Abstract:
:Osteoporosis and sarcopenia are degenerative diseases frequently associated with aging. The loss of bone and muscle results in significant morbidity, so preventing or attenuating osteoporosis and sarcopenia is an important public health goal. Dietary protein is crucial for development of bone and muscle, and recent evidence suggests that increasing dietary protein above the current Recommended Dietary Allowance (RDA) may help maintain bone and muscle mass in older individuals. Several epidemiological and clinical studies point to a salutary effect of protein intakes above the current RDA (0.8 g/kg per day) for adults aged 19 and older. There is evidence that the anabolic response of muscle to dietary protein is attenuated in elderly people, and as a result, the amount of protein needed to achieve anabolism is greater. Dietary protein also increases circulating insulin-like growth factor, which has anabolic effects on muscle and bone. Furthermore, increasing dietary protein increases calcium absorption, which could be anabolic for bone. Available evidence supports a beneficial effect of short-term protein intakes up to 1.6 to 1.8 g/kg per day, although long-term studies are needed to show safety and efficacy. Future studies should employ functional measures indicative of protein adequacy, as well as measures of muscle protein synthesis and maintenance of muscle and bone tissue, to determine the optimal level of dietary protein. Given the available data, increasing the RDA for older individuals to 1.0 to 1.2 g/kg per day would maintain normal calcium metabolism and nitrogen balance without affecting renal function and may represent a compromise while longer-term protein supplement trials are pending.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Gaffney-Stomberg E,Insogna KL,Rodriguez NR,Kerstetter JEdoi
10.1111/j.1532-5415.2009.02285.xsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
1073-9issue
6eissn
0002-8614issn
1532-5415pii
JGS2285journal_volume
57pub_type
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journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.2000.tb03027.x
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abstract::The hypochondriacal attitudes of 53 aged community residents were studied. No significant correlations were found with situational stress, sex, or ethnicity (English-speaking vs Spanish-speaking). The levels of hypochondriasis appeared to be inversely related to self-evaluation of memory ability. There was no indicati...
journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.1981.tb02392.x
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abstract:OBJECTIVES:To determine the independent prognostic effect of seven potential frailty criteria, including five from the Fried phenotype, on several adverse outcomes. DESIGN:Prospective cohort study. SETTING:Greater New Haven, Connecticut. PARTICIPANTS:Seven hundred fifty-four initially nondisabled, community-living p...
journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.2008.02008.x
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abstract:OBJECTIVES:To evaluate survival and causes of death in subjects with idiopathic senile gait disorders. DESIGN:A population-based longitudinal study. SETTING:Survival analysis of the oldest old within the Leiden 85-plus Study. PARTICIPANTS:We distinguished three different groups according to their gait: subjects with...
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doi:10.1111/j.1532-5415.2000.tb04786.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:To identify fracture types in a series of older adults with pelvic fractures and to determine whether the type of pelvic fracture affected short-term outcomes and morbidity. DESIGN:Retrospective chart review. SETTING:Teaching hospital. PARTICIPANTS:One hundred eighty-one individuals aged 65 and older with...
journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.2011.03455.x
更新日期:2011-07-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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doi:10.1111/jgs.15853
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journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.1975.tb00218.x
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journal_title:Journal of the American Geriatrics Society
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journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.1975.tb00389.x
更新日期:1975-02-01 00:00:00
abstract:OBJECTIVES:To estimate lifetime morbidity, mortality, and costs from hip fracture incorporating the effect of deficits in activities of daily living. DESIGN:Markov computer cohort simulation considering short- and long-term outcomes attributable to hip fractures. Data estimates were based on published literature, and ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To determine the utility of hypodermoclysis in the management of dehydration in nursing home residents and to review the recent literature on the use of clysis in older adults. DESIGN:A retrospective chart review. SETTING:Two continuing care retirement community nursing home units in Cincinnati. PARTICIPA...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1996.tb01870.x
更新日期:1996-08-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To determine whether the increasing fall death rate among people aged 65 and older is due in part to temporal changes in recording the underlying cause of death. DESIGN:Analyses of multiple cause of death data using the online Centers for Disease Control and Prevention Wide-ranging ON-line Data for Epidemio...
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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更新日期:2013-04-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
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journal_title:Journal of the American Geriatrics Society
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
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更新日期:1976-10-01 00:00:00