Drug interactions and the elderly.

Abstract:

:The elderly take more drugs than the young, and are therefore more susceptible to adverse drug interactions. Prescribing the minimum number of agents is recommended. Drug absorption, metabolism, and excretion may be altered by various interactions. Dose-response relationships of oral anticoagulants, oral hypoglycemics, anticonvulsants, steroid hormones, theophylline, and tricyclic antidepressants are significantly affected by changes in drug metabolism. Proper adjustment of dosage permits the safe, concomitant use of agents that interact with these drugs. Pharmacodynamic interactions also occur in the elderly. A common example is the additive effect of several drugs with central nervous system depressant activity, causing oversedation.

journal_name

J Am Geriatr Soc

authors

Reidenberg MM

doi

10.1111/j.1532-5415.1982.tb01358.x

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

S67-8

issue

11 Suppl

eissn

0002-8614

issn

1532-5415

journal_volume

30

pub_type

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