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Association Between Cognitive Impairment and Chronic Kidney Disease in Mexican Americans.

Abstract：

OBJECTIVES:To analyze the association between chronic kidney disease (CKD) and mild cognitive impairment (MCI) in Mexican Americans and to determine whether there is a blood-based proteomic profile linking CKD to MCI. DESIGN:Retrospective analysis of cohort study. SETTING:Health and Aging Brain among Latino Elders study. PARTICIPANTS:Mexican Americans (N = 437, 105 men, 332 women). MEASUREMENTS:Data were analyzed to examine the link between estimated glomerular filtration rate (eGFR) and detailed neuropsychological functioning. Serum proteomic markers were also examined. RESULTS:Lower eGFR levels were associated with significantly poorer neuropsychological functioning across multiple domains. After adjusting for age, sex, education, and diabetes mellitus, participants with an eGFR less than 45 mL/min per 1.73 m(2) performed significantly worse than those with an eGFR from 45 to 59 mL/min per 1.73 m(2) or 60 mL/min per 1.73 m(2) and higher in processing speed (F = 14.1, P < .001), executive functioning (F = 4.5, P = .01), visuospatial skills (F = 4.8, P = .009), and global cognitive functioning (F = 6.2, P = .002). Participants with an eGFR less than 45 mL/min per 1.73 m(2) also performed significantly worse than those with an eGFR of 60 mL/min per 1.73 m(2) or greater on delayed memory (F = 3.8, P = .02). There was a trend toward lower eGFR levels being associated with greater risk of MCI (odds ratio (OR) = 2.4, 95% confidence interval (CI) = 0.91-6.1, P = .07), which was stronger for men (OR = 9.6, 95% CI = 1.3-74.3, P = .03). A serum proteomic profile consisting of Factor VII, interleukin-10, C-reactive protein, and fatty acid binding protein was 93% accurate in detecting CKD-related MCI. CONCLUSION:Lower eGFR was associated with significantly poorer neuropsychological functioning in Mexican Americans. A blood-based profile was generated that was highly accurate in detecting CKD-related MCI. A blood profile capable of predicting CKD-related cognitive impairment would be of benefit for the design of clinical interventions.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Szerlip HM,Edwards ML,Williams BJ,Johnson LA,Vintimilla RM,O'Bryant SE

doi

10.1111/jgs.13665

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

2023-8

issue

eissn

0002-8614

issn

1532-5415

journal_volume

pub_type

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Association Between Cognitive Impairment and Chronic Kidney Disease in Mexican Americans.