当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN GERIATRICS SOCIETY期刊下所有文献 > Predictors of functional change: a longitudinal study of nondemented people aged 65 and older.

Predictors of functional change: a longitudinal study of nondemented people aged 65 and older.

Abstract：

OBJECTIVES:To identify factors associated with functional change in an older population and investigate interactions among selected potential risk factors. DESIGN:A population-based prospective cohort study. SETTING:A random sample was selected from the Group Health Cooperative members in the Seattle area from 1994 to 1996 and followed biennially. PARTICIPANTS:Two thousand five hundred eighty-one people aged 65 and older, cognitively intact at baseline. MEASUREMENTS:Functional status was measured by activities of daily living, instrumental activities of daily living, and performance-based physical function testing. RESULTS:The cohort status at the time of these analyses was: deceased, 391; withdrawn, 179; dementia, 152; and on study, 1,873. The mean follow-up time was 3.4 years. Using linear regressions with Generalized Estimating Equation, selected medical conditions (diabetes mellitus, hypertension, coronary heart disease, cerebrovascular disease (CVD), osteoporosis, arthritis, and cancer), low cognitive function, depression, and smoking were associated with worse functional outcomes. Exercise and moderate alcohol use were associated with better functional outcomes. Over the follow-up period, coronary heart disease, CVD, and depression were associated with increased rates of functional decline. Exercise and moderate alcohol consumption were associated with decreased rates of functional decline. Significant interactions were observed between exercise and coronary heart disease, moderate alcohol use and CVD, and cognition and CVD. CONCLUSIONS:Our study has identified not only risk factors associated with functional decline but also the interactions among these factors. These observations, along with other published research, add to the growing understanding of the underlying process of functional change and could provide a basis to design effective strategies to delay functional decline.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Wang L,van Belle G,Kukull WB,Larson EB

doi

10.1046/j.1532-5415.2002.50408.x

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1525-34

issue

eissn

0002-8614

issn

1532-5415

pii

jgs50408

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

在线工具

Predictors of functional change: a longitudinal study of nondemented people aged 65 and older.