstract:OBJECTIVES:To compare two sarcopenia definitions and examine the relationship between them and lower extremity function and other health related factors using data from the baseline examination of the Health Aging and Body Composition (Health ABC) Study. DESIGN:Observational cohort study. SETTING:Two U.S. communities...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2003.51534.x

    authors: Newman AB,Kupelian V,Visser M,Simonsick E,Goodpaster B,Nevitt M,Kritchevsky SB,Tylavsky FA,Rubin SM,Harris TB,Health ABC Study Investigators.

    更新日期:2003-11-01 00:00:00

  • Effect of chronic disease-related symptoms and impairments on universal health outcomes in older adults.

    abstract:OBJECTIVES:To determine the extent to which disease-related symptoms and impairments, which constitute measures of disease severity or targets of therapy, account for the associations between chronic diseases and universal health outcomes. DESIGN:Cross-sectional. SETTING:The Cardiovascular Health Study (CHS) and the ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03576.x

    authors: Tinetti ME,McAvay G,Chang SS,Ning Y,Newman AB,Fitzpatrick A,Fried TR,Harris TB,Nevitt MC,Satterfield S,Yaffe K,Peduzzi P

    更新日期:2011-09-01 00:00:00

  • Predictors of Independent Aging and Survival: A 16-Year Follow-Up Report in Octogenarian Men.

    abstract:OBJECTIVES:To examine the longitudinal associations between aging with preserved functionality, i.e. independent aging and survival, and lifestyle variables, dietary pattern and cardiovascular risk factors. DESIGN:Cohort study. SETTING:Uppsala Longitudinal Study of Adult Men, Sweden. PARTICIPANTS:Swedish men (n = 1,...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14971

    authors: Franzon K,Byberg L,Sjögren P,Zethelius B,Cederholm T,Kilander L

    更新日期:2017-09-01 00:00:00

  • Informing clinical practice guideline development and implementation: prevalence of coexisting conditions among adults with coronary heart disease.

    abstract:OBJECTIVES:To describe the prevalence of coexisting conditions that affect clinical decision-making in adults with coronary heart disease (CHD). DESIGN:Cross-sectional. SETTING:National Health and Nutrition Examination Survey, 1999 to 2004. PARTICIPANTS:Eight thousand six hundred fifty-four people aged 45 and older;...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03391.x

    authors: Boyd CM,Leff B,Wolff JL,Yu Q,Zhou J,Rand C,Weiss CO

    更新日期:2011-05-01 00:00:00

  • Self-reported sleep and nap habits and risk of mortality in a large cohort of older women.

    abstract:OBJECTIVES:To determine the association between self-reported sleep and nap habits and mortality in a large cohort of older women. DESIGN:Study of Osteoporotic Fractures prospective cohort study. SETTING:Four communities within the United States. PARTICIPANTS:Eight thousand one hundred one Caucasian women aged 69 an...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1532-5415.2008.02171.x

    authors: Stone KL,Ewing SK,Ancoli-Israel S,Ensrud KE,Redline S,Bauer DC,Cauley JA,Hillier TA,Cummings SR

    更新日期:2009-04-01 00:00:00

  • Predicting intellectual level from the Mini-Mental State Examination.

    abstract::The Mini-Mental State Examination and the WAIS-R were administered to 105 patients in the early stages of Alzheimer's disease. MMSE scores correlated 0.83 with full scale IQ, which indicates that the MMSE may be a reasonable alternative measure of overall intellectual functioning in Alzheimer patients, for whom more e...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1988.tb04020.x

    authors: Farber JF,Schmitt FA,Logue PE

    更新日期:1988-06-01 00:00:00

  • Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.

    abstract:BACKGROUND/OBJECTIVES:Delirium is common in older adults, especially following hospitalization. Because low vitamin D levels may be associated with increased delirium risk, we aimed to determine the prognostic value of blood vitamin D levels, extending our previous genetic analyses of this relationship. DESIGN:Prospec...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16853

    authors: Pilling LC,Jones LC,Masoli JAH,Delgado J,Atkins JL,Bowden J,Fortinsky RH,Kuchel GA,Melzer D

    更新日期:2020-10-05 00:00:00

  • Advance directive preferences among subpopulations of Asian nursing home residents in the Pacific Northwest.

    abstract:OBJECTIVE:To study advance directives (code status) among subgroups of Asian nursing home residents. DESIGN:Cross-sectional design. PARTICIPANTS AND SETTING:A total of 423 residents of Asian descent (aged >55) from two ethnic nursing homes in Seattle, Washington. METHODS:Chart review was conducted on 423 residents (...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2000.tb05003.x

    authors: Vaughn G,Kiyasu E,McCormick WC

    更新日期:2000-05-01 00:00:00

  • Differences in the signs and symptoms of hyperthyroidism in older and younger patients.

