当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN GERIATRICS SOCIETY期刊下所有文献 > Prospective association between low and high total and low-density lipoprotein cholesterol and coronary heart disease in elderly men.

Prospective association between low and high total and low-density lipoprotein cholesterol and coronary heart disease in elderly men.

Abstract：

OBJECTIVES:To examine the relationship between total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and the incidence of coronary heart disease (CHD) in elderly men. DESIGN:Prospective. SETTING:Population based. PARTICIPANTS:A sample of 2,424, Japanese-American men aged 71 to 93 was used. MEASUREMENTS:Six years of data on incident fatal plus nonfatal CHD were examined. RESULTS:Analysis revealed a significant U-shaped relationship between age-adjusted CHD rates and both TC and LDL-C. The ranges of TC and LDL-C with the lowest risk of CHD were 200 to 219 mg/dL and 120 to 139 mg/dL, respectively. As cholesterol concentrations declined and increased beyond these ranges, the risk of CHD increased. These U-shaped relationships remained significant after adjusting for age and other risk factors. CONCLUSION:The U-shaped associations between TC and LDL-C and CHD imply a complex relationship between lipids and CHD in late life. The results indicate that elevated lipid levels should continue to be treated in healthy elderly individuals, as they are in those who are younger, although pharmacologically lowering lipids to excessively low levels in the elderly may warrant further study, as does the contribution of subclinical frailty to the relationship of lipids to CHD risk.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Curb JD,Abbott RD,Rodriguez BL,Masaki K,Popper J,Chen R,Petrovitch H,Blanchette P,Schatz I,Yano K

doi

10.1111/j.1532-5415.2004.52551.x

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1975-80

issue

12

eissn

0002-8614

issn

1532-5415

pii

JGS52551

journal_volume

52

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY文献大全
  • The medical evaluation and management of the elderly surgical patient.

    abstract：:Contrary to earlier findings, elderly patients are not at significantly greater risk of perioperative morbidity or mortality than younger patients simply because of advanced age. Increased risk, when present, is attributable to pathologic changes that are not uniformly seen in all geriatric patients. Most perioperativ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1983.tb04606.x

    authors： Johnson JC

    更新日期：1983-10-01 00:00:00

  • Cochlear implant rehabilitation in older adults: literature review and proposal of a conceptual framework.

    abstract：OBJECTIVES:To review studies investigating cochlear implant (CI) outcomes in older adults, and to develop a conceptual framework demonstrating important interactions between characteristics of hearing disability, aging, and the CI intervention. DESIGN:Review of English literature with titles containing the words "coch...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,评审

    doi：10.1111/j.1532-5415.2012.04150.x

    authors： Clark JH,Yeagle J,Arbaje AI,Lin FR,Niparko JK,Francis HW

    更新日期：2012-10-01 00:00:00

  • Vitamin D and Physical Function in Sedentary Older Men.

    abstract：OBJECTIVES:To determine the effectiveness of vitamin D supplementation in preventing decline in physical function in older men. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Single-center study conducted at a Veterans Affairs Healthcare System. PARTICIPANTS:Sedentary men aged 65 to 90 (...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/jgs.14510

    authors： Levis S,Gómez-Marín O

    更新日期：2017-02-01 00:00:00

  • Testing the effect of function-focused care in assisted living.

    abstract：OBJECTIVES:To develop and test the Function-Focused Care in Assisted Living (FFC-AL) intervention so as to alter the decline that older adults in AL experience. DESIGN:Cluster-randomized controlled trial using repeated measures to test the effect of FFC-AL. SETTING:Four AL facilities with at least 100 beds. PARTICIP...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1532-5415.2011.03699.x

    authors： Resnick B,Galik E,Gruber-Baldini A,Zimmerman S

    更新日期：2011-12-01 00:00:00

  • Nocturnal Excretion in Healthy Older Women and Rationale for a Safer Approach to Sleep Disruption.

    abstract：OBJECTIVES:Insomnia, especially difficulty maintaining sleep, is prevalent among older adults and increases the incidence of falls and fractures. Moreover, the drugs used to treat it exacerbate the risk. Yet current therapies fail to address one of its most common causes in older adults: nocturia and its primary contri...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.16144

    authors： Tyagi S,Perera S,Clarkson BD,Tadic SD,Resnick NM

    更新日期：2019-12-01 00:00:00

  • Value of neuropsychological tests, neuroimaging, and biomarkers for diagnosing Alzheimer's disease in younger and older age cohorts.

