Abstract:
OBJECTIVES:To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia. DESIGN:Case-control study nested in a prospective cohort. SETTING:The Honolulu-Asia Aging Study, Oahu, Hawaii. PARTICIPANTS:Three thousand four hundred sixty-eight Japanese-American men (mean age 52 in 1965-1968) examined for dementia 25 years later. MEASUREMENTS:Men at low risk were defined as those with the following midlife characteristics: nonsmoking, body mass index (BMI) less than 25.0 kg/m(2) , physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated to saturated fat). Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for developing overall dementia, Alzheimer's disease (AD), and vascular dementia (VaD), adjusting for potential confounders. RESULTS:Dementia was diagnosed in 6.4% of men (52.5% with AD, 35.0% with VaD). Examining the risk factors individually, BMI was most strongly associated with greater risk of overall dementia (OR = 1.87, 95% CI = 1.26-2.77; BMI > 25.0 vs <22.6 kg/m(2) ). All of the individual risk factors except diet score were significantly associated with VaD, whereas none were significantly associated with AD alone. Men with all four low-risk characteristics (7.2% of the cohort) had the lowest OR for overall dementia (OR = 0.36, 95% CI = 0.15-0.84). There were no significant associations between the combined low-risk characteristics and the risk of AD alone. CONCLUSION:Among Japanese-American men, having a healthy lifestyle in midlife is associated with a lower risk of dementia in late life.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Gelber RP,Petrovitch H,Masaki KH,Abbott RD,Ross GW,Launer LJ,White LRdoi
10.1111/j.1532-5415.2011.03768.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
118-23issue
1eissn
0002-8614issn
1532-5415journal_volume
60pub_type
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