Abstract：
:Cerebral blood flow (CBF) was measured by the 133Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Screening Examination (CCSE). Cerebral vasomotor responses were calculated from differences in values of mean hemispheric gray matter blood flow (Delta CBF) measured during inhalation of 100% oxygen (hyperoxia) compared with CBF measured while breathing room air. Significant correlations were found between CCSE performance and vasomotor responsiveness in patients with MID (P less than .01), but not in patients with AD or in neurologically normal volunteers. Loss of vasomotor responsiveness is an indicator of cerebrovascular disease with rigidity and/or loss of reactivity of cerebral vessels, which impairs cerebrovascular responses to situational demands and predisposes to cerebral ischemia. Loss of cerebral vasomotor responsiveness among MID patients, which is a biologic marker of cerebrovascular disease, provides confirmatory evidence of the vascular etiology of MID and assists in separating MID from AD patients.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Judd BW,Meyer JS,Rogers RL,Gandhi S,Tanahashi N,Mortel KF,Tawaklna Tdoi
10.1111/j.1532-5415.1986.tb04318.xsubject
Has Abstractpub_date
1986-05-01 00:00:00pages
355-60issue
5eissn
0002-8614issn
1532-5415journal_volume
34pub_type
杂志文章abstract：OBJECTIVES:To assess the effect of exposure to evidence-based medication after hospital discharge for Medicare beneficiaries with acute myocardial infarction (AMI). DESIGN:A discrete-time hazard model was used to estimate time to outcome associated with exposure to four drug classes (angiotensin-converting enzyme inhi...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2012.04165.x
更新日期：2012-10-01 00:00:00
abstract：:Self-administered questionnaires were sent to all faculty and staff members of the departments of internal medicine and psychiatry in a school of medicine. The questionnaires asked for information about personal characteristics, practice characteristics, and interest in teaching geriatrics. Included also were measures...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1982.tb03703.x
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVES:To quantify incidence of tooth loss, prosthodontic dental restoration, and chewing difficulty onset and the effect of tooth loss and prosthodontic restoration on chewing difficulty onset. DESIGN:A prospective cohort study of oral health and related behaviors with in-person interviews and clinical examinatio...
journal_title：Journal of the American Geriatrics Society
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更新日期：2004-06-01 00:00:00
abstract：OBJECTIVES:To elucidate the relationship between stroke and depressive symptoms and to determine whether disability or cerebrovascular risk factors mediate that relationship. DESIGN:A prospective longitudinal epidemiological survey. SETTING:The mid-Monongahela Valley, a rural, nonfarm, low-socioeconomic-status commun...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2004.52217.x
更新日期：2004-05-01 00:00:00
abstract：:A case is presented of primary endolymphatic stromal sarcoma of the uterus in a debilitated elderly patient. Surgical intervention was contraindicated. Radium therapy was unsuccessful. A 4-month course of treatment with doxorubicin (Adriamycin) resulted in disappearance of the tumor. The patient is living 19 months af...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1976.tb03265.x
更新日期：1976-10-01 00:00:00
abstract：OBJECTIVE:To study the effectiveness of rehabilitative and medically oriented day hospital care on community-based long-term care patients. DESIGN:A randomized, controlled trial. SETTING AND PARTICIPANTS:177 patients on home-care in a rural area were randomized into two groups. Patients in one group were offered a 2-...
journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1532-5415.1998.tb06645.x
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.15182
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To determine whether older people who use nonsteroidal anti-inflammatory agents (NSAIDs) have increased levels of blood urea nitrogen (BUN), serum creatinine, and BUN:serum creatinine ratio. DESIGN:Cross-sectional, secondary data analysis. SETTING:Older people living in the communities of East Boston, MA, N...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1999.tb02561.x
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:To identify specific characteristics of patients, physicians, and treatment settings associated with decreased receipt of essential medications in a chronically ill, older population following a Medicaid three-prescription monthly reimbursement limit (cap). DESIGN:Quasi-experiment with bivariate and multivar...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2001.49158.x
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVES:To investigate whether proton pump inhibitor (PPI) therapy reduces the frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease (COPD). DESIGN:Twelve-month, randomized, observer-blind, controlled trial. SETTING:A university hospital and three city hospitals in Miya...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1532-5415.2009.02349.x
更新日期：2009-08-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 评论,杂志文章
doi：10.1046/j.1532-5415.2002.50418.x
更新日期：2002-09-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1992.tb01955.x
更新日期：1992-07-01 00:00:00
abstract：OBJECTIVES:To review the epidemiology, pathophysiology, and etiology of congestive heart failure (CHF) in older adults. METHODS:Published reports relevant to the epidemiology, pathophysiology, and etiology of CHF were systematically reviewed. Studies involving older adults and more recent studies were emphasized. RES...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/j.1532-5415.1997.tb02968.x
更新日期：1997-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/jgs.14956
更新日期：2017-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1532-5415.2004.52107.x
更新日期：2004-03-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2001.49270.x
更新日期：2001-10-01 00:00:00
abstract：OBJECTIVES:To compare hearing loss screening results of four simple tests with those of hand-held audiometry. DESIGN:Cross-sectional study of individuals screened during intake for physicals and other routine procedures. SETTING:Two primary care clinics in the San Francisco Bay area. PARTICIPANTS:Older adults not we...
journal_title：Journal of the American Geriatrics Society
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更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:To determine whether glycosylated hemoglobin (HbA1c) levels predict functional decline in older adults. DESIGN:Longitudinal cohort study. PARTICIPANTS:Community-dwelling, nursing home (NH)-eligible individuals with diabetes mellitus enrolled at On Lok between October 2002 and December 2008 (367 participant...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2012.04041.x
更新日期：2012-07-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
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更新日期：1983-10-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1999-04-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
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更新日期：2016-02-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,随机对照试验
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更新日期：2009-11-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-12-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
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更新日期：2018-10-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1998.tb03809.x
更新日期：1998-06-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2004.52273.x
更新日期：2004-06-01 00:00:00
abstract：:During 26 years of surveillance of the Framingham Study Cohort of 5,209 subjects, 176 men and 119 women developed occlusive peripheral arterial disease manifested as intermittent claudication (IC). The incidence increased sharply with age until the age of 75, with about a twofold male predominance at all ages. An inci...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1985.tb02853.x
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVES:To identify specific care management activities within a dementia care management intervention that are associated with 18-month change in caregiver mastery and relationship strain. DESIGN:Exploratory analysis, using secondary data (care management processes and caregiver outcomes) from the intervention arm...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1532-5415.2008.01643.x
更新日期：2008-05-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1986.tb05767.x
更新日期：1986-08-01 00:00:00
abstract：OBJECTIVES:To determine, in a sample of Ashkenazi Jewish aged 95 and older, whether there is a compression of morbidity similar to what has been reported in other cohorts with exceptional longevity. DESIGN:Case-control study. SETTING:Longevity Genes Project (LGP) and New England Centenarian Study (NECS). PARTICIPANT...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.14222
更新日期：2016-08-01 00:00:00
