The relationship between exercise and risk of venous thrombosis in elderly people.


OBJECTIVES:To study whether exercise is associated with the risk of venous thrombosis in elderly people. DESIGN:Observational study with a median follow-up of 11.6 years. SETTING:The Cardiovascular Health Study in four U.S. communities. PARTICIPANTS:People aged 65 and older without prior venous thrombosis (deep venous thrombosis or pulmonary embolism). MEASUREMENTS:Self-reported exercise was measured two or three times during follow-up and was defined as expending more than 500 kcal/wk on exercise, including walking for exercise. Venous thrombosis cases were verified using medical record review. RESULTS:Of 5,534 participants, 171 developed a first venous thrombosis. Self-reported exercise at baseline was not related to the risk of venous thrombosis after adjustment for sex, age, race, self-reported health, and body mass index (adjusted hazard ratio (HR(adj))=1.16, 95% confidence interval (CI)=0.84-1.61), although with exercise modeled as a time-varying exposure, overall results were in the direction of greater risk of venous thrombosis (HR(adj)=1.38, 95% CI=0.99-1.91). For mild-intensity exercise, such as walking, there was a nonsignificant finding in the direction of benefit (HR(adj)=0.75, 95% CI=0.49-1.16), but strenuous exercise, such as jogging, was associated with greater risk of venous thrombosis (HR(adj)=1.75, 95% CI=1.08-2.83) than no exercise at all. CONCLUSION:In elderly people, strenuous exercise was associated with a higher risk of venous thrombosis than no exercise at all. Future studies are needed to explain this unexpected higher risk.


J Am Geriatr Soc


van Stralen KJ,Doggen CJ,Lumley T,Cushman M,Folsom AR,Psaty BM,Siscovick D,Rosendaal FR,Heckbert SR




Has Abstract


2008-03-01 00:00:00














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