当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN GERIATRICS SOCIETY期刊下所有文献 > Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia.

Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia.

Abstract：

OBJECTIVES:To examine the risk associated with the use of proton pump inhibitors (PPIs) of conversion to mild cognitive impairment (MCI), dementia, and specifically Alzheimer's disease (AD). DESIGN:Observational, longitudinal study. SETTING:Tertiary academic Alzheimer's Disease Centers funded by the National Institute on Aging. PARTICIPANTS:Research volunteers aged 50 and older with two to six annual visits; 884 were taking PPIs at every visit, 1,925 took PPIs intermittently, and 7,677 never reported taking PPIs. All had baseline normal cognition or MCI. MEASUREMENTS:Multivariable Cox regression analyses evaluated the association between PPI use and annual conversion of baseline normal cognition to MCI or dementia or annual conversion of baseline MCI to dementia, controlling for demographic characteristics, vascular comorbidities, mood, and use of anticholinergics and histamine-2 receptor antagonists. RESULTS:Continuous (always vs never) PPI use was associated with lower risk of decline in cognitive function (hazard ratio (HR) = 0.78, 95% confidence interval (CI) =0.66-0.93, P = .005) and lower risk of conversion to MCI or AD (HR = 0.82, 95% CI = 0.69-0.98, P = .03). Intermittent use was also associated with lower risk of decline in cognitive function (HR = 0.84, 95% CI = 0.76-0.93, P = .001) and risk of conversion to MCI or AD (HR = 0.82, 95% CI = 0.74-0.91, P = .001). This lower risk was found for persons with normal cognition or MCI. CONCLUSION:Proton pump inhibitors were not associated with greater risk of dementia or of AD, in contrast to recent reports. Study limitations include reliance on self-reported PPI use and lack of dispensing data. Prospective studies are needed to confirm these results to guide empirically based clinical treatment recommendations.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Goldstein FC,Steenland K,Zhao L,Wharton W,Levey AI,Hajjar I

doi

10.1111/jgs.14956

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1969-1974

issue

9

eissn

0002-8614

issn

1532-5415

journal_volume

65

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY文献大全
  • The use of mammography by women aged 75 and older: factors related to health, functioning, and age.

    abstract：BACKGROUND AND OBJECTIVES:Mammographic screening for breast cancer is of uncertain clinical benefit for women 75 years of age and older. Some have argued against instituting routine screening in this age group, noting that disability and shorter life expectancy may diminish the desirability and cost-effectiveness of sc...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1998.tb02746.x

    authors： Blustein J,Weiss LJ

    更新日期：1998-08-01 00:00:00

  • Genetic variant of lactase-persistent C/T-13910 is associated with bone fractures in very old age.

    abstract：OBJECTIVES:To determine the relation between the C/T(-13910) single-nucleotide polymorphism residing 13,910 base pairs from the 5' end of the lactase gene associated with lactase persistence and the occurrence of bone fractures in elderly people. DESIGN:Population-based study. SETTING:Vantaa 85+ population-based stud...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2005.53014.x

    authors： Enattah NS,Sulkava R,Halonen P,Kontula K,Järvelä I

    更新日期：2005-01-01 00:00:00

  • Correlates of kyphosis in older women. The Fracture Intervention Trial Research Group.

    abstract：OBJECTIVE:To determine the association between kyphosis (degree of forward curvature of the thoracic spine) and measures of spinal osteoporosis (height loss and vertebral fractures) and chronic back pain and disability in older women. DESIGN:A cross-sectional study. SETTING:Eleven clinical centers in the United State...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1997.tb01470.x

    authors： Ensrud KE,Black DM,Harris F,Ettinger B,Cummings SR

    更新日期：1997-06-01 00:00:00

  • Educational interventions to improve recognition of delirium: a systematic review.

    abstract：:Delirium is a common and serious condition that is underrecognized in older adults in a variety of healthcare settings. It is poorly recognized because of deficiencies in provider knowledge and its atypical presentation. Early recognition of delirium is warranted to better manage the disease and prevent the adverse ou...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,评审

    doi：10.1111/jgs.12522

    authors： Yanamadala M,Wieland D,Heflin MT

    更新日期：2013-11-01 00:00:00

  • Candidacy for kidney transplantation of older adults.

    abstract：OBJECTIVES:To develop a prediction model for kidney transplantation (KT) outcomes specific to older adults with end-stage renal disease (ESRD) and to use this model to estimate the number of excellent older KT candidates who lack access to KT. DESIGN:Secondary analysis of data collected by the United Network for Organ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 社论,多中心研究

    doi：10.1111/j.1532-5415.2011.03652.x

    authors： Grams ME,Kucirka LM,Hanrahan CF,Montgomery RA,Massie AB,Segev DL

    更新日期：2012-01-01 00:00:00

  • Intentional prescription nonadherence (noncompliance) by the elderly.

