Abstract:
:The elderly take more drugs than the young, and are therefore more susceptible to adverse drug interactions. Prescribing the minimum number of agents is recommended. Drug absorption, metabolism, and excretion may be altered by various interactions. Dose-response relationships of oral anticoagulants, oral hypoglycemics, anticonvulsants, steroid hormones, theophylline, and tricyclic antidepressants are significantly affected by changes in drug metabolism. Proper adjustment of dosage permits the safe, concomitant use of agents that interact with these drugs. Pharmacodynamic interactions also occur in the elderly. A common example is the additive effect of several drugs with central nervous system depressant activity, causing oversedation.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Reidenberg MMdoi
10.1111/j.1532-5415.1982.tb01358.xsubject
Has Abstractpub_date
1982-11-01 00:00:00pages
S67-8issue
11 Suppleissn
0002-8614issn
1532-5415journal_volume
30pub_type
杂志文章abstract:OBJECTIVES:To investigate the effects of the changes in serum bioavailable and total testosterone (TT) levels with aging on visceral body fat distribution and muscle strength in Chinese men. DESIGN:Cross-sectional study. SETTING:Ambulatory care. PARTICIPANTS:Four hundred seventy-five healthy ambulatory Chinese men (...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.01746.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:To compare the ability of five measures of comorbidity to predict mortality and incident disability in basic activities of daily living (BADLs) in unselected older persons. DESIGN:An assessment of the data obtained from the Insufficienza Cardiaca negli Anziani Residenti a Dicomano (ICARe Dicomano) Study, a ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.00572.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility of cognitive screening in older veterans presenting for routine primary care. DESIGN:Quality improvement initiative. SETTING:Seven Veterans Affairs Medical Centers. PARTICIPANTS:Veterans aged 70 and older without a prior diagnosis of cognitive impairment. MEASUREMENTS:Scores fro...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1532-5415.2010.03249.x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To assess colonization and infection with methicillin-resistant Staphylococcus aureus (MRSA), high-level gentamicin-resistant enterococci (R-ENT) and gentamicin and/or ceftriaxone-resistant Gram-negative bacilli (R-GNB) and the factors that are associated with colonization and infection with these organisms. ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb06210.x
更新日期:1994-10-01 00:00:00
abstract::The US Department of Health and Human Services and the Foundation for the National Institutes of Health, through private sector support, sponsored the National Research Summit on Dementia Care: Building Evidence for Services and Supports (Summit) in 2017. Various workgroups were asked to address topics of interest in ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16341
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To determine the prognostic significance of subsyndromal delirium (SSD) presentations. DESIGN:Cohort study. SETTING:University-affiliated primary acute care hospital. PARTICIPANTS:One hundred sixty-four elderly medical inpatients who did not meet Diagnostic and Statistical Manual of Mental Disorders, Thir...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1365-2389.2003.51255.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:To identify valid tools to diagnose delirium superimposed on dementia. DESIGN:Systematic review of studies of delirium tools that explicitly included individuals with dementia. SETTING:Hospital. PARTICIPANTS:Studies were included if delirium assessment tools were validated against standard criteria, and t...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.2012.04199.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:To determine the extent to which disease-related symptoms and impairments, which constitute measures of disease severity or targets of therapy, account for the associations between chronic diseases and universal health outcomes. DESIGN:Cross-sectional. SETTING:The Cardiovascular Health Study (CHS) and the ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2011.03576.x
更新日期:2011-09-01 00:00:00
abstract::Many physicians report that Internet health information can affect their clinical decisions. Much of Internet geriatric health information (IGHI) is not controlled for quality, and there is no available process to assess the quality of IGHI used in clinical practice or in medical education. The objective of this proje...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.53272.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To determine whether a twice-weekly maintenance schedule of evening bright light exposure is effective in alleviating sleep maintenance insomnia on a long-term basis, after the establishment of a more favorable phase relationship between the core body temperature (CBT) rhythm and sleep. DESIGN:Subjects unde...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章
doi:10.1046/j.1532-5415.2002.50154.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:To assess mobility disability trajectories before death in a large sample of very old adults using two analytical approaches to determine how well they corresponded. DESIGN:Decedent sample from the Health, Aging and Body Composition (Health ABC) Study. Data were collected between 1997 and 2015. SETTING:Pit...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15224
更新日期:2018-03-01 00:00:00
abstract::Because of adverse publicity regarding increased risk of endometrial cancer in women receiving estrogen therapy, a 2-year prospective study was conducted in 1976 to determine the incidence of endometrial cancer in postmenopausal women. A retrospective study for the year 1975 was also added. A postmenopausal survey c...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1979.tb01673.x
更新日期:1979-09-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between gender and specific types of behavior problems that occur in patients with Alzheimer's disease. DESIGN:This was an observational study using the Dementia Behavior Disturbance Scale to quantify and define behavioral problems encountered by caregivers. Multiple regressions w...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1996.tb01447.x
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:To assess the satisfaction of surrogate decision-makers with the decision to place feeding tubes in elderly patients with impaired decision-making capacity. DESIGN:Inception cohort followed for 5 weeks. SETTING:Four hospitals in the greater Los Angeles area. PARTICIPANTS:Fifty-eight surrogate decision-make...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb04946.x