    abstract：OBJECTIVES:To examine the influence of age on the value of four techniques for diagnosing Alzheimer's disease (AD). DESIGN:Observational cohort study. SETTING:Alzheimer's Disease Neuroimaging Initiative. PARTICIPANTS:Individuals with mild cognitive impairment (MCI; n = 179), individuals with AD (n = 91), and normal ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2011.03539.x

    authors： Schmand B,Eikelenboom P,van Gool WA,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2011-09-01 00:00:00

  • Hearing impairment as a determinant of function in the elderly.

    abstract：:This clinical, practice-based study explores the research question: Is there a relationship between hearing loss and functional disturbance in elderly patients? We analyzed the impact of hearing impairment on 153 patients over 65 years of age screened in primary care practice. Functional and psychosocial impairment we...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1989.tb05870.x

    authors： Bess FH,Lichtenstein MJ,Logan SA,Burger MC,Nelson E

    更新日期：1989-02-01 00:00:00

  • The dynamics of disability and functional change in an elderly cohort: results from the Alameda County Study.

    abstract：OBJECTIVE:To examine changes in functional status over time by age, gender, and ethnicity in a representative sample of older persons. DESIGN:Six-year prospective cohort study. SETTING:Alameda County, California. PARTICIPANTS:508 persons 65 years old and older at baseline in 1984. MAIN OUTCOME MEASURES:Activities o...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1992.tb01852.x

    authors： Strawbridge WJ,Kaplan GA,Camacho T,Cohen RD

    更新日期：1992-08-01 00:00:00

  • Adenocarcinoma of the vermiform appendix.

    abstract：:Primary carcinoma of the appendix, though rare, occurs often enough to warrant its inclusion in diagnostic possibilities when the symptoms of acute appendicitis, without leukocytosis, are present in geriatric patients. A case of mucinous adenocarcinoma of the appendix in an 88-year-old white woman is presented. The su...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1982.tb05665.x

    authors： Witt CB Jr,Herrmann VA

    更新日期：1982-09-01 00:00:00

  • Use of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.

    abstract：OBJECTIVES:To evaluate the association between regular antiepileptic drug (AED) use and incident dementia. DESIGN:Case-control analysis. SETTING:Finnish public health register and German health insurance data. PARTICIPANTS:Individuals with dementia of any type (German data, N=20,325) and Alzheimer's disease (AD; Fin...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.15358

    authors： Taipale H,Gomm W,Broich K,Maier W,Tolppanen AM,Tanskanen A,Tiihonen J,Hartikainen S,Haenisch B

    更新日期：2018-07-01 00:00:00

  • Staphylococcus aureus bloodstream infections in older adults: clinical outcomes and risk factors for in-hospital mortality.

    abstract：OBJECTIVES:To assess clinical outcomes and identify risk factors for mortality in older adults with Staphylococcus aureus bloodstream infection (SAB). DESIGN:Retrospective review. SETTING:University of Michigan Health System, Ann Arbor. PARTICIPANTS:All patients aged 80 and older with SAB between January 2004 and Ju...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2009.02666.x

    authors： Big C,Malani PN

    更新日期：2010-02-01 00:00:00

  • Drug interactions and the elderly.

    abstract：:The elderly take more drugs than the young, and are therefore more susceptible to adverse drug interactions. Prescribing the minimum number of agents is recommended. Drug absorption, metabolism, and excretion may be altered by various interactions. Dose-response relationships of oral anticoagulants, oral hypoglycemics...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1982.tb01358.x

    authors： Reidenberg MM

    更新日期：1982-11-01 00:00:00

  • Evaluation of Simulated Presence: a personalized approach to enhance well-being in persons with Alzheimer's disease.

    abstract：OBJECTIVE:To evaluate the efficacy of Simulated Presence, a personalized approach to enhance well-being among nursing home residents with Alzheimer's disease and related dementia's (ADRD). DESIGN:Latin-Square, double blinded, 3-factor design with restrictive randomization of three treatments (the study intervention, a...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1532-5415.1999.tb07237.x

    authors： Camberg L,Woods P,Ooi WL,Hurley A,Volicer L,Ashley J,Odenheimer G,McIntyre K

    更新日期：1999-04-01 00:00:00

  • Use of self-report to predict ability to walk 400 meters in mobility-limited older adults.

    abstract：OBJECTIVES:To determine whether the ability to walk 400 m could be predicted from self-reported walking habits and abilities in older adults and to develop an accurate self-report measure appropriate for observational trials of mobility when functional measures are impractical to collect. DESIGN:Cross-sectional. SETT...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2004.52571.x

    authors： Sayers SP,Brach JS,Newman AB,Heeren TC,Guralnik JM,Fielding RA

    更新日期：2004-12-01 00:00:00

  • Fundic atrophic gastritis in an elderly population. Effect on hemoglobin and several serum nutritional indicators.