    abstract：:Prescription drugs are not always taken as directed. When there is a discrepancy between the use of a drug and the prescription directions, the drug-taking behavior is considered "nonadherent." To determine the extent of prescription non adherence by old persons and the reasons for nonadherence, an in-home survey was ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1982.tb05623.x

    authors： Cooper JK,Love DW,Raffoul PR

    更新日期：1982-05-01 00:00:00

  • Self-report of difficulty in performing functional activities identifies a broad range of disability in old age.

    abstract：OBJECTIVE:To describe a broad range of physical disability by examining the association between a four-level measure of disability, based on self-report of difficulty in performing functional activities, and previously identified risk factors for disability. DESIGN:Cross-sectional. SETTING:Community-based. PARTICIPA...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1996.tb04065.x

    authors： Langlois JA,Maggi S,Harris T,Simonsick EM,Ferrucci L,Pavan M,Sartori L,Enzi G

    更新日期：1996-12-01 00:00:00

  • Endothelial function in healthy younger and older hyperhomocysteinemic subjects.

    abstract：OBJECTIVES:To compare endothelium-dependent vasomotor response in healthy younger and older subjects without classic cardiovascular risk factors, with high and normal fasting homocysteine (tHcy) levels. DESIGN:We compared endothelium-dependent vasodilatation, using ultrasound, in healthy younger (aged 18-40) and older...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1046/j.1532-5415.2002.50255.x

    authors： Hirsch S,de la Maza P,Mendoza L,Petermann M,Glasinovic A,Paulinelli P,Barrera G,Rosenberg IH,Bunout D

    更新日期：2002-06-01 00:00:00

  • Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

    abstract：OBJECTIVES:To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality. DESIGN:Cross-sectional study. SETTING:Baltimore Longitudinal Study of Aging. PARTICIPANTS...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.12653

    authors： Moore AZ,Caturegli G,Metter EJ,Makrogiannis S,Resnick SM,Harris TB,Ferrucci L

    更新日期：2014-02-01 00:00:00

  • A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia.

    abstract：OBJECTIVES:To determine the efficacy of antidepressants in people with depression and dementia. DESIGN:A systematic review and meta-analysis based on a literature search of Medline and Cochrane Trials Registry for acute-phase, double-blind, placebo-controlled, parallel-design, random-assignment trials of antidepressan...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/j.1532-5415.2011.03355.x

    authors： Nelson JC,Devanand DP

    更新日期：2011-04-01 00:00:00

  • Disparities in influenza vaccine coverage in the United States, 2008.

    abstract：OBJECTIVES:To determine the distribution of influenza vaccine coverage in the United States in 2008. DESIGN:Cross-sectional analysis. SETTING:The 2008 Behavioral Risk Factor Surveillance Survey, which employs random-digit dialing to interview noninstitutionalized adults in the United States and territories. PARTICIP...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2010.02904.x

    authors： Linn ST,Guralnik JM,Patel KV

    更新日期：2010-07-01 00:00:00

  • Postantibiotic colonization with Clostridium difficile in nursing home patients.

    abstract：:Clostridium difficile causes pseudomembranous colitis and is responsible for 20% to 25% of cases of postantibiotic diarrhea. In an earlier study, nursing-home patients with C. difficile infection were noted to have a high mortality rate. Because most of these infected patients had been treated with antibiotics, it was...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1990.tb03539.x

    authors： Thomas DR,Bennett RG,Laughon BE,Greenough WB 3rd,Bartlett JG

    更新日期：1990-04-01 00:00:00

  • The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 1: comparison of therapeutic efficacy.

    abstract：:The long-held belief that outcome data from intervention trials in men are generalizable to women has created the framework in which the primary prevention of coronary heart disease (CHD) in women is viewed, but over the past decade, data have accumulated to refute such a supposition of generalizability. These lines o...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,评审

    doi：10.1111/jgs.12140

    authors： Hodis HN,Mack WJ

    更新日期：2013-06-01 00:00:00

  • Comparative Effectiveness of Medication Therapy Management Eligibility Criteria Across Racial/Ethnic Groups.

