Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial.

Abstract:

OBJECTIVES:To investigate the effect of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation on quality of life (QOL). DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:Independently living individuals from the general older Dutch population. PARTICIPANTS:Three hundred two individuals aged 65 and older without depression or dementia. INTERVENTION:1,800 mg/d EPA-DHA (n=96), 400 mg/d EPA-DHA (n=100), or placebo capsules (n=106) for 26 weeks. MEASUREMENTS:QOL was assessed using the short version of the World Health Organization QOL questionnaire (WHOQOL-BREF). The WHOQOL-BREF covers four domains: physical health, psychological health, social relationships, and satisfaction with environment. The total score range is 26 to 130, with higher scores indicating a more favorable condition. RESULTS:Mean age of the participants was 70, and 55% were male. Plasma concentrations of EPA-DHA increased 238% in the high-dose and 51% in the low-dose EPA-DHA group, reflecting excellent adherence. Median baseline total WHOQOL scores ranged from 107 to 110 in the three groups and were not significantly different from each other. After 26 weeks, the mean difference from placebo was -1.42 (95% confidence interval (CI)=-3.40-0.57) for the high-dose and 0.02 (95% CI=-1.95-1.99) for the low-dose fish oil group. Treatment with 1,800 mg or 400 mg EPA-DHA did not affect total QOL or any of the separate domains after 13 or 26 weeks of intervention. CONCLUSION:Supplementation with high or low doses of fish oil for 26 weeks did not influence the QOL of healthy older individuals.

journal_name

J Am Geriatr Soc

authors

van de Rest O,Geleijnse JM,Kok FJ,van Staveren WA,Olderikkert MG,Beekman AT,de Groot LC

doi

10.1111/j.1532-5415.2009.02361.x

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

1481-6

issue

8

eissn

0002-8614

issn

1532-5415

pii

JGS2361

journal_volume

57

pub_type

杂志文章,随机对照试验
  • The neuropsychological differentiation of patients with very mild Alzheimer's disease and/or major depression.

    abstract:OBJECTIVE:To evaluate the usefulness of standardized neuropsychological tests in the psychometric differentiation of patients with very mild or mild Alzheimer's Disease (AD) and/or major depression presenting in a tertiary clinic with memory/attention complaints. DESIGN:Controlled prospective clinicoexperimental desig...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1532-5415.1995.tb07402.x

    authors: desRosiers G,Hodges JR,Berrios G

    更新日期:1995-11-01 00:00:00

  • Tracking clerkship experience: just what do clinical clerks see on an Elder Care rotation?

    abstract::The Schulich School of Medicine, University of Western Ontario, Canada, has created a mandatory clerkship in Elder Care that consists of small group seminars, clinical experiences, and an Elder Care manual. This article describes the use of a paper-based log to track students' clinical encounters to determine whether ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2007.01206.x

    authors: Diachun LL,Van Bussel L,Ens A,Dumbrell AC,Hillier LM

    更新日期:2007-07-01 00:00:00

  • Hallucinations of widowhood.

    abstract::Widowed residents of two nursing homes who were oriented to person, time, and place were interviewed to determine the extent to which they had hallucinatory experiences of their deceased spouse. Fifty-two interviews were completed with 46 widows and six widowers. Results are reported for the widows. Twenty-eight (61%)...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1985.tb04619.x

    authors: Olson PR,Suddeth JA,Peterson PJ,Egelhoff C

    更新日期:1985-08-01 00:00:00

  • Implementation of a care transitions model for low-income older adults: a high-risk, vulnerable population.

    abstract::Low-income older adults are particularly vulnerable during care transitions. The present study evaluated the effectiveness of a transitional care model in this population. A quasi-experimental design was used to compare outcomes in the intervention group with historical controls at 30, 90, 180, and 365 days after disc...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12276

    authors: Ohuabunwa U,Jordan Q,Shah S,Fost M,Flacker J

    更新日期:2013-06-01 00:00:00

  • A randomized, controlled trial of comprehensive geriatric assessment and multidisciplinary intervention after discharge of elderly from the emergency department--the DEED II study.

    abstract:OBJECTIVES:To study the effects of comprehensive geriatric assessment (CGA) and multidisciplinary intervention on elderly patients sent home from the emergency department (ED). DESIGN:Prospective, randomized, controlled trial with 18 months of follow-up. SETTING:Large medical school-affiliated public hospital in an u...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2004.52401.x

    authors: Caplan GA,Williams AJ,Daly B,Abraham K

    更新日期:2004-09-01 00:00:00

  • The metabolic effects of calcium supplementation in the elderly.

