Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial.

Abstract:

OBJECTIVES:To examine the effects of dehydroepiandrosterone (DHEA) supplementation on cognitive function and quality of life in healthy older adults. DESIGN:Double-blind, randomized, controlled clinical trial. SETTING:Clinical research facility. PARTICIPANTS:One hundred ten men and 115 women aged 55 to 85 (mean +/- standard deviation 68 +/- 8). INTERVENTION:Fifty milligrams daily oral DHEA versus placebo for 1 year. MEASUREMENTS:Six cognitive function tests at baseline and 12 months, the Beck Depression Inventory (BDI), the Medical Outcomes Study 36-item Short Form Survey (SF-36), the Life Satisfaction Index-Z, the Satisfaction with Life Scale, the Female Sexual Function Index (in women), and the 15-item International Index of Erectile Function (in men) at baseline and 3, 6, and 12 months. RESULTS:There were no differences between the DHEA and placebo groups in change over time in cognitive function (P>.10). Over time, BDI scores decreased for men (P=.006) and women (P=.02), and Satisfaction with Life Scale scores increased for women (P=.004), but there were no differences between the DHEA and placebo groups over time on these measures or the SF-36, Life Satisfaction Index-Z scale, or sexual function scales (P>.10). CONCLUSION:DHEA supplementation has no benefit on cognitive performance or well-being in healthy older adults, and it should not be recommended for that purpose in the general population.

journal_name

J Am Geriatr Soc

authors

Kritz-Silverstein D,von Mühlen D,Laughlin GA,Bettencourt R

doi

10.1111/j.1532-5415.2008.01768.x

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

1292-8

issue

7

eissn

0002-8614

issn

1532-5415

pii

JGS1768

journal_volume

56

pub_type

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