    abstract：BACKGROUND/OBJECTIVES:Previous research indicates that eligibility criteria for medication therapy management (MTM) services in Medicare prescription drug (Part D) plans, defined under the Medicare Modernization Act (MMA), are associated with racial/ethnic disparities and ineffective in identifying individuals with med...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.15754

    authors： Spivey CA,Qiao Y,Wang J,Shih YT,Wan JY,Dagogo-Jack S,Cushman WC,Hines LE,Chisholm-Burns MA

    更新日期：2019-03-01 00:00:00

  • Increasing dietary protein requirements in elderly people for optimal muscle and bone health.

    abstract：:Osteoporosis and sarcopenia are degenerative diseases frequently associated with aging. The loss of bone and muscle results in significant morbidity, so preventing or attenuating osteoporosis and sarcopenia is an important public health goal. Dietary protein is crucial for development of bone and muscle, and recent ev...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 历史文章,杂志文章

    doi：10.1111/j.1532-5415.2009.02285.x

    authors： Gaffney-Stomberg E,Insogna KL,Rodriguez NR,Kerstetter JE

    更新日期：2009-06-01 00:00:00

  • Diagnosis and characteristics of syncope in older patients referred to geriatric departments.

    abstract：OBJECTIVES:To test the applicability and safety of a standardized diagnostic algorithm in geriatric departments and to define the prevalence of different causes of syncope in older patients. DESIGN:Multicenter cross-sectional observational study. SETTING:In-hospital geriatric acute care departments and outpatient cli...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1532-5415.2006.00891.x

    authors： Ungar A,Mussi C,Del Rosso A,Noro G,Abete P,Ghirelli L,Cellai T,Landi A,Salvioli G,Rengo F,Marchionni N,Masotti G,Italian Group for the Study of Syncope in the Elderly.

    更新日期：2006-10-01 00:00:00

  • Prevention of falls in the elderly.

    abstract：:To prevent falls effectively, one must first understand the underlying reasons. Although environmental factors are sometimes to blame, the fundamental cause is a decline in postural control which is partly age-related and partly due to pathologic changes in the central nervous system. Dizziness is a common complaint a...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1980.tb01125.x

    authors： Overstall PW

    更新日期：1980-11-01 00:00:00

  • The unknown profession: a geriatrician.

    abstract：:The term "plastic surgeon" is oddly uninformative, although it seems likely that most people know what plastic surgeons do. How well can a sample of individuals encountered on the street describe what geriatricians do? To answer this question, we strolled through downtown Baltimore's Inner Harbor, armed with a video c...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.12115

    authors： Campbell JY,Durso SC,Brandt LE,Finucane TE,Abadir PM

    更新日期：2013-03-01 00:00:00

  • Effectiveness of multidimensional exercises for the treatment of stress urinary incontinence in elderly community-dwelling Japanese women: a randomized, controlled, crossover trial.

    abstract：OBJECTIVES:To evaluate the effectiveness of pelvic floor muscle (PFM) and fitness exercises in reducing urine leakage in elderly women with stress urinary incontinence (UI). DESIGN:Randomized, crossover, follow-up trial. SETTING:Urban community in Japan. PARTICIPANTS:Seventy women aged 70 and older who reported urin...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1532-5415.2007.01447.x

    authors： Kim H,Suzuki T,Yoshida Y,Yoshida H

    更新日期：2007-12-01 00:00:00

  • Effects of a modified Hospital Elder Life Program on frailty in individuals undergoing major elective abdominal surgery.

    abstract：OBJECTIVES:To test the effects of a modified Hospital Elder Life Program (mHELP) on frailty. DESIGN:Matched and unmatched analyses of data from a before-and-after study. SETTING:Hospital, inpatient. PARTICIPANTS:Participants aged 65 and older (n = 189) undergoing major elective abdominal surgery at a medical center ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.12651

    authors： Chen CC,Chen CN,Lai IR,Huang GH,Saczynski JS,Inouye SK

    更新日期：2014-02-01 00:00:00

  • New or Worsening Symptoms and Signs in Community-Dwelling Persons with Dementia: Incidence and Relation to Use of Acute Medical Services.

    abstract：OBJECTIVES:To understand the range of symptoms that present to family caregivers of community-dwelling persons with Alzheimer's disease and related dementias (ADRD). DESIGN:Six-month longitudinal prospective study to identify the incidence of new or worsening symptoms and their association with acute care medical serv...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.14672

    authors： Sloane PD,Schifeling CH,Beeber AS,Ward KT,Reed D,Gwyther LP,Matchar B,Zimmerman S

    更新日期：2017-04-01 00:00:00

  • Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters.

    abstract：OBJECTIVES:To investigate the association between different types of physical activity behavior and incident mobility limitation in older men and women and to examine whether muscle parameters mediate these associations. DESIGN:Cohort study with 4.5-year follow-up. SETTING:Metropolitan areas surrounding Pittsburgh, P...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1532-5415.2005.53257.x

    authors： Visser M,Simonsick EM,Colbert LH,Brach J,Rubin SM,Kritchevsky SB,Newman AB,Harris TB,Health ABC Study.

