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Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation.

Abstract：

OBJECTIVES:Lower than recommended doses of direct-acting oral anticoagulants are often prescribed to older adults with nonvalvular atrial fibrillation (NVAF). Our goal was to determine the consequences of lower than recommended dosing on plasma apixaban concentrations during the clinical care of older adults with NVAF. DESIGN:Convenience sample of patients receiving anticoagulation during 2017. SETTING:Academic medical center. PARTICIPANTS:Stable adults older than 65 years with NVAF receiving apixaban on a chronic basis. MEASUREMENTS:Patient age, weight, creatinine, co-medications, and apixaban concentrations. RESULTS:A total of 110 older adults with NVAF (mean age = 80.4 y; range = 66-100 y with 45% women) were studied. Overall, 48 patients received recommended dosing of 5 mg twice/day, and 42 received lower than recommended dosing. One patient in each category had concentrations below the expected 5% to 95% range at time of peak concentrations. Differences in proportion of apixaban concentrations within or outside expected ranges were not significant between patients receiving lower than recommended doses and those dosed as recommended at 5 mg twice/day (P = .35). However, in patients dosed as recommended with 5 mg twice/day, four had concentrations above the 5% to 95% range for peak levels expected at 3 to 4 hours after dosing; in two, this occurred around the midpoint of the dosing interval. Twenty patients received 2.5 mg twice/day as recommended. One-third had apixaban concentrations higher than expected peak concentrations compared with the clinical trials, and more than two-thirds had levels above the reported median for peak concentrations. CONCLUSIONS:Apixaban concentrations in older adults with NVAF seen clinically were higher than expected based on clinical trial data. The findings raise questions about the optimal dosing of apixaban in older adults with NVAF encountered outside of clinical trials and suggest a role for the monitoring of apixaban concentrations during care of patients that differ from those in randomized trials or when considering dosing outside of published guidelines. J Am Geriatr Soc 67:1902-1906, 2019.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Sukumar S,Gulilat M,Linton B,Gryn SE,Dresser GK,Alfonsi JE,Schwarz UI,Kim RB,Schwartz JB

doi

10.1111/jgs.15982

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1902-1906

issue

eissn

0002-8614

issn

1532-5415

journal_volume

pub_type

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Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation.