Polymorphonuclear functions and aging in humans.

Abstract:

:To determine whether normal aging interferes with the functional capability of polymorphonuclear leukocytes (PMNs), 6 tests of PMN function were performed in 285 healthy subjects whose ages ranged from 20 to 97 years. A second selection based upon blood measurement and a review of medical histories 6 months later, eliminated 68 subjects. The 217 remaining persons were sub-classed by age into 7 groups including equal numbers of males and females. The functional properties of PMNs in the aged, when compared to those of younger adults, were characterized by: (a) a decrease in the chemotactic response in the 80+ age group: (b) increased adherence, with onset after age 70, maximal after age 80; (c) a progressive decrease of NBT dye reduction capability, up to age 70-79, followed by an unexplained increase of the mean value after age 80; (d) diminished Candida-killing activity, appearing in the 60+ group and becoming lowest in the oldest group; and (e) lack of changes in spontaneous migration and endocytosis. The mechanisms by which this impairment occurs are hypothetical. It is proposed that normal PMNs, after leaving the bone marrow, are influenced by various humoral components such as metabolic byproducts or immune processes altered by aging. Thus the defective PMN may represent only another victim of the aging process.

journal_name

J Am Geriatr Soc

authors

Corberand J,Ngyen F,Laharrague P,Fontanilles AM,Gleyzes B,Gyrard E,Senegas C

doi

10.1111/j.1532-5415.1981.tb02376.x

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

391-7

issue

9

eissn

0002-8614

issn

1532-5415

journal_volume

29

pub_type

杂志文章
  • Correlation of pressure sores and nutritional status.

    abstract::As life expectancy increases, so do the problems of the elderly population. One major problem is that of protein calorie malnutrition; another is the susceptibility of this population to pressure sores. The purpose of this study was to determine if a correlation exists between deteriorating nutritional status and the ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1986.tb03411.x

    authors: Pinchcofsky-Devin GD,Kaminski MV Jr

    更新日期:1986-06-01 00:00:00

  • Development and evaluation of a modification of the Fried frailty criteria using population-independent cutpoints.

    abstract:OBJECTIVES:To develop and evaluate a modification of the Fried frailty assessment using population-independent cutpoints and to determine frailty prevalence of community-dwelling elderly people in a German population. DESIGN:Cross-sectional analysis of 8-year follow-up data of a large German cohort study. SETTING:Saa...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2012.04192.x

    authors: Saum KU,Müller H,Stegmaier C,Hauer K,Raum E,Brenner H

    更新日期:2012-11-01 00:00:00

  • The diagnosis of depression in the elderly.

    abstract::The reported prevalence of depressive symptomatology among the elderly ranges from 5 to 65 percent in hospital and community populations. Depression is considered the most common emotional disorder of advanced age. One of the chief diagnostic problems has been the lack of differentiation between disorders manifested b...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1980.tb00205.x

    authors: Blazer D

    更新日期:1980-02-01 00:00:00

  • Level and change in cognitive test scores predict risk of first stroke.

    abstract:OBJECTIVES:To determine whether cognitive test scores and cognitive decline predict incidence of first diagnosed stroke. DESIGN:Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.02132.x

    authors: DeFries T,Avendaño M,Glymour MM

    更新日期:2009-03-01 00:00:00

  • An analysis of the use of the telephone in the management of patients in skilled nursing facilities.

    abstract:OBJECTIVE:To characterize the nature of telephone communication in the care of patients in skilled nursing facilities, noting numbers of calls, reasons for communication, and the outcomes of the interactions, and to implement a voice mail system to manage the burden of communication more effectively and describe the im...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1997.tb00980.x

    authors: Fowkes W,Christenson D,McKay D

    更新日期:1997-01-01 00:00:00

  • Changes in elderly welfare hotel residents during a one-year period.

    abstract::After a one-year interval, a structured interview designed to assess the quality of life was again conducted with most of the tenants in a single-room occupancy hotel in New York City. Comparisons was made between the two sets of findings. During the year, a program had been in effect to provide social, psychiatric, r...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1975.tb00316.x

    authors: Plutchik R,McCarthy M,Hall BH

    更新日期:1975-06-01 00:00:00

  • Incidence of in-hospital falls in geriatric patients before and after the introduction of an interdisciplinary team-based fall-prevention intervention.