    abstract::Because the value of calcium supplementation in age-related bone loss is controversial, we conducted a study to examine the effects of six months of calcium supplementation on parathyroid hormone (PTH) and other indices of bone metabolism. Calcium carbonate (1.2 grams elemental calcium/day) or placebo was administered...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.1991.tb01625.x

    authors: Kochersberger G,Westlund R,Lyles KW

    更新日期:1991-02-01 00:00:00

  • Improving decision-making for feeding options in advanced dementia: a randomized, controlled trial.

    abstract:OBJECTIVES:To test whether a decision aid improves quality of decision-making about feeding options in advanced dementia. DESIGN:Cluster randomized controlled trial. SETTING:Twenty-four nursing homes in North Carolina. PARTICIPANTS:Residents with advanced dementia and feeding problems and their surrogates. INTERVEN...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1532-5415.2011.03629.x

    authors: Hanson LC,Carey TS,Caprio AJ,Lee TJ,Ersek M,Garrett J,Jackman A,Gilliam R,Wessell K,Mitchell SL

    更新日期:2011-11-01 00:00:00

  • Multimorbidity and Risk of Mild Cognitive Impairment.

    abstract:OBJECTIVES:To determine the association between multiple chronic conditions and risk of incident mild cognitive impairment (MCI) and dementia. DESIGN:Prospective cohort study. SETTING:Olmsted County, Minnesota. PARTICIPANTS:Cognitively normal individuals (N = 2,176) enrolled in the Mayo Clinic Study of Aging (MCSA)....

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.13612

    authors: Vassilaki M,Aakre JA,Cha RH,Kremers WK,St Sauver JL,Mielke MM,Geda YE,Machulda MM,Knopman DS,Petersen RC,Roberts RO

    更新日期:2015-09-01 00:00:00

  • Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes.

    abstract:OBJECTIVES:To determine the priority that older adults with coexisting hypertension and fall risk give to optimizing cardiovascular outcomes versus fall- and medication symptom-related outcomes. DESIGN:Interview. SETTING:Community. PARTICIPANTS:One hundred twenty-three cognitively intact persons aged 70 and older wi...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.01815.x

    authors: Tinetti ME,McAvay GJ,Fried TR,Allore HG,Salmon JC,Foody JM,Bianco L,Ginter S,Fraenkel L

    更新日期:2008-08-01 00:00:00

  • Kidney function as a predictor of loss of lean mass in older adults: health, aging and body composition study.

    abstract:OBJECTIVES:To assess the association between kidney function and change in body composition in older individuals. DESIGN:Prospective cohort study. SETTING:Two sites, Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS:Three thousand twenty-six well-functioning, participants aged 70 to 79 in the Health, Ag...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1532-5415.2007.01398.x

    authors: Fried LF,Boudreau R,Lee JS,Chertow G,Kurella-Tamura M,Shlipak MG,Ding J,Sellmeyer D,Tylavsky FA,Simsonick E,Kritchevsky SB,Harris TB,Newman AB,Health, Aging and Body Composition Study.

    更新日期:2007-10-01 00:00:00

  • An evaluative study of Silver's Cerebral Function Test.

    abstract::The aim of this study was to evaluate the usefulness of Silver's Cerebral Function Test in predicting the management and placement of patients admitted to a psychogeriatric hospital. Overall, 205 consecutively admitted patients and 54 age-matched controls living in the community were examined, thereby greatly extendin...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1977.tb00409.x

    authors: Ross N,de L Horne DJ

    更新日期:1977-06-01 00:00:00

  • Electronic Medication Administration Records in Long-Term Care Facilities: A Scoping Review.

    abstract:OBJECTIVES:To map the extent, range, and nature of research on the effectiveness, level of use, and perceptions about electronic medication administration records (eMARs) in long-term care facilities (LTCFs) and identify gaps in current knowledge and priority areas for future research. DESIGN:Scoping review of quantit...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/jgs.15384

    authors: Fuller AEC,Guirguis LM,Sadowski CA,Makowsky MJ

    更新日期:2018-07-01 00:00:00

  • Long-term systemic inflammation and cognitive impairment in a population-based cohort.

    abstract:OBJECTIVES:Evidence suggests inflammation is associated with cognitive impairment, but previous epidemiological studies have reported conflicting results. DESIGN:Prospective population-based cohort. SETTING:Epidemiology of Hearing Loss Study participants. PARTICIPANTS:Individuals without cognitive impairment in 1998...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12994

    authors: Wichmann MA,Cruickshanks KJ,Carlsson CM,Chappell R,Fischer ME,Klein BE,Klein R,Tsai MY,Schubert CR