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN:Two independent population-based cohort studies. SETTING:The Rotterdam Study (mean follow-up 4.6 ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2007.01159.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:To determine whether obese older adults who qualify for nursing home (NH) placement are as likely as nonobese adults to be admitted to NHs that provide adequate quality of care. DESIGN:Retrospective study. SETTING:NHs in New York State. PARTICIPANTS:Individuals aged 65 and older newly admitted to a NH in ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14105
更新日期:2016-05-01 00:00:00
abstract::The author's concept of loneliness is described, especially as it concerns the elderly. An attempt is made to develop an understanding of the word, with its implications for guidance in the nursing profession. The nurse's defenses against her own feelings of loneliness and depression can inhibit therapeutic interactio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1978.tb05048.x
更新日期:1978-04-01 00:00:00
abstract::The contribution of frailty to human morbidity and mortality is immense. Yet it lacks a conceptual framework. By borrowing from the hypotheses provided by the thermophysicists, frailty can be understood in a way that both interrelates the relationship between form and function and provides medical science with an oper...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:To perform a systematic review to determine the effectiveness of interventions designed to reduce potentially inappropriate prescribing (PIP) in community-dwelling older adults. DESIGN:Systematic review and narrative synthesis. SETTING:Primary and community care. PARTICIPANTS:Community-dwelling older adul...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/jgs.14133
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To assess the incidence of chronic illness and its effect on veteran centenarians. DESIGN:Retrospective longitudinal cohort study. SETTING:United States Veterans Affairs Corporate Data Warehouse (CDW). PARTICIPANTS:Community-dwelling veterans born between 1910 and 1915 who survived to at least age 80 (N =...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14900
更新日期:2017-09-01 00:00:00
abstract:CONTEXT:Racial differences in receipt of cancer prevention services may be related to poorer outcomes for minorities. Understanding reasons for such differences could help target appropriate interventions. OBJECTIVES:To determine if racial differences exist in the use of cancer prevention services among older blacks a...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2000.tb04746.x
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between frequent falls in older drivers and motor vehicle collision (MVC) involvement. DESIGN:Cross-sectional. SETTING:North central Alabama. PARTICIPANTS:Population-based sample of 2,000 licensed drivers aged 70 and older. MEASUREMENTS:Self-reported history of falling two or ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12594
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:As a person's age increases and his/her health status declines, new challenges arise that may lead physicians to consider deprescribing statins. We aimed to provide insight into recommendations available in international cardiovascular disease prevention guidelines regarding discontinuation of statin treatme...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16219
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:To alert persons in the public and private healthcare professions to the increasing trends in higher proportions of persons aged 50 and older who are newly diagnosed with human immunodeficiency virus (HIV) and who are living with HIV and acquired immunodeficiency syndrome (AIDS). DESIGN:Data from the period...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2007.01295.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:To study how well the scoring on each item of the MMSE relates to the sum-score when the purpose is to identify persons with cognitive impairment, and to identify an equally effective subset of MMSE items for predicting cognitive impairment. DESIGN:Retrospective survey of MMSE data for 850 elderly. SETTING...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1992.tb01804.x
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVES:To determine whether exercise-induced silent ischemia in older master athletes following a 3-month period of deconditioning is a predictor of future cardiovascular events. DESIGN:A longitudinal study of a cohort of master athletes. SETTING:The Geriatric Research Education and Clinical Center (GRECC), Balti...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2000.tb04722.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:To describe the medical decisions confronting healthcare proxies (HCPs) of nursing home (NH) residents with advanced dementia and to identify factors associated with greater decision-making satisfaction. DESIGN:Prospective cohort study. SETTING:Twenty-two Boston-area NHs. PARTICIPANTS:Three hundred twenty...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02304.x
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Coffee and tea are two of the most widely consumed beverages worldwide and have been associated with reduced risk of mortality in some studies. However, it is unknown whether consumption of these beverages is associated with survival to an advanced age. OBJECTIVE:To examine associations of coffee and tea co...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16467
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:To determine whether sex differences in large-artery stiffness contribute to the greater prevalence of systolic hypertension in elderly women than in elderly men. DESIGN:During a single visit arterial stiffness was assessed in the unmedicated state using four parameters. PARTICIPANTS:Three hundred seventy-...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52107.x
更新日期:2004-03-01 00:00:00
abstract::Older driver safety is a growing public health concern for which interventions are currently being sought. Statistics show that older drivers suffer a disproportionately high rate of motor vehicle fatalities compared with other adult drivers. This disproportion is due to two factors: an increased crash rate per vehicl...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52025.x
更新日期:2004-01-01 00:00:00