    abstract::Falls are among the most common unwanted events in older hospital inpatients, but evidence of effective prevention is still limited compared with that in the community and in long-term care facilities. This article describes a prevention program and its effects on the incidence of falls in geriatric hospital wards. It...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2007.01424.x

    authors: von Renteln-Kruse W,Krause T

    更新日期:2007-12-01 00:00:00

  • Reduced serum albumin concentration in the elderly: a report from the Boston Collaborative Drug Surveillance Program.

    abstract::The relation of serum albumin concentration to age was assessed in a series of hospitalized medical patients. Those with disease states (e.g., dysproteinemia, renal insufficiency, hepatic dysfunction, malnutrition) potentially associated with abnormal serum albumin levels were excluded, leaving a study population of 1...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1979.tb01715.x

    authors: Greenblatt DJ

    更新日期:1979-01-01 00:00:00

  • Effects of home-based primary care on Medicare costs in high-risk elders.

    abstract:OBJECTIVES:To determine the effect of home-based primary care (HBPC) on Medicare costs and mortality in frail elders. DESIGN:Case-control concurrent study using Medicare administrative data. SETTING:HBPC practice in Washington, District of Columbia. PARTICIPANTS:HBPC cases (n = 722) and controls (n = 2,161) matched ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12974

    authors: De Jonge KE,Jamshed N,Gilden D,Kubisiak J,Bruce SR,Taler G

    更新日期:2014-10-01 00:00:00

  • Does Physician Retirement Affect Patients? A Systematic Review.

    abstract:OBJECTIVES:Older patients that have aged with their doctors will likely experience their physician retiring. It is unclear if this interruption in continuity of care leaves patients at risk for adverse events or whether a new physician improves care. We sought to identify and synthesize findings from all articles exami...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16216

    authors: Lam K,Arnold CG,Savage RD,Stall NM,Zhu L,Wu W,Piggott K,Bronskill SE,Rochon PA

    更新日期:2020-03-01 00:00:00

  • Predictors of functional change: a longitudinal study of nondemented people aged 65 and older.

    abstract:OBJECTIVES:To identify factors associated with functional change in an older population and investigate interactions among selected potential risk factors. DESIGN:A population-based prospective cohort study. SETTING:A random sample was selected from the Group Health Cooperative members in the Seattle area from 1994 t...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1532-5415.2002.50408.x

    authors: Wang L,van Belle G,Kukull WB,Larson EB

    更新日期:2002-09-01 00:00:00

  • Drug therapy for cardiovascular disease in the aged.

    abstract::Cardiovascular diseases and their treatment in the aged are discussed under the headings of ischemic heart disease, hypertension, cardiac failure (with special reference to the use of diuretics and digoxin), infective carditis and thyroid disorders. Advanced age modifies the approach to treatment; the choice of drugs ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.1975.tb00970.x

    authors: Kennedy RD

    更新日期:1975-03-01 00:00:00

  • Using the Mini-Mental State Examination for tracking cognition in the older population based on longitudinal data.

    abstract:OBJECTIVES:To estimate population norms for use in assessment of individuals in relation to their age-matched peers using true longitudinal patterns of decline. DESIGN:Longitudinal study of 10 years of follow-up data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) on the most commonly ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1532-5415.2007.01216.x

    authors: Chatfield M,Matthews FE,Brayne C,Medical Research Council Cognitive Function and Ageing Study.

    更新日期:2007-07-01 00:00:00

  • Insulin resistance and executive dysfunction in older persons.

    abstract:OBJECTIVES:To evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia. DESIGN:Cross-sectional study. SETTING:Outpatient clinic in Greve in Chianti and Bagno a Ripoli, Italy. PARTICIPANTS:A total ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52466.x

    authors: Abbatecola AM,Paolisso G,Lamponi M,Bandinelli S,Lauretani F,Launer L,Ferrucci L

    更新日期:2004-10-01 00:00:00

  • Prevalence of cognitive impairment in older adults with heart failure.