    更新日期:2014-09-01 00:00:00

  • Medicare Expenditures of Individuals with Alzheimer's Disease and Related Dementias or Mild Cognitive Impairment Before and After Diagnosis.

    abstract:OBJECTIVES:To characterize Medicare expenditure and usage trends in individuals with a coded diagnosis of Alzheimer's disease and related dementia (ADRD) or mild cognitive impairment (MCI) during the periods leading up to and after diagnosis. DESIGN:Retrospective observational cohort study. SETTING:Five percent sampl...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14227

    authors: Lin PJ,Zhong Y,Fillit HM,Chen E,Neumann PJ

    更新日期:2016-08-01 00:00:00

  • Changing Trends in, and Characteristics Associated with, Not Undergoing Cardiac Catheterization in Elderly Adults Hospitalized with ST-Segment Elevation Acute Myocardial Infarction.

    abstract:OBJECTIVES:To describe decade- long trends (1999-2009) in the rates of not undergoing cardiac catheterization and percutaneous coronary intervention (PCI) in individuals aged 65 and older presenting with an ST-segment elevation acute myocardial infarction (STEMI) and factors associated with not undergoing these procedu...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgs.13399

    authors: Tisminetzky M,Erskine N,Chen HY,Gore J,Gurwitz J,Yarzebski J,Joffe S,Shaw P,Goldberg R

    更新日期:2015-05-01 00:00:00

  • Functional disability and nursing resource use are predictive of antimicrobial resistance in nursing homes.

    abstract:OBJECTIVES:To use a simple measure of activities of daily living, wounds, and indwelling devices (urinary catheter, feeding tube) to predict prevalent, new, and intermittent multidrug-resistant organism (MDRO) acquisition in nursing home (NH) residents. DESIGN:Secondary analysis, prospective cohort study. SETTING:Sou...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.13353

    authors: Min L,Galecki A,Mody L

    更新日期:2015-04-01 00:00:00

  • Treating geriatric depression: a 26-week interim analysis.

    abstract::Two concurrent studies of geriatric outpatients who received diagnoses of depression were conducted. In the first, patients were treated with one of two tricyclic antidepressants or with a placebo. In the second, patients were assigned to groups receiving either psychodynamic group therapy or cognitive-behavioral grou...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1982.tb01987.x

    authors: Jarvik LF,Mintz J,Steuer J,Gerner R

    更新日期:1982-11-01 00:00:00

  • An evaluation of an adapted U.S. model of pharmaceutical care to improve psychoactive prescribing for nursing home residents in northern ireland (fleetwood northern ireland study).

    abstract:OBJECTIVES:To test the effect of an adapted U.S. model of pharmaceutical care on prescribing of inappropriate psychoactive (anxiolytic, hypnotic, and antipsychotic) medications and falls in nursing homes for older people in Northern Ireland (NI). DESIGN:Cluster randomized controlled trial. SETTING:Nursing homes rando...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2009.02617.x

    authors: Patterson SM,Hughes CM,Crealey G,Cardwell C,Lapane KL

    更新日期:2010-01-01 00:00:00

  • Association between serum cholesterol and noncardiovascular mortality in older age.

    abstract:OBJECTIVES:To clarify the association between cholesterol and noncardiovascular mortality and to evaluate how this association varies across age groups. DESIGN:Prospective population-based cohort study. SETTING:Rotterdam, the Netherlands. PARTICIPANTS:Adults aged 55 to 99 (N = 5,750). MEASUREMENTS:Participants were...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03593.x

    authors: Newson RS,Felix JF,Heeringa J,Hofman A,Witteman JC,Tiemeier H

    更新日期:2011-10-01 00:00:00

  • An analysis of the use of the telephone in the management of patients in skilled nursing facilities.

    abstract:OBJECTIVE:To characterize the nature of telephone communication in the care of patients in skilled nursing facilities, noting numbers of calls, reasons for communication, and the outcomes of the interactions, and to implement a voice mail system to manage the burden of communication more effectively and describe the im...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1997.tb00980.x

    authors: Fowkes W,Christenson D,McKay D

    更新日期:1997-01-01 00:00:00

  • Effect of aging on serum albumin.

    abstract::Some studies have shown a negative association between age and serum albumin. Several of these studies included older people with known disease. Disease may reduce albumin in any age group. Other studies have shown no association between age and albumin. To investigate the association of age and albumin, albumin level...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1989.tb06917.x

    authors: Cooper JK,Gardner C

    更新日期:1989-11-01 00:00:00

  • The use of mammography by women aged 75 and older: factors related to health, functioning, and age.

