Abstract：
OBJECTIVES:To determine whether serum calcium is associated with cognitive function in elderly individuals in the general population. DESIGN:Prospective follow-up study of two independent, population-based cohorts. SETTING:The Rotterdam Study (median follow-up 11 years) and the Leiden 85-plus Study (median follow-up 5 years). PARTICIPANTS:Three thousand nine hundred ninety-four individuals, mean age 71, from the Rotterdam Study and 560 individuals, all aged 85, from the Leiden 85-plus Study. MEASUREMENTS:Global cognitive function was assessed in both cohorts using the Mini-Mental State Examination; attention, psychomotor speed, and memory function were assessed in the Leiden 85-plus Study only. Linear regression and linear mixed models were used for statistical analyses. RESULTS:In the Rotterdam Study, high serum calcium was associated with worse global cognitive function at baseline (P<.05) and a faster rate of decline in cognitive function during follow-up (P=.005) in individuals aged 75 and older but not in younger individuals. In the Leiden 85-plus Study, high serum calcium was associated with worse global cognitive function from age 85 through 90 (P<.001). This observation also held for the specific cognitive domains tested (all P<.01). These results did not change when individuals with serum calcium levels greater than normal (>2.55 mmol/L) were excluded from the analyses. CONCLUSION:In the general population, high serum calcium levels are associated with faster decline in cognitive function over the age of 75.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Schram MT,Trompet S,Kamper AM,de Craen AJ,Hofman A,Euser SM,Breteler MM,Westendorp RGdoi
10.1111/j.1532-5415.2007.01418.xsubject
Has Abstractpub_date
2007-11-01 00:00:00pages
1786-92issue
11eissn
0002-8614issn
1532-5415pii
JGS1418journal_volume
55pub_type
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