    abstract:OBJECTIVES:To determine the prevalence of cognitive impairment in older adults with heart failure (HF). DESIGN:Cross-sectional analysis of the 2004 wave of the nationally representative Health and Retirement Study linked to 2002 to 2004 Medicare administrative claims. SETTING:United States, community. PARTICIPANTS:S...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2012.04097.x

    authors: Gure TR,Blaum CS,Giordani B,Koelling TM,Galecki A,Pressler SJ,Hummel SL,Langa KM

    更新日期:2012-09-01 00:00:00

  • Morbidity, disability, and health status of black American elderly: a new look at the oldest-old.

    abstract::There are over 2.5 million black Americans aged 65 and over living in the United States today, including some 258,000 persons aged 85 years and over. The post-World War II baby boom within the US black population should ensure that the numbers of persons aged 65 and over will increase into the 21st Century. If present...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1992.tb04485.x

    authors: Miles TP,Bernard MA

    更新日期:1992-10-01 00:00:00

  • Logical bases for action in nutrition and aging.

    abstract::Logical bases (five of which are outlined) underlie action in nutrition and aging. First, nutrition, health, and aging form an integral triad affecting all. This basis has been applied to the conceptualization of the Nutrition Program for Older Americans (NPOA). Second, in North America, malnutrition is a sequitur of ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1978.tb01958.x

    authors: Watkin DM

    更新日期:1978-05-01 00:00:00

  • Educational interventions to improve recognition of delirium: a systematic review.

    abstract::Delirium is a common and serious condition that is underrecognized in older adults in a variety of healthcare settings. It is poorly recognized because of deficiencies in provider knowledge and its atypical presentation. Early recognition of delirium is warranted to better manage the disease and prevent the adverse ou...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/jgs.12522

    authors: Yanamadala M,Wieland D,Heflin MT

    更新日期:2013-11-01 00:00:00

  • Strategies for obtaining compliance with medications regimens.

    abstract::Case examples of doctor-patient interactions are used to examine educational strategies employed by physicians to obtain compliance with medication regimens from elderly patients. The problems addressed by the physicians included the complexities of pharmaco-therapy in the elderly (the patients each presented multiple...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1984.tb06138.x

    authors: Coe RM,Prendergast CG,Psathas G

    更新日期:1984-08-01 00:00:00

  • Septic arthritis in patients aged 80 and older: a comparison with younger adults.

    abstract:OBJECTIVES:To compare the frequency and characteristics of septic arthritis in patients younger than 80 and aged 80 and older. DESIGN:Retrospective. SETTING:Single hospital center. PARTICIPANTS:Patients admitted between 1979 and 2002 for septic arthritis. MEASUREMENTS:Age, sex, time to diagnosis, predisposing facto...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2005.53373.x

    authors: Gavet F,Tournadre A,Soubrier M,Ristori JM,Dubost JJ

    更新日期:2005-07-01 00:00:00

  • Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.

    abstract:BACKGROUND/OBJECTIVES:The extent to which the prevalence of muscle weakness in the US population varies by different putative grip strength constructs developed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) has not been described. DESIGN:Cross-sectional analysis. SETTING:Two nationally representative c...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16419

    authors: Patel SM,Duchowny KA,Kiel DP,Correa-de-Araujo R,Fielding RA,Travison T,Magaziner J,Manini T,Xue QL,Newman AB,Pencina KM,Santanasto AJ,Bhasin S,Cawthon PM

    更新日期:2020-07-01 00:00:00

  • A geriatric-anesthesiologic program to reduce acute confusional states in elderly patients treated for femoral neck fractures.

    abstract::The aim of this study was to evaluate the effect of a geriatric-anesthesiologic intervention program for the prevention and treatment of acute confusional states (ACS) in elderly patients treated for femoral neck fractures. The intervention program was based on the results of previous prospective studies in similar pa...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1991.tb03618.x

    authors: Gustafson Y,Brännström B,Berggren D,Ragnarsson JI,Sigaard J,Bucht G,Reiz S,Norberg A,Winblad B

    更新日期:1991-07-01 00:00:00

  • The geriatric floating interdisciplinary transition team.

    abstract::Older adults often receive suboptimal care during hospitalizations and transitions to postacute settings. Inpatient geriatric services have been shown to increase care quality but have not improved patient outcomes consistently. Acute Care for the Elderly units improve patient outcomes but are resource intensive. Tran...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02682.x

    authors: Arbaje AI,Maron DD,Yu Q,Wendel VI,Tanner E,Boult C,Eubank KJ,Durso SC

    更新日期:2010-02-01 00:00:00

  • Objectively Measured Physical Activity Reduces the Risk of Mortality among Brazilian Older Adults.

    abstract:OBJECTIVES:Use of objectively measured physical activity (PA) in older adults to assess relationship between PA and risk of all-causes mortality is scarce. This study evaluated the associations of PA based on accelerometry and a questionnaire with the risk of mortality among older adults from a city in Southern Brazil....