    abstract:BACKGROUND AND OBJECTIVES:Mammographic screening for breast cancer is of uncertain clinical benefit for women 75 years of age and older. Some have argued against instituting routine screening in this age group, noting that disability and shorter life expectancy may diminish the desirability and cost-effectiveness of sc...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1998.tb02746.x

    authors: Blustein J,Weiss LJ

    更新日期:1998-08-01 00:00:00

  • The ethics committee in the nursing home. Results of a national survey.

    abstract::As the complexity, prevalence and visibility of ethical dilemmas in medical care of the elderly have grown, hospitals and nursing homes have attempted to develop mechanisms for responding to these difficult ethical issues. While it is known that many hospitals rely on education and advice provided by an ethics committ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1988.tb01786.x

    authors: Glasser G,Zweibel NR,Cassel CK

    更新日期:1988-02-01 00:00:00

  • Serum thyrotropin and thyroid hormone levels in elderly and middle-aged euthyroid persons.

    abstract:OBJECTIVE:To determine whether serum thyrotropin (TSH) levels are altered in euthyroid older persons compared with middle-aged adults. DESIGN:Serum TSH and thyroid hormone levels were measured in a large group of older persons (> 70 years old, n = 216) and their middle-aged offspring (40-60 years old, n = 211) after e...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1993.tb06177.x

    authors: Hershman JM,Pekary AE,Berg L,Solomon DH,Sawin CT

    更新日期:1993-08-01 00:00:00

  • Prognostic significance of potential frailty criteria.

    abstract:OBJECTIVES:To determine the independent prognostic effect of seven potential frailty criteria, including five from the Fried phenotype, on several adverse outcomes. DESIGN:Prospective cohort study. SETTING:Greater New Haven, Connecticut. PARTICIPANTS:Seven hundred fifty-four initially nondisabled, community-living p...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.02008.x

    authors: Rothman MD,Leo-Summers L,Gill TM

    更新日期:2008-12-01 00:00:00

  • Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy.

    abstract::In a 78-year-old woman receiving perhexiline maleate for intractable angina pectoris, a syndrome of parkinsonism and peripheral neuropathy developed. The neuropathy was confirmed by electromyographic and nerve conduction studies. The parkinsonism and peripheral neuropathy disappeared when perhexiline maleate was disco...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1981.tb02188.x

    authors: Gordon M,Gordon AS

    更新日期:1981-06-01 00:00:00

  • Maximizing Participant and Staff Safety During Assessment of Physical Function in the COVID-19 Era.

    abstract::Physical performance measures, including cardiopulmonary exercise testing (CPXT), are widely used in geriatric practice and aging research. Theoretically, research participants and study personnel could get infected in the closed environment of the exercise laboratory by contact with respiratory droplets from an infec...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16968

    authors: Storer TW,Latham NK,Bhasin S

    更新日期:2021-01-01 00:00:00

  • A Randomized Clinical Trial of Wheeled Mobility for Pressure Injury Prevention and Better Function.

    abstract:OBJECTIVES:To evaluate the effectiveness of wheelchair assessment and configuration on pressure injury incidence, mobility, and functioning in a wheelchair. DESIGN:Randomized controlled trial with participants individually randomized into intervention and control groups. SETTING:Nursing home. PARTICIPANTS:Nursing ho...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jgs.15495

    authors: Brienza DM,Karg PE,Bertolet M,Schmeler M,Poojary-Mazzotta P,Vlachos H,Wilkinson D

    更新日期:2018-09-01 00:00:00

  • Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine.

    abstract:OBJECTIVES:To estimate in a community-dwelling elderly population the magnitude of renal function misclassification, occurring when persons with normal serum creatinine have reduced glomerular filtration rate (GFR), and to describe the participant characteristics related to misclassification. DESIGN:Cross-sectional. ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2007.01196.x

    authors: Giannelli SV,Patel KV,Windham BG,Pizzarelli F,Ferrucci L,Guralnik JM

    更新日期:2007-06-01 00:00:00

  • Practicing physician education in geriatrics: lessons learned from a train-the-trainer model.

    abstract::Evidence of poor performance in the evaluation and management of common geriatric conditions suggests the need for changing physician behavior in these areas. Traditional lecture-style continuing medical education (CME) has not been shown to be effective. Expert faculty initially trained 60 nonexpert peer educators to...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2007.01205.x

    authors: Levine SA,Brett B,Robinson BE,Stratos GA,Lascher SM,Granville L,Goodwin C,Dunn K,Barry PP

    更新日期:2007-08-01 00:00:00