    更新日期：2005-05-01 00:00:00

  • Building a Culturally Competent Workforce to Care for Diverse Older Adults: Scope of the Problem and Potential Solutions.

    abstract：:The population of minority older adults is going to explode over the next four decades. Older adults from racial and ethnic minorities face persistent and pervasive health disparities. Health disparities exert a huge fiscal burden on the nation. The national financial cost of health disparities for the years 2002 to 2...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.15939

    authors： Periyakoil VS

    更新日期：2019-05-01 00:00:00

  • Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort.

    abstract：OBJECTIVES:To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and subgroups with MCI. DESIGN:Prospective cohort; 10 years of follow...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2005.53566.x

    authors： Purser JL,Fillenbaum GG,Pieper CF,Wallace RB

    更新日期：2005-11-01 00:00:00

  • Absence of nocturnal fall in blood pressure in elderly persons with Alzheimer-type dementia.

    abstract：:Circadian changes of the blood pressure and heart rate in elderly normotensive bedridden patients with severe dementia of the Alzheimer type (group D) were compared with those in elderly normotensive bedridden patients without dementia (group R), normotensive subjects with normal daily activity (group N), and hyperten...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1990.tb04418.x

    authors： Otsuka A,Mikami H,Katahira K,Nakamoto Y,Minamitani K,Imaoka M,Nishide M,Ogihara T

    更新日期：1990-09-01 00:00:00

  • Derivation and validation of the detection of indicators and vulnerabilities for emergency room trips scale for classifying the risk of emergency department use in frail community-dwelling older adults.

    abstract：OBJECTIVES:To develop and validate a prognostic case finding tool that classifies the risk of emergency department (ED) use in an older home care population. DESIGN:Population-based retrospective cohort study using routinely collected data from home care clinical assessments linked prospectively to ED records. SETTIN...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.13336

    authors： Costa AP,Hirdes JP,Bell CM,Bronskill SE,Heckman GA,Mitchell L,Poss JW,Sinha SK,Stolee P

    更新日期：2015-04-01 00:00:00

  • Immunologic response to a single dose of tetanus toxoid in older people.

    abstract：OBJECTIVES:Several studies have demonstrated that a large percentage of older people are inadequately immunized against tetanus. The aim of this study was to assess the immunity against tetanus in a group of individuals aged 69 and older and to examine the immune response to a single dose of tetanus toxoid. DESIGN:A c...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2000.tb06893.x

    authors： Shohat T,Marva E,Sivan Y,Lerman I,Mates A,Cohen A

    更新日期：2000-08-01 00:00:00

  • Social structure and intracohort variation in physical fitness among elderly males in a traditional Third World society.

    abstract：:This paper examines the relationship between physical fitness and activity among elderly males in the traditional rural community of Chetbesi, Nepal. It takes advantage of the unique character of the Hindu caste system to implement a quasiexperimental research design that approximates random assignment to high and low...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1985.tb07151.x

    authors： Beall CM,Goldstein MC,Feldman ES

    更新日期：1985-06-01 00:00:00

  • Left ventricular hypertrophy on electrocardiogram: prognostic implications from a 10-year cohort study of older subjects: a report from the Bronx Longitudinal Aging Study.

    abstract：OBJECTIVE:The objective of this study was to report on the prevalence, incidence and prognosis of left ventricular hypertrophy (LVH) on the electrocardiogram (ECG) in a cohort of ambulatory older men and women. DESIGN:A prospective, longitudinal study of 10 years duration with ECGs obtained at baseline and on an annua...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1996.tb01437.x

    authors： Kahn S,Frishman WH,Weissman S,Ooi WL,Aronson M

    更新日期：1996-05-01 00:00:00

  • Cognitive function and oral health-related quality of life in older adults.

    abstract：OBJECTIVES:To examine the relationship between cognitive function and self-reported oral health-related quality of life (HRQoL) in community-dwelling older adults. DESIGN:Cross-sectional. SETTING:Community in West Virginia. PARTICIPANTS:Two hundred twenty-six community-dwelling older adults. MEASUREMENTS:Oral HRQoL...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.12402

    authors： Lee KH,Wu B,Plassman BL

    更新日期：2013-09-01 00:00:00