    abstract：:The ratio of pepsinogen I to pepsinogen II in the circulation decreases progressively with increasing severity of atrophic gastritis of the fundic gland mucosa. Fasting blood was obtained from 359 free-living and institutionalized elderly people (age range, 60 to 99 years). A pepsinogen I/pepsinogen II ratio less than...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1986.tb03985.x

    authors： Krasinski SD,Russell RM,Samloff IM,Jacob RA,Dallal GE,McGandy RB,Hartz SC

    更新日期：1986-11-01 00:00:00

  • Sarcopenia: alternative definitions and associations with lower extremity function.

    abstract：OBJECTIVES:To compare two sarcopenia definitions and examine the relationship between them and lower extremity function and other health related factors using data from the baseline examination of the Health Aging and Body Composition (Health ABC) Study. DESIGN:Observational cohort study. SETTING:Two U.S. communities...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1046/j.1532-5415.2003.51534.x

    authors： Newman AB,Kupelian V,Visser M,Simonsick E,Goodpaster B,Nevitt M,Kritchevsky SB,Tylavsky FA,Rubin SM,Harris TB,Health ABC Study Investigators.

    更新日期：2003-11-01 00:00:00

  • Sleep disturbances and frailty status in older community-dwelling men.

    abstract：OBJECTIVES:To test the hypothesis that sleep disturbances are independently associated with frailty status in older men. DESIGN:Cross-sectional analysis of prospective cohort study. SETTING:Six U.S. centers. PARTICIPANTS:Three thousand one hundred thirty-three men aged 67 and older. MEASUREMENTS:Self-reported sleep...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2009.02490.x

    authors： Ensrud KE,Blackwell TL,Redline S,Ancoli-Israel S,Paudel ML,Cawthon PM,Dam TT,Barrett-Connor E,Leung PC,Stone KL,Osteoporotic Fractures in Men Study Group.

    更新日期：2009-11-01 00:00:00

  • Cryosurgery for life-threatening bleeding hemorrhoids in the elderly.

    abstract：:Forty-three elderly patients with massive bleeding of hemorrhoidal varices were treated by cryosurgery at a single outpatient session, using nitrous oxide gas, without premedication or anesthesia. The results were excellent in all but one patient, who had ulcerative colitis and required another session of cryotherapy ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1984.tb05152.x

    authors： Mashiah A,Mashiah T

    更新日期：1984-01-01 00:00:00

  • Cost-effectiveness of increasing access to mammography through mobile mammography for older women.

    abstract：OBJECTIVES:To compare the costs of mobile and stationary mammography and examine the incremental cost-effectiveness of using mobile mammography to increase screening rates. DESIGN:A cost-effectiveness analysis was performed using effectiveness data from a randomized clinical trial and modeling of costs associated with...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1532-5415.2008.02105.x

    authors： Naeim A,Keeler E,Bassett LW,Parikh J,Bastani R,Reuben DB

    更新日期：2009-02-01 00:00:00

  • Medicare Expenditures of Individuals with Alzheimer's Disease and Related Dementias or Mild Cognitive Impairment Before and After Diagnosis.

    abstract：OBJECTIVES:To characterize Medicare expenditure and usage trends in individuals with a coded diagnosis of Alzheimer's disease and related dementia (ADRD) or mild cognitive impairment (MCI) during the periods leading up to and after diagnosis. DESIGN:Retrospective observational cohort study. SETTING:Five percent sampl...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.14227

    authors： Lin PJ,Zhong Y,Fillit HM,Chen E,Neumann PJ

    更新日期：2016-08-01 00:00:00

  • Personality Changes During the Transition from Cognitive Health to Mild Cognitive Impairment.

    abstract：BACKGROUND/OBJECTIVES:Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.15182

    authors： Caselli RJ,Langlais BT,Dueck AC,Henslin BR,Johnson TA,Woodruff BK,Hoffman-Snyder C,Locke DEC

    更新日期：2018-04-01 00:00:00

  • Risk factors for disability subtypes in older persons.

    abstract：OBJECTIVES:To identify risk factors for five different subtypes of disability. DESIGN:Prospective cohort study. SETTING:Greater New Haven, Connecticut. PARTICIPANTS:Seven hundred fifty-four community-living residents aged 70 and older and initially nondisabled in four essential activities of daily living (bathing, d...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2009.02443.x

    authors： Gill TM,Murphy TE,Barry LC,Allore HG

    更新日期：2009-10-01 00:00:00

  • Aging and the prevalence of cardiovascular disease risk factors in older American Indians: the Strong Heart Study.