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16180

    authors: Bielemann RM,LaCroix AZ,Bertoldi AD,Tomasi E,Demarco FF,Gonzalez MC,Crespo da Silva PA,Wendt A,Mohnsam da Silva IC,Brage S,Ekelund U,Pratt M

    更新日期:2020-01-01 00:00:00

  • Nurse Practitioners and Physician Assistants: An Underestimated Workforce for Older Adults with Cancer.

    abstract:OBJECTIVES:To describe the composition of the US provider workforce for adults with cancer older than 65 years and to determine whether there were differences in patients who received care from different providers (eg, nurse practitioners [NPs], physician assistants [PAs], and specialty physicians). DESIGN:Observation...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15931

    authors: Coombs LA,Max W,Kolevska T,Tonner C,Stephens C

    更新日期:2019-07-01 00:00:00

  • Infections in long-term care populations in the United States.

    abstract:OBJECTIVES:To estimate infection prevalence and explore associated risk factors in nursing home (NH) residents, individuals receiving home health care (HHC), and individuals receiving hospice care. DESIGN:Cross-sectional. SETTING:Nationally representative samples of 1,174 U.S. NHs in the 2004 National Nursing Home Su...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgs.12153

    authors: Dwyer LL,Harris-Kojetin LD,Valverde RH,Frazier JM,Simon AE,Stone ND,Thompson ND

    更新日期:2013-03-01 00:00:00

  • Greater risk of dementia when spouse has dementia? The Cache County study.

    abstract:OBJECTIVES:To examine the effects of caring for a spouse with dementia on the caregiver's risk for incident dementia. DESIGN:Population-based study of incident dementia in spouses of persons with dementia. SETTING:Rural county in northern Utah. PARTICIPANTS:Two thousand four hundred forty-two subjects (1,221 married...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2010.02806.x

    authors: Norton MC,Smith KR,Østbye T,Tschanz JT,Corcoran C,Schwartz S,Piercy KW,Rabins PV,Steffens DC,Skoog I,Breitner JC,Welsh-Bohmer KA,Cache County Investigators.

    更新日期:2010-05-01 00:00:00

  • Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters.

    abstract:OBJECTIVES:To investigate the association between different types of physical activity behavior and incident mobility limitation in older men and women and to examine whether muscle parameters mediate these associations. DESIGN:Cohort study with 4.5-year follow-up. SETTING:Metropolitan areas surrounding Pittsburgh, P...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2005.53257.x

    authors: Visser M,Simonsick EM,Colbert LH,Brach J,Rubin SM,Kritchevsky SB,Newman AB,Harris TB,Health ABC Study.

    更新日期:2005-05-01 00:00:00

  • The Association Between Low-Density Lipoprotein Cholesterol and Incident Atherosclerotic Cardiovascular Disease in Older Adults: Results From the National Institutes of Health Pooled Cohorts.

    abstract:BACKGROUND/OBJECTIVES:Elevated low-density lipoprotein cholesterol (LDL-C) in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). The strength of the association between LDL-C and ASCVD among older adults, however, is less understood. DESIGN:We examined individual-level...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16123

    authors: Nanna MG,Navar AM,Wojdyla D,Peterson ED

    更新日期:2019-12-01 00:00:00

  • Prosopo-affective agnosia and computerized tomography findings in patients with cerebral disorders.

    abstract::Thirty-nine male patients (median age 61, range 19-92) from a neurologic ward were examined by a test for prosopo-affective agnosia (PAA), i.e., impairment in the recognition of facial affect (emotions) with no impairment in the recognition of facial features (PA, prosopo-agnosia). The scores for patients without hemi...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1980.tb01123.x

    authors: Kurucz J,Soni A,Feldmar G,Slade WR

    更新日期:1980-10-01 00:00:00