    abstract:OBJECTIVES:To determine if aging modifies the clinical presentation of hyperthyroidism and the signs of thyrotoxicosis in older people. DESIGN:Prospective cohort study. SETTING:A French university hospital. SUBJECTS:Eighty-four new patients with overt hyperthyroidism confirmed chemically between January 1992 and Jan...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1996.tb05637.x

    authors: Trivalle C,Doucet J,Chassagne P,Landrin I,Kadri N,Menard JF,Bercoff E

    更新日期:1996-01-01 00:00:00

  • Serum IL-6 level and the development of disability in older persons.

    abstract:BACKGROUND:The serum concentration of interleukin 6 (IL-6), a cytokine that plays a central role in inflammation, increases with age. Because inflammation is a component of many age-associated chronic diseases, which often cause disability, high circulating levels of IL-6 may contribute to functional decline in old age...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1999.tb01583.x

    authors: Ferrucci L,Harris TB,Guralnik JM,Tracy RP,Corti MC,Cohen HJ,Penninx B,Pahor M,Wallace R,Havlik RJ

    更新日期:1999-06-01 00:00:00

  • Improving the quality of life for the elderly.

    abstract::The United States Senator from Maryland, as speaker at the Awards luncheon of the American Geriatrics Society (Washington meeting), presented his views on priorities in various health programs for the elderly, and asked for the Society's cooperation in making some of the difficult decisions that lie ahead. An importan...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1979.tb01672.x

    authors: Mathias CM Jr

    更新日期:1979-09-01 00:00:00

  • Age-related determinants of outcome after acute myocardial infarction: a dobutamine-atropine stress echocardiographic study.

    abstract:OBJECTIVES:To investigate the cause of worse survival in older patients after myocardial infarction (MI). DESIGN:Prospective 18-month and longer follow-up study of a cohort of 167 patients (mean age +/- standard deviation 58 +/- 12, including 71 aged >or=65) with acute MI for cardiac events, defined as cardiac death, ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2002.t01-1-50302.x

    authors: Smart S,Sagar K,Tresch D

    更新日期:2002-07-01 00:00:00

  • Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists.

    abstract:OBJECTIVES:To compare the risk of congestive heart failure (CHF) in elderly individuals treated with any peripheral alpha-1 antagonist for hypertension with any thiazide, test whether the risk persists in subjects without cardiovascular disease (CVD) at baseline, and examine CHF risk in normotensive men with prostatism...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52456.x

    authors: Bryson CL,Smith NL,Kuller LH,Chaves PH,Manolio TA,Lewis W,Boyko EJ,Furberg CD,Psaty BM

    更新日期:2004-10-01 00:00:00

  • Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial.

    abstract:OBJECTIVES:To investigate the effect of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation on quality of life (QOL). DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:Independently living individuals from the general older Dutch population. PARTICIPANTS:Three hundred two ind...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2009.02361.x

    authors: van de Rest O,Geleijnse JM,Kok FJ,van Staveren WA,Olderikkert MG,Beekman AT,de Groot LC

    更新日期:2009-08-01 00:00:00

  • Case-mix and quality indicators in Chinese elder care homes: are there differences between government-owned and private-sector facilities?

    abstract:OBJECTIVES:To assess the association between ownership of Chinese elder care facilities and their performance quality and to compare the case-mix profile of residents and facility characteristics in government-owned and private-sector homes. DESIGN:Cross-sectional study. SETTING:Census of elder care homes surveyed in...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12647

    authors: Liu C,Feng Z,Mor V

    更新日期:2014-02-01 00:00:00

  • Issues in clinical trials with the depressed elderly.

    abstract::Despite the fact that there is a high prevalence of depression among the elderly, little research on the efficacy of psychotherapy or pharmacotherapy with the elderly has been reported in the literature. This paper describes a sample of 18 elderly patients who received both psychotherapy and pharmacotherapy for the tr...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.1982.tb01982.x

    authors: Rothblum ED,Sholomskas AJ,Berry C,Prusoff BA

    更新日期:1982-11-01 00:00:00

  • Adult immunization in university-based primary care and specialty practices.

    abstract::The purpose of this study was to assess vaccination status of adults in primary and specialty care practices in a retrospective review of medical records from 1997 to 2000 at one university medical center. Eligible patients were aged 50 and older and had two or more visits to primary and specialty care practices (N=14...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52273.x

    authors: Daniels NA,Nguyen TT,Gildengorin G,Pérez-Stable EJ

    更新日期:2004-06-01 00:00:00

  • Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial.

    abstract:OBJECTIVES:To examine the effects of dehydroepiandrosterone (DHEA) supplementation on cognitive function and quality of life in healthy older adults. DESIGN:Double-blind, randomized, controlled clinical trial. SETTING:Clinical research facility. PARTICIPANTS:One hundred ten men and 115 women aged 55 to 85 (mean +/- ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2008.01768.x

    authors: Kritz-Silverstein D,von Mühlen D,Laughlin GA,Bettencourt R

    更新日期:2008-07-01 00:00:00