    abstract：OBJECTIVES:To describe longitudinal changes in the prevalence of major cardiovascular disease (CVD) risk factors in aging American Indians. DESIGN:Population-based ongoing epidemiological study. SETTING:The Strong Heart Study is a study of CVD and its risk factors. Standardized examinations were repeated in 1993 to 1...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2006.01018.x

    authors： Rhoades DA,Welty TK,Wang W,Yeh F,Devereux RB,Fabsitz RR,Lee ET,Howard BV

    更新日期：2007-01-01 00:00:00

  • Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone.

    abstract：:One hundred seventy-one patients, 60 years of age or older with isolated systolic hypertension, were randomly assigned to receive chlorthalidone 12.5, 25.0, or 50.0 mg or placebo once daily for 12 weeks. The majority of the patients receiving chlorthalidone 12.5 mg achieved therapeutic success with no clinically signi...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1532-5415.1986.tb04203.x

    authors： Morledge JH,Ettinger B,Aranda J,McBarron F,Barra P,Gorwit J,Davidov M

    更新日期：1986-03-01 00:00:00

  • Comparison of cyclic guanosine monophosphate response to infusion of atrial natriuretic peptide in young and elderly subjects.

    abstract：OBJECTIVE:To compare the sensitivity to atrial natriuretic peptide (ANP) in young and elderly subjects. DESIGN:Double-blind, random-order, placebo-controlled study using two different rates of ANP infusion. SUBJECTS:Eight healthy young (23 +/- 3 years, mean +/- SD) and eight healthy elderly (76 +/- 4 years) subjects ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1532-5415.1993.tb07309.x

    authors： Tan AC,Jansen TL,Thien T,Kloppenborg PW,Benraad TJ

    更新日期：1993-11-01 00:00:00

  • Perioperative Optimization of Senior Health in Spine Surgery: Impact on Postoperative Delirium.

    abstract：BACKGROUND:Delirium is a common postoperative complication in geriatric patients, especially in those with underlying risk factors. Multicomponent nonpharmacologic interventions are effective in preventing delirium, however, implementation of these measures is variable in perioperative care. The aim of our study was to...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.17006

    authors： Pernik MN,Deme PR,Nguyen ML,Aoun SG,Adogwa O,Hall K,Stewart NA,Dosselman LJ,El Tecle NE,McDonald SR,Bagley CA,Wingfield SA

    更新日期：2020-12-31 00:00:00

  • Selected as the best paper in the 1990s: Reducing frailty and falls in older persons: an investigation of tai chi and computerized balance training.

    abstract：OBJECTIVES:To evaluate the effects of two exercise approaches, tai chi (TC) and computerized balance training (BT), on specified primary outcomes (biomedical, functional, and psychosocial indicators of frailty) and secondary outcomes (occurrences of fall). DESIGN:The Atlanta Frailty and Injuries: Cooperative Studies a...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 传,古典文章,临床试验,历史文章,杂志文章,随机对照试验

    doi：10.1046/j.1532-5415.2003.51566.x

    authors： Wolf SL,Barnhart HX,Kutner NG,McNeely E,Coogler C,Xu T,Atlanta FICSIT Group.

    更新日期：2003-12-01 00:00:00

  • Psychometric characteristics of the minimum data set II: validity.

    abstract：OBJECTIVE:To determine the validity of the Minimum Data Set (MDS). DESIGN:MDS domain scores were correlated with a variety of independently obtained measures of basic behavioral and mental health functions of 513 nursing home residents. SETTING:All participants were residents of the Philadelphia Geriatric Center. PA...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1998.tb03809.x

    authors： Lawton MP,Casten R,Parmelee PA,Van Haitsma K,Corn J,Kleban MH

    更新日期：1998-06-01 00:00:00

  • Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale.

    abstract：OBJECTIVE:To assess the validity of the Neurobehavioral Rating Scale (NRS) in patients with Alzheimer's disease (AD) or multi-infarct dementia (MID) and to characterize the cognitive, psychiatric, and behavioral disturbances that occur in these patients. DESIGN:Cross-sectional evaluation. SETTING:West Los Angeles VAM...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1992.tb02101.x

    authors： Sultzer DL,Levin HS,Mahler ME,High WM,Cummings JL

    更新日期：1992-06-01 00:00:00

  • A real-world study of the effect of timing of insulin initiation on outcomes in older medicare beneficiaries with type 2 diabetes mellitus.

    abstract：OBJECTIVES:To compare clinical and economic outcomes of early insulin initiation with those of delayed initiation in older adults with type 2 diabetes mellitus (T2DM). DESIGN:Retrospective cohort study. SETTING:Humana Medicare Advantage health insurance plan. PARTICIPANTS:Older (≥65) Medicare beneficiaries with T2DM...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.13388

    authors： Bhattacharya R,Zhou S,Wei W,Ajmera M,Sambamoorthi U

    更新日期：2015-05-01 00:00:00